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WO2002028367A1 - Procede de revetement de particules fines avec un film de lipides - Google Patents

Procede de revetement de particules fines avec un film de lipides Download PDF

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Publication number
WO2002028367A1
WO2002028367A1 PCT/JP2001/008759 JP0108759W WO0228367A1 WO 2002028367 A1 WO2002028367 A1 WO 2002028367A1 JP 0108759 W JP0108759 W JP 0108759W WO 0228367 A1 WO0228367 A1 WO 0228367A1
Authority
WO
WIPO (PCT)
Prior art keywords
lipid film
fine particle
coating fine
lipid
fine particles
Prior art date
Application number
PCT/JP2001/008759
Other languages
English (en)
Japanese (ja)
Inventor
Yasuki Kato
Masahiro Yamauchi
Hiroko Kusano
Takeshi Iwata
Takaaki Uochi
Shiro Akinaga
Original Assignee
Kyowa Hakko Kogyo Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE60141078T priority Critical patent/DE60141078D1/de
Priority to EP01974690A priority patent/EP1323415B1/fr
Priority to CA2424619A priority patent/CA2424619C/fr
Priority to KR1020037004615A priority patent/KR100822684B1/ko
Priority to AU9418501A priority patent/AU9418501A/xx
Priority to AT01974690T priority patent/ATE454883T1/de
Application filed by Kyowa Hakko Kogyo Co., Ltd. filed Critical Kyowa Hakko Kogyo Co., Ltd.
Priority to AU2001294185A priority patent/AU2001294185B2/en
Priority to US10/398,222 priority patent/US7678415B2/en
Priority to JP2002531993A priority patent/JP4554883B2/ja
Publication of WO2002028367A1 publication Critical patent/WO2002028367A1/fr
Priority to US12/656,487 priority patent/US9757344B2/en
Priority to US14/683,674 priority patent/US20150265545A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • B01J13/22—Coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

L'invention concerne un procédé simple de revêtement de fines particules avec un film de lipides, réalisée de manière sûre et efficace. Ledit procédé est caractérisé en ce qu'une solution aqueuse de solvant organique polaire, renfermant de fines particules dispersées et un lipide dissous, est modifiée de manière à réduire la proportion du solvant organique polaire, afin de recouvrir chaque fine particule d'un film de lipides.
PCT/JP2001/008759 2000-10-04 2001-10-04 Procede de revetement de particules fines avec un film de lipides WO2002028367A1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP01974690A EP1323415B1 (fr) 2000-10-04 2001-10-04 Procede de revetement de particules fines avec un film de lipides
CA2424619A CA2424619C (fr) 2000-10-04 2001-10-04 Procede de revetement de particules fines avec un film de lipides
KR1020037004615A KR100822684B1 (ko) 2000-10-04 2001-10-04 지질막에 의한 미립자의 피복방법
AU9418501A AU9418501A (en) 2000-10-04 2001-10-04 Method of coating fine particle with lipid film
AT01974690T ATE454883T1 (de) 2000-10-04 2001-10-04 Methode zur beschichtung feiner teilchen mit einem lipidfilm
DE60141078T DE60141078D1 (de) 2000-10-04 2001-10-04 Methode zur beschichtung feiner teilchen mit einem lipidfilm
AU2001294185A AU2001294185B2 (en) 2000-10-04 2001-10-04 Method of coating fine particles with lipid membrane
US10/398,222 US7678415B2 (en) 2000-10-04 2001-10-04 Method of coating fine particles with lipid film
JP2002531993A JP4554883B2 (ja) 2000-10-04 2001-10-04 脂質膜による微粒子の被覆方法
US12/656,487 US9757344B2 (en) 2000-10-04 2010-02-01 Fine particles coated with lipid membrane
US14/683,674 US20150265545A1 (en) 2000-10-04 2015-04-10 Method for coating fine particles with lipid membrane

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000305065 2000-10-04
JP2000-305065 2000-10-04

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10/398,222 A-371-Of-International US7678415B2 (en) 2000-10-04 2001-10-04 Method of coating fine particles with lipid film
US10398222 A-371-Of-International 2001-10-04
US12/656,487 Division US9757344B2 (en) 2000-10-04 2010-02-01 Fine particles coated with lipid membrane

Publications (1)

Publication Number Publication Date
WO2002028367A1 true WO2002028367A1 (fr) 2002-04-11

Family

ID=18786007

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/008759 WO2002028367A1 (fr) 2000-10-04 2001-10-04 Procede de revetement de particules fines avec un film de lipides

Country Status (11)

Country Link
US (3) US7678415B2 (fr)
EP (2) EP1323415B1 (fr)
JP (4) JP4554883B2 (fr)
KR (1) KR100822684B1 (fr)
CN (1) CN1284523C (fr)
AT (1) ATE454883T1 (fr)
AU (2) AU9418501A (fr)
CA (1) CA2424619C (fr)
DE (1) DE60141078D1 (fr)
ES (1) ES2336766T3 (fr)
WO (1) WO2002028367A1 (fr)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005089926A1 (fr) * 2004-03-23 2005-09-29 Kyowa Hakko Kogyo Co., Ltd. Méthode de production de fines particules enrobées
WO2005092389A1 (fr) * 2004-03-10 2005-10-06 Kyowa Hakko Kogyo Co., Ltd. Particule composite et particule composite revetue
WO2006080451A1 (fr) * 2005-01-28 2006-08-03 Kyowa Hakko Kogyo Co., Ltd. Procede de production d’une particule fine enrobee
WO2006080118A1 (fr) * 2005-01-28 2006-08-03 Kyowa Hakko Kogyo Co., Ltd. Composition inhibant l'expression d'un gene cible
WO2007080902A1 (fr) 2006-01-11 2007-07-19 Kyowa Hakko Kogyo Co., Ltd. Composition inhibant l’expression d’un gene cible du globe oculaire et remede pour une maladie du globe oculaire
WO2010013815A1 (fr) 2008-08-01 2010-02-04 協和発酵キリン株式会社 Composition destinée à inhiber l'expression d'un gène cible
JP2010193875A (ja) * 2009-02-26 2010-09-09 Keiichi Kato 遺伝子導入ベクターとしての非イオン性界面活性剤Ｓｐａｎ８０二重ベシクルの調製と遺伝子導入機能
WO2011136369A1 (fr) 2010-04-28 2011-11-03 協和発酵キリン株式会社 Lipide cationique
WO2011136368A1 (fr) 2010-04-28 2011-11-03 協和発酵キリン株式会社 Lipide cationique
WO2012098692A1 (fr) 2011-01-19 2012-07-26 協和発酵キリン株式会社 Composition pour l'inhibition de l'expression d'un gène cible
WO2013065825A1 (fr) 2011-11-02 2013-05-10 協和発酵キリン株式会社 Lipide cationique
WO2013089151A1 (fr) 2011-12-12 2013-06-20 協和発酵キリン株式会社 Nanoparticules lipidiques pour système d'administration de médicament contenant des lipides cationiques
WO2013089152A1 (fr) 2011-12-12 2013-06-20 協和発酵キリン株式会社 Nanoparticules lipidiques contenant des associations de lipides cationiques
JP5221126B2 (ja) * 2005-01-28 2013-06-26 協和発酵キリン株式会社 水溶性物質で表面修飾された微粒子の製造方法
WO2014007398A1 (fr) 2012-07-06 2014-01-09 協和発酵キリン株式会社 Lipide cationique
WO2014013995A1 (fr) 2012-07-16 2014-01-23 協和発酵キリン株式会社 Composition pharmaceutique de type arni capable de supprimer l'expression du gène kras
WO2014058079A1 (fr) * 2012-10-12 2014-04-17 帝人株式会社 Vésicule de type à fixation électrostatique comprenant des microparticules métalliques
JP2014196358A (ja) * 2008-05-23 2014-10-16 ザ ユニヴァーシティ オブ ブリティッシュ コロンビア リポソームナノ粒子中で使用するための修飾薬物
WO2017111172A1 (fr) 2015-12-25 2017-06-29 協和発酵キリン株式会社 Composés utilisés comme lipides cationiques

Families Citing this family (16)

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Publication number Priority date Publication date Assignee Title
CA2424619C (fr) * 2000-10-04 2010-05-18 Kyowa Hakko Kogyo Co., Ltd. Procede de revetement de particules fines avec un film de lipides
US8067032B2 (en) * 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
FR2870741B1 (fr) 2004-05-25 2008-03-14 Coletica Sa Phase lamellaires hydratees ou liposomes, contenant une monoamine grasse ou un polymere cationique favorisant la penetration intercellulaire, et composition cosmetique ou pharmaceutique la contenant.
CN1311867C (zh) * 2004-09-27 2007-04-25 侯新朴 一种用于鼻腔给药的神经生长因子制剂
US20070059318A1 (en) * 2005-08-15 2007-03-15 Balu-Iyer Sathy V Lipid nano particulates containing antigens as cancer vaccines
US20070224637A1 (en) * 2006-03-24 2007-09-27 Mcauliffe Joseph C Oxidative protection of lipid layer biosensors
US20140335166A1 (en) * 2013-05-08 2014-11-13 Michael W. Fountain Methods of Making and Using Nano Scale Particles
WO2009097319A2 (fr) * 2008-01-28 2009-08-06 University Of Florida Research Foundation, Inc. Nanocristaux solubles dans l'eau par l'intermédiaire de ligands à interaction double
CN103041409B (zh) * 2013-01-10 2014-08-20 上海交通大学 内水相负载磁性碳量子点的pH及热双敏性脂质体的制备方法
CN106573877B (zh) * 2014-08-07 2021-04-13 武田药品工业株式会社 阳离子脂质
CN105581979A (zh) * 2016-02-24 2016-05-18 南京大学 一种抑制her-2表达的核酸脂质体纳米药物及其制备方法和应用
CN106561653A (zh) * 2016-11-04 2017-04-19 淮海工学院 甘油糖脂类化合物的抑藻用途及抑藻活性的测定方法
EP3530265A1 (fr) * 2018-02-27 2019-08-28 LipoCoat B.V. Procédé universel de préparation de revêtements à base de lipides
AU2019359299B2 (en) 2018-10-09 2022-04-21 The University Of British Columbia Compositions and systems comprising transfection-competent vesicles free of organic-solvents and detergents and methods related thereto
CN113058042B (zh) * 2021-04-01 2023-06-30 易慧生物技术(上海)有限公司 一种可鼻喷的稳定递载rna分子的脂质纳米颗粒制备方法
CN115624539A (zh) * 2022-12-16 2023-01-20 首都医科大学附属北京朝阳医院 一种脂质纳米颗粒及其制备方法和应用

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WO2005092389A1 (fr) * 2004-03-10 2005-10-06 Kyowa Hakko Kogyo Co., Ltd. Particule composite et particule composite revetue
WO2005089926A1 (fr) * 2004-03-23 2005-09-29 Kyowa Hakko Kogyo Co., Ltd. Méthode de production de fines particules enrobées
JP2012072181A (ja) * 2005-01-28 2012-04-12 Kyowa Hakko Kirin Co Ltd 標的遺伝子の発現を抑制する組成物
WO2006080451A1 (fr) * 2005-01-28 2006-08-03 Kyowa Hakko Kogyo Co., Ltd. Procede de production d’une particule fine enrobee
WO2006080118A1 (fr) * 2005-01-28 2006-08-03 Kyowa Hakko Kogyo Co., Ltd. Composition inhibant l'expression d'un gene cible
JP5221126B2 (ja) * 2005-01-28 2013-06-26 協和発酵キリン株式会社 水溶性物質で表面修飾された微粒子の製造方法
JPWO2006080118A1 (ja) * 2005-01-28 2008-06-19 協和醗酵工業株式会社 標的遺伝子の発現を抑制する組成物
JP2013010786A (ja) * 2005-01-28 2013-01-17 Kyowa Hakko Kirin Co Ltd 標的遺伝子の発現を抑制する組成物
JP5085313B2 (ja) * 2005-01-28 2012-11-28 協和発酵キリン株式会社 被覆微粒子の製造方法
JP2014196344A (ja) * 2005-01-28 2014-10-16 協和発酵キリン株式会社 標的遺伝子の発現を抑制する組成物
WO2007080902A1 (fr) 2006-01-11 2007-07-19 Kyowa Hakko Kogyo Co., Ltd. Composition inhibant l’expression d’un gene cible du globe oculaire et remede pour une maladie du globe oculaire
JP2016190881A (ja) * 2008-05-23 2016-11-10 ザ ユニヴァーシティ オブ ブリティッシュ コロンビア リポソームナノ粒子中で使用するための修飾薬物
JP2014196358A (ja) * 2008-05-23 2014-10-16 ザ ユニヴァーシティ オブ ブリティッシュ コロンビア リポソームナノ粒子中で使用するための修飾薬物
US9061042B2 (en) 2008-08-01 2015-06-23 Kyowa Hakko Kirin Co., Ltd. Composition for suppressing expression of target gene
KR20110042294A (ko) 2008-08-01 2011-04-26 교와 핫꼬 기린 가부시키가이샤 표적 유전자의 발현을 억제하는 조성물
WO2010013815A1 (fr) 2008-08-01 2010-02-04 協和発酵キリン株式会社 Composition destinée à inhiber l'expression d'un gène cible
JP2010193875A (ja) * 2009-02-26 2010-09-09 Keiichi Kato 遺伝子導入ベクターとしての非イオン性界面活性剤Ｓｐａｎ８０二重ベシクルの調製と遺伝子導入機能
WO2011136369A1 (fr) 2010-04-28 2011-11-03 協和発酵キリン株式会社 Lipide cationique
WO2011136368A1 (fr) 2010-04-28 2011-11-03 協和発酵キリン株式会社 Lipide cationique
WO2012098692A1 (fr) 2011-01-19 2012-07-26 協和発酵キリン株式会社 Composition pour l'inhibition de l'expression d'un gène cible
EP3301086A1 (fr) 2011-11-02 2018-04-04 Kyowa Hakko Kirin Co., Ltd. Lipide cationique
WO2013065825A1 (fr) 2011-11-02 2013-05-10 協和発酵キリン株式会社 Lipide cationique
WO2013089151A1 (fr) 2011-12-12 2013-06-20 協和発酵キリン株式会社 Nanoparticules lipidiques pour système d'administration de médicament contenant des lipides cationiques
WO2013089152A1 (fr) 2011-12-12 2013-06-20 協和発酵キリン株式会社 Nanoparticules lipidiques contenant des associations de lipides cationiques
WO2014007398A1 (fr) 2012-07-06 2014-01-09 協和発酵キリン株式会社 Lipide cationique
WO2014013995A1 (fr) 2012-07-16 2014-01-23 協和発酵キリン株式会社 Composition pharmaceutique de type arni capable de supprimer l'expression du gène kras
JPWO2014058079A1 (ja) * 2012-10-12 2016-09-05 帝人株式会社 金属微粒子を含む静電結合型ベシクル
JP5912186B2 (ja) * 2012-10-12 2016-05-11 帝人株式会社 金属微粒子を含む静電結合型ベシクル
WO2014058079A1 (fr) * 2012-10-12 2014-04-17 帝人株式会社 Vésicule de type à fixation électrostatique comprenant des microparticules métalliques
WO2017111172A1 (fr) 2015-12-25 2017-06-29 協和発酵キリン株式会社 Composés utilisés comme lipides cationiques

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AU9418501A (en) 2002-04-15
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ES2336766T3 (es) 2010-04-16
US20040022938A1 (en) 2004-02-05
CN1284523C (zh) 2006-11-15
AU2001294185B2 (en) 2006-12-21
CA2424619A1 (fr) 2003-04-03
EP1323415A4 (fr) 2005-05-11
CA2424619C (fr) 2010-05-18
US9757344B2 (en) 2017-09-12
JP5161895B2 (ja) 2013-03-13
US20100166847A1 (en) 2010-07-01
US20150265545A1 (en) 2015-09-24
KR20030041999A (ko) 2003-05-27
JP5512780B2 (ja) 2014-06-04
KR100822684B1 (ko) 2008-04-17
DE60141078D1 (de) 2010-03-04
EP2241308A2 (fr) 2010-10-20
JPWO2002028367A1 (ja) 2004-02-12
EP2241308A3 (fr) 2010-11-17
ATE454883T1 (de) 2010-01-15
JP2009007378A (ja) 2009-01-15
EP1323415A1 (fr) 2003-07-02
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