+

WO2002014359A3 - Serpine humaine zserp15 - Google Patents

Serpine humaine zserp15 Download PDF

Info

Publication number
WO2002014359A3
WO2002014359A3 PCT/US2001/024650 US0124650W WO0214359A3 WO 2002014359 A3 WO2002014359 A3 WO 2002014359A3 US 0124650 W US0124650 W US 0124650W WO 0214359 A3 WO0214359 A3 WO 0214359A3
Authority
WO
WIPO (PCT)
Prior art keywords
zserp15
serine protease
serpin
serine
human serpin
Prior art date
Application number
PCT/US2001/024650
Other languages
English (en)
Other versions
WO2002014359A2 (fr
Inventor
James L Holloway
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to AU2001281116A priority Critical patent/AU2001281116A1/en
Publication of WO2002014359A2 publication Critical patent/WO2002014359A2/fr
Publication of WO2002014359A3 publication Critical patent/WO2002014359A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Les membres de la famille des sérine protéases jouent un rôle dans des procédés contrôlés avec soin, tels que la coagulation sanguine, la fibrinolyse, l'activation de compléments, la fertilisation et la production d'hormones. L'activité enzymatique des sérine protéases est partiellement régulée par les serpines, qui sont des inhibiteurs de sérine protéase. La dysfonction des serpines est associée à divers troubles, y compris l'emphysème, les troubles de la coagulation sanguine, la cirrhose, la maladie d'Alzheimer et la maladie de Parkinson. Zserp15 est un nouveau membre de la famille des inhibiteurs de sérine protéase.
PCT/US2001/024650 2000-08-10 2001-08-06 Serpine humaine zserp15 WO2002014359A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001281116A AU2001281116A1 (en) 2000-08-10 2001-08-06 Human serpin zserp15

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22445000P 2000-08-10 2000-08-10
US60/224,450 2000-08-10

Publications (2)

Publication Number Publication Date
WO2002014359A2 WO2002014359A2 (fr) 2002-02-21
WO2002014359A3 true WO2002014359A3 (fr) 2002-08-01

Family

ID=22840738

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024650 WO2002014359A2 (fr) 2000-08-10 2001-08-06 Serpine humaine zserp15

Country Status (2)

Country Link
AU (1) AU2001281116A1 (fr)
WO (1) WO2002014359A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003046006A1 (fr) * 2001-11-27 2003-06-05 Bayer Healthcare Ag Polynucleotides codant pour l'inhibiteur d'une serine protease parente de la nexine
FR2842534B1 (fr) * 2002-07-19 2006-01-20 Inst Nat Sante Rech Med Amplification multiplex quantitative a l'echelle d'un genome, et applications a la detection de remaniements genomiques

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999041381A1 (fr) * 1998-02-13 1999-08-19 Peter Sonderegger Neuroserpine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999041381A1 (fr) * 1998-02-13 1999-08-19 Peter Sonderegger Neuroserpine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] EBI, Hinxton, UK; 19 May 1993 (1993-05-19), VASSALLI ET AL.: "M. musculus PN-1 mRNA for protease-nexin 1", XP002199160, Database accession no. X70296 *
WHISSTOCK JAMES ET AL: "An atlas of serpin conformations.", TRENDS IN BIOCHEMICAL SCIENCES, vol. 23, no. 2, February 1998 (1998-02-01), pages 63 - 67, XP002199159, ISSN: 0968-0004 *
WORRALL D M ET AL: "The expanding superfamily of serpins: Searching for the real targets.", BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 27, no. 4, August 1999 (1999-08-01), Meeting of the Biochemical Society, Irish Area Section;Dublin, Ireland; September 9-10, 1998, pages 746 - 750, XP001076869, ISSN: 0300-5127 *

Also Published As

Publication number Publication date
AU2001281116A1 (en) 2002-02-25
WO2002014359A2 (fr) 2002-02-21

Similar Documents

Publication Publication Date Title
Patel et al. Purification and physicochemical characterization of a serine protease with fibrinolytic activity from latex of a medicinal herb Euphorbia hirta
PT94016A (pt) Processo para a producao de inibidores de proteinases
SE0201980D0 (sv) Novel compounds
CA2058935A1 (fr) Compositions pharmaceutiques et methode de traitement a l'aide de peptides amyloides d'alzheimer
EP1383731A4 (fr) Composes biaryle utilises comme inhibiteurs de serine protease
WO2006076246A3 (fr) Derives de phenylglycinamide utilises comme anticoagulants
TR199902692T2 (xx) Serin proteaz inhibit�rleri.
MXPA03009130A (es) Compuestos de biarilo que funcionan como inhibidores de proteasa serina.
NZ606504A (en) Modified proteases that inhibit complement activation
WO2006076575A3 (fr) Composes de biaryle substitue en tant qu'inhibiteurs du facteur xia
NZ596269A (en) Protease screening methods and proteases identified thereby
JP2014240389A5 (fr)
WO2005099709A3 (fr) Heterocycles bicycliques convenant comme inhibiteurs de la serine protease
WO1996035788A3 (fr) Peptides inhibiteurs de proteases de type kunitz
WO2001044172A8 (fr) Salicylamides utiles en tant qu'inhibiteurs des serines proteases
AU2003243097A1 (en) Novel compounds
WO2002061064A3 (fr) Procede de preparation de trypsine recombinee
WO2002014359A3 (fr) Serpine humaine zserp15
NZ319474A (en) Guanidino protease inhibitors
WO2003099202A3 (fr) Inhibiteurs de beta-secretase
WO2001038534A3 (fr) Serpine humaine
WO2001031033A3 (fr) Traitement de plaies
SE0203712D0 (sv) Novel compounds
WO2003070229A3 (fr) Utilisation d'inhibiteurs de proteinases pour le traitement de maladies auto-immunes
WO2001077097A3 (fr) 4-pyrones polycycliques a substitution aryle et heteroaryle utiles pour l'inhibition selective de la cascade de coagulation

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载