WO2002009719A1 - Agents antitumoraux - Google Patents

Agents antitumoraux Download PDF

Info

Publication number: WO2002009719A1
Authority: WO; WIPO (PCT)
Prior art keywords: antitumor agents; acid; erythrodiol; uvaol; betulin
Prior art date: 2000-07-31

Application number

PCT/JP2001/006393

Other languages

English (en)

French (fr)

Inventor

Noriyasu Kuno

Gou Shinohara

Tosiyuki Inui

Original Assignee

The Nisshin Oillio, Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-31

Filing date

2001-07-25

Publication date

2002-02-07

2001-07-25 Application filed by The Nisshin Oillio, Ltd. filed Critical The Nisshin Oillio, Ltd.

2001-07-25 Priority to EP01984400A priority Critical patent/EP1321145A4/en

2001-07-25 Priority to AU2002224595A priority patent/AU2002224595A1/en

2001-07-25 Priority to CA002418117A priority patent/CA2418117A1/en

2002-02-07 Publication of WO2002009719A1 publication Critical patent/WO2002009719A1/ja

2003-01-31 Priority to US10/355,201 priority patent/US20030153538A1/en

Links

239000002246 antineoplastic agent Substances 0.000 title abstract 2
XUARCIYIVXVTAE-ZAPOICBTSA-N uvaol Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(CO)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C XUARCIYIVXVTAE-ZAPOICBTSA-N 0.000 abstract 2
QGJZLNKBHJESQX-UHFFFAOYSA-N 3-Epi-Betulin-Saeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(=C)C)C5C4CCC3C21C QGJZLNKBHJESQX-UHFFFAOYSA-N 0.000 abstract 1
CLOUCVRNYSHRCF-UHFFFAOYSA-N 3beta-Hydroxy-20(29)-Lupen-3,27-oic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C(O)=O)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C CLOUCVRNYSHRCF-UHFFFAOYSA-N 0.000 abstract 1
DIZWSDNSTNAYHK-XGWVBXMLSA-N Betulinic acid Natural products CC(=C)[C@@H]1C[C@H]([C@H]2CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(=O)O DIZWSDNSTNAYHK-XGWVBXMLSA-N 0.000 abstract 1
PSZDOEIIIJFCFE-UHFFFAOYSA-N Oleanolic alcohol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(CO)CCC(C)(C)CC5C4=CCC3C21C PSZDOEIIIJFCFE-UHFFFAOYSA-N 0.000 abstract 1
JYDNKGUBLIKNAM-UHFFFAOYSA-N Oxyallobutulin Natural products C1CC(=O)C(C)(C)C2CCC3(C)C4(C)CCC5(CO)CCC(C(=C)C)C5C4CCC3C21C JYDNKGUBLIKNAM-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
FVWJYYTZTCVBKE-ROUWMTJPSA-N betulin Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(CO)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C FVWJYYTZTCVBKE-ROUWMTJPSA-N 0.000 abstract 1
MVIRREHRVZLANQ-UHFFFAOYSA-N betulin Natural products CC(=O)OC1CCC2(C)C(CCC3(C)C2CC=C4C5C(CCC5(CO)CCC34C)C(=C)C)C1(C)C MVIRREHRVZLANQ-UHFFFAOYSA-N 0.000 abstract 1
QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
MDZKJHQSJHYOHJ-UHFFFAOYSA-N crataegolic acid Natural products C1C(O)C(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MDZKJHQSJHYOHJ-UHFFFAOYSA-N 0.000 abstract 1
PZXJOHSZQAEJFE-UHFFFAOYSA-N dihydrobetulinic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(C)C)C5C4CCC3C21C PZXJOHSZQAEJFE-UHFFFAOYSA-N 0.000 abstract 1
PSZDOEIIIJFCFE-OSQDELBUSA-N erythrodiol Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(CO)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C PSZDOEIIIJFCFE-OSQDELBUSA-N 0.000 abstract 1
HTZRWCSRPTWJCT-UHFFFAOYSA-N erythrodiol Natural products CC1(C)CCC2(CO)CCC3C(CCC4C3(C)CCC5C(C)(C)C(O)CCC45C)C2C1 HTZRWCSRPTWJCT-UHFFFAOYSA-N 0.000 abstract 1
MDZKJHQSJHYOHJ-LLICELPBSA-N maslinic acid Chemical compound C1[C@@H](O)[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MDZKJHQSJHYOHJ-LLICELPBSA-N 0.000 abstract 1
MQYXUWHLBZFQQO-UHFFFAOYSA-N nepehinol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C MQYXUWHLBZFQQO-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
SYFNOXYZEIYOSE-UHFFFAOYSA-N uvaol Natural products CC1CCC2(O)CCC3(C)C(=CCC4(C)C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C SYFNOXYZEIYOSE-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PCT/JP2001/006393 2000-07-31 2001-07-25 Agents antitumoraux WO2002009719A1 (fr)

Priority Applications (4)

Application Number	Priority Date	Filing Date	Title
EP01984400A EP1321145A4 (en)	2000-07-31	2001-07-25	ANTITUMOR SUBSTANCES
AU2002224595A AU2002224595A1 (en)	2000-07-31	2001-07-25	Antitumor agents
CA002418117A CA2418117A1 (en)	2000-07-31	2001-07-25	Antitumor agent
US10/355,201 US20030153538A1 (en)	2000-07-31	2003-01-31	Antitumor agent

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2000-230254		2000-07-31
JP2000230254		2000-07-31
JP2000366297		2000-11-30
JP2000-366297		2000-11-30

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
US10/355,201 Continuation US20030153538A1 (en)	2000-07-31	2003-01-31	Antitumor agent

Publications (1)

Publication Number	Publication Date
WO2002009719A1 true WO2002009719A1 (fr)	2002-02-07

Family

ID=26596992

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PCT/JP2001/006393 WO2002009719A1 (fr)	2000-07-31	2001-07-25	Agents antitumoraux

Country Status (6)

Country	Link
US (1)	US20030153538A1 (ja)
EP (1)	EP1321145A4 (ja)
CN (1)	CN1450900A (ja)
AU (1)	AU2002224595A1 (ja)
CA (1)	CA2418117A1 (ja)
WO (1)	WO2002009719A1 (ja)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003057224A1 (fr) *	2001-12-28	2003-07-17	The Nisshin Oillio, Ltd.	Inducteur d'apoptose
JP2006508968A (ja) *	2002-11-21	2006-03-16	武漢利元亨薬物技術有限公司	ウルソル酸−大豆レシチン凍結乾燥ナノ粒子注射剤およびその製造方法
US7091195B2 (en)	2000-08-18	2006-08-15	The Board Of Trustees Of The University Of Illinois	Method of preparing and use of prodrugs of betulinic acid derivatives
EP1507542A4 (en) *	2002-05-24	2008-01-23	Greystone Medical Group Inc	ANTICANCER PREPARATION
US7414042B2 (en)	1995-03-21	2008-08-19	The Board Of Trustees Of The University Of Illinois	Method and composition for selectively inhibiting melanoma
JP2009530405A (ja) *	2006-03-23	2009-08-27	アドバンストライフサイエンシズインコーポレイテッド	合成五環性トリテルペノイド、ならびにベツリン酸およびベツリンの誘導体
JP2011225538A (ja) *	2010-03-31	2011-11-10	Toyama Prefecture	がん免疫抑制解除剤、がん免疫治療用組成物及びがん免疫治療方法
JP2013010715A (ja) *	2011-06-29	2013-01-17	Nippon Flour Mills Co Ltd	う蝕予防剤、歯周病予防剤及び口腔用組成物
JP2016033135A (ja) *	2005-05-09	2016-03-10	小野薬品工業株式会社	ＰｒｏｇｒａｍｍｅｄＤｅａｔｈ１（ＰＤ−１）に対するヒトモノクローナル抗体および抗ＰＤ−１抗体単独または他の免疫療法と併用した癌治療方法

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FR2822821B1 (fr) *	2001-04-03	2004-05-07	Pharmascience Lab	Extrait de coques de graines de lupin contenant du lupeol, en particulier extrait riche en lupeol et son procede de preparation
KR100559489B1 (ko) *	2003-08-05	2006-03-10	한국생명공학연구원	대추 추출물 및 그로부터 분리된 화합물을 유효성분으로함유하는 항암제 및 암전이 억제제
US8008280B2 (en) *	2004-09-10	2011-08-30	Biorings Llc	Betulinol derivatives as anti-HIV agents
ES2301369B1 (es) *	2006-06-21	2009-06-12	Consejo Superior Investig. Cientificas	Utilizacion del editrodiol para la preparacion de un medicamento inductor de muerte por desarraigo en celulas malignas de tumores solidos.
ES2328999B1 (es) *	2008-04-03	2010-10-27	Biomaslinic S.L.	Uso del acido maslinico para el tratamiento de patologias y sus sintomas mediante la inhibicion de cox-2.
CN102008715B (zh) *	2009-09-07	2013-02-20	华东师范大学	抗肿瘤的MA-TNFα药物组合物及其应用
CN102241723B (zh) *	2010-05-11	2015-06-03	上海开拓者医药发展有限公司	一种熊果酸盐及其制备方法和晶体
CN104688745B (zh)	2010-05-20	2019-11-12	爱荷华大学研究基金会	用于抑制肌萎缩的方法
US11090313B2 (en)	2010-05-20	2021-08-17	University Of Iowa Research Foundation	Methods for inhibiting muscle atrophy
CN102106858A (zh) *	2010-09-27	2011-06-29	林秀坤	山楂酸的抗宫颈癌作用及其药物制剂
CN102106861A (zh) *	2010-09-27	2011-06-29	林秀坤	山楂酸的抗结肠癌作用及其药物制剂
CN102091078A (zh) *	2010-09-27	2011-06-15	林秀坤	山楂酸的抗肝癌作用及其药物制剂
CN102106859A (zh) *	2010-09-27	2011-06-29	林秀坤	山楂酸的抗乳腺癌作用及其药物制剂
CN102225068A (zh) *	2010-09-27	2011-10-26	林秀坤	山楂酸的抗卵巢癌作用及其药物制剂
CN102151276A (zh) *	2010-11-07	2011-08-17	林秀坤	山楂酸的抗胰腺癌作用及其药物制剂
EP3520793B1 (en)	2011-06-06	2023-03-29	University of Iowa Research Foundation	Substances and compostions for use in methods of inhibiting muscle atrophy
RU2475025C1 (ru) *	2011-07-27	2013-02-20	Федеральное государственное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет"	Средство для обработки семян зерновых и зернобобовых культур, пораженных фузариозом
CN103202898B (zh) *	2013-03-29	2014-04-16	阚兆云	中药组合物及其制备方法
JP7670482B2 (ja)	2017-09-13	2025-04-30	エミオンインコーポレイテッド	ウルソール酸モルホリン塩及びジエタノールアミン塩
CN108686220A (zh) *	2018-07-13	2018-10-23	刘慧荣	一种针对甲状腺癌的抗肿瘤剂
CN112353827B (zh) *	2020-12-07	2022-05-27	山东省分析测试中心	Vsm在制备治疗横纹肌肉瘤药物中的应用

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2001
- 2001-07-25 CN CN01815073A patent/CN1450900A/zh active Pending
- 2001-07-25 CA CA002418117A patent/CA2418117A1/en not_active Abandoned
- 2001-07-25 WO PCT/JP2001/006393 patent/WO2002009719A1/ja not_active Application Discontinuation
- 2001-07-25 AU AU2002224595A patent/AU2002224595A1/en not_active Abandoned
- 2001-07-25 EP EP01984400A patent/EP1321145A4/en not_active Withdrawn
2003
- 2003-01-31 US US10/355,201 patent/US20030153538A1/en not_active Abandoned

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7414042B2 (en)	1995-03-21	2008-08-19	The Board Of Trustees Of The University Of Illinois	Method and composition for selectively inhibiting melanoma
US7091195B2 (en)	2000-08-18	2006-08-15	The Board Of Trustees Of The University Of Illinois	Method of preparing and use of prodrugs of betulinic acid derivatives
WO2003057224A1 (fr) *	2001-12-28	2003-07-17	The Nisshin Oillio, Ltd.	Inducteur d'apoptose
EP1507542A4 (en) *	2002-05-24	2008-01-23	Greystone Medical Group Inc	ANTICANCER PREPARATION
JP2006508968A (ja) *	2002-11-21	2006-03-16	武漢利元亨薬物技術有限公司	ウルソル酸−大豆レシチン凍結乾燥ナノ粒子注射剤およびその製造方法
JP4896401B2 (ja) *	2002-11-21	2012-03-14	武漢利元亨薬物技術有限公司	ウルソル酸−大豆レシチン凍結乾燥ナノ粒子注射剤およびその製造方法
JP2016033135A (ja) *	2005-05-09	2016-03-10	小野薬品工業株式会社	ＰｒｏｇｒａｍｍｅｄＤｅａｔｈ１（ＰＤ−１）に対するヒトモノクローナル抗体および抗ＰＤ−１抗体単独または他の免疫療法と併用した癌治療方法
JP2009530405A (ja) *	2006-03-23	2009-08-27	アドバンストライフサイエンシズインコーポレイテッド	合成五環性トリテルペノイド、ならびにベツリン酸およびベツリンの誘導体
JP2011225538A (ja) *	2010-03-31	2011-11-10	Toyama Prefecture	がん免疫抑制解除剤、がん免疫治療用組成物及びがん免疫治療方法
JP2013010715A (ja) *	2011-06-29	2013-01-17	Nippon Flour Mills Co Ltd	う蝕予防剤、歯周病予防剤及び口腔用組成物

Also Published As

Publication number	Publication date
AU2002224595A1 (en)	2002-02-13
EP1321145A4 (en)	2006-03-22
US20030153538A1 (en)	2003-08-14
CA2418117A1 (en)	2003-01-30
EP1321145A1 (en)	2003-06-25
CN1450900A (zh)	2003-10-22

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