WO2002003983A1 - Analogues d'acides gras destines au traitement du cancer - Google Patents
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- WO2002003983A1 WO2002003983A1 PCT/NO2001/000301 NO0100301W WO0203983A1 WO 2002003983 A1 WO2002003983 A1 WO 2002003983A1 NO 0100301 W NO0100301 W NO 0100301W WO 0203983 A1 WO0203983 A1 WO 0203983A1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- EP 345.038 describes the use of non- ⁇ -oxidizable fatty acid analogues for the treatment of hyperlipidaemic conditions and for reducing the concentration of cholesterol and triglycerides in the blood of mammals.
- tumour progression is thought to occur when variant cells having selective growth properties arise within a tumour cell population, and one of the final stages of tumour progression is the appearance of the metastatic phenotype.
- the tumour cells invade the blood vessels, survive against circulating host immune defences, and then extravasate, implant, and grow at sites distant from the primary tumour. This ability of tumour cells to invade neighbouring tissues and to colonise other organs is among the leading causes of cancer related deaths.
- Metastases may form when circulating tumour cells with adherent lymphocytes and platelets are trapped in capillaries and the tumour cell membrane interacts with the capillary endotheliu .
- the capillary endothelial junctions retract, and tumour cell ligands bind to receptors on the endothelial and basement membranes.
- Tumour cells then release collagenase IV, which destroys collagen IV, a major component of the underlying basement membrane.
- Invasion of the subcapillary connective tissue is aided by binding to the glycoproteins laminin and fibronectin, by the release of proteases that destroy the matrix, and by the secretion of motility and chemotactic factors.
- the present invention relates to the use of fatty acid analogues of the general formula (I) :
- the total pharmaceutically effective amount of each of the compounds administered parenterally per dose will preferably be in the range of about 5 mg/kg/day to 1000 mg/kg/day of patient body weight, although, as noted above, this will be subject to a great deal of therapeutic discretion.
- a dose of 100 - 500 mg/kg/day is preferable, and for TSA the dosage could probably in the range of from 10 to 100 mg/kg/day.
- X is a selenium atom: the seleno-substituted compound used according to the present invention may be prepared by the following general procedure
- TTA and TSA did not induce mutations in strains of Salmonella typhimurium and Escherichia coli . Furthermore, TTA was not mutagenic when tested in mouse lymphoma cells and L5178Y.
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
L'invention concerne des analogues d'acides gras de formule générale (I): R1- [xi - CH2]n - COOR2, dans laquelle R1 représente: un alcène en C1-C24 avec une ou plusieurs doubles liaisons et/ou une ou plusieurs liaisons triples, et/ou un alcyne en C1-C24, et/ou un alkyle en C1-C24, ou un alkyle substitué sur une ou plusieurs positions par un ou plusieurs composés choisis parmi le groupe comprenant un groupe fluorure, chlorure, hydroxy, alkoxy en C1-C4, alkylthio en C1-C4, acyloxy en C2-C5 ou alkyle en C1-C4, dans laquelle R2 représente un atome d'hydrogène ou un alkyle en C1-C4, dans laquelle n est un entier prenant la valeur de 1 à 12, et dans laquelle i est un nombre impair qui indique la position relative par rapport au groupe COOR2, et dans laquelle les Xi indépendants les uns des autres sont choisis parmi le groupe comprenant un atome d'O, de S, un groupe SO, SO2, un atome de Se et un groupe CH2, pour autant qu'un des Xi au moins ne soit pas un groupe CH2. Les composés de l'invention peuvent être utilisés dans le traitement et/ou la prévention de néoplasmes métastatiques primaires et secondaires.
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ523316A NZ523316A (en) | 2000-07-13 | 2001-07-13 | Fatty acid analogues for the treatment of cancer |
| EP01952065A EP1313463B1 (fr) | 2000-07-13 | 2001-07-13 | Analogues d'acides gras destines au traitement du cancer |
| BR0112399-8A BR0112399A (pt) | 2000-07-13 | 2001-07-13 | Análogos de ácido graxo para o tratamento de câncer |
| CA002414480A CA2414480A1 (fr) | 2000-07-13 | 2001-07-13 | Analogues d'acides gras destines au traitement du cancer |
| US10/312,901 US7378443B2 (en) | 2000-07-13 | 2001-07-13 | Fatty acid analogues for the treatment of cancer |
| AU7286001A AU7286001A (en) | 2000-07-13 | 2001-07-13 | Fatty acid analogues for the treatment of cancer |
| JP2002508437A JP2004502732A (ja) | 2000-07-13 | 2001-07-13 | 癌治療のための脂肪酸類似体 |
| KR1020037000477A KR100861428B1 (ko) | 2000-07-13 | 2001-07-13 | 암 치료용 지방산 유사체 |
| DE60118198T DE60118198T2 (de) | 2000-07-13 | 2001-07-13 | Fettsäure-analoge zur behandlung von krebs |
| MXPA02012944A MXPA02012944A (es) | 2000-07-13 | 2001-07-13 | Analogos de acido graso para el tratamiento de cancer. |
| AU2001272860A AU2001272860B2 (en) | 2000-07-13 | 2001-07-13 | Fatty acid analogues for the treatment of cancer |
| NO20025930A NO324634B1 (no) | 2000-07-13 | 2002-12-11 | Fettsyreanaloger for behandling av cancer |
| HK04100292.1A HK1057473A1 (en) | 2000-07-13 | 2004-01-15 | Fatty acid analogues for the treatment of cancer |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20003591 | 2000-07-13 | ||
| NO20003591A NO20003591L (no) | 2000-07-13 | 2000-07-13 | Fettsyreanaloger for behandling av kreft |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2002003983A1 true WO2002003983A1 (fr) | 2002-01-17 |
Family
ID=19911376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/NO2001/000301 WO2002003983A1 (fr) | 2000-07-13 | 2001-07-13 | Analogues d'acides gras destines au traitement du cancer |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7378443B2 (fr) |
| EP (1) | EP1313463B1 (fr) |
| JP (1) | JP2004502732A (fr) |
| KR (2) | KR100861428B1 (fr) |
| CN (1) | CN100569228C (fr) |
| AT (1) | ATE320802T1 (fr) |
| AU (2) | AU2001272860B2 (fr) |
| BR (1) | BR0112399A (fr) |
| CA (1) | CA2414480A1 (fr) |
| DE (1) | DE60118198T2 (fr) |
| ES (1) | ES2261441T3 (fr) |
| HK (1) | HK1057473A1 (fr) |
| MX (1) | MXPA02012944A (fr) |
| NO (2) | NO20003591L (fr) |
| NZ (1) | NZ523316A (fr) |
| RU (1) | RU2283105C2 (fr) |
| WO (1) | WO2002003983A1 (fr) |
| ZA (1) | ZA200210028B (fr) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007011231A2 (fr) * | 2005-07-18 | 2007-01-25 | Thia Medica As | Utilisation de composes comprenant des entites d'acides gras |
| US7902399B2 (en) | 2000-03-03 | 2011-03-08 | Thia Medica As | Fatty acids analogous |
| US8178713B2 (en) | 2002-06-20 | 2012-05-15 | Pronovo Biopharma Norge AS | Sulfur-containing phospholipid derivatives |
| WO2014140934A2 (fr) | 2013-03-11 | 2014-09-18 | Life Science Nutrition As | Lipides naturels contenant des acides gras non oxydables |
| WO2021014027A1 (fr) * | 2019-07-25 | 2021-01-28 | Coegin Pharma As | Inhibiteurs de phospholipase-2 pour la prévention des métastases cancéreuses |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1784223A2 (fr) | 2004-07-19 | 2007-05-16 | Thia Medica AS | Composition comprenant des huiles de plantes et/ou de poisson et des composes non oxydables d'acides gras |
| US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
| US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
| US8650937B2 (en) | 2008-09-19 | 2014-02-18 | Tandem Diabetes Care, Inc. | Solute concentration measurement device and related methods |
| EP3284494A1 (fr) | 2009-07-30 | 2018-02-21 | Tandem Diabetes Care, Inc. | Système de pompe à perfusion portable |
| US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
| US9555186B2 (en) | 2012-06-05 | 2017-01-31 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
| WO2014143614A1 (fr) | 2013-03-11 | 2014-09-18 | Jan Remmereit | Compositions lipidiques contenant des acides gras bioactifs |
| US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
| DE102014116958B9 (de) * | 2014-11-19 | 2017-10-05 | Trumpf Laser- Und Systemtechnik Gmbh | Optisches System zur Strahlformung eines Laserstrahls, Laserbearbeitungsanlage, Verfahren zur Materialbearbeitung und Verwenden einer gemeinsamen langgezogenen Fokuszone zur Lasermaterialbearbeitung |
| CA2989157A1 (fr) * | 2015-06-11 | 2016-12-15 | University Of Miami | Traitement et diagnostic du cancer |
| CN105498622B (zh) * | 2015-12-10 | 2017-10-17 | 江南大学 | 一种含硒表面活性剂及其制备方法和应用 |
| CN107235880B (zh) * | 2017-06-30 | 2018-10-30 | 江南大学 | 一种含硒阳离子表面活性剂及其应用 |
| AU2020405068A1 (en) | 2019-12-18 | 2022-07-07 | Stinginn Llc | Substituted 1,2, 4-triazoles and methods of use |
| US11897888B1 (en) | 2020-04-30 | 2024-02-13 | Stinginn Llc | Small molecular inhibitors of sting signaling compositions and methods of use |
| CN115260964A (zh) * | 2022-08-29 | 2022-11-01 | 烟台市福山义昌精细化工厂 | 一种石油油管丝扣专用密封胶及其制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997003663A1 (fr) * | 1995-07-14 | 1997-02-06 | Rolf Berge | ANALOGUES D'ACIDE GRAS NON β-OXYDABLES, LEURS UTILISATIONS EN TANT QUE MEDICAMENTS THERAPEUTIQUES ACTIFS ET LEUR PREPARATION |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0686377B2 (ja) * | 1985-09-30 | 1994-11-02 | 日清製粉株式会社 | がん転移抑制剤 |
| JPH0797320A (ja) * | 1993-08-04 | 1995-04-11 | Takuma Sasaki | 制癌剤 |
| US6358915B1 (en) * | 1995-03-07 | 2002-03-19 | George Washington University | Methods for inhibiting metastasis |
| WO1996032101A1 (fr) * | 1995-04-10 | 1996-10-17 | Taiho Pharmaceutical Co., Ltd. | Inhibiteur de la metastase cancereuse |
| WO1999058120A1 (fr) * | 1998-05-08 | 1999-11-18 | Rolf Berge | Utilisation d'analogues d'acides gras non beta-oxydables pour traiter les etats lies au syndrome x |
| JP4993878B2 (ja) * | 2005-06-28 | 2012-08-08 | ダイキョーニシカワ株式会社 | 多気筒エンジンの吸気装置 |
-
2000
- 2000-07-13 NO NO20003591A patent/NO20003591L/no not_active Application Discontinuation
-
2001
- 2001-07-13 KR KR1020037000477A patent/KR100861428B1/ko not_active Expired - Lifetime
- 2001-07-13 NZ NZ523316A patent/NZ523316A/en not_active IP Right Cessation
- 2001-07-13 WO PCT/NO2001/000301 patent/WO2002003983A1/fr active IP Right Grant
- 2001-07-13 BR BR0112399-8A patent/BR0112399A/pt not_active Application Discontinuation
- 2001-07-13 RU RU2002134754/15A patent/RU2283105C2/ru not_active IP Right Cessation
- 2001-07-13 US US10/312,901 patent/US7378443B2/en not_active Expired - Fee Related
- 2001-07-13 EP EP01952065A patent/EP1313463B1/fr not_active Expired - Lifetime
- 2001-07-13 AU AU2001272860A patent/AU2001272860B2/en not_active Ceased
- 2001-07-13 CN CNB018127177A patent/CN100569228C/zh not_active Expired - Fee Related
- 2001-07-13 KR KR1020087014318A patent/KR20080071598A/ko not_active Withdrawn
- 2001-07-13 AU AU7286001A patent/AU7286001A/xx active Pending
- 2001-07-13 ES ES01952065T patent/ES2261441T3/es not_active Expired - Lifetime
- 2001-07-13 MX MXPA02012944A patent/MXPA02012944A/es active IP Right Grant
- 2001-07-13 DE DE60118198T patent/DE60118198T2/de not_active Expired - Fee Related
- 2001-07-13 CA CA002414480A patent/CA2414480A1/fr not_active Abandoned
- 2001-07-13 JP JP2002508437A patent/JP2004502732A/ja active Pending
- 2001-07-13 AT AT01952065T patent/ATE320802T1/de not_active IP Right Cessation
-
2002
- 2002-12-11 NO NO20025930A patent/NO324634B1/no not_active IP Right Cessation
- 2002-12-11 ZA ZA200210028A patent/ZA200210028B/en unknown
-
2004
- 2004-01-15 HK HK04100292.1A patent/HK1057473A1/xx not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997003663A1 (fr) * | 1995-07-14 | 1997-02-06 | Rolf Berge | ANALOGUES D'ACIDE GRAS NON β-OXYDABLES, LEURS UTILISATIONS EN TANT QUE MEDICAMENTS THERAPEUTIQUES ACTIFS ET LEUR PREPARATION |
Non-Patent Citations (4)
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7902399B2 (en) | 2000-03-03 | 2011-03-08 | Thia Medica As | Fatty acids analogous |
| US8178713B2 (en) | 2002-06-20 | 2012-05-15 | Pronovo Biopharma Norge AS | Sulfur-containing phospholipid derivatives |
| WO2007011231A2 (fr) * | 2005-07-18 | 2007-01-25 | Thia Medica As | Utilisation de composes comprenant des entites d'acides gras |
| WO2007011231A3 (fr) * | 2005-07-18 | 2007-10-18 | Thia Medica As | Utilisation de composes comprenant des entites d'acides gras |
| WO2014140934A2 (fr) | 2013-03-11 | 2014-09-18 | Life Science Nutrition As | Lipides naturels contenant des acides gras non oxydables |
| WO2021014027A1 (fr) * | 2019-07-25 | 2021-01-28 | Coegin Pharma As | Inhibiteurs de phospholipase-2 pour la prévention des métastases cancéreuses |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001272860B2 (en) | 2005-11-24 |
| CN1441671A (zh) | 2003-09-10 |
| NZ523316A (en) | 2004-09-24 |
| EP1313463A1 (fr) | 2003-05-28 |
| NO20003591D0 (no) | 2000-07-13 |
| NO20025930D0 (no) | 2002-12-11 |
| US20040024063A1 (en) | 2004-02-05 |
| DE60118198D1 (de) | 2006-05-11 |
| CN100569228C (zh) | 2009-12-16 |
| HK1057473A1 (en) | 2004-04-08 |
| NO20003591L (no) | 2002-01-14 |
| ZA200210028B (en) | 2004-01-26 |
| EP1313463B1 (fr) | 2006-03-22 |
| CA2414480A1 (fr) | 2002-01-17 |
| AU7286001A (en) | 2002-01-21 |
| NO324634B1 (no) | 2007-11-26 |
| KR20030016399A (ko) | 2003-02-26 |
| ES2261441T3 (es) | 2006-11-16 |
| MXPA02012944A (es) | 2004-05-17 |
| ATE320802T1 (de) | 2006-04-15 |
| US7378443B2 (en) | 2008-05-27 |
| NO20025930L (no) | 2003-01-13 |
| KR100861428B1 (ko) | 2008-10-02 |
| KR20080071598A (ko) | 2008-08-04 |
| BR0112399A (pt) | 2003-05-27 |
| RU2283105C2 (ru) | 2006-09-10 |
| DE60118198T2 (de) | 2007-01-25 |
| JP2004502732A (ja) | 2004-01-29 |
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