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WO2002034890A3 - Cellules souches pluripotentes - Google Patents

Cellules souches pluripotentes Download PDF

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Publication number
WO2002034890A3
WO2002034890A3 PCT/GB2001/004747 GB0104747W WO0234890A3 WO 2002034890 A3 WO2002034890 A3 WO 2002034890A3 GB 0104747 W GB0104747 W GB 0104747W WO 0234890 A3 WO0234890 A3 WO 0234890A3
Authority
WO
WIPO (PCT)
Prior art keywords
stem cells
somatic
lower relative
relative potency
derived
Prior art date
Application number
PCT/GB2001/004747
Other languages
English (en)
Other versions
WO2002034890A2 (fr
Inventor
Austin Gerrard Smith
Qi Long Ying
Original Assignee
Univ Edinburgh
Austin Gerrard Smith
Qi Long Ying
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Edinburgh, Austin Gerrard Smith, Qi Long Ying filed Critical Univ Edinburgh
Priority to AU2001295793A priority Critical patent/AU2001295793A1/en
Publication of WO2002034890A2 publication Critical patent/WO2002034890A2/fr
Publication of WO2002034890A3 publication Critical patent/WO2002034890A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/235—Leukemia inhibitory factor [LIF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/08—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cells of the nervous system

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des cellules souches de mammifères dérivées de cellules souches somatiques d'une puissance relativement inférieure. En particulier, les cellules souches pluripotentes sont obtenues à partir de cellules souches somatiques présentant une puissance relative inférieure. L'invention traite également de lignées cellulaires souches de mammifères qui peuvent se régénérer in vitro avec stabilité, lesquelles lignées sont dérivées de cellules souches somatiques de puissance relative inférieure. En outre les procédés selon l'invention sont prévus pour produire des cellules souches de mammifères, des lignées cellulaires et des cellules de mammifères non humains dérivées de cellules souches somatiques présentant une puissance relative inférieure. L'invention traite aussi de procédés permettant de reprogrammer un noyau d'une cellule somatique afin de devenir une cellule souche moins différentiée.
PCT/GB2001/004747 2000-10-26 2001-10-26 Cellules souches pluripotentes WO2002034890A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001295793A AU2001295793A1 (en) 2000-10-26 2001-10-26 Pluripotential stem cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0026252A GB0026252D0 (en) 2000-10-26 2000-10-26 Pluripotential stem cells
GB0026252.7 2000-10-26

Publications (2)

Publication Number Publication Date
WO2002034890A2 WO2002034890A2 (fr) 2002-05-02
WO2002034890A3 true WO2002034890A3 (fr) 2002-11-14

Family

ID=9902036

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/004747 WO2002034890A2 (fr) 2000-10-26 2001-10-26 Cellules souches pluripotentes

Country Status (3)

Country Link
AU (1) AU2001295793A1 (fr)
GB (1) GB0026252D0 (fr)
WO (1) WO2002034890A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2381292C (fr) 1999-08-05 2016-05-24 Mcl Llc Cellules souches adultes toutes-puissantes et procede d'isolement
US10638734B2 (en) 2004-01-05 2020-05-05 Abt Holding Company Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US8252280B1 (en) 1999-08-05 2012-08-28 Regents Of The University Of Minnesota MAPC generation of muscle
US8609412B2 (en) 1999-08-05 2013-12-17 Regents Of The University Of Minnesota Mapc generation of lung tissue
JP2004532648A (ja) * 2000-11-30 2004-10-28 ステムロン インコーポレイテッド 単離されたホモ接合性幹細胞、これ由来の分化細胞、ならびにこれを作製及び使用するための材料及び方法
JP2004529621A (ja) 2001-02-14 2004-09-30 ティー ファークト，レオ 多能性成体幹細胞、その起源、それを得る方法および維持する方法、それを分化させる方法、その使用法、ならびにそれ由来の細胞
US7422736B2 (en) * 2002-07-26 2008-09-09 Food Industry Research And Development Institute Somatic pluripotent cells
US20060228798A1 (en) 2002-11-27 2006-10-12 Catherine Verfaillie Homologous recombination in multipotent adult progenitor cells
AU2006304318B2 (en) 2005-10-14 2012-12-06 Regents Of The University Of Minnesota Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype
CA2670497A1 (fr) 2006-11-24 2008-05-29 Regents Of The University Of Minnesota Cellules progenitrices endothermiques
CA2712496C (fr) 2008-01-18 2021-01-12 Wei-Shou Hu Agregats de cellules souches et procedes de preparation et d'utilisation
US9057051B2 (en) 2008-10-31 2015-06-16 Katholieke Universiteit Leuven Optimized methods for differentiation of cells into cells with hepatocyte progenitor phenotypes, cells produced by the methods, and methods of using the cells
CA2798895A1 (fr) 2010-05-12 2011-11-17 Abt Holding Company Modulation des splenocytes en therapie cellulaire
WO2011158125A2 (fr) 2010-06-17 2011-12-22 Katholieke Universiteit Leuven Procédé de différenciation de cellules en cellules étoilées du foie et en cellules endothéliales sinusoïdales du foie, cellules produites par ces procédés, et procédés d'utilisation des cellules
EP2609191B1 (fr) 2010-08-24 2017-11-22 Regents Of The University Of Minnesota Culture en suspension non statique d'agrégats cellulaires
PL2983680T3 (pl) 2013-04-12 2021-03-08 Houston Methodist Hospital Ulepszanie narządów do przeszczepu

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453357A (en) * 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
WO2002024873A1 (fr) * 2000-09-20 2002-03-28 Christopher Ralph Franks Therapie a base de cellules souches

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453357A (en) * 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
WO2002024873A1 (fr) * 2000-09-20 2002-03-28 Christopher Ralph Franks Therapie a base de cellules souches

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SVENDSEN C N & SMITH A G: "New prospects for human stem-cell therapy in the nervous system", TRENDS IN NEUROSCIENCE, vol. 22, no. 8, 1999, pages 357 - 364, XP001030096, ISSN: 0166-2236 *

Also Published As

Publication number Publication date
AU2001295793A1 (en) 2002-05-06
WO2002034890A2 (fr) 2002-05-02
GB0026252D0 (en) 2000-12-13

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