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WO2002030259A3 - Disease prevention by reactivation of the thymus - Google Patents

Disease prevention by reactivation of the thymus Download PDF

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Publication number
WO2002030259A3
WO2002030259A3 PCT/IB2001/002745 IB0102745W WO0230259A3 WO 2002030259 A3 WO2002030259 A3 WO 2002030259A3 IB 0102745 W IB0102745 W IB 0102745W WO 0230259 A3 WO0230259 A3 WO 0230259A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
thymus
patient
lhrh
gene
Prior art date
Application number
PCT/IB2001/002745
Other languages
French (fr)
Other versions
WO2002030259A9 (en
WO2002030259A2 (en
Original Assignee
Boyd Richard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPR0745A external-priority patent/AUPR074500A0/en
Priority claimed from US09/755,965 external-priority patent/US20010046486A1/en
Priority claimed from US09/965,395 external-priority patent/US20020081276A1/en
Priority to KR10-2003-7005252A priority Critical patent/KR20030072336A/en
Priority to NZ525830A priority patent/NZ525830A/en
Priority to CA002462681A priority patent/CA2462681A1/en
Priority to AU1632302A priority patent/AU1632302A/en
Priority to JP2002533709A priority patent/JP2004517817A/en
Application filed by Boyd Richard filed Critical Boyd Richard
Priority to APAP/P/2003/002796A priority patent/AP2003002796A0/en
Priority to AU2002216323A priority patent/AU2002216323C1/en
Priority to EP01986582A priority patent/EP1363703A4/en
Priority to BR0114642-4A priority patent/BR0114642A/en
Priority to IL15541401A priority patent/IL155414A0/en
Publication of WO2002030259A2 publication Critical patent/WO2002030259A2/en
Publication of WO2002030259A3 publication Critical patent/WO2002030259A3/en
Publication of WO2002030259A9 publication Critical patent/WO2002030259A9/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2046—IL-7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2086—IL-13 to IL-16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0006—Contraceptive vaccins; Vaccines against sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C12N2510/00—Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)

Abstract

The present disclosure provides methods for gene therapy utilizing hematopoietic stem cells, lymphoid progenitor cells, and/or myeloid progenitor cells. The cells are genetically modified to provide a gene that is expressed in these cells and their progeny after differentiation. In a preferred embodiment the cells contain a gene or gene fragment that confers to the cells resistance to HIV infection and/or replication. The cells are administered to a patient in conjunction with treatment to reactivate the patient's thymus. The cells may be autologous, syngeneic, allogeneic or xenogeneic, as tolerance to foreign cells is created in the patient during reactivation of the thymus. In a preferred embodiment the hematopoietic stem cells are CD34+. The patient's thymus is reactivated by disruption of sex steroid mediated signaling to the thymus. In a preferred embodiment, this disruption is created by administration of LHRH agonists, LHRH antagonists, anti-LHRH receptor antibodies, anti-LHRH vaccines or combinations thereof.
PCT/IB2001/002745 2000-10-13 2001-10-12 Disease prevention by reactivation of the thymus WO2002030259A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
EP01986582A EP1363703A4 (en) 2000-10-13 2001-10-12 PREVENTION OF DISEASES BY THYME REACTIVATION
BR0114642-4A BR0114642A (en) 2000-10-13 2001-10-12 Disease prevention through thymus reactivation
IL15541401A IL155414A0 (en) 2000-10-13 2001-10-12 Disease prevention by reactivation of the thymus
AU2002216323A AU2002216323C1 (en) 2000-10-13 2001-10-12 Disease prevention by reactivation of the thymus
CA002462681A CA2462681A1 (en) 2000-10-13 2001-10-12 Disease prevention by reactivation of the thymus
AU1632302A AU1632302A (en) 2000-10-13 2001-10-12 Disease prevention by reactivation of the thymus
JP2002533709A JP2004517817A (en) 2000-10-13 2001-10-12 Prevent disease by reactivating the thymus
KR10-2003-7005252A KR20030072336A (en) 2000-10-13 2001-10-12 Disease prevention by reactivation of the thymus
APAP/P/2003/002796A AP2003002796A0 (en) 2000-10-13 2001-10-12 Disease prevention by reactivation of the thymus
NZ525830A NZ525830A (en) 2000-10-13 2001-10-12 Disease prevention by reactivation of the thymus

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US79528600A 2000-10-13 2000-10-13
US79530200A 2000-10-13 2000-10-13
US09/795,286 2000-10-13
US09/795,302 2000-10-13
AUPR0745A AUPR074500A0 (en) 2000-10-13 2000-10-13 Treatment of t cell disorders
AUPR0745 2000-10-13
US75598301A 2001-01-05 2001-01-05
US75564601A 2001-01-05 2001-01-05
US09/755,965 2001-01-05
US09/755,965 US20010046486A1 (en) 2000-04-17 2001-01-05 Stimulation of thymus for vaccination development
US09/755,983 2001-01-05
US09/755,646 2001-01-05
US75891001A 2001-01-10 2001-01-10
US09/758,910 2001-01-10
US09/965,395 2001-09-26
US09/965,395 US20020081276A1 (en) 1999-04-15 2001-09-26 Disease prevention by reactivation of the thymus

Publications (3)

Publication Number Publication Date
WO2002030259A2 WO2002030259A2 (en) 2002-04-18
WO2002030259A3 true WO2002030259A3 (en) 2002-07-04
WO2002030259A9 WO2002030259A9 (en) 2003-08-07

Family

ID=27570138

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/002745 WO2002030259A2 (en) 2000-10-13 2001-10-12 Disease prevention by reactivation of the thymus

Country Status (9)

Country Link
EP (1) EP1363703A4 (en)
CN (1) CN100406025C (en)
AP (1) AP2003002796A0 (en)
AU (1) AU1632302A (en)
BR (1) BR0114642A (en)
CA (1) CA2462681A1 (en)
IL (1) IL155414A0 (en)
NZ (1) NZ525830A (en)
WO (1) WO2002030259A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004241949A1 (en) * 2003-04-18 2004-12-02 Norwood Immunology, Ltd Disease prevention and vaccination prior to thymic reactivations
WO2009040070A2 (en) * 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of helodermin as a therapeutic agent
AU2010282280B2 (en) 2009-08-14 2016-06-09 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of IL-15 to increase thymic output and to treat lymphopenia
ES2529143B1 (en) 2011-10-21 2015-10-26 Abbvie Inc. COMBINATION OF AT LEAST TWO DIRECT ACTION ANTIVIRAL AGENTS, RIBAVIRINE BUT NOT INTERFERONED FOR THE USE OF HCV TREATMENT
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
US8809265B2 (en) 2011-10-21 2014-08-19 Abbvie Inc. Methods for treating HCV
CN109689063A (en) 2016-04-28 2019-04-26 埃默里大学 Nucleotide containing alkynes and nucleosides therapeutic combination and its associated uses

Citations (1)

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WO2000062657A2 (en) * 1999-04-15 2000-10-26 Monash University Improvement of t cell mediated immunity

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US4049805A (en) * 1975-09-30 1977-09-20 Akzona Incorporated Steroidal erythropoietic agents and therapeutic compositions and methods
CN1058500C (en) * 1993-02-03 2000-11-15 施塞克龙药品公司 Thymosin alpha-1 derivatives
ATE222111T1 (en) * 1993-05-17 2002-08-15 Gen Hospital Corp A THYMUS TRANSPLANT
AUPP971499A0 (en) * 1999-04-12 1999-05-06 Opentec Pty. Limited On-line electoral system

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Non-Patent Citations (7)

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Title
BONYHADI M. ET AL: "RevM10-expressing T cells derived in vivo from transduced human hematopoietic stem-progenitor cells inhibit human immunodeficiency virus replication", J. VIROL., vol. 71, no. 6, 1997, pages 4707 - 4716, XP002971217 *
FABRIS N. ET AL: "Plasticity of neuro-endocrine-thymus interaction during aging", CELLULAR AND MOLEC. BIOL., vol. 43, no. 4, 1997, pages 529 - 541, XP002972504 *
GREENSTEIN B. ET AL: "Regeneration of the thymus in old male rats treated with a stable analogue of LHRH", J. ENDOCR., vol. 112, 1987, pages 345 - 350, XP002972503 *
NIKOLIC B. ET AL.: "A novel application of cyclosporin A in nonmyeloablative pretransplant host conditioning for allogeneic BMT", BLOOD, vol. 96, no. 3, August 2000 (2000-08-01), pages 1166 - 1172, XP002971216 *
PENIT C. ET AL: "Cell proliferation and thymocyte subset reconstitution in sublethally irradiated mice: Compared kinetics of endogenous and intrathymically transferred progenitors", PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 5547 - 5551, XP002971775 *
WINDMILL K. ET AL: "Effects of castration on the lymphocytes of the thymus, spleen and lymph node", TISSUE & CELL, vol. 30, no. 1, 1998, pages 104 - 111, XP009023772 *
WINDMILL K. ET AL: "Influences of surgical castration on the thymus of male rats", J. REPROD. IMMUN., vol. 44, 1999, pages 29 - 39, XP002971218 *

Also Published As

Publication number Publication date
WO2002030259A9 (en) 2003-08-07
NZ525830A (en) 2005-07-29
AU1632302A (en) 2002-04-22
CN1505537A (en) 2004-06-16
CA2462681A1 (en) 2002-04-18
EP1363703A2 (en) 2003-11-26
EP1363703A4 (en) 2006-06-07
CN100406025C (en) 2008-07-30
AP2003002796A0 (en) 2003-06-30
IL155414A0 (en) 2003-11-23
BR0114642A (en) 2004-01-20
WO2002030259A2 (en) 2002-04-18

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