WO2002017898A3 - Compositions et procedes visant a induire une vasorelaxation - Google Patents
Compositions et procedes visant a induire une vasorelaxation Download PDFInfo
- Publication number
- WO2002017898A3 WO2002017898A3 PCT/US2001/026983 US0126983W WO0217898A3 WO 2002017898 A3 WO2002017898 A3 WO 2002017898A3 US 0126983 W US0126983 W US 0126983W WO 0217898 A3 WO0217898 A3 WO 0217898A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- nitric oxide
- antioxidant
- patient
- vasorelaxation
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000001196 vasorelaxation Effects 0.000 title abstract 3
- 230000001939 inductive effect Effects 0.000 title 1
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical class O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract 5
- 239000003963 antioxidant agent Substances 0.000 abstract 3
- 230000003078 antioxidant effect Effects 0.000 abstract 3
- 239000002840 nitric oxide donor Substances 0.000 abstract 3
- 206010047139 Vasoconstriction Diseases 0.000 abstract 1
- 230000005779 cell damage Effects 0.000 abstract 1
- CMFNMSMUKZHDEY-UHFFFAOYSA-N peroxynitrous acid Chemical compound OON=O CMFNMSMUKZHDEY-UHFFFAOYSA-N 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 230000000451 tissue damage Effects 0.000 abstract 1
- 230000025033 vasoconstriction Effects 0.000 abstract 1
- 230000024883 vasodilation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU8852301A AU8852301A (en) | 2000-09-01 | 2001-08-29 | Compositions and methods for inducing vasorelaxation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65388700A | 2000-09-01 | 2000-09-01 | |
US09/653,887 | 2000-09-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002017898A2 WO2002017898A2 (fr) | 2002-03-07 |
WO2002017898A3 true WO2002017898A3 (fr) | 2002-07-04 |
Family
ID=24622672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/026983 WO2002017898A2 (fr) | 2000-09-01 | 2001-08-29 | Compositions et procedes visant a induire une vasorelaxation |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU8852301A (fr) |
WO (1) | WO2002017898A2 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7566714B2 (en) | 2003-11-17 | 2009-07-28 | Biomarin Pharmaceutical Inc. | Methods and compositions for the treatment of metabolic disorders |
US8927030B2 (en) | 2003-07-09 | 2015-01-06 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of nitrite salts for the treatment of cardiovascular conditions |
US9216178B2 (en) | 2011-11-02 | 2015-12-22 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006206521A (ja) * | 2005-01-28 | 2006-08-10 | Univ Of Tokyo | 一酸化窒素供与体としてのn−ニトロソアミン化合物 |
WO2006125123A2 (fr) | 2005-05-19 | 2006-11-23 | University Of Cincinnati | Procedes pour le traitement d'infections des voies respiratoires chez un sujet utilisant du nitrite acidifie |
US7975699B2 (en) | 2007-10-30 | 2011-07-12 | The Invention Science Fund I, Llc | Condoms configured to facilitate release of nitric oxide |
US8642093B2 (en) | 2007-10-30 | 2014-02-04 | The Invention Science Fund I, Llc | Methods and systems for use of photolyzable nitric oxide donors |
US7862598B2 (en) | 2007-10-30 | 2011-01-04 | The Invention Science Fund I, Llc | Devices and systems that deliver nitric oxide |
US8221690B2 (en) | 2007-10-30 | 2012-07-17 | The Invention Science Fund I, Llc | Systems and devices that utilize photolyzable nitric oxide donors |
WO2008080194A1 (fr) * | 2006-12-29 | 2008-07-10 | The University Of Queensland | Compositions analgésiques et leurs utilisations |
US8822509B2 (en) | 2006-12-29 | 2014-09-02 | The University Of Queensland | Pain-relieving compositions and uses therefor |
US7897399B2 (en) | 2007-10-30 | 2011-03-01 | The Invention Science Fund I, Llc | Nitric oxide sensors and systems |
US7846400B2 (en) | 2007-10-30 | 2010-12-07 | The Invention Science Fund I, Llc | Substrates for nitric oxide releasing devices |
US8877508B2 (en) | 2007-10-30 | 2014-11-04 | The Invention Science Fund I, Llc | Devices and systems that deliver nitric oxide |
US10080823B2 (en) | 2007-10-30 | 2018-09-25 | Gearbox Llc | Substrates for nitric oxide releasing devices |
US8980332B2 (en) | 2007-10-30 | 2015-03-17 | The Invention Science Fund I, Llc | Methods and systems for use of photolyzable nitric oxide donors |
WO2011011092A1 (fr) | 2009-07-22 | 2011-01-27 | University Of Massachusetts | Procédés et compositions pour réduire le stress oxydatif |
WO2023283332A1 (fr) * | 2021-07-07 | 2023-01-12 | Emory University | Utilisations d'inhibiteurs d'arginase pour la gestion d'une maladie rénale et de troubles cardiovasculaires |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997016983A1 (fr) * | 1995-11-09 | 1997-05-15 | The Board Of Trustees Of The Leland Stanford Junior University | Amelioration de la fonction vasculaire par modulation de la production ou de l'activite de l'oxyde nitrique endogene |
WO1999038507A1 (fr) * | 1998-01-30 | 1999-08-05 | David George Le Couteur | Inversion et prevention des aspects du vieillissement importants du point de vue clinique via l'administration par voie orale d'un vasodilatateur de l'artere hepatique et d'autres agents augmentant l'oxygenation hepatique |
WO2001035961A1 (fr) * | 1999-10-29 | 2001-05-25 | Nitromed, Inc. | Methodes de traitement de maladies vasculaires caracterisees par une insuffisance du monoxyde d'azote |
-
2001
- 2001-08-29 AU AU8852301A patent/AU8852301A/xx active Pending
- 2001-08-29 WO PCT/US2001/026983 patent/WO2002017898A2/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997016983A1 (fr) * | 1995-11-09 | 1997-05-15 | The Board Of Trustees Of The Leland Stanford Junior University | Amelioration de la fonction vasculaire par modulation de la production ou de l'activite de l'oxyde nitrique endogene |
WO1999038507A1 (fr) * | 1998-01-30 | 1999-08-05 | David George Le Couteur | Inversion et prevention des aspects du vieillissement importants du point de vue clinique via l'administration par voie orale d'un vasodilatateur de l'artere hepatique et d'autres agents augmentant l'oxygenation hepatique |
WO2001035961A1 (fr) * | 1999-10-29 | 2001-05-25 | Nitromed, Inc. | Methodes de traitement de maladies vasculaires caracterisees par une insuffisance du monoxyde d'azote |
Non-Patent Citations (4)
Title |
---|
H.H. TING E.A.: "Vitamin C improves endothelium-dependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia", CIRCULATION, vol. 95, no. 12, 1997, pages 2617 - 2622, XP008003101 * |
P.J. LAD E.A.: "Activation of rat lung soluble guanylate cyclase by sodium nitroprusside: effects of hemoglobin and reducing agents", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 103, no. 2, 1981, pages 629 - 637, XP008003108 * |
S. DIKLOV: "Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicals: effect of vitamin C", FREE RADICAL BIOLOGY & MEDICINE, vol. 27, no. 1-2, 1999, pages 170 - 176, XP001076816 * |
S. TADDEI E.A.: "Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes", CIRCULATION, vol. 101, no. 25, 2000, pages 2896 - 2901, XP001076818 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8927030B2 (en) | 2003-07-09 | 2015-01-06 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of nitrite salts for the treatment of cardiovascular conditions |
US9387224B2 (en) | 2003-07-09 | 2016-07-12 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Treatment of specific cardiovascular conditions with nitrite |
US7566714B2 (en) | 2003-11-17 | 2009-07-28 | Biomarin Pharmaceutical Inc. | Methods and compositions for the treatment of metabolic disorders |
US9216178B2 (en) | 2011-11-02 | 2015-12-22 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
Also Published As
Publication number | Publication date |
---|---|
AU8852301A (en) | 2002-03-13 |
WO2002017898A2 (fr) | 2002-03-07 |
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