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WO2002007660A3 - Methods and instruments for refractive ophthalmic surgery - Google Patents

Methods and instruments for refractive ophthalmic surgery Download PDF

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Publication number
WO2002007660A3
WO2002007660A3 PCT/US2001/022936 US0122936W WO0207660A3 WO 2002007660 A3 WO2002007660 A3 WO 2002007660A3 US 0122936 W US0122936 W US 0122936W WO 0207660 A3 WO0207660 A3 WO 0207660A3
Authority
WO
WIPO (PCT)
Prior art keywords
flap
cornea
operative
model
corneal
Prior art date
Application number
PCT/US2001/022936
Other languages
French (fr)
Other versions
WO2002007660A2 (en
Inventor
Cynthia Roberts
William J Dupps Jr
Noriko Katsube
Original Assignee
Univ Ohio State
Cynthia Roberts
William J Dupps Jr
Noriko Katsube
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ohio State, Cynthia Roberts, William J Dupps Jr, Noriko Katsube filed Critical Univ Ohio State
Priority to AU2001277038A priority Critical patent/AU2001277038A1/en
Priority to EP01954818A priority patent/EP1301155A2/en
Priority to US10/332,891 priority patent/US20030208190A1/en
Priority to JP2002513398A priority patent/JP2004504105A/en
Priority to CA002416598A priority patent/CA2416598A1/en
Publication of WO2002007660A2 publication Critical patent/WO2002007660A2/en
Publication of WO2002007660A3 publication Critical patent/WO2002007660A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F9/00802Methods or devices for eye surgery using laser for photoablation
    • A61F9/00804Refractive treatments
    • A61F9/00806Correction of higher orders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F2009/00855Calibration of the laser system
    • A61F2009/00857Calibration of the laser system considering biodynamics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F2009/00861Methods or devices for eye surgery using laser adapted for treatment at a particular location
    • A61F2009/00872Cornea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F2009/00878Planning
    • A61F2009/0088Planning based on wavefront
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F2009/00878Planning
    • A61F2009/00882Planning based on topography

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Optics & Photonics (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
  • Laser Surgery Devices (AREA)

Abstract

Biomechanical responses of the eye are used to improve photorefractive procedures. LASIK or PRK treatments, for example, can be improved by taking pre-operative measurement and predicting the corneas's biodynamic response to the ablative treatment. Predicitve use is mad of the biodynamic response of the cornea due to laser or mechanical keratectomy, that is, creating a corneal flap characterisitc of LASIK. Comparison of pre-flap and post-flap, (pre-ablation) data of the cornea such as corneal thickness, flap thickness, corneal topography and wavefront, for example, can provide predictive information applicable to modifying an ablation alorithm before the laser is engaged, either for a current operation or the development of a model. Modeling, by finite element analysis or other mathematical techniques, can also be used to predict post-operative outcomes based on a pre-operative (no flap cut or other surgical intervention) data for the cornea that is input for an accurate eye model that, in consideration of biodynamic response ∫i⊃via∫/i⊃ the model, provides predictive information for optimizing the sucess of the refractive surgery and ultimately patient satisfaction.
PCT/US2001/022936 2000-07-20 2001-07-20 Methods and instruments for refractive ophthalmic surgery WO2002007660A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2001277038A AU2001277038A1 (en) 2000-07-21 2001-07-20 Methods and instruments for improving refractive ophthalmic surgery
EP01954818A EP1301155A2 (en) 2000-07-20 2001-07-20 Methods and instruments for refractive ophthalmic surgery
US10/332,891 US20030208190A1 (en) 2001-07-20 2001-07-20 Methods and instruments for refractive ophthalmic surgery
JP2002513398A JP2004504105A (en) 2000-07-21 2001-07-20 Method and apparatus for refractive eye surgery
CA002416598A CA2416598A1 (en) 2000-07-21 2001-07-20 Methods and instruments for refractive ophthalmic surgery

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22001900P 2000-07-21 2000-07-21
US60/220,019 2000-07-21

Publications (2)

Publication Number Publication Date
WO2002007660A2 WO2002007660A2 (en) 2002-01-31
WO2002007660A3 true WO2002007660A3 (en) 2002-05-30

Family

ID=22821710

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/022936 WO2002007660A2 (en) 2000-07-20 2001-07-20 Methods and instruments for refractive ophthalmic surgery

Country Status (6)

Country Link
EP (1) EP1301155A2 (en)
JP (1) JP2004504105A (en)
AU (1) AU2001277038A1 (en)
CA (1) CA2416598A1 (en)
SG (1) SG127691A1 (en)
WO (1) WO2002007660A2 (en)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4854849B2 (en) 1998-03-04 2012-01-18 ヴィズイクス・インコーポレーテッド Method and system for laser treatment of presbyopia using offset imaging
US7130835B2 (en) 2002-03-28 2006-10-31 Bausch & Lomb Incorporated System and method for predictive ophthalmic correction
EP1513477A1 (en) 2002-05-31 2005-03-16 Carl Zeiss Meditec AG Method for controlling a device for treating the human eye
US7992569B2 (en) 2002-10-15 2011-08-09 The Ohio State University Customized transition zone system and method for an ablation pattern
US6939342B2 (en) * 2002-12-12 2005-09-06 Bausch And Lomb Incorporated System and method for evaluating a secondary LASIK treatment
EP1575466B1 (en) 2002-12-16 2012-04-18 The Ohio State University Parametric model based ablative surgical systems and methods
US7004902B2 (en) * 2003-03-21 2006-02-28 Reichert, Inc. Method and apparatus for measuring biomechanical characteristics of corneal tissue
US7703919B2 (en) * 2003-03-28 2010-04-27 Digital Vision, Llc Application of neuro-ocular wavefront data in vision correction
EP1462074A1 (en) * 2003-03-28 2004-09-29 Cesar C. Dr. Carriazo Ablation depth control system for corneal surgery
EP1615575B1 (en) 2003-04-18 2014-11-05 AMO Manufacturing USA, LLC Systems and methods for correcting high order aberrations in laser refractive surgery
ES2253951B1 (en) * 2003-09-08 2007-08-01 INSTITUTO NACIONAL DE TECNICA AEROESPACIAL "ESTEBAN TERRADAS". SYSTEM FOR THE DESIGN OF PERSONALIZED CORNEAL PHOTO-ABLATION PATTERNS, OBTAINED PATTERN AND LASER SURGERY SYSTEM FOR CORNEA CARVING.
WO2005079546A2 (en) * 2004-02-20 2005-09-01 Ophthonix, Inc. System and method for analyzing wavefront aberrations
CA2555705C (en) 2004-02-20 2015-04-07 Visx, Incorporated Volumetric point spread function for eye diagnosis and treatment
ES2253078B1 (en) * 2004-06-11 2007-07-16 Consejo Superior De Investigaciones Cientificas. PROCEDURE TO AVOID THE INDUCTION OF ABERRATIONS IN LASER REFRACTIVE SURGERY SYSTEMS.
DE102004033819B8 (en) * 2004-07-13 2011-11-10 Wavelight Gmbh Method for generating control data of a laser system for ophthalmological procedures
US10729585B2 (en) 2006-07-19 2020-08-04 Alcon Inc. Computer program for ophthalmological surgery
EP2276420B1 (en) 2008-04-04 2021-10-06 Journey1, Inc. Device to treat an eye having an epithelium with a defect
KR101255797B1 (en) * 2008-06-30 2013-04-17 웨이브라이트 게엠베하 Device for ophthalmologic refractive laser surgery, machine-readable data medium storing a control program for such device, and method for generating the control program
JP5323937B2 (en) * 2008-08-29 2013-10-23 ウェイブライト ゲーエムベーハー Method for calibrating the pulse energy of a laser device using a coherence optical interferometry instrument
DE102008046834A1 (en) 2008-09-11 2010-03-18 Iroc Ag Control program for controlling electromagnetic radiation for cross-linking of eye tissue
ES2649890T3 (en) 2009-10-23 2018-01-16 Nexisvision, Inc. Corneal enervation for the treatment of eye pain
US8591025B1 (en) 2012-09-11 2013-11-26 Nexisvision, Inc. Eye covering and refractive correction methods for LASIK and other applications
US9498385B2 (en) 2009-10-23 2016-11-22 Nexisvision, Inc. Conformable therapeutic shield for vision and pain
US8409178B2 (en) 2010-03-30 2013-04-02 Amo Development Llc. Systems and methods for evaluating treatment tables for refractive surgery
US9642518B2 (en) 2010-03-30 2017-05-09 Amo Development, Llc Random eye generation systems and methods
JP2013544132A (en) 2010-10-25 2013-12-12 ネクシスビジョン, インコーポレイテッド Method and apparatus for identifying eye coverings for vision
US10582847B2 (en) 2010-12-30 2020-03-10 Amo Wavefront Sciences, Llc Method and system for eye measurements and cataract surgery planning using vector function derived from prior surgeries
US10583039B2 (en) 2010-12-30 2020-03-10 Amo Wavefront Sciences, Llc Method and system for eye measurements and cataract surgery planning using vector function derived from prior surgeries
EP3213724B1 (en) 2010-12-30 2019-09-18 Amo Wavefront Sciences, LLC Improved treatment planning method and system for controlling laser refractive surgery
US10582846B2 (en) 2010-12-30 2020-03-10 Amo Wavefront Sciences, Llc Method and system for eye measurements and cataract surgery planning using vector function derived from prior surgeries
US9501621B2 (en) 2011-03-18 2016-11-22 Amo Development, Llc Treatment validation systems and methods
US12044905B2 (en) 2011-04-28 2024-07-23 Journey1 Inc Contact lenses for refractive correction
AU2012249773A1 (en) 2011-04-28 2013-11-07 Nexisvision, Inc. Eye covering and refractive correction methods and apparatus having improved tear flow, comfort, and/or applicability
CA2841373C (en) * 2011-07-28 2017-08-29 Wavelight Gmbh Device for assisting in the preparation of an operation on the human eye
DE102011083789A1 (en) * 2011-09-29 2013-04-04 Oculus Optikgeräte GmbH Ophthalmological analysis method
JP2013153881A (en) * 2012-01-27 2013-08-15 Canon Inc Image processing system, processing method, and program
CA2871027A1 (en) 2012-04-20 2013-12-12 Nexisvision, Inc. Contact lenses for refractive correction
US9465233B2 (en) 2012-04-20 2016-10-11 Nexisvision, Inc. Bimodular contact lenses
JP6310072B2 (en) 2013-06-26 2018-04-11 ネクシスビジョン, インコーポレイテッド Contact lenses for refractive correction
EP2824599A1 (en) 2013-07-10 2015-01-14 ISS Integrated Scientific Device and method for the modelling of a cornea
US9341864B2 (en) 2013-11-15 2016-05-17 Nexisvision, Inc. Contact lenses having a reinforcing scaffold
WO2015116559A1 (en) 2014-01-29 2015-08-06 Nexisvision, Inc. Multifocal bimodulus contact lenses
KR101581834B1 (en) * 2015-03-24 2015-12-31 박기성 Integrated corneal photoablation system for correction of both shape error and curvature error
JP2019505257A (en) * 2015-12-08 2019-02-28 ナラヤナ ネスララヤ ファウンデーション Bowman's membrane quantification index for disease diagnosis and treatment prognosis in human cornea
US10426551B2 (en) 2016-12-09 2019-10-01 Microsoft Technology Licensing, Llc Personalized refractive surgery recommendations for eye patients
US11701258B2 (en) 2018-11-20 2023-07-18 Mark Lobanoff Intelligent corneal procedure advisor
US11638661B2 (en) 2018-11-20 2023-05-02 Mark Lobanoff Intelligent topographic corneal procedure advisor
CN114269302B (en) * 2019-05-03 2024-06-28 雷萨公司 Cloud-based cataract treatment database and algorithm system
WO2021173843A1 (en) * 2020-02-25 2021-09-02 Mark Lobanoff Epithelial thickness mapping and corneal procedure advisor
CN114522020B (en) * 2022-02-21 2022-12-02 华中科技大学 A Personalized Refractive Surgery Device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721379A (en) * 1985-01-16 1988-01-26 Lri L.P. Apparatus for analysis and correction of abnormal refractive errors of the eye
US4941093A (en) * 1985-09-12 1990-07-10 Summit Technology, Inc. Surface erosion using lasers
US5098426A (en) * 1989-02-06 1992-03-24 Phoenix Laser Systems, Inc. Method and apparatus for precision laser surgery
WO1993016631A1 (en) * 1992-02-27 1993-09-02 Phoenix Laser Systems, Inc. Automated laser workstation for high precision surgical and industrial interventions
US5891131A (en) * 1993-02-01 1999-04-06 Arizona Board Of Regents Method and apparatus for automated simulation and design of corneal refractive procedures

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11128264A (en) * 1997-10-24 1999-05-18 Nidek Co Ltd Ablation rate meter and ablation device with the same
WO2001028477A1 (en) * 1999-10-21 2001-04-26 Technolas Gmbh Ophthalmologische Systeme Multi-step laser correction of ophthalmic refractive errors
US6419671B1 (en) * 1999-12-23 2002-07-16 Visx, Incorporated Optical feedback system for vision correction
US7275827B2 (en) * 2000-04-11 2007-10-02 Benedikt Jean Selective corneal aberrometry
US6582078B2 (en) * 2001-02-27 2003-06-24 Barton L. Halpern Method and system for planning corrective refractive surgery

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721379A (en) * 1985-01-16 1988-01-26 Lri L.P. Apparatus for analysis and correction of abnormal refractive errors of the eye
US4941093A (en) * 1985-09-12 1990-07-10 Summit Technology, Inc. Surface erosion using lasers
US5098426A (en) * 1989-02-06 1992-03-24 Phoenix Laser Systems, Inc. Method and apparatus for precision laser surgery
WO1993016631A1 (en) * 1992-02-27 1993-09-02 Phoenix Laser Systems, Inc. Automated laser workstation for high precision surgical and industrial interventions
US5891131A (en) * 1993-02-01 1999-04-06 Arizona Board Of Regents Method and apparatus for automated simulation and design of corneal refractive procedures

Also Published As

Publication number Publication date
EP1301155A2 (en) 2003-04-16
JP2004504105A (en) 2004-02-12
CA2416598A1 (en) 2002-01-31
AU2001277038A1 (en) 2002-02-05
WO2002007660A2 (en) 2002-01-31
SG127691A1 (en) 2006-12-29

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