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WO2002013843A3 - Chemotherapeutic agents conjugated to p97 and their methods of use in treating neurological tumours - Google Patents

Chemotherapeutic agents conjugated to p97 and their methods of use in treating neurological tumours Download PDF

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Publication number
WO2002013843A3
WO2002013843A3 PCT/CA2001/001158 CA0101158W WO0213843A3 WO 2002013843 A3 WO2002013843 A3 WO 2002013843A3 CA 0101158 W CA0101158 W CA 0101158W WO 0213843 A3 WO0213843 A3 WO 0213843A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemotherapeutic agents
methods
treating neurological
agents conjugated
pharmaceutical compositions
Prior art date
Application number
PCT/CA2001/001158
Other languages
French (fr)
Other versions
WO2002013843A2 (en
Inventor
Reinhard Gabathuler
Gerrassimos Kolaitis
Robert Charles Brooks
Qingqi Chen
Delara M Karkan
Gavin D Arthur
Pierre Jean Paul St
Wilfred Jeffries
Original Assignee
Univ British Columbia
Reinhard Gabathuler
Gerrassimos Kolaitis
Robert Charles Brooks
Qingqi Chen
Delara M Karkan
Gavin D Arthur
Pierre Jean Paul St
Wilfred Jeffries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ British Columbia, Reinhard Gabathuler, Gerrassimos Kolaitis, Robert Charles Brooks, Qingqi Chen, Delara M Karkan, Gavin D Arthur, Pierre Jean Paul St, Wilfred Jeffries filed Critical Univ British Columbia
Priority to AU2001283740A priority Critical patent/AU2001283740A1/en
Publication of WO2002013843A2 publication Critical patent/WO2002013843A2/en
Publication of WO2002013843A3 publication Critical patent/WO2002013843A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/644—Transferrin, e.g. a lactoferrin or ovotransferrin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides pharmaceutical compositions of chemotherapeutic agents that demonstrate therapeutic efficacy against brain tumours and other neoplasia localized in or around the brain. In certain aspects, the pharmaceutical compositions comprise a chemotherapeutic agent conjugated to p97; and a pharmaceutically acceptable carrier therefor. Preferred chemotherapeutic agents include, but are not limited to, adriamycin, cisplatin, and paclitaxel.
PCT/CA2001/001158 2000-08-17 2001-08-17 Chemotherapeutic agents conjugated to p97 and their methods of use in treating neurological tumours WO2002013843A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001283740A AU2001283740A1 (en) 2000-08-17 2001-08-17 Chemotherapeutic agents conjugated to p97 and their methods of use in treating neurological tumours

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22625400P 2000-08-17 2000-08-17
US60/226,254 2000-08-17

Publications (2)

Publication Number Publication Date
WO2002013843A2 WO2002013843A2 (en) 2002-02-21
WO2002013843A3 true WO2002013843A3 (en) 2002-12-12

Family

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Family Applications (1)

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PCT/CA2001/001158 WO2002013843A2 (en) 2000-08-17 2001-08-17 Chemotherapeutic agents conjugated to p97 and their methods of use in treating neurological tumours

Country Status (2)

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AU (1) AU2001283740A1 (en)
WO (1) WO2002013843A2 (en)

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