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WO2002003071A3 - Modulateurs de l'activite de la proteine trk, et compositions et methodes d'utilisation - Google Patents

Modulateurs de l'activite de la proteine trk, et compositions et methodes d'utilisation Download PDF

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Publication number
WO2002003071A3
WO2002003071A3 PCT/US2001/021472 US0121472W WO0203071A3 WO 2002003071 A3 WO2002003071 A3 WO 2002003071A3 US 0121472 W US0121472 W US 0121472W WO 0203071 A3 WO0203071 A3 WO 0203071A3
Authority
WO
WIPO (PCT)
Prior art keywords
trk
compositions
trk protein
modulators
binding
Prior art date
Application number
PCT/US2001/021472
Other languages
English (en)
Other versions
WO2002003071A2 (fr
Inventor
Alan Thomas Bates
Original Assignee
Pangene Corporation
Alan Thomas Bates
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pangene Corporation, Alan Thomas Bates filed Critical Pangene Corporation
Priority to AU2001273245A priority Critical patent/AU2001273245A1/en
Publication of WO2002003071A2 publication Critical patent/WO2002003071A2/fr
Publication of WO2002003071A3 publication Critical patent/WO2002003071A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychology (AREA)
  • Food Science & Technology (AREA)
  • Psychiatry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention porte sur des tyrosine kinases réceptrices et les ligands à cet effet modulant la croissance, la différentiation et la survie des cellules. Elle porte particulièrement sur la famille Trk des tyrosine kinases réceptrices connues pour médier les activités des neurotrophines, les protéines Trk étant également des proto-oncogènes connus; sur des compositions de petites molécules modulant la fixation et l'activité de la protéine Trk; et sur des procédés de criblage de petites molécules pouvant se fixer à la protéine Trk en se fixant à un ou plusieurs de ses déterminants de fixation à la neurotrophine.
PCT/US2001/021472 2000-07-05 2001-07-05 Modulateurs de l'activite de la proteine trk, et compositions et methodes d'utilisation WO2002003071A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001273245A AU2001273245A1 (en) 2000-07-05 2001-07-05 Modulators of trk protein activity, compositions and uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21577800P 2000-07-05 2000-07-05
US60/215,778 2000-07-05

Publications (2)

Publication Number Publication Date
WO2002003071A2 WO2002003071A2 (fr) 2002-01-10
WO2002003071A3 true WO2002003071A3 (fr) 2003-01-30

Family

ID=22804345

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021472 WO2002003071A2 (fr) 2000-07-05 2001-07-05 Modulateurs de l'activite de la proteine trk, et compositions et methodes d'utilisation

Country Status (2)

Country Link
AU (1) AU2001273245A1 (fr)
WO (1) WO2002003071A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7196061B2 (en) * 2003-09-10 2007-03-27 Wyeth Compounds that modulate neuronal growth and their uses
CN1897977A (zh) * 2003-10-20 2007-01-17 Ns基因公司 帕金森氏病的体内基因治疗
JP2008029296A (ja) * 2006-07-31 2008-02-14 Hisamitsu Pharmaceut Co Inc 神経芽種の治療薬及びそのスクリーニング方法、並びに、神経芽種の予後の判定方法
CN111655031B (zh) * 2017-11-30 2022-11-18 瑞泽恩制药公司 包含人源化trkb基因座的非人动物
JPWO2022009992A1 (fr) * 2020-07-10 2022-01-13

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622862A (en) * 1991-04-23 1997-04-22 Regeneron Pharmaceuticals, Inc. Assay systems for trkB neurotrophin activity
WO1999033482A1 (fr) * 1997-12-31 1999-07-08 University Of Utah Research Foundation Utilisation de peptides alpha-conotoxines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622862A (en) * 1991-04-23 1997-04-22 Regeneron Pharmaceuticals, Inc. Assay systems for trkB neurotrophin activity
WO1999033482A1 (fr) * 1997-12-31 1999-07-08 University Of Utah Research Foundation Utilisation de peptides alpha-conotoxines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
URFER R ET AL: "AN IMMUNOGLOBULIN-LIKE DOMAIN DETERMINES THE SPECIFICITY OF NEUROTROPHIN RECEPTORS", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 14, no. 12, 15 June 1995 (1995-06-15), pages 2795 - 2805, XP000568880, ISSN: 0261-4189 *
WINDISCH J M ET AL: "BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND NEUROTROPHIN-4 BIND TO A SINGLE LEUCINE-RICH MOTIF OF TRKB", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 34, no. 35, 5 September 1995 (1995-09-05), pages 11256 - 11263, XP002062138, ISSN: 0006-2960 *

Also Published As

Publication number Publication date
AU2001273245A1 (en) 2002-01-14
WO2002003071A2 (fr) 2002-01-10

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