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WO2002032920A3 - Nucleosides modifies pour traiter des infections virales et une proliferation cellulaire anormale - Google Patents

Nucleosides modifies pour traiter des infections virales et une proliferation cellulaire anormale Download PDF

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Publication number
WO2002032920A3
WO2002032920A3 PCT/US2001/046113 US0146113W WO0232920A3 WO 2002032920 A3 WO2002032920 A3 WO 2002032920A3 US 0146113 W US0146113 W US 0146113W WO 0232920 A3 WO0232920 A3 WO 0232920A3
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WO
WIPO (PCT)
Prior art keywords
cellular proliferation
abnormal cellular
treatment
hcv
viral infections
Prior art date
Application number
PCT/US2001/046113
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English (en)
Other versions
WO2002032920A2 (fr
Inventor
Lieven Stuyver
Kyoichi A Watanabe
Original Assignee
Pharmasset Ltd
Lieven Stuyver
Kyoichi A Watanabe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26934330&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2002032920(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CA2426187A priority Critical patent/CA2426187C/fr
Priority to DK01987756.2T priority patent/DK1411954T3/da
Priority to CN01820816.9A priority patent/CN1646141B/zh
Priority to AU2002228749A priority patent/AU2002228749B2/en
Priority to AT01987756T priority patent/ATE491459T1/de
Priority to KR1020117007042A priority patent/KR101195019B1/ko
Priority to KR1020107014460A priority patent/KR101201552B1/ko
Application filed by Pharmasset Ltd, Lieven Stuyver, Kyoichi A Watanabe filed Critical Pharmasset Ltd
Priority to KR10-2003-7005461A priority patent/KR20040028657A/ko
Priority to EP01987756A priority patent/EP1411954B1/fr
Priority to BRPI0114837-0A priority patent/BR0114837A/pt
Priority to AU2874902A priority patent/AU2874902A/xx
Priority to JP2002536301A priority patent/JP2004533406A/ja
Priority to DE60143672T priority patent/DE60143672D1/de
Publication of WO2002032920A2 publication Critical patent/WO2002032920A2/fr
Publication of WO2002032920A3 publication Critical patent/WO2002032920A3/fr
Priority to HK05110563.1A priority patent/HK1078482A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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Abstract

L'invention concerne une composition et une méthode pour traiter une infection Flaviviridae (comprenant BVDV et HCV), Orthomyxoviridae (comprenant influenza A et influenza B) ou Paramyxoviridae (comprenant RSV) infection, ou des états dus à une prolifération cellulaire anormale chez un sujet, qui peut être animal et plus particulièrement humain, en faisant appel à un nucléoside de formule générale (I)-(XXIII) ou à son sel ou à son promédicament pharmaceutiquement acceptable. La présente invention porte également sur un processus efficace pour quantifier la charge virale, en particulier la charge virale BVDV, HCV ou la charge du virus West Nile, chez un sujet, par amplification en chaîne par polymérase en temps réel ('RT-PCR'). En outre, l'invention concerne aussi des molécules sondes qui fluorescent proportionnellement à la quantité de virus présente dans un échantillon.
PCT/US2001/046113 2000-10-18 2001-10-18 Nucleosides modifies pour traiter des infections virales et une proliferation cellulaire anormale WO2002032920A2 (fr)

Priority Applications (14)

Application Number Priority Date Filing Date Title
DE60143672T DE60143672D1 (de) 2000-10-18 2001-10-18 Modifizierte nukleoside zur behandlung von virusinfektionen und abnormaler zellulärer proliferation
KR10-2003-7005461A KR20040028657A (ko) 2000-10-18 2001-10-18 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한변형된 뉴클레오시드
CN01820816.9A CN1646141B (zh) 2000-10-18 2001-10-18 用于治疗病毒感染和异常细胞增殖的修饰核苷类化合物
AU2002228749A AU2002228749B2 (en) 2000-10-18 2001-10-18 Modified nucleosides for treatment of viral infections and abnormal cellular proliferation
AT01987756T ATE491459T1 (de) 2000-10-18 2001-10-18 Modifizierte nukleoside zur behandlung von virusinfektionen und abnormaler zellulärer proliferation
KR1020117007042A KR101195019B1 (ko) 2000-10-18 2001-10-18 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
KR1020107014460A KR101201552B1 (ko) 2000-10-18 2001-10-18 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
CA2426187A CA2426187C (fr) 2000-10-18 2001-10-18 Nucleosides modifies pour le traitement des infections virales et de la proliferation cellulaire anormale
BRPI0114837-0A BR0114837A (pt) 2000-10-18 2001-10-18 nucleosìdeos modificados para tratamento de infecções viróticas e proliferação celular anormal
DK01987756.2T DK1411954T3 (da) 2000-10-18 2001-10-18 Modificerede nukleosider til behandling af virusinfektioner og abnorm cellulær proliferation
EP01987756A EP1411954B1 (fr) 2000-10-18 2001-10-18 Nucleosides modifies pour traiter des infections virales et une proliferation cellulaire anormale
AU2874902A AU2874902A (en) 2000-10-18 2001-10-18 Modified nucleosides for treatment of viral infections and abnormal cellular proliferation
JP2002536301A JP2004533406A (ja) 2000-10-18 2001-10-18 ウイルス感染症および異常細胞増殖を治療するための修飾ヌクレオシド
HK05110563.1A HK1078482A1 (en) 2000-10-18 2005-11-22 Modified nucleosides for treatment of viral infections and abnormal cellular proliferation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24148800P 2000-10-18 2000-10-18
US60/241,488 2000-10-18
US28215601P 2001-04-06 2001-04-06
US60/282,156 2001-04-06

Publications (2)

Publication Number Publication Date
WO2002032920A2 WO2002032920A2 (fr) 2002-04-25
WO2002032920A3 true WO2002032920A3 (fr) 2004-02-19

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PCT/US2001/046113 WO2002032920A2 (fr) 2000-10-18 2001-10-18 Nucleosides modifies pour traiter des infections virales et une proliferation cellulaire anormale

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US (3) US20030087873A1 (fr)
EP (2) EP2251015B1 (fr)
JP (4) JP2004533406A (fr)
KR (6) KR20040028657A (fr)
CN (2) CN1646141B (fr)
AT (1) ATE491459T1 (fr)
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