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WO2003046564A3 - Marqueurs biopolymeres proteiques predictifs de la maladie d'alzheimer - Google Patents

Marqueurs biopolymeres proteiques predictifs de la maladie d'alzheimer Download PDF

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Publication number
WO2003046564A3
WO2003046564A3 PCT/CA2002/001639 CA0201639W WO03046564A3 WO 2003046564 A3 WO2003046564 A3 WO 2003046564A3 CA 0201639 W CA0201639 W CA 0201639W WO 03046564 A3 WO03046564 A3 WO 03046564A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
alzheimers disease
absence
ability
biopolymer markers
Prior art date
Application number
PCT/CA2002/001639
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English (en)
Other versions
WO2003046564A2 (fr
Inventor
George Jackowski
John Marshall
Original Assignee
Syn X Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syn X Pharma Inc filed Critical Syn X Pharma Inc
Priority to JP2003547952A priority Critical patent/JP2005510720A/ja
Priority to AU2002335963A priority patent/AU2002335963A1/en
Publication of WO2003046564A2 publication Critical patent/WO2003046564A2/fr
Publication of WO2003046564A3 publication Critical patent/WO2003046564A3/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne l'utilisation d'une combinaison d'opérations préparatoires conjointement avec des procédés de spectrométrie de masse et de détection de temps de vol pour maximiser la diversité des biopolymères vérifiables dans un échantillon particulier. La cohorte de biopolymères vérifiés dans ledit échantillon sont considérés par rapport à leur aptitude à montrer au moins un état pathologique particulier, ce qui permet au médecin de caractériser la présence ou l'absence dudit état pathologique en fonction de la détermination de la présence et/ou de l'absence dudit polymère, de prévoir l'évaluation des risques de contracter la maladie, et de mettre au point des méthodes thérapeutiques contre la maladie en question.
PCT/CA2002/001639 2001-11-23 2002-10-31 Marqueurs biopolymeres proteiques predictifs de la maladie d'alzheimer WO2003046564A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2003547952A JP2005510720A (ja) 2001-11-23 2002-10-31 アルツハイマー病を予測するタンパク質バイオポリマーマーカー
AU2002335963A AU2002335963A1 (en) 2001-11-23 2002-10-31 Protein biopolymer markers predictive of alzheimers disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99329801A 2001-11-23 2001-11-23
US09/993,298 2001-11-23

Publications (2)

Publication Number Publication Date
WO2003046564A2 WO2003046564A2 (fr) 2003-06-05
WO2003046564A3 true WO2003046564A3 (fr) 2004-02-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/001639 WO2003046564A2 (fr) 2001-11-23 2002-10-31 Marqueurs biopolymeres proteiques predictifs de la maladie d'alzheimer

Country Status (3)

Country Link
JP (1) JP2005510720A (fr)
AU (1) AU2002335963A1 (fr)
WO (1) WO2003046564A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2537955A1 (fr) * 2003-09-05 2005-03-17 Royal Women's Hospital Marqueur pour le diagnostic du cancer de l'ovaire

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018801A2 (fr) * 1998-09-29 2000-04-06 Roenn Lars Christian B Composes se liant aux n-cam
WO2001005422A2 (fr) * 1999-07-15 2001-01-25 Biomerieux Stelhys Utilisation d'un polypeptique pour detecter, prevenir ou traiter un etat pathologique associe a une maladie degenerative, neurologique autoimmune
WO2001057275A2 (fr) * 2000-02-04 2001-08-09 Aeomica, Inc. Sondes d'acide nucleique a un seul exon derivees du genome humain utiles pour analyser l'expression genique dans le cerveau humain

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018801A2 (fr) * 1998-09-29 2000-04-06 Roenn Lars Christian B Composes se liant aux n-cam
WO2001005422A2 (fr) * 1999-07-15 2001-01-25 Biomerieux Stelhys Utilisation d'un polypeptique pour detecter, prevenir ou traiter un etat pathologique associe a une maladie degenerative, neurologique autoimmune
WO2001057275A2 (fr) * 2000-02-04 2001-08-09 Aeomica, Inc. Sondes d'acide nucleique a un seul exon derivees du genome humain utiles pour analyser l'expression genique dans le cerveau humain

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DING LI ET AL: "The cloning and characterization of a novel human diacylglycerol kinase, DGKiota", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 49, 4 December 1998 (1998-12-04), pages 32746 - 32752, XP001154741, ISSN: 0021-9258 *
HARRIS E ET AL: "GAIN-OF-FUNCTION MUTATIONS IN A HUMAN CALMODULIN-LIKE PROTEIN IDENTIFY RESIDUES CRITICAL FOR CALMODULIN ACTION IN YEAST", MOLECULAR AND GENERAL GENETICS, SPRINGER VERLAG, BERLIN,, DE, vol. 247, no. 2, 1995, pages 137 - 147, XP000887215, ISSN: 0026-8925 *
HEMPERLY J J ET AL: "Characterization of cDNA clones defining variant forms of human neural cell adhesion molecule N-CAM.", JOURNAL OF MOLECULAR NEUROSCIENCE: MN. UNITED STATES 1990, vol. 2, no. 2, 1990, pages 71 - 78, XP009020161, ISSN: 0895-8696 *
KRIEG P A ET AL: "Primary structure and developmental expression of a large cytoplasmic domain form of Xenopus laevis neural cell adhesion molecule (NCAM).", NUCLEIC ACIDS RESEARCH. ENGLAND 25 DEC 1989, vol. 17, no. 24, 25 December 1989 (1989-12-25), pages 10321 - 10335, XP001155781, ISSN: 0305-1048 *
SMITH FRANCES J D ET AL: "Cloning of human, murine, and marsupial keratin 7 and a survey of K7 expression in the mouse.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 297, no. 4, 4 October 2002 (2002-10-04), October 4, 2002, pages 818 - 827, XP001152981, ISSN: 0006-291X *
YANG F ET AL: "IDENTIFICATION AND CHARACTERIZATION OF HUMAN HAPTO GLOBIN COMPLEMENTARY DNA", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 80, no. 19, 1983, 1983, pages 5875 - 5879, XP009020251, ISSN: 0027-8424 *
YASWEN ET AL: "Down-regulation of a calmodulin-related gene during transformation of human mammary epithelial cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 87, October 1990 (1990-10-01), pages 7360 - 7364, XP002116285, ISSN: 0027-8424 *
ZATLOUKAL KURT ET AL: "p62 is a common component of cytoplasmic inclusions in protein aggregation diseases.", AMERICAN JOURNAL OF PATHOLOGY, vol. 160, no. 1, January 2002 (2002-01-01), January, 2002, pages 255 - 263, XP009012659, ISSN: 0002-9440 *

Also Published As

Publication number Publication date
AU2002335963A1 (en) 2003-06-10
JP2005510720A (ja) 2005-04-21
WO2003046564A2 (fr) 2003-06-05

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