+

WO2002008393A3 - Serine protease from yersinia enterocolitica - Google Patents

Serine protease from yersinia enterocolitica Download PDF

Info

Publication number
WO2002008393A3
WO2002008393A3 PCT/GB2001/003357 GB0103357W WO0208393A3 WO 2002008393 A3 WO2002008393 A3 WO 2002008393A3 GB 0103357 W GB0103357 W GB 0103357W WO 0208393 A3 WO0208393 A3 WO 0208393A3
Authority
WO
WIPO (PCT)
Prior art keywords
serine protease
yersinia enterocolitica
protein
termed
fragments
Prior art date
Application number
PCT/GB2001/003357
Other languages
French (fr)
Other versions
WO2002008393A2 (en
Inventor
Christopher Benjamin Phelps
Richard Joseph Fagan
Original Assignee
Inpharmatica Ltd
Christopher Benjamin Phelps
Richard Joseph Fagan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inpharmatica Ltd, Christopher Benjamin Phelps, Richard Joseph Fagan filed Critical Inpharmatica Ltd
Priority to AU2002224552A priority Critical patent/AU2002224552A1/en
Publication of WO2002008393A2 publication Critical patent/WO2002008393A2/en
Publication of WO2002008393A3 publication Critical patent/WO2002008393A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/24—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

This invention relates to a protein, termed CAB46586.1, isolated from the bacteria 'Yersinia enterocolitica' herein identified as a serine protease and to the use of this protein, fragments of this protein and nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment of disease.
PCT/GB2001/003357 2000-07-24 2001-07-24 Serine protease from yersinia enterocolitica WO2002008393A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002224552A AU2002224552A1 (en) 2000-07-24 2001-07-24 Serine protease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0018125.5 2000-07-24
GBGB0018125.5A GB0018125D0 (en) 2000-07-24 2000-07-24 Novel proteins

Publications (2)

Publication Number Publication Date
WO2002008393A2 WO2002008393A2 (en) 2002-01-31
WO2002008393A3 true WO2002008393A3 (en) 2002-06-20

Family

ID=9896234

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/003357 WO2002008393A2 (en) 2000-07-24 2001-07-24 Serine protease from yersinia enterocolitica

Country Status (3)

Country Link
AU (1) AU2002224552A1 (en)
GB (1) GB0018125D0 (en)
WO (1) WO2002008393A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998014461A1 (en) * 1996-09-30 1998-04-09 Smithkline Beecham Plc NOVEL spsB

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998014461A1 (en) * 1996-09-30 1998-04-09 Smithkline Beecham Plc NOVEL spsB

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BURTSEVA T I ET AL: "Secreted trypsin-like proteinase from Yersinia pseudotuberculosis.", BIOCHEMISTRY (MOSCOW), vol. 60, no. 10, 1995, pages 1213 - 1217, XP001053556, ISSN: 0006-2979 *
DATABASE EM_PRO EMBL; 1 July 1999 (1999-07-01), RAKIN A.V.: "Yersinia enterocolitica WA 314 right arm of the high-pathogenicity island", XP002190030 *
PALLEN M J ET AL: "THE HTRA FAMILY OF SERINE PROTEASES", MOLECULAR MICROBIOLOGY, BLACKWELL SCIENTIFIC, OXFORD, GB, vol. 26, no. 2, 1997, pages 209 - 221, XP000946617, ISSN: 0950-382X *
RAKIN A ET AL: "COMMON AND SPECIFIC CHARACTERISTICS OF THE HIGH-PATHOGENICITY ISLAND OF YERSINIA ENTEROCOLITICA", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 67, no. 10, October 1999 (1999-10-01), pages 5265 - 5274, XP000882235, ISSN: 0019-9567 *
RAKIN A ET AL: "Local hopping of IS3 elements into the A+T-rich part of the high-pathogenicity island in Yersinia enterocolitica 1B, O:8.", FEMS MICROBIOLOGY LETTERS, vol. 182, no. 2, 15 January 2000 (2000-01-15), pages 225 - 229, XP002190029, ISSN: 0378-1097 *
RAKIN ALEXANDER ET AL: "Virulence-associated fyuA / irp2 gene cluster of Yersinia enterocolitica biotype 1B carries a novel insertion sequence IS1328.", FEMS MICROBIOLOGY LETTERS, vol. 129, no. 2-3, 1995, pages 287 - 292, XP001053551, ISSN: 0378-1097 *
WILLIAMS KERSTIN ET AL: "Investigation into the role of the serine protease HtrA in Yersinia pestis pathogenesis.", FEMS MICROBIOLOGY LETTERS, vol. 186, no. 2, 15 May 2000 (2000-05-15), pages 281 - 286, XP001053517, ISSN: 0378-1097 *

Also Published As

Publication number Publication date
GB0018125D0 (en) 2000-09-13
AU2002224552A1 (en) 2002-02-05
WO2002008393A2 (en) 2002-01-31

Similar Documents

Publication Publication Date Title
WO2005002526A3 (en) Method and compositions for treatment of viral infections
WO2003048205A3 (en) Novel proteins with il-6 inhibiting activity
WO2003054012A3 (en) Leptin proteins
WO2004053117A3 (en) Serine protease
WO2003044047A3 (en) Virulence proteins of the genus yersinia and uses thereof
WO2002008393A3 (en) Serine protease from yersinia enterocolitica
WO2007049065A3 (en) Vwfa, collagen and kunitz domain containing protein
WO2002033058A3 (en) Novel cysteine proteases and uses thereof
WO2002029023A8 (en) Nicastrin protein
WO2004056983A3 (en) Metalloprotease proteins
WO2002070563A3 (en) Nuclear hormone receptor ligand binding domain
AU2001292326A1 (en) Nucleic acid of novel human kinesin-associated gene, protein encoded by the nucleic acid, peptide fragment thereof and anticancer agents comprising the nucleic acid and the like
EP1293570A3 (en) Application of aprataxin gene to diagnosis and treatment for early-onset spinocerebellar ataxia (EAOH)
WO2002062976A3 (en) Serine proteases
WO2002046380A3 (en) Protein kinase
WO2002034901A8 (en) Protein kinase
WO2002062845A3 (en) Adhesion molecules
WO2003054178A3 (en) Metalloprotease proteins
WO2002050116A3 (en) Adhesion molecule protein
ATE456576T1 (en) SPLICE VARIANT OF HUMAN HYPOPHYSICAL GROWTH HORMONE
WO2002088341A3 (en) P450 proteins
WO2004009633A8 (en) Serotonin receptor
WO2002044382A8 (en) Cytokine-like proteins
WO2004056863A8 (en) Splice variant of human placental growth hormone
WO2004024762A3 (en) Il-8 like protein

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载