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WO2002002541A3 - Inhibiteur d'amine oxydases contenant du cuivre - Google Patents

Inhibiteur d'amine oxydases contenant du cuivre Download PDF

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Publication number
WO2002002541A3
WO2002002541A3 PCT/FI2001/000637 FI0100637W WO0202541A3 WO 2002002541 A3 WO2002002541 A3 WO 2002002541A3 FI 0100637 W FI0100637 W FI 0100637W WO 0202541 A3 WO0202541 A3 WO 0202541A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
inhibitors
ssao
function
amine oxidases
Prior art date
Application number
PCT/FI2001/000637
Other languages
English (en)
Other versions
WO2002002541A2 (fr
Inventor
David John Smith
Markku Jalkanen
Ferenc Fueloep
Laszlo Lazar
Zsolt Szakonyi
Gabor Bernath
Original Assignee
Biotie Therapies Corp
David John Smith
Markku Jalkanen
Ferenc Fueloep
Laszlo Lazar
Zsolt Szakonyi
Gabor Bernath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotie Therapies Corp, David John Smith, Markku Jalkanen, Ferenc Fueloep, Laszlo Lazar, Zsolt Szakonyi, Gabor Bernath filed Critical Biotie Therapies Corp
Priority to PL36035301A priority Critical patent/PL360353A1/xx
Priority to IL15376701A priority patent/IL153767A0/xx
Priority to JP2002507795A priority patent/JP2004502682A/ja
Priority to NZ523463A priority patent/NZ523463A/en
Priority to CA002414799A priority patent/CA2414799A1/fr
Priority to HU0301625A priority patent/HUP0301625A3/hu
Priority to AU2001282162A priority patent/AU2001282162A1/en
Priority to EP01960763A priority patent/EP1301495A2/fr
Publication of WO2002002541A2 publication Critical patent/WO2002002541A2/fr
Publication of WO2002002541A3 publication Critical patent/WO2002002541A3/fr
Priority to NO20026282A priority patent/NO20026282L/no

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne des composés du type 1,3,4-oxydiazine jouant le rôle d'inhibiteurs d'amine oxydases contenant du cuivre, généralement connues sous le nom d'amine oxydases sensibles au semicarbazide (SSAO), y compris la SSAO humaine connue en tant que protéine-1 d'adhésion vasculaire (VAP-1). Ces inhibiteurs de SSAO peuvent être utilisés, sur le plan thérapeutique, comme médicaments pour traiter des états et des maladies comprenant, de façon non exclusive, un certain nombre d'états et de maladies inflammatoires (en particulier d'états inflammatoires chroniques, telles que l'arthrite chronique, les maladies intestinales inflammatoires et les dermatoses chroniques), les maladies associées au métabolisme des hydrates de carbone et aux aberrations de la différenciation ou de la fonction adipocytaires et de la fonction cellulaire des muscles lisses, et les maladies vasculaires. Lesdits composés correspondent à la formule générale (I), dans laquelle R?1, R2, R3, R4, R5, R6, R7 et R8¿ correspondent à la définition donnée dans la description. L'invention concerne également un tautomère, un isomère, un produit de dégradation alcoolique hydrazino, ou un solvate, hydrate ou sel pharmaceutiquement acceptable de ces composés.
PCT/FI2001/000637 2000-07-05 2001-07-04 Inhibiteur d'amine oxydases contenant du cuivre WO2002002541A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
PL36035301A PL360353A1 (en) 2000-07-05 2001-07-04 Inhibitors of copper-containing amine oxidases
IL15376701A IL153767A0 (en) 2000-07-05 2001-07-04 Inhibitors of copper-containing amine oxidases
JP2002507795A JP2004502682A (ja) 2000-07-05 2001-07-04 銅含有アミン・オキシダーゼの阻害剤
NZ523463A NZ523463A (en) 2000-07-05 2001-07-04 Inhibitors of copper-containing amine oxidases
CA002414799A CA2414799A1 (fr) 2000-07-05 2001-07-04 Inhibiteur d'amine oxydases contenant du cuivre
HU0301625A HUP0301625A3 (en) 2000-07-05 2001-07-04 1,3,4-oxadiazine-compounds as inhibitors of copper-containing amine oxidases, process for their preparation and their use for preparation of pharmaceutical compositions
AU2001282162A AU2001282162A1 (en) 2000-07-05 2001-07-04 Inhibitors of copper-containing amine oxidases
EP01960763A EP1301495A2 (fr) 2000-07-05 2001-07-04 Inhibiteur d'amine oxydases contenant du cuivre
NO20026282A NO20026282L (no) 2000-07-05 2002-12-30 Inhibitorer av kobberholdige aminoksydaser

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21634100P 2000-07-05 2000-07-05
US60/216,341 2000-07-05

Publications (2)

Publication Number Publication Date
WO2002002541A2 WO2002002541A2 (fr) 2002-01-10
WO2002002541A3 true WO2002002541A3 (fr) 2002-04-18

Family

ID=22806663

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/FI2001/000638 WO2002002090A2 (fr) 2000-07-05 2001-07-04 Inhibiteur d'amines oxydases contenant du cuivre
PCT/FI2001/000637 WO2002002541A2 (fr) 2000-07-05 2001-07-04 Inhibiteur d'amine oxydases contenant du cuivre

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/FI2001/000638 WO2002002090A2 (fr) 2000-07-05 2001-07-04 Inhibiteur d'amines oxydases contenant du cuivre

Country Status (14)

Country Link
US (2) US6624202B2 (fr)
EP (2) EP1313718A2 (fr)
JP (2) JP2004501962A (fr)
CN (2) CN1450997A (fr)
AU (3) AU2001282162A1 (fr)
CA (2) CA2414799A1 (fr)
HU (2) HUP0301625A3 (fr)
IL (2) IL153766A0 (fr)
NO (2) NO20026282L (fr)
NZ (2) NZ523463A (fr)
PL (2) PL360374A1 (fr)
RU (2) RU2003103291A (fr)
WO (2) WO2002002090A2 (fr)
ZA (2) ZA200300063B (fr)

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RU2003103291A (ru) 2000-07-05 2005-01-27 Байотай Терапис Корпорейшн (Fi) Ингибиторы медьсодержащих аминооксидаз
US6982286B2 (en) 2001-07-12 2006-01-03 Biotie Therapies Corp. Carbocyclic hydrazino inhibitors of copper-containing amine oxidases
KR101154163B1 (ko) 2003-01-27 2012-06-14 아스텔라스세이야쿠 가부시키가이샤 티아졸 유도체 및 ｖａｐ-1 저해제로서의 용도
EP1608365B1 (fr) 2003-03-31 2013-10-02 R-Tech Ueno, Ltd. Procede de traitement de maladie vasculaire hyperpermeable
ES2335769T3 (es) * 2003-05-26 2010-04-05 Biotie Therapies Corp. Vap-1 cristalina y sus usos.
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WO2005072738A1 (fr) * 2004-01-30 2005-08-11 Faron Pharmaceuticals Oy Compositions particulierement utiles au traitement ou a la prevention du syndrome metabolique
US8119651B2 (en) 2004-01-30 2012-02-21 Biotie Therapies Corp. Compositions useful especially for treatment or prevention of metabolic syndrome
FI20040136A0 (fi) * 2004-01-30 2004-01-30 Faron Pharmaceuticals Oy Erityisesti diabeetikoille soveltuvia koostumuksia
FI20040270A0 (fi) * 2004-02-20 2004-02-20 Biotie Therapies Oyj Kuparia sisältävien amiinioksidaasien imhibiittoreina käyttökelpoiset hydratsinoalkoholijohdannaiset
CA2575411A1 (fr) * 2004-07-27 2006-02-02 Astellas Pharma Inc. Derives de thiazole presentant une activite d'inhibition de la vap-1
EP1791835A2 (fr) * 2004-09-09 2007-06-06 Astellas Pharma Inc. Derives du thiazole presentant une activite inhibitrice de la proteine 1 d'adhesion vasculaire
JP4140630B2 (ja) * 2005-11-10 2008-08-27 Ｔｄｋ株式会社 磁気ヘッドアセンブリ及び磁気ヘッドアセンブリの製造方法
US8636995B2 (en) * 2006-08-31 2014-01-28 Cardiac Pacemakers, Inc. Methods and devices to regulate stem cell homing
US8372399B2 (en) 2006-08-31 2013-02-12 Cardiac Pacemakers, Inc. Bispecific antibodies and agents to enhance stem cell homing
US20080058922A1 (en) * 2006-08-31 2008-03-06 Cardiac Pacemakers, Inc. Methods and devices employing vap-1 inhibitors
FI20061156A0 (fi) 2006-12-27 2006-12-27 Elina Kivi Uusia peptidejä
US20090170770A1 (en) * 2007-11-06 2009-07-02 Ali Hafezi-Moghadam Methods and compositions for treating conditions associated with angiogenesis using a vascular adhesion protein-1 (vap 1) inhibitor
NZ585528A (en) 2007-11-21 2012-08-31 Pharmaxis Ltd Haloallylamine inhibitors of ssao/vap-1 and uses therefor
TWI437986B (zh) 2008-01-31 2014-05-21 R Tech Ueno Ltd 噻唑衍生物及使用該衍生物作為ｖａｐ－１抑制劑之用途
TWI490214B (zh) * 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
EP2357252A4 (fr) 2008-09-03 2012-05-16 Univ Barcelona Autonoma Méthodes et compositions pour le traitement et le diagnostic de la transformation hémorragique
RU2400233C1 (ru) 2009-07-07 2010-09-27 Общество с ограниченной ответственностью "Вирфарм" Способ лечения заболеваний печени различного генеза
UA112154C2 (uk) 2009-09-08 2016-08-10 Біоті Терапіс Корп. Застосування повністю людського анти-vap-1-антитіла для лікування фіброзних станів
WO2011034078A1 (fr) 2009-09-16 2011-03-24 アステラス製薬株式会社 Composé de glycine
RU2010145439A (ru) 2010-11-08 2012-05-20 Виктор Вениаминович Тец (RU) Средство для лечения поражений печени, вызванных воздействием химических или биологических агентов
FI20115234A0 (fi) 2011-03-08 2011-03-08 Biotie Therapies Corp Uusia pyridatsinoni- ja pyridoniyhdisteitä
SG193307A1 (en) 2011-03-15 2013-10-30 Astellas Pharma Inc Guanidine compound
US20160113893A1 (en) 2013-06-12 2016-04-28 Proximagen Limited New therapeutic uses of enzyme inhibitors
HUE042625T2 (hu) 2014-04-15 2019-07-29 Pecsi Tudomanyegyetem Szemikarbazid-szenzitiv amin-oxidáz gátlók fájdalomcsillapítóként való alkalmazásra traumás neuropátiában és neurogén gyulladásban
WO2015189534A1 (fr) 2014-06-12 2015-12-17 Proximagen Limited Inhibiteurs de vap-1 pour le traitement de la dystrophie musculaire
RU2595868C1 (ru) 2015-03-27 2016-08-27 Виктор Вениаминович Тец Лекарственное средство с гепатопротекторной активностью
JP2018076236A (ja) 2015-06-05 2018-05-17 株式会社アールテック・ウエノ がんを処置するための医薬組成物
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