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WO2002038769A3 - Für expression in eukaryonten optimierte hpv 16-l1 und hpv 16-l2 kodierende dna-sequenzen - Google Patents

Für expression in eukaryonten optimierte hpv 16-l1 und hpv 16-l2 kodierende dna-sequenzen Download PDF

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WO2002038769A3
WO2002038769A3 PCT/DE2001/003618 DE0103618W WO0238769A3 WO 2002038769 A3 WO2002038769 A3 WO 2002038769A3 DE 0103618 W DE0103618 W DE 0103618W WO 0238769 A3 WO0238769 A3 WO 0238769A3
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hpv
dna sequences
optimised
eukaryotic
code
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PCT/DE2001/003618
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French (fr)
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WO2002038769A2 (de
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Martin Mueller
Christoph Leder
Juergen Kleinschmidt
Uwe Sonnewald
Sophia Biemelt
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Deutsches Krebsforsch
Martin Mueller
Christoph Leder
Juergen Kleinschmidt
Uwe Sonnewald
Sophia Biemelt
Ipk Inst Fuer Pflanzengenetik
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Application filed by Deutsches Krebsforsch, Martin Mueller, Christoph Leder, Juergen Kleinschmidt, Uwe Sonnewald, Sophia Biemelt, Ipk Inst Fuer Pflanzengenetik filed Critical Deutsches Krebsforsch
Priority to AU2002213806A priority Critical patent/AU2002213806A1/en
Publication of WO2002038769A2 publication Critical patent/WO2002038769A2/de
Publication of WO2002038769A3 publication Critical patent/WO2002038769A3/de

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Mycology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Abstract

Beschrieben werden hinsichtlich der Codon-Verwendung optimierte DNA-Sequenzen, die ein HPV 16-Kapsidprotein L1 bzw. HPV 16-Kapsidprotein L2 kodieren. Diese DNA-Sequenzen umfassen die in den Figuren 5, 6 oder 7 gezeigten DNA-Sequenzen oder Fragmente oder Varianten dieser DNA-Sequenzen und erlauben die einfache rekombinante Herstellung von HPV 16-L1- bzw. L2-Kapsidproteinen oder Fragmenten davon mit hoher Ausbeute unter Vermeidung der Verwendung viraler Vektoren, vorzugsweise zur Herstellung von Vakzinen.
PCT/DE2001/003618 2000-11-09 2001-09-19 Für expression in eukaryonten optimierte hpv 16-l1 und hpv 16-l2 kodierende dna-sequenzen WO2002038769A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002213806A AU2002213806A1 (en) 2000-11-09 2001-09-19 Dna sequences, which code for optimised eukaryotic hpv 16-l1 and hpv 16-l2

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10055545.4 2000-11-09
DE10055545A DE10055545A1 (de) 2000-11-09 2000-11-09 Für Expression in Eukaryonten optimierte HPV 16-L1 und HPV 16-L2 kodierende DNA Sequenzen

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WO2002038769A2 WO2002038769A2 (de) 2002-05-16
WO2002038769A3 true WO2002038769A3 (de) 2003-01-09

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PCT/DE2001/003618 WO2002038769A2 (de) 2000-11-09 2001-09-19 Für expression in eukaryonten optimierte hpv 16-l1 und hpv 16-l2 kodierende dna-sequenzen

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AU (1) AU2002213806A1 (de)
DE (1) DE10055545A1 (de)
WO (1) WO2002038769A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003018624A1 (en) * 2001-08-31 2003-03-06 University Of Cape Town Vectors, constructs, and transgenic plants for hpv-11 and hpv-16 l1 capsid protein
KR20060003903A (ko) * 2003-05-05 2006-01-11 이스티투토 디 리세르쉐 디 비올로지아 몰레콜라레 피. 안젤레티에스.피.에이. 사람 암배아 항원을 암호화하는 합성 유전자 및 이의 용도
CA2555013C (en) 2004-02-11 2013-10-15 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Carcinoembryonic antigen fusions and uses thereof
WO2008026869A1 (en) 2006-08-28 2008-03-06 Sungkyunkwan University Foundation For Corporate Collaboration A dna vaccine for treating or preventing cervical cancer comprising a gene encoding hpv protein
MX2010005699A (es) * 2007-11-23 2010-09-14 Shanghai Zerun Biotechnology C Genes que codifican para la proteina l1 mayor de la capside del virus del papiloma humano y uso de los mismos.
BR102019025802A2 (pt) 2019-12-05 2022-01-18 Instituto Butantan Processo de produção de uma composição imunológica de dna profilática e terapêutica contra hpv e cânceres associados ao vírus, proteína híbrida, vetor de expressão, composição imunológica e seus usos

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WO1999002694A1 (en) * 1997-07-09 1999-01-21 The University Of Queensland Nucleic acid sequence and method for selectively expressing a protein in a target cell or tissue
WO1999018220A1 (en) * 1997-10-06 1999-04-15 Loyola University Of Chicago Papilloma virus capsomere vaccine formulations and methods of use
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WO1994012632A1 (en) * 1992-11-27 1994-06-09 University College London Improvements in nucleic acid synthesis by pcr
US6114148A (en) * 1996-09-20 2000-09-05 The General Hospital Corporation High level expression of proteins
US6114148C1 (en) * 1996-09-20 2012-05-01 Gen Hospital Corp High level expression of proteins
WO1999002694A1 (en) * 1997-07-09 1999-01-21 The University Of Queensland Nucleic acid sequence and method for selectively expressing a protein in a target cell or tissue
WO1999018220A1 (en) * 1997-10-06 1999-04-15 Loyola University Of Chicago Papilloma virus capsomere vaccine formulations and methods of use
CA2229955A1 (en) * 1998-02-20 1999-08-20 Medigene Gmbh Papilloma virus capsomere vaccine formulations and methods of use
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WO2001014416A2 (en) * 1999-08-25 2001-03-01 Merck & Co., Inc. Synthetic papillomavirus genes optimized for expression in human cells

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DE10055545A1 (de) 2002-07-25
WO2002038769A2 (de) 2002-05-16
AU2002213806A1 (en) 2002-05-21

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