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WO2002005787A1 - Fabrication pour produits lyophilises - Google Patents

Fabrication pour produits lyophilises Download PDF

Info

Publication number
WO2002005787A1
WO2002005787A1 PCT/JP2001/006115 JP0106115W WO0205787A1 WO 2002005787 A1 WO2002005787 A1 WO 2002005787A1 JP 0106115 W JP0106115 W JP 0106115W WO 0205787 A1 WO0205787 A1 WO 0205787A1
Authority
WO
WIPO (PCT)
Prior art keywords
freeze
layer
dried
frozen
ice layer
Prior art date
Application number
PCT/JP2001/006115
Other languages
English (en)
Japanese (ja)
Inventor
Muneo Nonomura
Kei Mukai
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Priority to AU2001269524A priority Critical patent/AU2001269524A1/en
Publication of WO2002005787A1 publication Critical patent/WO2002005787A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)

Abstract

Cette invention concerne un procédé de fabrication pour produits lyophilisés destiné à empêcher par exemple un gâteau lyophilisé de s'émietter et de s'éparpiller et qui accélère la sublimation de l'eau gelée. Ce procédé consiste à :former une couche gelée d'une solution aqueuse renfermant une substance destinée à être desséchée dans un récipient de lyophilisation dont la surface intérieure est recouverte entièrement ou en partie d'une couche de glace ; et lyophiliser le matériau à dessécher. Ce procédé se caractérise en ce que la couche gelée est telle que la couche de glace est partiellement exposée à la surface de la couche gelée de la solution aqueuse renfermant le matériau à dessécher ou bien que l'on agit sur la température pour que la température du récipient de lyophilisation soit maintenue à 0 °C ou plus pendant la phase initiale de sublimation de l'eau gelée, puis soit abaissée jusqu'à 0 °C pendant la sublimation.
PCT/JP2001/006115 2000-07-17 2001-07-16 Fabrication pour produits lyophilises WO2002005787A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001269524A AU2001269524A1 (en) 2000-07-17 2001-07-16 Production method for freeze-dried products

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2000-215778 2000-07-17
JP2000215778 2000-07-17
JP2000-215782 2000-07-17
JP2000215782 2000-07-17

Publications (1)

Publication Number Publication Date
WO2002005787A1 true WO2002005787A1 (fr) 2002-01-24

Family

ID=26596132

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/006115 WO2002005787A1 (fr) 2000-07-17 2001-07-16 Fabrication pour produits lyophilises

Country Status (2)

Country Link
AU (1) AU2001269524A1 (fr)
WO (1) WO2002005787A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7666856B2 (en) 2006-10-10 2010-02-23 Medivir Ab Antiviral nucleosides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6168412A (ja) * 1984-09-10 1986-04-08 Fujisawa Pharmaceut Co Ltd 医薬品の凍結乾燥方法
JPH02104527A (ja) * 1988-10-11 1990-04-17 Kayaku:Kk １−〔（４´‐ヒドロキシ‐２´‐ブテノキシ）メチル〕‐２‐ニトロイミダゾールの凍結乾燥製剤の製造法
WO1999037288A1 (fr) * 1998-01-21 1999-07-29 Takeda Chemical Industries, Ltd. Procede de lyophilisation de preparations a liberation prolongee

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6168412A (ja) * 1984-09-10 1986-04-08 Fujisawa Pharmaceut Co Ltd 医薬品の凍結乾燥方法
JPH02104527A (ja) * 1988-10-11 1990-04-17 Kayaku:Kk １−〔（４´‐ヒドロキシ‐２´‐ブテノキシ）メチル〕‐２‐ニトロイミダゾールの凍結乾燥製剤の製造法
WO1999037288A1 (fr) * 1998-01-21 1999-07-29 Takeda Chemical Industries, Ltd. Procede de lyophilisation de preparations a liberation prolongee

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7666856B2 (en) 2006-10-10 2010-02-23 Medivir Ab Antiviral nucleosides
US7825239B2 (en) 2006-10-10 2010-11-02 Medivir Ab Antiviral nucleosides
US7935681B2 (en) 2006-10-10 2011-05-03 Medivir Ab Antiviral nucleosides
EP2361922A1 (fr) 2006-10-10 2011-08-31 Medivir AB Intermediaire pour la synthèse d'inhibiteurs nucleosidique du HCV
US8158779B2 (en) 2006-10-10 2012-04-17 Medivir Ab Antiviral nucleosides

Also Published As

Publication number Publication date
AU2001269524A1 (en) 2002-01-30

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