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WO2002013759A3 - Methode de traitement du syndrome du diabete de type ii humain - Google Patents

Methode de traitement du syndrome du diabete de type ii humain Download PDF

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Publication number
WO2002013759A3
WO2002013759A3 PCT/US2001/022466 US0122466W WO0213759A3 WO 2002013759 A3 WO2002013759 A3 WO 2002013759A3 US 0122466 W US0122466 W US 0122466W WO 0213759 A3 WO0213759 A3 WO 0213759A3
Authority
WO
WIPO (PCT)
Prior art keywords
diabetes
syndrome
treating
type
opiates
Prior art date
Application number
PCT/US2001/022466
Other languages
English (en)
Other versions
WO2002013759A2 (fr
Inventor
Anton H Clemens
Original Assignee
Cpd Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cpd Llc filed Critical Cpd Llc
Priority to AU2001275959A priority Critical patent/AU2001275959A1/en
Priority to EP01953517A priority patent/EP1365756A2/fr
Publication of WO2002013759A2 publication Critical patent/WO2002013759A2/fr
Publication of WO2002013759A3 publication Critical patent/WO2002013759A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une méthode de traitement d'un humain souffrant du syndrome du diabète de type II. Cette méthode consiste à administrer, selon un mode efficace sur le plan pharmacologique, une composition médicamenteuse comprenant des opiacés possédant une activité agoniste ν.
PCT/US2001/022466 2000-08-15 2001-07-17 Methode de traitement du syndrome du diabete de type ii humain WO2002013759A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001275959A AU2001275959A1 (en) 2000-08-15 2001-07-17 Method of treating the syndrome of type 2 diabetes in humans
EP01953517A EP1365756A2 (fr) 2000-08-15 2001-07-17 Methode de traitement du syndrome du diabete de type ii humain

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63893000A 2000-08-15 2000-08-15
US09/638,930 2000-08-15

Publications (2)

Publication Number Publication Date
WO2002013759A2 WO2002013759A2 (fr) 2002-02-21
WO2002013759A3 true WO2002013759A3 (fr) 2003-07-10

Family

ID=24562030

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/022466 WO2002013759A2 (fr) 2000-08-15 2001-07-17 Methode de traitement du syndrome du diabete de type ii humain

Country Status (3)

Country Link
EP (1) EP1365756A2 (fr)
AU (1) AU2001275959A1 (fr)
WO (1) WO2002013759A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100469500B1 (ko) 2002-06-29 2005-02-02 엘지전자 주식회사 이동통신단말기의 송수신장치
EP2001456B1 (fr) * 2006-04-04 2009-12-02 Emodys GmbH Utilisation de compositions contenant des antagonistes des récepteurs opioïdes kappa pour traiter des troubles dissociatifs
SI2724722T1 (sl) * 2006-10-20 2017-07-31 Neurendo Pharma, Llc Postopek za obnovitev učinka inkretina
EP2561866A1 (fr) * 2011-08-26 2013-02-27 Heinrich-Heine-Universität Düsseldorf Dérivés de morphinane pour traiter les diabètes et troubles associés
EP2747754B1 (fr) * 2011-08-26 2017-04-05 Deutsche Diabetes-Forschungsgesellschaft e. V. Dérivés de morphinane pour traiter le diabètes et des troubles associés
CN107405343A (zh) 2014-11-07 2017-11-28 明尼苏达大学董事会 可用于治疗疾病的盐和组合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999059997A1 (fr) * 1998-05-18 1999-11-25 Novo Nordisk A/S Nouvelles 1,3,8-triazaspiro[4.5]decanones possedant une affinite elevee pour les sous-types du recepteur opioide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999059997A1 (fr) * 1998-05-18 1999-11-25 Novo Nordisk A/S Nouvelles 1,3,8-triazaspiro[4.5]decanones possedant une affinite elevee pour les sous-types du recepteur opioide

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; AHLGREN, GUNNAR: "Insulin -like action of morphine and certain morphine derivatives", XP002222946, retrieved from STN Database accession no. 24:20275 HCA *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GREEN, I. C. ET AL: "Opioid peptide effects on isolated hepatocytes and islets of Langerhans", XP002222947, retrieved from STN Database accession no. 105:203461 HCA *
DATABASE MEDLINE [online] August 1980 (1980-08-01), GREEN I C ET AL: "Effect of enkephalins and morphine on insulin secretion from isolated rat islets.", XP002222945, Database accession no. NLM6998819 *
DATABASE MEDLINE [online] January 1987 (1987-01-01), BAILEY C J ET AL: "Increased responsiveness to glucoregulatory effect of opiates in obese-diabetic ob/ob mice.", XP002222948, Database accession no. NLM3032718 *
DIABETOLOGIA. GERMANY, WEST AUG 1980, vol. 19, no. 2, August 1980 (1980-08-01), pages 158 - 161, ISSN: 0012-186X *
DIABETOLOGIA. GERMANY, WEST JAN 1987, vol. 30, no. 1, January 1987 (1987-01-01), pages 33 - 37, ISSN: 0012-186X *
INTERNATIONAL CONGRESS SERIES (1986), 700(DIABETES 1985), 258-62 *
LIU I M ET AL: "Activation of opioid mu-receptor by loperamide to lower plasma glucose in streptozotocin-induced diabetic rats.", NEUROSCIENCE LETTERS. IRELAND 23 APR 1999, vol. 265, no. 3, 23 April 1999 (1999-04-23), pages 183 - 186, XP001108832, ISSN: 0304-3940 *
SKAND, ARCH. PHYSIOL (1930), 58, 153-72 *

Also Published As

Publication number Publication date
EP1365756A2 (fr) 2003-12-03
WO2002013759A2 (fr) 2002-02-21
AU2001275959A1 (en) 2002-02-25

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