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WO2002004497A3 - Multiple antigenic peptides immunogenic against streptococcus pneumoniae - Google Patents

Multiple antigenic peptides immunogenic against streptococcus pneumoniae Download PDF

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Publication number
WO2002004497A3
WO2002004497A3 PCT/US2001/021626 US0121626W WO0204497A3 WO 2002004497 A3 WO2002004497 A3 WO 2002004497A3 US 0121626 W US0121626 W US 0121626W WO 0204497 A3 WO0204497 A3 WO 0204497A3
Authority
WO
WIPO (PCT)
Prior art keywords
streptococcus pneumoniae
antigenic peptides
against streptococcus
multiple antigenic
peptides
Prior art date
Application number
PCT/US2001/021626
Other languages
French (fr)
Other versions
WO2002004497A2 (en
Inventor
Edwin W Ades
Scott E Johnson
Danny L Jue
Jacquelyn S Sampson
George M Carlone
Original Assignee
Us Gov Health & Human Serv
Edwin W Ades
Scott E Johnson
Danny L Jue
Jacquelyn S Sampson
George M Carlone
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/613,092 external-priority patent/US6903184B1/en
Application filed by Us Gov Health & Human Serv, Edwin W Ades, Scott E Johnson, Danny L Jue, Jacquelyn S Sampson, George M Carlone filed Critical Us Gov Health & Human Serv
Priority to JP2002509360A priority Critical patent/JP4703091B2/en
Priority to EP01950993A priority patent/EP1301530A2/en
Priority to CA2416224A priority patent/CA2416224C/en
Priority to AU2001271935A priority patent/AU2001271935B2/en
Priority to AU7193501A priority patent/AU7193501A/en
Publication of WO2002004497A2 publication Critical patent/WO2002004497A2/en
Publication of WO2002004497A3 publication Critical patent/WO2002004497A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides multiple antigenic peptides (MAPs) that confer protection against S. pneumoniae challenge. These multiple antigen peptides comprise peptides that immunospecifically bind to the monoclonal antibodies. Also provided are vaccines comprising such immunogenic peptides, and methods of conferring protective immunity against Streptococcus pneumoniae infection by administering a therapeutic composition comprising the MAPs of the invention.
PCT/US2001/021626 2000-07-10 2001-07-10 Multiple antigenic peptides immunogenic against streptococcus pneumoniae WO2002004497A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2002509360A JP4703091B2 (en) 2000-07-10 2001-07-10 Multiple antigenic peptides that are immunogenic against Streptococcus pneumoniae
EP01950993A EP1301530A2 (en) 2000-07-10 2001-07-10 Multiple antigenic peptides immunogenic against streptococcus pneumoniae
CA2416224A CA2416224C (en) 2000-07-10 2001-07-10 Multiple antigenic peptides immunogenic against streptococcus pneumoniae
AU2001271935A AU2001271935B2 (en) 2000-07-10 2001-07-10 Multiple antigenic peptides immunogenic against streptococcus pneumoniae
AU7193501A AU7193501A (en) 2000-07-10 2001-07-10 Multiple antigenic peptides immunogenic against streptococcus pneumoniae

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/613,092 US6903184B1 (en) 1998-03-02 2000-07-10 Multiple antigenic peptides immunogenic against Streptococcus pneumonia
US09/613,092 2000-07-10

Publications (2)

Publication Number Publication Date
WO2002004497A2 WO2002004497A2 (en) 2002-01-17
WO2002004497A3 true WO2002004497A3 (en) 2002-08-01

Family

ID=24455832

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021626 WO2002004497A2 (en) 2000-07-10 2001-07-10 Multiple antigenic peptides immunogenic against streptococcus pneumoniae

Country Status (5)

Country Link
EP (1) EP1301530A2 (en)
JP (2) JP4703091B2 (en)
AU (2) AU2001271935B2 (en)
CA (1) CA2416224C (en)
WO (1) WO2002004497A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6903184B1 (en) 1998-03-02 2005-06-07 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Multiple antigenic peptides immunogenic against Streptococcus pneumonia
US7919104B2 (en) 2005-05-19 2011-04-05 The United States Of America As Represented By The Department Of Health And Human Services, Centers For Disease Control And Prevention Functional epitopes of Streptococcus pneumoniae PsaA antigen and uses thereof
TW200806315A (en) * 2006-04-26 2008-02-01 Wyeth Corp Novel formulations which stabilize and inhibit precipitation of immunogenic compositions
JP6739702B2 (en) 2014-06-11 2020-08-12 国立研究開発法人理化学研究所 Multiple alloantigen peptides
JP2018070571A (en) * 2016-11-04 2018-05-10 国立研究開発法人理化学研究所 Immunity inducing agent

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854416A (en) * 1991-11-14 1998-12-29 The United States Of America As Represented By The Department Of Health And Human Services Streptococcus pneumoniae 37-KDA surface adhesin a protein and nucleic acids coding therefor
WO1999040200A1 (en) * 1998-02-03 1999-08-12 Center For Disease Control And Prevention RECOMBINANT LIPIDATED PsaA PROTEIN, METHODS OF PREPARATION AND USE
WO1999045121A1 (en) * 1998-03-02 1999-09-10 The Government Of The United States Of America, Represented By The Secretary Of The Department Health And Human Services EPITOPE PEPTIDES IMMUNOGENIC AGAINST $i(STREPTOCOCCUS PNEUMONIAE)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229490A (en) * 1987-05-06 1993-07-20 The Rockefeller University Multiple antigen peptide system
US5981478A (en) * 1993-11-24 1999-11-09 La Jolla Cancer Research Foundation Integrin-binding peptides
JP2002533115A (en) * 1998-12-31 2002-10-08 ザ ジェネラル ホスピタル コーポレーション PTH functional domain binder peptides, derivatives thereof, and novel tethered ligand-receptor molecules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854416A (en) * 1991-11-14 1998-12-29 The United States Of America As Represented By The Department Of Health And Human Services Streptococcus pneumoniae 37-KDA surface adhesin a protein and nucleic acids coding therefor
WO1999040200A1 (en) * 1998-02-03 1999-08-12 Center For Disease Control And Prevention RECOMBINANT LIPIDATED PsaA PROTEIN, METHODS OF PREPARATION AND USE
WO1999045121A1 (en) * 1998-03-02 1999-09-10 The Government Of The United States Of America, Represented By The Secretary Of The Department Health And Human Services EPITOPE PEPTIDES IMMUNOGENIC AGAINST $i(STREPTOCOCCUS PNEUMONIAE)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KATHERINE E. MORRISON ET AL.: "Confirmation of psaA in all 90 serotypes of Streptococcus pneumoniae by PCR and potential of this assay for identification and diagnosis", JOURNAL OF CLINICAL MICROBIOLOGY, vol. 38, no. 1, January 2000 (2000-01-01), pages 434 - 437, XP002192347 *
N. SRIVASTAVA ET AL.: "Selection of an immunogenic and protective epitope of the psaA protein of Streptococcus pneumoniae using a phage display library", HYBRIDOMA, vol. 19, no. 1, February 2000 (2000-02-01), pages 23 - 31, XP001064205 *
SAMPSON ET AL: "Limited Diversity of Streptococcus pneumoniae psaA among Pneumococcal Vaccine Serotypes", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 65, no. 5, May 1997 (1997-05-01), pages 1967 - 1971, XP002108304, ISSN: 0019-9567 *

Also Published As

Publication number Publication date
JP2004502782A (en) 2004-01-29
JP2011057691A (en) 2011-03-24
AU7193501A (en) 2002-01-21
AU2001271935B2 (en) 2006-09-14
JP4703091B2 (en) 2011-06-15
CA2416224A1 (en) 2002-01-17
EP1301530A2 (en) 2003-04-16
WO2002004497A2 (en) 2002-01-17
CA2416224C (en) 2015-08-25

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