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WO2003040119A8 - Inhibiteurs de l'angiogenese - Google Patents

Inhibiteurs de l'angiogenese

Info

Publication number
WO2003040119A8
WO2003040119A8 PCT/FR2002/003721 FR0203721W WO03040119A8 WO 2003040119 A8 WO2003040119 A8 WO 2003040119A8 FR 0203721 W FR0203721 W FR 0203721W WO 03040119 A8 WO03040119 A8 WO 03040119A8
Authority
WO
WIPO (PCT)
Prior art keywords
angiogenesis inhibitors
octan
oxa
spiro
human
Prior art date
Application number
PCT/FR2002/003721
Other languages
English (en)
Other versions
WO2003040119A1 (fr
Inventor
Jacques Eustache
Jean-Guy Boiteau
Celine Tarnus
Vincent Rodeschini
De Weghe Pierre Van
Original Assignee
Galderma Res & Dev
Jacques Eustache
Jean-Guy Boiteau
Celine Tarnus
Vincent Rodeschini
De Weghe Pierre Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev, Jacques Eustache, Jean-Guy Boiteau, Celine Tarnus, Vincent Rodeschini, De Weghe Pierre Van filed Critical Galderma Res & Dev
Priority to JP2003542165A priority Critical patent/JP2005519026A/ja
Priority to EP02795355A priority patent/EP1480964A1/fr
Publication of WO2003040119A1 publication Critical patent/WO2003040119A1/fr
Publication of WO2003040119A8 publication Critical patent/WO2003040119A8/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention se rapporte à de nouveaux dérivés du 1-oxa-spiro [2, 5] octan-6-0l de formule générale (1): ainsi qu'à leur méthode de préparation, et leur utilisation dans des compositions pharmaceutiques destinées à un usage en médicine humaine ou vétérinaire, ou dans des compositions cosmétiques.
PCT/FR2002/003721 2001-11-09 2002-10-29 Inhibiteurs de l'angiogenese WO2003040119A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2003542165A JP2005519026A (ja) 2001-11-09 2002-10-29 血管新生阻害剤
EP02795355A EP1480964A1 (fr) 2001-11-09 2002-10-29 Inhibiteurs de l'angiogenese

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR01/14542 2001-11-09
FR0114542A FR2832149B1 (fr) 2001-11-09 2001-11-09 Nouveaux inhibiteurs de l'angiogenese et leur utilisation pharmaceutique et cosmetique

Publications (2)

Publication Number Publication Date
WO2003040119A1 WO2003040119A1 (fr) 2003-05-15
WO2003040119A8 true WO2003040119A8 (fr) 2003-11-27

Family

ID=8869256

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2002/003721 WO2003040119A1 (fr) 2001-11-09 2002-10-29 Inhibiteurs de l'angiogenese

Country Status (5)

Country Link
EP (1) EP1480964A1 (fr)
JP (1) JP2005519026A (fr)
AR (1) AR037341A1 (fr)
FR (1) FR2832149B1 (fr)
WO (1) WO2003040119A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2872511B1 (fr) * 2004-06-30 2006-08-11 Galderma Res & Dev Nouveaux inhibiteurs de l'angiogenese et leur utilisation pharmaceutique et cosmetique
US8299067B2 (en) * 2008-03-27 2012-10-30 Versitech Limited 5-demethoxyfumagillol and derivatives thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68915900T2 (de) * 1988-09-01 1994-11-24 Childrens Medical Center Angiogenese hemmendes Mittel.
EP0682020A1 (fr) * 1988-09-01 1995-11-15 Takeda Chemical Industries, Ltd. Dérivés de fumagillol utiles comme inhibiteurs d'angiogenèse
DE69001187T2 (de) * 1989-03-06 1993-07-08 Takeda Chemical Industries Ltd 6-epifumagillole, ihre herstellung und ihre verwendung.
US6017954A (en) * 1989-08-10 2000-01-25 Children's Medical Center Corp. Method of treating tumors using O-substituted fumagillol derivatives
ATE219928T1 (de) * 1995-02-28 2002-07-15 Gillette Co Verwendung von angiogenese-suppressoren zur hemmung des haarwuchses
WO1998056372A1 (fr) * 1997-06-09 1998-12-17 Massachusetts Institute Of Technology Inhibiteurs de la methionine aminopeptidase de type 2 et leurs utilisations
WO1999061432A1 (fr) * 1998-05-12 1999-12-02 Biochem Pharma Inc. Analogues de fumagillin et leur utilisation comme inhibiteurs de l'angiogenese

Also Published As

Publication number Publication date
EP1480964A1 (fr) 2004-12-01
JP2005519026A (ja) 2005-06-30
AR037341A1 (es) 2004-11-03
WO2003040119A1 (fr) 2003-05-15
FR2832149B1 (fr) 2006-01-06
FR2832149A1 (fr) 2003-05-16

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