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WO2002002620A3 - Acide nucleique, polypeptide de crmp-5 et utilisations de ceux-ci - Google Patents

Acide nucleique, polypeptide de crmp-5 et utilisations de ceux-ci Download PDF

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Publication number
WO2002002620A3
WO2002002620A3 PCT/US2001/020507 US0120507W WO0202620A3 WO 2002002620 A3 WO2002002620 A3 WO 2002002620A3 US 0120507 W US0120507 W US 0120507W WO 0202620 A3 WO0202620 A3 WO 0202620A3
Authority
WO
WIPO (PCT)
Prior art keywords
crmp
polypeptide
nucleic acid
encoding nucleic
polypeptides
Prior art date
Application number
PCT/US2001/020507
Other languages
English (en)
Other versions
WO2002002620A2 (fr
Inventor
Vanda A Lennon
Zhiya Yu
Thomas J Kryzer
Guy E Griesmann
Original Assignee
Mayo Foundation
Vanda A Lennon
Zhiya Yu
Thomas J Kryzer
Guy E Griesmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation, Vanda A Lennon, Zhiya Yu, Thomas J Kryzer, Guy E Griesmann filed Critical Mayo Foundation
Publication of WO2002002620A2 publication Critical patent/WO2002002620A2/fr
Publication of WO2002002620A3 publication Critical patent/WO2002002620A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne des acides nucléiques et polypeptides de CRMP-5. Les polypeptides de CRMP-5 sont utiles pour détecter des auto-anticorps anti-CRMP-5 chez un sujet présentant des manifestations neurologiques paranéoplasiques. Une association a été établie entre les auro-anticorps anti-CRMP-5 et des néoplasmes. De plus, l'invention concerne des anticorps possédant une affinité de liaison spécifique pour CRMP-5. Les anticorps monoclonaux sont utiles pour détecter la présence de polypeptides de CRMP-5 chez des sujets, sur la base d'une association établie entre les polypeptides de CRMP-5 et des néoplasmes.
PCT/US2001/020507 2000-06-29 2001-06-28 Acide nucleique, polypeptide de crmp-5 et utilisations de ceux-ci WO2002002620A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60692400A 2000-06-29 2000-06-29
US09/606,924 2000-06-29

Publications (2)

Publication Number Publication Date
WO2002002620A2 WO2002002620A2 (fr) 2002-01-10
WO2002002620A3 true WO2002002620A3 (fr) 2002-08-29

Family

ID=24430079

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/020507 WO2002002620A2 (fr) 2000-06-29 2001-06-28 Acide nucleique, polypeptide de crmp-5 et utilisations de ceux-ci

Country Status (1)

Country Link
WO (1) WO2002002620A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2853909A1 (fr) * 2003-04-16 2004-10-22 Galderma Res & Dev Genes du psoriasis
CN101466390B (zh) * 2006-06-15 2014-03-12 优时比制药有限公司 用于治疗难治性癫痫持续状态的肽类化合物
EP3564670A1 (fr) * 2018-05-03 2019-11-06 Hospices Civils de Lyon Anticorps dirigés contre trim9 et/ou trim67 dans des syndromes neurologiques paranéoplasiques

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2759701A1 (fr) * 1997-02-19 1998-08-21 Inst Nat Sante Rech Med Utilisation des proteines ulip dans le diagnostic et la therapie des cancers et des syndromes neurologiques paraneoplasiques
WO2001064737A1 (fr) * 2000-02-29 2001-09-07 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nouvelle proteine ulip/crmp humaine et son utilisation dans le diagnostic et la therapie des cancers et des syndromes neurologiques paraneoplasiques

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2759701A1 (fr) * 1997-02-19 1998-08-21 Inst Nat Sante Rech Med Utilisation des proteines ulip dans le diagnostic et la therapie des cancers et des syndromes neurologiques paraneoplasiques
WO2001064737A1 (fr) * 2000-02-29 2001-09-07 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nouvelle proteine ulip/crmp humaine et son utilisation dans le diagnostic et la therapie des cancers et des syndromes neurologiques paraneoplasiques

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 31 March 1999 (1999-03-31), NCI/NINDS-CGAP: "Homo sapiens cDNA clone", XP002198484, Database accession no. AI571188 *
DATABASE EMBL [online] EBI; 14 March 2001 (2001-03-14), AGUERA M. ET AL.: "Ulip6, a new human Unc-33-like phosphoprotein", XP002198485, Database accession no. AF264015 *
DATABASE GENEMBL 21 June 2000 (2000-06-21), HORIUCHI: "Homo sapiens mRNA for hypothetical protein (ORF1)", XP002157137 *
FUKADA ET AL: "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 275, no. 48, 1 December 2000 (2000-12-01), pages 37957 - 37965, XP002157133, ISSN: 0021-9258 *
GALANIS EVANTHIA ET AL: "Neuronal autoantibody titers in the course of small-cell lung carcinoma and platinum-associated neuropathy.", CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 48, no. 2-3, May 1999 (1999-05-01), pages 85 - 90, XP002198483, ISSN: 0340-7004 *
HAMAJIMA N ET AL: "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 180, no. 1-2, 21 November 1996 (1996-11-21), pages 157 - 163, XP004071911, ISSN: 0378-1119 *
HONNORAT J ET AL: "ANTIBODIES TO A SUBPOPULATION OF GLIAL CELLS AND A 66 KDA DEVELOPMENTAL PROTEIN IN PATIENTS WITH PARANEOPLASTIC NEUROLOGICAL SYNDROMES", JOURNAL OF NEUROLOGY NEUROSURGERY & PSYCHIATRY, XX, XX, vol. 61, no. 3, 1 September 1996 (1996-09-01), pages 270 - 278, XP002045119, ISSN: 0022-3050 *
HORIUCHI M. ET AL: "Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain", FEBS LETTERS, vol. 480, no. 2-3, 1 September 2000 (2000-09-01), pages 283 - 286, XP004337538 *
INATOME R ET AL: "IDENTIFICATION OF CRAM, A NOVEL UNC-33 GENE FAMILY PROTEIN THAT ASSOCIATES WITH CRMP3 AND PROTEIN-TYROSINE KINASE(S) IN THE DEVELOPING RAT BRAIN*", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 275, no. 35, 1 September 2000 (2000-09-01), pages 27291 - 27302, XP000960549, ISSN: 0021-9258 *
QUACH T T ET AL: "Collapsin response mediator protein-3/unc-33-like protein-4 gene: organization, chromosomal mapping and expression in the developing mouse brain", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 242, no. 1-2, January 2000 (2000-01-01), pages 175 - 182, XP004196517, ISSN: 0378-1119 *
YANAGI ET AL: "Rattus norvegicus mRNA for dihydropyrimininase-related protein, complete cds", GENEMBL, 19 January 2000 (2000-01-19), XP002157134 *

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Publication number Publication date
WO2002002620A2 (fr) 2002-01-10

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