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WO2002004664A3 - Aus tumorzellen isolierbare gene mit kodierenden mononucleotid- oder dinucleotid-mikrosatelliten - Google Patents

Aus tumorzellen isolierbare gene mit kodierenden mononucleotid- oder dinucleotid-mikrosatelliten Download PDF

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Publication number
WO2002004664A3
WO2002004664A3 PCT/DE2001/002510 DE0102510W WO0204664A3 WO 2002004664 A3 WO2002004664 A3 WO 2002004664A3 DE 0102510 W DE0102510 W DE 0102510W WO 0204664 A3 WO0204664 A3 WO 0204664A3
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WO
WIPO (PCT)
Prior art keywords
microsatellites
genes
isolated
dinucleotide
tumour cells
Prior art date
Application number
PCT/DE2001/002510
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English (en)
French (fr)
Other versions
WO2002004664A9 (de
WO2002004664A2 (de
Inventor
Doeberitz Von Magnus Knebel
Peer Bork
Yan Ping Yuan
Johannes Gebert
Stefan Woerner
Michael Linnebacher
Original Assignee
Doeberitz Von Magnus Knebel
Peer Bork
Yan Ping Yuan
Johannes Gebert
Stefan Woerner
Michael Linnebacher
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Doeberitz Von Magnus Knebel, Peer Bork, Yan Ping Yuan, Johannes Gebert, Stefan Woerner, Michael Linnebacher filed Critical Doeberitz Von Magnus Knebel
Priority to CA002415199A priority Critical patent/CA2415199A1/en
Priority to JP2002509517A priority patent/JP2004512021A/ja
Priority to US10/332,522 priority patent/US20040265803A1/en
Priority to EP01960106A priority patent/EP1352088A2/de
Priority to AU2001281708A priority patent/AU2001281708A1/en
Publication of WO2002004664A2 publication Critical patent/WO2002004664A2/de
Publication of WO2002004664A9 publication Critical patent/WO2002004664A9/de
Priority to NO20030052A priority patent/NO20030052L/no
Publication of WO2002004664A3 publication Critical patent/WO2002004664A3/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Die vorliegende Erfindung betrifft Gene mit kodierenden Mononukleotid-Mikrosatelliten (cMNR) oder Dinukleotid-Mikrosatelliten (cDNR), wobei die Gene aus MSI+ -Tumorzellen isolierbar sind und sich von den entsprechenden Genen aus nicht-MSI+(Tumor)zellen durch Mutationen in den cMNR oder cDNR unterscheiden und für Neo-Peptide umfassende Genprodukte kodieren. Ferner betrifft die Erfindung die Verwendung der Gene bzw. deren Genprodukte zur Prävention, Diagnose und/Therapie von MSI+ -Tumoren.
PCT/DE2001/002510 2000-07-07 2001-07-04 Aus tumorzellen isolierbare gene mit kodierenden mononucleotid- oder dinucleotid-mikrosatelliten WO2002004664A2 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002415199A CA2415199A1 (en) 2000-07-07 2001-07-04 Genes and their genetic products pertinent to microsatellite instable (msi+) tumours
JP2002509517A JP2004512021A (ja) 2000-07-07 2001-07-04 ミクロサテライト不安定（ｍｓｉ＋）腫瘍に適切な遺伝子およびその遺伝子産物
US10/332,522 US20040265803A1 (en) 2000-07-07 2001-07-04 Genes and their genetic products pertinent to microsatellite instable (msi+) tumours
EP01960106A EP1352088A2 (de) 2000-07-07 2001-07-04 Aus tumorzellen isolierbare gene mit kodierenden mononucleotid- oder dinucleotid-mikrosatelliten
AU2001281708A AU2001281708A1 (en) 2000-07-07 2001-07-04 Genes comprising coding mononucleotide microsatellites or dinucleotide microsatellites that can be isolated from tumour cells
NO20030052A NO20030052L (no) 2000-07-07 2003-01-06 Gener og deres genprodukter relevante for mikrosatelitt ustabile (MSI+)tumorer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10032608.0 2000-07-07
DE10032608A DE10032608A1 (de) 2000-07-07 2000-07-07 Für mikrosatelliteninstabile (MSI+)-Tumore relevante Gene und ihre Genprodukte

Publications (3)

Publication Number Publication Date
WO2002004664A2 WO2002004664A2 (de) 2002-01-17
WO2002004664A9 WO2002004664A9 (de) 2002-09-19
WO2002004664A3 true WO2002004664A3 (de) 2003-06-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2001/002510 WO2002004664A2 (de) 2000-07-07 2001-07-04 Aus tumorzellen isolierbare gene mit kodierenden mononucleotid- oder dinucleotid-mikrosatelliten

Country Status (8)

Country Link
US (1) US20040265803A1 (de)
EP (1) EP1352088A2 (de)
JP (1) JP2004512021A (de)
AU (1) AU2001281708A1 (de)
CA (1) CA2415199A1 (de)
DE (1) DE10032608A1 (de)
NO (1) NO20030052L (de)
WO (1) WO2002004664A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8053552B2 (en) 2002-04-18 2011-11-08 Mtm Laboratories, Ag Neopeptides and methods useful for detection and treatment of cancer
EP1361286A1 (de) * 2002-04-18 2003-11-12 MTM Laboratories AG Methode, um Krebs zu detektieren
EP1354895A1 (de) * 2002-04-18 2003-10-22 MTM Laboratories AG Neopeptide verwendbar zum Nachweis und zur Behandlung von Krebs
US9732131B2 (en) * 2006-02-27 2017-08-15 Calviri, Inc. Identification and use of novopeptides for the treatment of cancer
AU2007220042A1 (en) * 2006-02-27 2007-09-07 Arizona Board Of Regents For And On Behalf Of Arizona State University Identification and use of novopeptides for the treatment of cancer
JP2019505512A (ja) 2016-01-08 2019-02-28 バッシボディ アクスイェ セルスカプ 治療用抗癌ネオエピトープワクチン
WO2018223092A1 (en) 2017-06-02 2018-12-06 Arizona Board Of Regents On Behalf Of Arizona State University A method to create personalized cancer vaccines
WO2019055618A1 (en) 2017-09-15 2019-03-21 Arizona Board Of Regents On Behalf Of Arizona State University METHODS OF CLASSIFYING RESPONSES TO ANTICANCER IMMUNOTHERAPY
WO2021067550A1 (en) 2019-10-02 2021-04-08 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for identifying neoantigens for use in treating and preventing cancer

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WO2002012328A2 (en) * 2000-08-03 2002-02-14 Corixa Corporation Compositions and methods for the therapy and diagnosis of colon cancer

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Publication number Priority date Publication date Assignee Title
AU744157B2 (en) * 1997-07-28 2002-02-14 Fox Chase Cancer Center Novel gene encoding a DNA repair endonuclease and methods of use thereof

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US5741650A (en) * 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples
WO2002012328A2 (en) * 2000-08-03 2002-02-14 Corixa Corporation Compositions and methods for the therapy and diagnosis of colon cancer

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Also Published As

Publication number Publication date
WO2002004664A9 (de) 2002-09-19
CA2415199A1 (en) 2003-01-07
DE10032608A1 (de) 2002-01-24
WO2002004664A2 (de) 2002-01-17
AU2001281708A1 (en) 2002-01-21
NO20030052L (no) 2003-03-07
EP1352088A2 (de) 2003-10-15
US20040265803A1 (en) 2004-12-30
NO20030052D0 (no) 2003-01-06
JP2004512021A (ja) 2004-04-22

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