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WO2002026960A3 - Modulation de l'expression genique au moyen de domaines de localisation - Google Patents

Modulation de l'expression genique au moyen de domaines de localisation Download PDF

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Publication number
WO2002026960A3
WO2002026960A3 PCT/US2001/042377 US0142377W WO0226960A3 WO 2002026960 A3 WO2002026960 A3 WO 2002026960A3 US 0142377 W US0142377 W US 0142377W WO 0226960 A3 WO0226960 A3 WO 0226960A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene expression
modulation
domains
localization domains
localization
Prior art date
Application number
PCT/US2001/042377
Other languages
English (en)
Other versions
WO2002026960A2 (fr
Inventor
Alan P Di Wolffe
Fyodor Urnov
Albert Lai
Eva Raschke
Original Assignee
Sangamo Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sangamo Biosciences Inc filed Critical Sangamo Biosciences Inc
Priority to AU2002213431A priority Critical patent/AU2002213431A1/en
Publication of WO2002026960A2 publication Critical patent/WO2002026960A2/fr
Publication of WO2002026960A3 publication Critical patent/WO2002026960A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
    • C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/822—Reducing position variability, e.g. by the use of scaffold attachment region/matrix attachment region (SAR/MAR); Use of SAR/MAR to regulate gene expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Insects & Arthropods (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention porte sur des procédés et des compositions permettant de réguler l'expression génique, et notamment sur de procédés et des compositions comprenant des domaines de localisation, et des fusions de domaines de localisation avec des domaines de liaison de l'ADN, et éventuellement des domaines régulateurs.
PCT/US2001/042377 2000-09-29 2001-09-28 Modulation de l'expression genique au moyen de domaines de localisation WO2002026960A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002213431A AU2002213431A1 (en) 2000-09-29 2001-09-28 Modulation of gene expression using localization domains

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23688400P 2000-09-29 2000-09-29
US60/236,884 2000-09-29

Publications (2)

Publication Number Publication Date
WO2002026960A2 WO2002026960A2 (fr) 2002-04-04
WO2002026960A3 true WO2002026960A3 (fr) 2003-04-17

Family

ID=22891390

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/042377 WO2002026960A2 (fr) 2000-09-29 2001-09-28 Modulation de l'expression genique au moyen de domaines de localisation

Country Status (2)

Country Link
AU (1) AU2002213431A1 (fr)
WO (1) WO2002026960A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050136040A1 (en) * 2001-10-11 2005-06-23 Imperial College Innovations Limited Control of gene expression using a complex of an oligonucleotide and a regulatory peptide
US20060247192A1 (en) * 2002-12-05 2006-11-02 Jenkinson John D Control of apoptosis
EP1678315B1 (fr) 2003-09-19 2011-08-03 Sangamo BioSciences, Inc. Proteines a doigt de zinc issues du genie genetique pour la regulation de l'expression genique
EP2412812B1 (fr) 2006-12-14 2015-02-11 Dow AgroSciences LLC Protéines à doigts de zinc non canoniques optimisées
CA3237482A1 (fr) 2021-11-03 2023-05-11 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Edition precise du genome a l'aide de retrons
WO2023141602A2 (fr) 2022-01-21 2023-07-27 Renagade Therapeutics Management Inc. Rétrons modifiés et méthodes d'utilisation
WO2024044723A1 (fr) 2022-08-25 2024-02-29 Renagade Therapeutics Management Inc. Rétrons modifiés et méthodes d'utilisation
WO2025049959A2 (fr) 2023-09-01 2025-03-06 Renagade Therapeutics Management Inc. Systèmes et compositions d'édition génique, et méthodes de traitement du syndrome vexas

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997011972A1 (fr) * 1995-09-28 1997-04-03 The Trustees Of Columbia University In The City Of New York Proteine chimere de polypeptide et d'acide nucleique de liaison d'adn et d'adn methyltransferase et ses utilisations
WO2000041566A1 (fr) * 1999-01-12 2000-07-20 Sanagamo Biosciences, Inc. Regulation de l'expression genique endogene dans des cellules au moyen de proteines a doigts de zinc
WO2000042219A1 (fr) * 1999-01-12 2000-07-20 Sangamo Biosciences, Inc. Selection de sites cibles pour proteines a doigts de zinc et methodes de fabrication de proteines a doigts de zinc destinees a se lier avec des sites preselectionnes
WO2001030843A1 (fr) * 1999-10-25 2001-05-03 Novartis Ag Proteines de regulateur de transcription activees par un ligand
WO2001083793A2 (fr) * 2000-04-28 2001-11-08 Sangamo Biosciences, Inc. Modification ciblee de la structure de chromatine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997011972A1 (fr) * 1995-09-28 1997-04-03 The Trustees Of Columbia University In The City Of New York Proteine chimere de polypeptide et d'acide nucleique de liaison d'adn et d'adn methyltransferase et ses utilisations
WO2000041566A1 (fr) * 1999-01-12 2000-07-20 Sanagamo Biosciences, Inc. Regulation de l'expression genique endogene dans des cellules au moyen de proteines a doigts de zinc
WO2000042219A1 (fr) * 1999-01-12 2000-07-20 Sangamo Biosciences, Inc. Selection de sites cibles pour proteines a doigts de zinc et methodes de fabrication de proteines a doigts de zinc destinees a se lier avec des sites preselectionnes
WO2001030843A1 (fr) * 1999-10-25 2001-05-03 Novartis Ag Proteines de regulateur de transcription activees par un ligand
WO2001083793A2 (fr) * 2000-04-28 2001-11-08 Sangamo Biosciences, Inc. Modification ciblee de la structure de chromatine

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BOEKE JOERN ET AL: "The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 45, 18 August 2000 (2000-08-18), pages 34963 - 34967, XP002215833, ISSN: 0021-9258 *
CROSS S H ET AL: "PURIFICATION OF CPG ISLANDS USING A METHYLATED DNA BINDING COLUMN", NATURE GENETICS, NEW YORK, NY, US, vol. 6, no. 3, 1 March 1994 (1994-03-01), pages 236 - 244, XP000578157, ISSN: 1061-4036 *
KALUDOV NIKOLA K ET AL: "MeCP2 driven transcriptional repression in vitro: Selectivity for methylated DNA, action at a distance and contacts with the basal transcription machinery.", NUCLEIC ACIDS RESEARCH, vol. 28, no. 9, 1 May 2000 (2000-05-01), pages 1921 - 1928, XP002215832, ISSN: 0305-1048 *
NAN XINSHENG ET AL: "MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin.", CELL, vol. 88, no. 4, 1997, pages 471 - 481, XP002215831, ISSN: 0092-8674 *
STEENSEL VAN B ET AL: "Identification of in vivo DNA targets of chromatin proteins using tethered Dam methyltransferase", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 18, no. 4, April 2000 (2000-04-01), pages 424 - 428, XP002187507, ISSN: 1087-0156 *
WOLFFE A P ET AL: "CO-REPRESSOR COMPLEXES AND REMODELLING CHROMATIN FOR REPRESSION", BIOCHEMICAL SOCIETY TRANSACTIONS, COLCHESTER, ESSEX, GB, vol. 28, no. 4, August 2000 (2000-08-01), pages 379 - 386, XP001052910, ISSN: 0300-5127 *

Also Published As

Publication number Publication date
AU2002213431A1 (en) 2002-04-08
WO2002026960A2 (fr) 2002-04-04

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