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WO2002037944A3 - Multiplexed cell analysis system - Google Patents

Multiplexed cell analysis system Download PDF

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Publication number
WO2002037944A3
WO2002037944A3 PCT/US2001/051413 US0151413W WO0237944A3 WO 2002037944 A3 WO2002037944 A3 WO 2002037944A3 US 0151413 W US0151413 W US 0151413W WO 0237944 A3 WO0237944 A3 WO 0237944A3
Authority
WO
WIPO (PCT)
Prior art keywords
analysis system
cell analysis
multiplexed cell
multiplexed
amalysis
Prior art date
Application number
PCT/US2001/051413
Other languages
French (fr)
Other versions
WO2002037944A2 (en
Inventor
Ilva Ravkin
Simon Goldbard
Michael A Zarowitz
Oren E Beske
Original Assignee
Virtual Arrays Inc
Ilva Ravkin
Simon Goldbard
Michael A Zarowitz
Oren E Beske
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virtual Arrays Inc, Ilva Ravkin, Simon Goldbard, Michael A Zarowitz, Oren E Beske filed Critical Virtual Arrays Inc
Priority to EP01986240A priority Critical patent/EP1395601A4/en
Priority to AU2002236691A priority patent/AU2002236691A1/en
Priority to CA002424176A priority patent/CA2424176A1/en
Priority to GB0311360A priority patent/GB2384777B/en
Priority to JP2002540546A priority patent/JP2004537712A/en
Priority to AU3669102A priority patent/AU3669102A/en
Priority to US10/120,900 priority patent/US7557070B2/en
Publication of WO2002037944A2 publication Critical patent/WO2002037944A2/en
Priority to PCT/US2002/033350 priority patent/WO2004034012A2/en
Priority to US10/273,605 priority patent/US20030129654A1/en
Priority to EP02807992A priority patent/EP1585958A4/en
Priority to AU2002368207A priority patent/AU2002368207A1/en
Priority to US10/282,904 priority patent/US20030134330A1/en
Priority to US10/382,797 priority patent/US20030166015A1/en
Priority to US10/382,818 priority patent/US20030219800A1/en
Priority to US10/407,630 priority patent/US20030207249A1/en
Priority to US10/444,573 priority patent/US20040018485A1/en
Publication of WO2002037944A3 publication Critical patent/WO2002037944A3/en
Priority to US10/842,954 priority patent/US7338773B2/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00513—Essentially linear supports
    • B01J2219/0052—Essentially linear supports in the shape of elongated tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00533—Sheets essentially rectangular
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00545—Colours
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00565—Electromagnetic means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • B01J2219/00743—Cells
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Systems including apparatus, methods, compositions, and kits for multiplexed amalysis of biological systems using nonpositional and/or positional arrays of coded carriers.
PCT/US2001/051413 1999-04-15 2001-10-18 Multiplexed cell analysis system WO2002037944A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
EP01986240A EP1395601A4 (en) 2000-10-18 2001-10-18 Multiplexed cell analysis system
AU2002236691A AU2002236691A1 (en) 2000-10-18 2001-10-18 Multiplexed cell analysis system
CA002424176A CA2424176A1 (en) 2000-10-18 2001-10-18 Multiplexed cell analysis system
GB0311360A GB2384777B (en) 2000-10-18 2001-10-18 Multiplexed cell analysis system
JP2002540546A JP2004537712A (en) 2000-10-18 2001-10-18 Multiple cell analysis system
AU3669102A AU3669102A (en) 2000-10-18 2001-10-19 Multiplexed cell analysis system
US10/120,900 US7557070B2 (en) 2000-10-18 2002-04-10 Multiplexed cell analysis system
AU2002368207A AU2002368207A1 (en) 2001-10-18 2002-10-18 Coded particles for multiplexed analysis of biological samples
US10/273,605 US20030129654A1 (en) 1999-04-15 2002-10-18 Coded particles for multiplexed analysis of biological samples
PCT/US2002/033350 WO2004034012A2 (en) 2001-10-18 2002-10-18 Coded particles for multiplexed analysis of biological samples
EP02807992A EP1585958A4 (en) 2001-10-18 2002-10-18 Coded particles for multiplexed analysis of biological samples
US10/282,904 US20030134330A1 (en) 1999-04-15 2002-10-28 Chemical-library composition and method
US10/382,797 US20030166015A1 (en) 1999-04-15 2003-03-05 Multiplexed analysis of cell-substrate interactions
US10/382,818 US20030219800A1 (en) 2001-10-18 2003-03-05 Multiplexed cell transfection using coded carriers
US10/407,630 US20030207249A1 (en) 1999-04-15 2003-04-04 Connection of cells to substrates using association pairs
US10/444,573 US20040018485A1 (en) 1999-04-15 2003-05-23 Multiplexed analysis of cells
US10/842,954 US7338773B2 (en) 2000-04-14 2004-05-10 Multiplexed assays of cell migration

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
US24171400P 2000-10-18 2000-10-18
US60/241,714 2000-10-18
US25941600P 2000-12-28 2000-12-28
US60/259,416 2000-12-28
US29386301P 2001-05-24 2001-05-24
US60/293,863 2001-05-24
US29926701P 2001-06-18 2001-06-18
US60/299,267 2001-06-18
US29981001P 2001-06-20 2001-06-20
US60/299,810 2001-06-20
US30765001P 2001-07-24 2001-07-24
US30764901P 2001-07-24 2001-07-24
US60/307,649 2001-07-24
US60/307,650 2001-07-24
US31054001P 2001-08-06 2001-08-06
US60/310,540 2001-08-06
US31740901P 2001-09-04 2001-09-04
US60/317,409 2001-09-04
US31815601P 2001-09-07 2001-09-07
US60/318,156 2001-09-07
US32861501P 2001-10-10 2001-10-10

Publications (2)

Publication Number Publication Date
WO2002037944A2 WO2002037944A2 (en) 2002-05-16
WO2002037944A3 true WO2002037944A3 (en) 2003-12-24

Family

ID=27582746

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/051413 WO2002037944A2 (en) 1999-04-15 2001-10-18 Multiplexed cell analysis system

Country Status (4)

Country Link
AU (1) AU2002236691A1 (en)
CA (1) CA2424176A1 (en)
GB (1) GB2384777B (en)
WO (1) WO2002037944A2 (en)

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US20040115692A1 (en) * 2000-04-03 2004-06-17 Cytyc Corporation Methods, compositions and apparatuses for detecting a target in a preservative solution
US7338773B2 (en) 2000-04-14 2008-03-04 Millipore Corporation Multiplexed assays of cell migration
JP2004537712A (en) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド Multiple cell analysis system
US6977152B2 (en) 2001-09-07 2005-12-20 Virtual Arrays, Inc. Biological assays using coded RNA reporters
AU2002368207A1 (en) * 2001-10-18 2004-05-04 Virtual Arrays, Inc. Coded particles for multiplexed analysis of biological samples
US7381375B2 (en) 2001-10-26 2008-06-03 Millipore Corporation Assay systems with adjustable fluid communication
AU2003213790A1 (en) * 2002-03-05 2003-09-22 Vitra Bioscience, Inc. Multiplexed analysis of cell-substrate interactions
US20070054266A1 (en) * 2002-05-28 2007-03-08 National Institute Of Advanced Industrial Science And Technology Chemical sensor system
GB2391230A (en) * 2002-07-26 2004-02-04 Smartbead Technologies Ltd Multiparameter assays using coded supports
US7105347B2 (en) 2002-07-30 2006-09-12 Corning Incorporated Method and device for protein delivery into cells
US7691580B2 (en) 2003-01-29 2010-04-06 Corning Incorporated Reverse protein delivery into cells on coded microparticles
US7488451B2 (en) 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
WO2005064338A1 (en) * 2003-12-23 2005-07-14 University Of Florida Research Foundation, Inc. Microparticles for use in diagnostic methods
GB2423581A (en) * 2005-02-28 2006-08-30 Smartbead Technologies Ltd Particulate sets carrying a unique identifier for assays
DE102008057067A1 (en) * 2008-11-13 2010-05-20 BF-BIOlabs Schneider und Zeltz GbR (Vertretungsberechtigten Gesellschafter: Dr. Patric Zeltz 79211 Denzlingen und Stephan Schneider 79211 Denzlingen Apparatus for parallel micro-array experiments, e.g. in DNA analysis, has a micro-titration plate with reaction vessels and a micro-array to one side of them
WO2011149009A1 (en) 2010-05-28 2011-12-01 オリンパス株式会社 Cell sorter, cell sorting system, and cell sorting method
CN103221800B (en) 2010-11-19 2015-07-15 奥林巴斯株式会社 Method for preparing biological sample
CN103547905B (en) 2011-05-20 2015-09-09 奥林巴斯株式会社 The manufacture method of substrate film
JP5996550B2 (en) 2011-11-24 2016-09-21 オリンパス株式会社 Cell sorting device and cell sorting method
CN103645308B (en) * 2013-12-09 2015-06-03 东南大学 Two-dimensional coding method of micro-carrier
WO2017178621A2 (en) 2016-04-14 2017-10-19 Morgan Innovation & Technology Ltd Methods and devices for measuring the levels of analytes in body fluids

Citations (1)

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US6083763A (en) * 1996-12-31 2000-07-04 Genometrix Inc. Multiplexed molecular analysis apparatus and method

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US5961923A (en) * 1995-04-25 1999-10-05 Irori Matrices with memories and uses thereof
WO1997020074A1 (en) * 1995-11-30 1997-06-05 Wlodek Mandecki Electronically-solid-phase assay biomolecules
US6210910B1 (en) * 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
US6093370A (en) * 1998-06-11 2000-07-25 Hitachi, Ltd. Polynucleotide separation method and apparatus therefor
US7225082B1 (en) * 1999-10-01 2007-05-29 Oxonica, Inc. Colloidal rod particles as nanobar codes

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US6083763A (en) * 1996-12-31 2000-07-04 Genometrix Inc. Multiplexed molecular analysis apparatus and method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1395601A4 *

Also Published As

Publication number Publication date
GB2384777A (en) 2003-08-06
WO2002037944A2 (en) 2002-05-16
GB2384777B (en) 2005-03-02
AU2002236691A1 (en) 2002-05-21
CA2424176A1 (en) 2002-05-16
GB0311360D0 (en) 2003-06-25

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