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WO2002009807A1 - Recipient pour fluide de ionophorese muni d'un distributeur et electrode associee - Google Patents

Recipient pour fluide de ionophorese muni d'un distributeur et electrode associee Download PDF

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Publication number
WO2002009807A1
WO2002009807A1 PCT/IT2001/000421 IT0100421W WO0209807A1 WO 2002009807 A1 WO2002009807 A1 WO 2002009807A1 IT 0100421 W IT0100421 W IT 0100421W WO 0209807 A1 WO0209807 A1 WO 0209807A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
electrode
flask
conductive element
carrier fluid
Prior art date
Application number
PCT/IT2001/000421
Other languages
English (en)
Inventor
Elisabetta Rossi
Original Assignee
Elisabetta Rossi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elisabetta Rossi filed Critical Elisabetta Rossi
Priority to AU2001284399A priority Critical patent/AU2001284399A1/en
Publication of WO2002009807A1 publication Critical patent/WO2002009807A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/044—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir

Definitions

  • the present invention relates to a container and an electrode for a gel or liquid suspension or other type of carrier, for drug molecules, phytotherapic, homeopathic or cosmetic products, for carbon dioxide, oxygen, nitrogen, or other substances, for an active principle to be delivered via ionophoresis or other techniques involving the application of an electric field, which favours the penetration of the molecules to be delivered through the epidermis and beyond the dermic barrier.
  • Ionophoresis is a known technique for transdermal delivery of drugs or other products, for various purposes. This technique provides for disposing the ionisable molecules of a substance to be delivered, within a container and then bringing a portion of the container in contact with the skin of the patient to whom the substance is to be administered.
  • the container is closed by an osmotic or partially permeable membrane.
  • the patient and the container with the molecules to be delivered are located within an electric circuit having a voltage and/or frequency source whose output can be varied in a controllable manner, which causes the ionisation of the molecules and the migration of the ions through the osmotic membrane and patient's skin, thereby entering within the tissues beneath the epidermis down to a depth depending on the applied frequency.
  • the electrical circuit is closed by one or more electrodes applied at suitable body positions on the patient under treatment.
  • EP-A-0292930 discloses an apparatus wherein the container for the solution with the molecules to be delivered, has an osmotic membrane through which the ions generated by the electric field produced by a suitable apparatus, migrate. The molecules are in a liquid solution within the container sealed by the osmotic membrane.
  • US-A-5084008 describes a different container for the drug to be administered by ionophoresis.
  • the container is specially fit for using with molecules contained in a gel, and the same container is closed by a permeable layer having the function of leaving the ions to pass through and, at the same time, of preventing the gel from drying during the time the container is stored.
  • the container is characterized by a particular configuration of the means for distributing the current inside the drug.
  • WO-8808729 discloses an electrode for ionophoresis consisting of a plate of conducting material to which a porous membrane is applied, having therein the molecules to be delivered. The membrane is protected by a removable protecting sheet which is removed when applying the electrode on the patient.
  • WO-9622810 describes a container for a drug to be delivered by ionophoresis, after having frozen the solution containing said drug.
  • the container is made up of two portions reversibly joined to each other and defining an inner volume which is intended to hold the solution containing the drug to be administered.
  • the container with the relevant content is frozen and, when used, the upper section of the container is removed to expose the block formed by the frozen solution.
  • the latter is put in contact with the patient's epidermis.
  • the portion of the container which is not removed, and within which the base of the block of frozen solution is housed, contains the electrode suitably shaped to ensure the electric contact with the block of frozen solution.
  • This container has remarkable drawbacks which are due to: the lack of devices for reliably stabilizing one upon the other the two portions of the container, when the latter is to be filled with the solution containing the medicine; the lack of a suitable closure ensuring the hygiene of the product, as the container is open on top to allow the filling thereof; the impossibility of ensuring that the container will be used only once, for the sake of hygiene. Moreover, this container is suited only and exclusively for the application of solutions frozen beforehand.
  • the electrode is unstable and is likely to get drenched because of the melting of the ice block, with the risk of electric discharges.
  • the object of the present invention is that of providing and electrode for delivering an active e principle dispersed in a liquid, gel or other similar carrier, by ionophoresis or other similar technique, which overcomes the drawbacks and limits of the currently known systems .
  • the object of the present invention is to provide a storing and delivering device suitable for the administration by means of an electric field, of principles dispersed in said carrier.
  • an electrode for transdermal administration of an active principle contained in a carrier, characterized in that it comprises an elongated conductive element; a supporting member for reversible connection of said electrode to a container containing the carrier and the active principle .
  • a protection cage structure made of electrically insulating material.
  • the conductive element is advantageously an extended lamina or a conductive bar.
  • the invention relates also to a device for transdermal delivery of an active principle contained in a carrier, by the application of an electric field, characterized in that it comprises an electrode as defined above and a container reversibly engaged with said electrode, said container having at least a wall portion permeable to the ionised molecules of said active principle .
  • This wall portion may be simply perforated to allow the molecules, and possibly part of the carrier, to pass through .
  • Fig. 2 shows a flask to which the electrode of Fig. 1 can be associated;
  • Fig. 3 to 6 show further possible embodiments of the present invention.
  • the embodiment of electrode shown therein generally indicated by 1 comprises a conductive bar 3 which forms the proper electrode, electrically linked to a cable 5 for connection with a voltage-generating machine, such as a machine for ionophoresis of a type known per se .
  • the conductive bar 3 is supported by a bush 7 of insulating material passed through by the conductive element of the connecting cable 5, which is thus electrically linked to the bar 3.
  • the bush 7 carries in an axial position with respect to the conductive bar 3, a protection cage 9 of insulating material, for instance of a sufficiently rigid plastics .
  • the bush 7 is also provided with an external thread 11.
  • the latter makes if possible to screw down the electrode 1 in the mouth 13 of a flask generally indicated by 15, in which a carrier is disposed such as a gel or a liquid that can contain the active principle or wherein the latter and/or the carrier can be added at the time of use.
  • the flask 15 may be of disposable type with a closure 17 consisting, for example, of a film heat-sealed or glued on the mouth 13 of the flask.
  • the film making up the closure 17 is removed and to this purpose it may be provided with a handgrip appendix 17A.
  • the active principle my be added to the carrier V, if it is not already disposed in the flask 15, or if it is necessary to add a further active principles to the one already present therein.
  • the bottom 19 of the flask 15 has a wall permeable to the molecules of the active principle, that is, a wall through which it is possible to establish a flow of ions formed by the ionised molecules of the active principle contained in the carrier V.
  • the bottom of the flask may be simply provided with holes having a dimension sufficiently small to avoid an excessive dispersion of the carrier.
  • the bottom of the container 15 may in turn be protected by a second film 21, possibly having an appendix 21A which makes it easy to remove said film.
  • a second film 21 possibly having an appendix 21A which makes it easy to remove said film.
  • the electrode 1 is inserted into the flask 15 and blocked therein by screwing the bush 7 in the thread of the mouth 13 of flask 15.
  • the removal of the film 21 exposes the osmotic wall, which defines the bottom 19 of the flask, to allow the ionophoresis treatment.
  • a voltage difference is applied in a variable manner with time according to a predetermined law.
  • the counter-electrode is applied to a suitable portion of the patient's body, while the bottom 19 of the flask 15 (into which the electrode 1 has been introduced) is applied in correspondence of the region of the patient's body where the active principle, contained in the carrier V inside the flask, is to be administered.
  • the flask 15 may be unscrewed from the bush 11 and disposed of, while the electrode 1 can be cleaned for using again in further treatments with a new flask.
  • the flask 15 may also be empty and be filled before use thereof, with the carrier and active principle as necessary. In this case, the protection formed by the films 17 and 21 can be omitted. Although the presence thereof is to be preferred for the sake of hygiene.
  • the electrode includes a conductive bar having elongated cylindrical or prismatic shape .
  • the electrode may be a relatively thin and long lamina, or a lamina with rectangular or square configuration.
  • the shape of the container will be compatible with that of the electrode.
  • the protective cage will have a shape correspondingly suited for protecting the conductive element .
  • the term cage refers to any structure having a consistence sufficient to form a protection around the conductive element and to allow the flow of the carrier.
  • the first two embodiments show a device for transdermal delivery of substances contained in a carrier fluid, denoted in its entirety by 30.
  • This device comprises a plastic or glass flask 31, containing a carrier fluid for the substances to be delivered and having at its bottom 32 a rubber, plastic or other similar material, socket 33; in its initial condition, i.e. in the condition where the flask is produced ready for distribution, this socket is sealed with a layer 34 of tin foil or other material which can be removed by means of tearing, likewise it occurs for ordinary drug packagings .
  • the flask 31 is provided with a threaded mouth 35 suitable for the application of a normal screw-cap (not shown in the drawings) in the initial condition already mentioned above, or with a dispensing head 37 for performing a treatment involving transcutaneous administration of the substances .
  • the dispensing head 37 has a threaded ring 38 for screwing it onto the mouth 35 of the flask and terminates in a hemispherical cap provided with small holes 40.
  • the device of this example of the invention also comprises an electrode 41 consisting of a bar-shaped conductive element 42, connected to an electric power supply line 43 and mounted on an insulating support 44.
  • the electrode 41 is inserted into the flask 31 via the socket 33 after removal of the sealing foil 34, until the support 44 engages the bush 33.
  • the conductive bar 42 extends along the flask as far as the dispensing head 37 and allows the movement of the ions of the substances to be delivered, contained in the carrier fluid, likewise it has already been described for the preceding example.
  • the holes 40 of the cap allows the carrier fluid to flow thereby forming a film on the skin which allows the transdermal administration of the substances.
  • the dispensing head 37 screwed onto the bottle terminates, instead of the perforated cap, with a roller supported in a freely rotatable manner; for this purpose a space is left between the surface of the roller and the bottom edge of the head 37, sufficient to allow rotation of the roller about its axis when it is covered with a film of carrier fluid.
  • the device according to this example is used in a manner similar to that of the preceding one, causing the roller 50 to roll over the part of the body to be treated, with the flask kept in the overturned condition shown in Fig. 5.
  • a film of carrier fluid is deposited on the portion of its surface which is located inside the dispensing head and is then spread onto the skin when this portion turns outside.
  • FIG. 6 A further possible embodiment of the administration delivery device is shown in Figure 6, wherein the dispensing head has been replaced with a pad 60 of sponge or other similar material, which is impregnated with the carrier fluid contained in the flask so as to spread it over the zone of the body to be treated.
  • This pad is associated (for example by means of gluing) with the threaded ring 38 so as to be fixed on the mouth of the bottle.
  • the shape of the electrode and associated conductive element may differ from the elongated shape which, although it is undoubtedly the most suitable for insertion into a flask as seen before, could nevertheless be replaced by an electrode plate-shaped or in any case shaped differently from the conductive bar; obviously, in these circumstances, the socket for insertion of the electrode into the flask should also be replaced with an opening suitable for receiving and supporting electrodes shaped differently from those seen.
  • the conductive element may be protected with a cage structure made of insulating material, likewise explained above.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Electrotherapy Devices (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne une électrode (1) et un récipient (15) destinés à l'administration transcutanée de molécules contenues dans un produit support (V). Ladite électrode comporte un élément conducteur (3), une cage protectrice (9) disposée autour de cet élément conducteur, ainsi qu'un élément (7) destiné à connecter ladite électrode de manière réversible à un récipient (15) contenant le produit support (V) et un principe actif.
PCT/IT2001/000421 2000-08-02 2001-07-31 Recipient pour fluide de ionophorese muni d'un distributeur et electrode associee WO2002009807A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001284399A AU2001284399A1 (en) 2000-08-02 2001-07-31 Iontophoresis fluid container with dispenser and electrode

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000FI000173A IT1316594B1 (it) 2000-08-02 2000-08-02 Elettrodo e contenitore per la somministrazione per via transcutaneadi molecole contenute in un prodotto veicolante
ITFI2000A000173 2000-08-02

Publications (1)

Publication Number Publication Date
WO2002009807A1 true WO2002009807A1 (fr) 2002-02-07

Family

ID=11441940

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2001/000421 WO2002009807A1 (fr) 2000-08-02 2001-07-31 Recipient pour fluide de ionophorese muni d'un distributeur et electrode associee

Country Status (3)

Country Link
AU (1) AU2001284399A1 (fr)
IT (1) IT1316594B1 (fr)
WO (1) WO2002009807A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2372705A (en) * 2000-11-03 2002-09-04 Kieron Loy A hand-held self-administered iontophoretic drug applicator with roller-ball skin electrode
EP1454652A1 (fr) * 2003-03-07 2004-09-08 M & T S.r.l. Dispositif pour l'administration transcutanée de substances en utilisant l'iontophorèse
US7522954B2 (en) 2004-06-01 2009-04-21 M & T S.R.L. Device for the transcutaneous administration of substances by means of iontophoresis
WO2013118114A1 (fr) * 2012-02-08 2013-08-15 Gurovich, Martin Dispositif d'administration transdermique

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111744111B (zh) * 2020-07-17 2024-11-19 深圳德技创新实业有限公司 药剂瓶及离子导入装置

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2126070A (en) * 1932-04-29 1938-08-09 Wappler Frederick Charles Electrotherapy
US3163166A (en) * 1961-04-28 1964-12-29 Colgate Palmolive Co Iontophoresis apparatus
FR1476657A (fr) * 1966-01-27 1967-04-14 Bombe aérosol à effet galvanique ou faradique ou galvano-faradique
WO1988008729A1 (fr) 1987-05-15 1988-11-17 Newman Martin H Systeme d'administration de medicament par inophorese iontophorese
EP0292930A1 (fr) 1987-05-28 1988-11-30 Drug Delivery Systems Inc. Système pulsatoire de délivrance transdermique de médicament
US5084008A (en) 1989-12-22 1992-01-28 Medtronic, Inc. Iontophoresis electrode
WO1996022810A1 (fr) 1995-01-27 1996-08-01 Alessandro Aloisi Dispositif de physiotherapie par ionophorese a l'aide de cristaux medicamenteux congeles
US5730714A (en) * 1988-01-29 1998-03-24 The Regents Of The University Of California Method for the iontophoretic non-invasive determination of the in vivo concentration level of glucose
WO1999004850A1 (fr) * 1997-07-22 1999-02-04 Emed Corporation Aiguille pour l'injection iontophoretique d'une substance active
US5908401A (en) * 1996-05-08 1999-06-01 The Aps Organization, Llp Method for iontophoretic delivery of antiviral agents
US6023639A (en) * 1998-05-01 2000-02-08 Hakky; Said Non-invasive bodily fluid withdrawal and monitoring system
US6065649A (en) * 1997-10-23 2000-05-23 Scoggins; Lester E. Dispensing container with top and bottom access ports and a dispensing manifold therefore
WO2000056400A1 (fr) * 1999-03-22 2000-09-28 Africa Antonino D Dispositif destine a l'administration iontophoretique transcutanee de molecules

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2126070A (en) * 1932-04-29 1938-08-09 Wappler Frederick Charles Electrotherapy
US3163166A (en) * 1961-04-28 1964-12-29 Colgate Palmolive Co Iontophoresis apparatus
FR1476657A (fr) * 1966-01-27 1967-04-14 Bombe aérosol à effet galvanique ou faradique ou galvano-faradique
WO1988008729A1 (fr) 1987-05-15 1988-11-17 Newman Martin H Systeme d'administration de medicament par inophorese iontophorese
EP0292930A1 (fr) 1987-05-28 1988-11-30 Drug Delivery Systems Inc. Système pulsatoire de délivrance transdermique de médicament
US5730714A (en) * 1988-01-29 1998-03-24 The Regents Of The University Of California Method for the iontophoretic non-invasive determination of the in vivo concentration level of glucose
US5084008A (en) 1989-12-22 1992-01-28 Medtronic, Inc. Iontophoresis electrode
WO1996022810A1 (fr) 1995-01-27 1996-08-01 Alessandro Aloisi Dispositif de physiotherapie par ionophorese a l'aide de cristaux medicamenteux congeles
US5908401A (en) * 1996-05-08 1999-06-01 The Aps Organization, Llp Method for iontophoretic delivery of antiviral agents
WO1999004850A1 (fr) * 1997-07-22 1999-02-04 Emed Corporation Aiguille pour l'injection iontophoretique d'une substance active
US6065649A (en) * 1997-10-23 2000-05-23 Scoggins; Lester E. Dispensing container with top and bottom access ports and a dispensing manifold therefore
US6023639A (en) * 1998-05-01 2000-02-08 Hakky; Said Non-invasive bodily fluid withdrawal and monitoring system
WO2000056400A1 (fr) * 1999-03-22 2000-09-28 Africa Antonino D Dispositif destine a l'administration iontophoretique transcutanee de molecules

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2372705A (en) * 2000-11-03 2002-09-04 Kieron Loy A hand-held self-administered iontophoretic drug applicator with roller-ball skin electrode
EP1454652A1 (fr) * 2003-03-07 2004-09-08 M & T S.r.l. Dispositif pour l'administration transcutanée de substances en utilisant l'iontophorèse
US7522954B2 (en) 2004-06-01 2009-04-21 M & T S.R.L. Device for the transcutaneous administration of substances by means of iontophoresis
WO2013118114A1 (fr) * 2012-02-08 2013-08-15 Gurovich, Martin Dispositif d'administration transdermique
US9522267B2 (en) 2012-02-08 2016-12-20 Derma Dream Group Ltd Transdermal delivery device

Also Published As

Publication number Publication date
AU2001284399A1 (en) 2002-02-13
ITFI20000173A0 (it) 2000-08-02
IT1316594B1 (it) 2003-04-24
ITFI20000173A1 (it) 2002-02-02

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