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WO2002031478A8 - Methods and devices for assays using analyte-binding partners - Google Patents

Methods and devices for assays using analyte-binding partners

Info

Publication number
WO2002031478A8
WO2002031478A8 PCT/US2001/028626 US0128626W WO0231478A8 WO 2002031478 A8 WO2002031478 A8 WO 2002031478A8 US 0128626 W US0128626 W US 0128626W WO 0231478 A8 WO0231478 A8 WO 0231478A8
Authority
WO
WIPO (PCT)
Prior art keywords
analyte
binding partner
test portion
sample
assays
Prior art date
Application number
PCT/US2001/028626
Other languages
French (fr)
Other versions
WO2002031478A2 (en
WO2002031478A3 (en
Inventor
Thomas R Witty
Carol D Gustafson
Joel H Hapke
Original Assignee
Quantech Ltd
Thomas R Witty
Carol D Gustafson
Joel H Hapke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantech Ltd, Thomas R Witty, Carol D Gustafson, Joel H Hapke filed Critical Quantech Ltd
Priority to AU2001289066A priority Critical patent/AU2001289066A1/en
Publication of WO2002031478A2 publication Critical patent/WO2002031478A2/en
Publication of WO2002031478A3 publication Critical patent/WO2002031478A3/en
Publication of WO2002031478A8 publication Critical patent/WO2002031478A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Plasma & Fusion (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

In a device and method for determining a presence of an analyte in a sample, a first analyte-binding partner (120) is disposed on a test portion of a surface (106). The test portion is then contacted with the sample to bind the analyte (122), if present in the sample, to the first analyte-binding partner. The test portion is subsequently contacted with a second analyte-binding partner (124) to bind the second analyte-binding partner. This second analyte-binding partner also includes a catalyst (126). A substrate (128) is then brought into contact with the catalyst. The catalyst converts the substrate into a product material (130) that is then deposited on the test portion of the reflective surface. The presence of the analyte is then determined by observing a characteristic (e.g., a surface plasmon resonance) of the test portion of the surface. In at least some instances, the device can also provide information regarding the amount or concentration of analyte in the sample.
PCT/US2001/028626 2000-10-06 2001-09-12 Methods and devices for assays using analyte-binding partners WO2002031478A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001289066A AU2001289066A1 (en) 2000-10-06 2001-09-12 Methods and devices for assays using analyte-binding partners

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68070200A 2000-10-06 2000-10-06
US09/680,702 2000-10-06

Publications (3)

Publication Number Publication Date
WO2002031478A2 WO2002031478A2 (en) 2002-04-18
WO2002031478A3 WO2002031478A3 (en) 2002-09-12
WO2002031478A8 true WO2002031478A8 (en) 2003-11-20

Family

ID=24732155

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/028626 WO2002031478A2 (en) 2000-10-06 2001-09-12 Methods and devices for assays using analyte-binding partners

Country Status (2)

Country Link
AU (1) AU2001289066A1 (en)
WO (1) WO2002031478A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020135771A1 (en) * 2001-01-19 2002-09-26 Quantech Ltd System and method of reducing particulate interference in fluid analyte detection
DE10319572A1 (en) * 2003-04-30 2004-11-25 Kist-Europe Forschungsgesellschaft Mbh Method for determining the concentration of an analyte
CZ299489B6 (en) * 2005-01-12 2008-08-13 Ústav fotoniky a elektroniky AV CR, v. v. i. Spectroscopy method of surface plasmons for sensors with surface plasmons and sensor element for making the same
JP5397577B2 (en) * 2007-03-05 2014-01-22 オムロン株式会社 Surface plasmon resonance sensor and chip for the sensor
CN109073642A (en) 2015-09-17 2018-12-21 格哈德·马勒 Sensor devices for biosensing and other applications

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494829A (en) * 1992-07-31 1996-02-27 Biostar, Inc. Devices and methods for detection of an analyte based upon light interference

Also Published As

Publication number Publication date
AU2001289066A1 (en) 2002-04-22
WO2002031478A2 (en) 2002-04-18
WO2002031478A3 (en) 2002-09-12

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