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WO2002038126A3 - A process for production of particles for pharmaceutical compositions having increased bioavailability - Google Patents

A process for production of particles for pharmaceutical compositions having increased bioavailability Download PDF

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Publication number
WO2002038126A3
WO2002038126A3 PCT/DK2001/000715 DK0100715W WO0238126A3 WO 2002038126 A3 WO2002038126 A3 WO 2002038126A3 DK 0100715 W DK0100715 W DK 0100715W WO 0238126 A3 WO0238126 A3 WO 0238126A3
Authority
WO
WIPO (PCT)
Prior art keywords
particles
production
increased bioavailability
pharmaceutical compositions
hpmcas
Prior art date
Application number
PCT/DK2001/000715
Other languages
French (fr)
Other versions
WO2002038126A2 (en
Inventor
Ove Emil Hansen
Original Assignee
Ove Emil Hansen
Aeromatic Fielder Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ove Emil Hansen, Aeromatic Fielder Ag filed Critical Ove Emil Hansen
Priority to AU2002212102A priority Critical patent/AU2002212102A1/en
Publication of WO2002038126A2 publication Critical patent/WO2002038126A2/en
Publication of WO2002038126A3 publication Critical patent/WO2002038126A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for production of particles for a pharmaceutical composition having increased bioavailability is disclosed. the process involves spraying a core with a solution or dispersion comprising hydroxypropylmethylcellulose acetate succinate (HPMCAS) and a sparingly water-soluble pharmaceutical active compound in an evaporable liquid, evaporating the liquid to obtain a deposit of HPMCAS and the sparingly water-soluble pharmaceutical active compounds, and repeating the process until a predetermined particle size or weight is obtained.
PCT/DK2001/000715 2000-11-08 2001-10-29 A process for production of particles for pharmaceutical compositions having increased bioavailability WO2002038126A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002212102A AU2002212102A1 (en) 2000-11-08 2001-10-29 A process for production of particles for pharmaceutical compositions having increased bioavailability

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70796600A 2000-11-08 2000-11-08
US09/707,966 2000-11-08

Publications (2)

Publication Number Publication Date
WO2002038126A2 WO2002038126A2 (en) 2002-05-16
WO2002038126A3 true WO2002038126A3 (en) 2002-10-10

Family

ID=24843867

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2001/000715 WO2002038126A2 (en) 2000-11-08 2001-10-29 A process for production of particles for pharmaceutical compositions having increased bioavailability

Country Status (2)

Country Link
AU (1) AU2002212102A1 (en)
WO (1) WO2002038126A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103153343B (en) * 2010-06-14 2015-02-11 陶氏环球技术有限责任公司 Hydroxypropyl methyl cellulose acetate succinate with enhanced acetate and succinate substitution
US9084727B2 (en) 2011-05-10 2015-07-21 Bend Research, Inc. Methods and compositions for maintaining active agents in intra-articular spaces

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10026698A1 (en) 2000-05-30 2001-12-06 Basf Ag Self-emulsifying active ingredient formulation and use of this formulation
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
DE10355461A1 (en) 2003-11-27 2005-06-23 Bayer Healthcare Ag Solid, high bioavailabilty oral formulations of N-substituted 5-chloro-2-thiophene-carboxamide derivative in hydrophilized form, useful for combating thrombo-embolic diseases
WO2005115330A2 (en) * 2004-05-28 2005-12-08 Pfizer Products Inc. Pharmaceutical compositions with enhanced performance
JP4947658B2 (en) 2004-06-24 2012-06-06 バーテックス ファーマシューティカルズ インコーポレイテッド ATP-binding cassette transporter modulator
BRPI0620960A2 (en) 2005-12-28 2011-11-29 Vertex Pharmaceuticals Incorporated n- [2,4-bis (1,1-dimethylethyl) -5-hydroxyphenyl] -1,4-didro-4-oxyquinoline-3-carboxamide solid forms
MX361711B (en) 2009-03-20 2018-12-14 Vertex Pharmaceuticals Incorporated Star Process for making modulators of cystic fibrosis transmembrane conductance regulator.
NZ629199A (en) 2012-02-27 2017-01-27 Vertex Pharma Pharmaceutical compositions comprising a solid dispersion of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US9701639B2 (en) 2014-10-07 2017-07-11 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0344603A1 (en) * 1988-05-30 1989-12-06 Zeria Pharmaceutical Co., Ltd. Pharmaceutical composition of dihydropyridine compound
WO1993000991A1 (en) * 1991-07-03 1993-01-21 Smithkline Beecham Plc Process for preparing drug substances in beadlet form
WO1995020432A1 (en) * 1994-01-27 1995-08-03 Aeromatic-Fielder Ag An apparatus for coating solid particles
EP0901786A2 (en) * 1997-08-11 1999-03-17 Pfizer Products Inc. Solid pharmaceutical dispersions with enhanced bioavailability
US5985322A (en) * 1997-05-29 1999-11-16 Eli Lilly And Company Method for the treatment of CNS disorders
WO2000040339A1 (en) * 1998-12-30 2000-07-13 Aeromatic-Fielder Ag An apparatus and a process for coating tablets

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0344603A1 (en) * 1988-05-30 1989-12-06 Zeria Pharmaceutical Co., Ltd. Pharmaceutical composition of dihydropyridine compound
WO1993000991A1 (en) * 1991-07-03 1993-01-21 Smithkline Beecham Plc Process for preparing drug substances in beadlet form
WO1995020432A1 (en) * 1994-01-27 1995-08-03 Aeromatic-Fielder Ag An apparatus for coating solid particles
US5985322A (en) * 1997-05-29 1999-11-16 Eli Lilly And Company Method for the treatment of CNS disorders
EP0901786A2 (en) * 1997-08-11 1999-03-17 Pfizer Products Inc. Solid pharmaceutical dispersions with enhanced bioavailability
WO2000040339A1 (en) * 1998-12-30 2000-07-13 Aeromatic-Fielder Ag An apparatus and a process for coating tablets

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103153343B (en) * 2010-06-14 2015-02-11 陶氏环球技术有限责任公司 Hydroxypropyl methyl cellulose acetate succinate with enhanced acetate and succinate substitution
US9084727B2 (en) 2011-05-10 2015-07-21 Bend Research, Inc. Methods and compositions for maintaining active agents in intra-articular spaces

Also Published As

Publication number Publication date
AU2002212102A1 (en) 2002-05-21
WO2002038126A2 (en) 2002-05-16

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