WO2002018587A1 - Procede de production de biopterines - Google Patents

Procede de production de biopterines Download PDF

Info

Publication number: WO2002018587A1
Authority: WO; WIPO (PCT)
Prior art keywords: biopterins; producing; transformed; cells; producing biopterins
Prior art date: 2000-08-31

Application number

PCT/JP2001/007395

Other languages

English (en)

French (fr)

Inventor

Masayuki Yabuta

Kazuaki Furukawa

Nobue Miyamoto

Katsuhiko Yamamoto

Kazuhiro Ohsuye

Original Assignee

Suntory Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-31

Filing date

2001-08-28

Publication date

2002-03-07

2001-08-28 Priority to AU2001280215A priority Critical patent/AU2001280215B9/en

2001-08-28 Priority to EP01958584A priority patent/EP1314782B1/en

2001-08-28 Priority to JP2002522494A priority patent/JP4817590B2/ja

2001-08-28 Priority to KR1020037003005A priority patent/KR100916163B1/ko

2001-08-28 Priority to US10/362,914 priority patent/US20040014167A1/en

2001-08-28 Priority to BR0113411-6A priority patent/BR0113411A/pt

2001-08-28 Application filed by Suntory Limited filed Critical Suntory Limited

2001-08-28 Priority to IL15453001A priority patent/IL154530A0/xx

2001-08-28 Priority to CA002420374A priority patent/CA2420374A1/en

2001-08-28 Priority to DE60138029T priority patent/DE60138029D1/de

2002-03-07 Publication of WO2002018587A1 publication Critical patent/WO2002018587A1/ja

2003-02-18 Priority to IL154530A priority patent/IL154530A/en

2005-08-02 Priority to US11/194,564 priority patent/US7807421B2/en

Links

108090000790 Enzymes Proteins 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
FNKQXYHWGSIFBK-RPDRRWSUSA-N sapropterin Chemical compound N1=C(N)NC(=O)C2=C1NC[C@H]([C@@H](O)[C@@H](O)C)N2 FNKQXYHWGSIFBK-RPDRRWSUSA-N 0.000 abstract 1
229960004617 sapropterin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)

PCT/JP2001/007395 2000-08-31 2001-08-28 Procede de production de biopterines WO2002018587A1 (fr)

Priority Applications (11)

Application Number	Priority Date	Filing Date	Title
EP01958584A EP1314782B1 (en)	2000-08-31	2001-08-28	Process for producing biopterins
JP2002522494A JP4817590B2 (ja)	2000-08-31	2001-08-28	ビオプテリン類の製造方法
KR1020037003005A KR100916163B1 (ko)	2000-08-31	2001-08-28	비오프테린류의 제조방법
US10/362,914 US20040014167A1 (en)	2000-08-31	2001-08-28	Process for producing biopterin
BR0113411-6A BR0113411A (pt)	2000-08-31	2001-08-28	Processo para a produção do composto de biopterina
AU2001280215A AU2001280215B9 (en)	2000-08-31	2001-08-28	Process for Production of Biopterin Compound
IL15453001A IL154530A0 (en)	2000-08-31	2001-08-28	Process for production of biopterin compound
CA002420374A CA2420374A1 (en)	2000-08-31	2001-08-28	Process for production of biopterin compound
DE60138029T DE60138029D1 (de)	2000-08-31	2001-08-28	Verfahren zur herstellung von biopterinen
IL154530A IL154530A (en)	2000-08-31	2003-02-18	Process for the production of a bioptrine compound and the use of a cell that has changed in the process
US11/194,564 US7807421B2 (en)	2000-08-31	2005-08-02	Process for production of biopterin compound

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2000262973		2000-08-31
JP2000-262973		2000-08-31

Related Child Applications (2)

Application Number	Title	Priority Date	Filing Date
US10362914 A-371-Of-International		2001-08-28
US11/194,564 Continuation US7807421B2 (en)	2000-08-31	2005-08-02	Process for production of biopterin compound

Publications (1)

Publication Number	Publication Date
WO2002018587A1 true WO2002018587A1 (fr)	2002-03-07

Family

ID=18750574

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PCT/JP2001/007395 WO2002018587A1 (fr)	2000-08-31	2001-08-28	Procede de production de biopterines

Country Status (13)

Country	Link
US (2)	US20040014167A1 (ja)
EP (1)	EP1314782B1 (ja)
JP (1)	JP4817590B2 (ja)
KR (1)	KR100916163B1 (ja)
CN (1)	CN1247778C (ja)
AT (1)	ATE426021T1 (ja)
AU (1)	AU2001280215B9 (ja)
BR (1)	BR0113411A (ja)
CA (1)	CA2420374A1 (ja)
DE (1)	DE60138029D1 (ja)
ES (1)	ES2320531T3 (ja)
IL (2)	IL154530A0 (ja)
WO (1)	WO2002018587A1 (ja)

Cited By (4)

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WO2006085535A1 (ja) *	2005-02-09	2006-08-17	Kaneka Corporation	テトラヒドロビオプテリン生合成酵素を用いたビオプテリン類の製造方法
JP2007511536A (ja) *	2003-11-17	2007-05-10	バイオマリンファーマシューティカルインコーポレイテッド	代謝障害の処置のための方法及び組成物
JP2009139315A (ja) *	2007-12-10	2009-06-25	Kao Corp	血圧調節剤のスクリーニング方法及び評価方法
JP2020068734A (ja) *	2018-11-01	2020-05-07	国立大学法人東京工業大学	Ｓｐｒをコードするポリヌクレオチドを含む組換えベクター、及びそれを含む組成物

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US7442372B2 (en)	2003-08-29	2008-10-28	Biomarin Pharmaceutical Inc.	Delivery of therapeutic compounds to the brain and other tissues
US8003126B2 (en)	2004-11-17	2011-08-23	Biomarin Pharmaceutical Inc.	Stable tablet formulation
PL2139485T3 (pl)	2007-04-11	2013-03-29	Biomarin Pharm Inc	Metoda podawania tetrahydrobiopteryny, powiązane kompozycje i sposoby pomiaru
RU2470642C2 (ru)	2008-01-03	2012-12-27	Байомарин Фармасьютикл Инк.	Аналоги птерина для лечения состояния, чувствительного к вн4
JP2011508781A (ja)	2008-01-07	2011-03-17	ビオマリンプハルマセウトイカルインコーポレイテッド	テトラヒドロビオプテリンの合成方法
WO2012135389A2 (en) *	2011-03-28	2012-10-04	The Regents Of The University Of California	Host cells and methods for oxidizing aromatic amino acids
KR101229912B1 (ko) *	2011-04-06	2013-02-05	강원대학교산학협력단	재조합 대장균을 이용한 세피아프테린의 제조방법
US9216178B2 (en)	2011-11-02	2015-12-22	Biomarin Pharmaceutical Inc.	Dry blend formulation of tetrahydrobiopterin
CN102516246B (zh) *	2011-11-30	2014-08-06	安徽农业大学	一种从蚕体中提取纯化高纯度墨蝶呤的方法
EP2820121A1 (en) *	2012-02-29	2015-01-07	Danmarks Tekniske Universitet	Microorganisms for the production of melatonin
WO2013127914A1 (en) *	2012-02-29	2013-09-06	Danmarks Tekniske Universitet	Microorganisms for the production of 5-hydroxytryptophan
CN102925476B (zh) *	2012-11-15	2014-12-03	中国科学院上海巴斯德研究所	酵母中自组装的具有免疫原性的肠道病毒病毒样颗粒的制备方法及其应用
CN103952367B (zh) *	2013-04-16	2016-06-01	中国人民解放军军事医学科学院基础医学研究所	一种发酵培养基及利用其生产黑色素瘤治疗性质粒DNA疫苗pSVK-CAVA的方法
US20160230200A1 (en) *	2013-09-05	2016-08-11	Danmarks Tekniske Universitet	Microorganisms for efficient production of melatonin and related compounds
US10023889B2 (en) *	2014-05-16	2018-07-17	University Of Georgia Research Foundation, Inc.	Microbial approach for the production of 5-hydroxytryptophan
WO2016109769A1 (en) *	2015-01-02	2016-07-07	Georgia Tech Research Corporation	Pterin-dependent biocatalysts and uses thereof
EP3436595B1 (en)	2016-03-31	2024-02-28	Danmarks Tekniske Universitet	Optimized microbial cells for production of melatonin and other compounds
US10851365B2 (en)	2016-03-31	2020-12-01	Danmarks Tekniske Universitet	Optimized microbial cells for production of melatonin and other compounds
WO2017202897A1 (en)	2016-05-24	2017-11-30	Danmarks Tekniske Universitet	Variants of acetylserotonin o-methyltransferase and uses thereof
ES2963672T3 (es)	2016-12-13	2024-04-01	Univ Danmarks Tekniske	Arilalquilamina N-acetiltransferasa y usos de la misma
WO2019175328A1 (en)	2018-03-14	2019-09-19	Imba - Institut Für Molekulare Biotechnologie Gmbh	Bh4pathwayactivationandusethereoffortreatingcancer
WO2019175332A1 (en)	2018-03-14	2019-09-19	Imba - Institut Für Molekulare Biotechnologie Gmbh	Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity
CA3132417A1 (en)	2019-03-15	2020-09-24	Danmarks Tekniske Universitet	Engineered cells for production of indole-derivatives
CN111073884A (zh) *	2020-02-14	2020-04-28	昆明理工大学	提高非编码区域距离＜50bp的SNP中具有功能效应的SNP位点检测准确率的方法
CN111505179B (zh) *	2020-04-07	2021-07-13	厦门大学	海洋水体中生物蝶呤的检测方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0153696A2 (en) *	1984-02-23	1985-09-04	Kanegafuchi Kagaku Kogyo Kabushiki Kaisha	Process for preparing 5,6,7,8-tetrahydro-6-(l-erythro-1',2'-dihydroxypropyl) pterin
JPS619296A (ja) *	1984-06-22	1986-01-16	Kanegafuchi Chem Ind Co Ltd	微生物によるｌ−エリスロ−ビオプテリンの製造法
JPS6152296A (ja) *	1984-08-21	1986-03-14	Kanegafuchi Chem Ind Co Ltd	微生物によるｌ−エリスロ−ビオプテリンの製造法
EP0318926A2 (en) *	1987-11-30	1989-06-07	Kabushiki Kaisha Vitamin Kenkyusyo	Intermediates for synthesizing 5,6,7,8-tetrahydro-L-erythro-biopterin and its derivatives
JPH01221380A (ja) *	1988-02-29	1989-09-04	Nisshin Flour Milling Co Ltd	２，３−ジアシルオキシ−４−ヒドロキシ−トペンタナールおよびその製造方法
JPH0482888A (ja) *	1990-07-21	1992-03-16	Suntory Ltd	テトラヒドロビオプテリンの製法およびそれに用いる酵素

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JP2674707B2 (ja) *	1988-06-22	1997-11-12	株式会社ビタミン研究所	Ｌ‐ビオプテリンの製法
JP2754959B2 (ja)	1991-07-24	1998-05-20	三菱電機株式会社	空気調和機のセンサ識別装置
KR100456062B1 (ko) *	2001-06-18	2004-11-08	박영식	재조합 대장균에 의한 테리딘 화합물의 제조방법

2001
- 2001-08-28 JP JP2002522494A patent/JP4817590B2/ja not_active Expired - Fee Related
- 2001-08-28 ES ES01958584T patent/ES2320531T3/es not_active Expired - Lifetime
- 2001-08-28 AU AU2001280215A patent/AU2001280215B9/en not_active Ceased
- 2001-08-28 IL IL15453001A patent/IL154530A0/xx active IP Right Grant
- 2001-08-28 US US10/362,914 patent/US20040014167A1/en not_active Abandoned
- 2001-08-28 BR BR0113411-6A patent/BR0113411A/pt not_active IP Right Cessation
- 2001-08-28 CN CNB018146325A patent/CN1247778C/zh not_active Expired - Fee Related
- 2001-08-28 DE DE60138029T patent/DE60138029D1/de not_active Expired - Lifetime
- 2001-08-28 WO PCT/JP2001/007395 patent/WO2002018587A1/ja active Application Filing
- 2001-08-28 KR KR1020037003005A patent/KR100916163B1/ko not_active Expired - Fee Related
- 2001-08-28 CA CA002420374A patent/CA2420374A1/en not_active Abandoned
- 2001-08-28 AT AT01958584T patent/ATE426021T1/de active
- 2001-08-28 EP EP01958584A patent/EP1314782B1/en not_active Expired - Lifetime
2003
- 2003-02-18 IL IL154530A patent/IL154530A/en not_active IP Right Cessation
2005
- 2005-08-02 US US11/194,564 patent/US7807421B2/en not_active Expired - Fee Related

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0153696A2 (en) *	1984-02-23	1985-09-04	Kanegafuchi Kagaku Kogyo Kabushiki Kaisha	Process for preparing 5,6,7,8-tetrahydro-6-(l-erythro-1',2'-dihydroxypropyl) pterin
JPS619296A (ja) *	1984-06-22	1986-01-16	Kanegafuchi Chem Ind Co Ltd	微生物によるｌ−エリスロ−ビオプテリンの製造法
JPS6152296A (ja) *	1984-08-21	1986-03-14	Kanegafuchi Chem Ind Co Ltd	微生物によるｌ−エリスロ−ビオプテリンの製造法
EP0318926A2 (en) *	1987-11-30	1989-06-07	Kabushiki Kaisha Vitamin Kenkyusyo	Intermediates for synthesizing 5,6,7,8-tetrahydro-L-erythro-biopterin and its derivatives
JPH01221380A (ja) *	1988-02-29	1989-09-04	Nisshin Flour Milling Co Ltd	２，３−ジアシルオキシ−４−ヒドロキシ−トペンタナールおよびその製造方法
JPH0482888A (ja) *	1990-07-21	1992-03-16	Suntory Ltd	テトラヒドロビオプテリンの製法およびそれに用いる酵素

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2007511536A (ja) *	2003-11-17	2007-05-10	バイオマリンファーマシューティカルインコーポレイテッド	代謝障害の処置のための方法及び組成物
US9433624B2 (en)	2003-11-17	2016-09-06	Biomarin Pharmaceutical Inc.	Methods and compositions for the treatment of metabolic disorders
US9993481B2 (en)	2003-11-17	2018-06-12	Biomarin Pharmaceutical Inc.	Methods and compositions for the treatment of metabolic disorders
WO2006085535A1 (ja) *	2005-02-09	2006-08-17	Kaneka Corporation	テトラヒドロビオプテリン生合成酵素を用いたビオプテリン類の製造方法
JP2009139315A (ja) *	2007-12-10	2009-06-25	Kao Corp	血圧調節剤のスクリーニング方法及び評価方法
JP2020068734A (ja) *	2018-11-01	2020-05-07	国立大学法人東京工業大学	Ｓｐｒをコードするポリヌクレオチドを含む組換えベクター、及びそれを含む組成物
JP7553906B2 (ja)	2018-11-01	2024-09-19	宏一瀬	Ｓｐｒをコードするポリヌクレオチドを含む組換えベクター、及びそれを含む組成物

Also Published As

Publication number	Publication date
JP4817590B2 (ja)	2011-11-16
EP1314782A4 (en)	2005-01-12
KR20030033042A (ko)	2003-04-26
IL154530A0 (en)	2003-09-17
AU8021501A (en)	2002-03-13
US20060008869A1 (en)	2006-01-12
CA2420374A1 (en)	2003-02-24
IL154530A (en)	2011-02-28
BR0113411A (pt)	2004-01-06
US7807421B2 (en)	2010-10-05
CN1449442A (zh)	2003-10-15
US20040014167A1 (en)	2004-01-22
ES2320531T3 (es)	2009-05-25
AU2001280215B9 (en)	2007-03-22
EP1314782A1 (en)	2003-05-28
EP1314782B1 (en)	2009-03-18
ATE426021T1 (de)	2009-04-15
AU2001280215B2 (en)	2006-08-03
JPWO2002018587A1 (ja)	2004-01-15
CN1247778C (zh)	2006-03-29
KR100916163B1 (ko)	2009-09-08
DE60138029D1 (de)	2009-04-30

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WO2002018587A1 (fr)	2002-03-07	Procede de production de biopterines
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