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WO2002000279A1 - Dispositif d'administration - Google Patents

Dispositif d'administration Download PDF

Info

Publication number
WO2002000279A1
WO2002000279A1 PCT/GB2001/002854 GB0102854W WO0200279A1 WO 2002000279 A1 WO2002000279 A1 WO 2002000279A1 GB 0102854 W GB0102854 W GB 0102854W WO 0200279 A1 WO0200279 A1 WO 0200279A1
Authority
WO
WIPO (PCT)
Prior art keywords
actuator
cover
medicament
delivery device
mouthpiece
Prior art date
Application number
PCT/GB2001/002854
Other languages
English (en)
Inventor
Philip Braithwaite
Trevor COUPE
Steve Williams
Sam Lucking
Original Assignee
Ml Laboratories Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ml Laboratories Plc filed Critical Ml Laboratories Plc
Priority to AU2001270749A priority Critical patent/AU2001270749A1/en
Publication of WO2002000279A1 publication Critical patent/WO2002000279A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Definitions

  • This invention relates to a novel medicament delivery device, for example, an inhalation device, and to a novel means of delivering medicaments.
  • US Patent No. 4,834,083 describes a pressurised aerosol inhaler which is provided with a catch means for prevention of unintended depression of the actuator and means for opening and closing the mouthpiece which is operably linked to the catch means.
  • European Patent No 428 380 describes a pressurised aerosol inhaler which is provided with a protective casing which comprises a removable mouthpiece cover which is linked to means for cocking the inhaler.
  • Dry powder inhalers are known, such as TECHNOHALER, being developed by Innovata Biomed in the UK. Such a device is described in International Patent Application No WO 93/16748 (PCT/GB93/00335).
  • WO '748 describes an inhaler which comprises a disc shaped cartridge having a plurality of medicament carrying receptacles around the periphery of the cartridge.
  • Each receptacle comprises a spool housed in a spool carrier.
  • Each spool has a flange at each end which forms a tight slidable fit within the body of the spool carrier. The space left between the body of the spool and the spool carrier is filled with an appropriate medicament.
  • the AccuhalerTM comprises a disc shaped inhaler provided with a peripheral mouthpiece and peripheral actuator.
  • a protective cover is provided which is rotatable about a central spigot, from a closed position to an open position wherein the actuator and mouthpiece are both exposed.
  • the actuator and mouthpiece are exposed sequentially.
  • One disadvantage of the Accuhaler device is that when the mouthpiece cover is rotated and the mouthpiece exposed, the actuator is primed ready for a single activation. However if multiple actuations are desirable this can only be achieved by closing the mouthpiece cover and then reopening it. Such a process adds complexity to the operations required to use the device; is time consuming and may present particular difficulties to the elderly or those with arthritic joints.
  • the Jago dry powder inhaler which is being developed by Skyepharma AG, comprises a system which can be loaded and activated by only a single movement of the mouthpiece cover.
  • the hinged mouthpiece is pull downwards and once the medicament is inhaled, in order to re-cock the inhaler the mouthpiece must be replaced and subsequently removed.
  • the mouthpiece cover must be repeatedly closed and opened.
  • a medicament delivery device e.g. an inhalation device and, in particular, a dry powder inhaler, which prevents activation of an actuator until a protective cover is removed, but which also permits multiple actuations of the device.
  • a medicament delivery device comprising a metering member adapted to dispense a measured amount of medicament, an actuator, a medicament delivery passage and a delivery passage cover adapted to move from a closed to an open position, characterised in that the device includes means to prevent activation of the actuator until the cover is moved to the fully open position, said actuator being capable of subsequent multiple activations without moving the cover back to the closed position.
  • the delivery device of the invention may comprise a single metering member; however, the device may optionally comprise a plurality of metering members.
  • the means to prevent activation of the actuator may comprise a locking mechanism.
  • a locking mechanism may comprise an actuator lever adapted to engage with a plunger, said plunger being adapted to act upon a metering member, when the cover is in the closed position the locking mechanism acts to lock the plunger, and when the cover is in the open position the plunger is unlocked.
  • the actuator requires the plunger to act in a radial direction thus the locking mechanism is such that in the locked position it acts to prevent radial movement of the plunger whilst in the open position radial movement is permitted.
  • the cover may be rotatably mounted and may be operably linked to a rotatably mounted plunger locking plate, such that rotation of the cover from a closed position rotates the locking plate from a locked to an unlocked position.
  • the locking plate comprises a channel adapted to co-operate with at least a portion of the plunger, said channel comprising an arcuate circumferential portion provided with a closed end, the other end opening to a radial portion.
  • the plunger is positioned at the closed end of the circumferential channel and radial movement of the plunger is prevented.
  • the actuator lever may now be operated so as to cause radial movement of the plunger and thus actuation of the metering member.
  • the channel may comprise a groove in the locking plate but is preferentially partially or wholly an aperture.
  • the plunger is provided with a spigot, preferentially at one end of the plunger, i.e. distal to the portion which acts upon the medicament metering member, the spigot being perpendicular to the operation of the plunger and positioned so as to engage with the actuator and the locking plate.
  • the spigot may engage directly with the actuator or it may engage with an actuator plate which may be separate to or integral with the actuator.
  • the actuator plate may be provided with a groove or an aperture and the plunger, e.g. the spigot, may rests against the wall of the groove or aperture, such that activation of the actuator causes the actuator plate to rotate.
  • the actuator plate groove or aperture is also caused to rotate and the wall of the groove or aperture pushes against the spigot to cause radial movement.
  • a guide plate may be provided to guide the plunger.
  • the guide plate may optionally be positioned between actuator plate and the plunger.
  • the guide plate may be provided with means for guiding the radial movement of the spigot and/or the plunger. Therefore, preferentially, the guide means may comprise a radial aperture through which the spigot projects. The dimensions of the guide aperture being such that the spigot forms a snug fit between the aperture walls.
  • the medicament delivery device may be an inhaler, for example, a dry powder inhaler (DPI).
  • DPI dry powder inhaler
  • an inhalation device comprising a metering member adapted to dispense a measured amount of medicament, an actuator, an inhalation passage, a mouthpiece and a mouthpiece cover adapted to move from a closed to an open position characterised in that the device includes means to prevent activation of the actuator until the cover is moved to an open position, said actuator being capable of multiple activations without moving the cover back to the closed position.
  • a further disadvantage of the Accuhaler device is that it is possible to only partially rotate the cover to an intermediate position so that the actuator is exposed whilst the mouthpiece is not. This intermediate position can enable the actuator to be depressed and medicament ejected even though the mouthpiece is not exposed. This can lead to inadvertent depression of the actuator or, for example, in the case of children who may not want to take medication, deliberate actuation whilst avoiding inhalation.
  • a further embodiment of the present invention also overcomes this additional disadvantage.
  • the means to prevent activation of the actuator may comprise a delivery passage cover which is also an integral actuator cover, the cover being adapted to move from a closed position in which the delivery passage and actuator are both covered to an open position wherein the delivery passage and actuator are exposed simultaneously.
  • the delivery device is preferentially an inhaler, for example, a dry powder inhaler.
  • an inhalation device comprising a metering member adapted to dispense a measured amount of medicament, an actuator, an inhalation passage, a mouthpiece and a mouthpiece cover wherein the mouthpiece cover also forms an integral actuator cover, the integral actuator cover being adapted to move from a closed position in which the mouthpiece and actuator are both covered to an open position wherein the mouthpiece and actuator are exposed characterised in that the mouthpiece and actuator are exposed simultaneously.
  • the inhalation device of the invention may comprise any conventionally known inhaler.
  • the inhaler is a dry powder inhaler (DPI).
  • DPI dry powder inhaler
  • the integral mouthpiece and actuator cover may be used on any conventionally known DPIs, however, a preferred DPI is that known as TECHNOHALER.
  • the inhaler is preferentially a flat or disc shaped inhaler.
  • the actuator may be positioned on the periphery of a disc shaped inhaler.
  • both the actuator and the mouthpiece are situated on the circumferential or peripheral edge of the inhaler.
  • the integral cover will comprise a first and second limb, the first limb comprising a mouthpiece cover and the second limb comprising an actuator cover.
  • An aperture is provided between the first and second limbs and a second aperture is provided adjacent at least on of the first or second limbs, distal to the other limb.
  • the actuator is positioned in one of the fiat surfaces of the disc shaped inhaler.
  • a variety of actuator types may be used in the inhaler of the invention, but preferably the actuator is provided in the form of a push button.
  • An inhaler of the TECHNOHALER type is provided with one or more spools containing medicament to be dispensed.
  • the inhaler comprises a cartridge provided with a plurality of medicament chambers, each provided with a spool and a pre-set amount of medicament.
  • the actuator may simply provide a push rod which is attached to push button which is provided with biasing means, eg a spring.
  • the integral mouthpiece and actuator cover is rotatable from a closed position in which the mouthpiece and actuator are both covered, to an open position in which the mouthpiece and actuator are both exposed.
  • the cover may therefore be rotatable about a central spigot which may be situated on one or both sides of the inhaler.
  • the cover may comprise a plastics strip wherein a first end comprises a mouthpiece cover and a second end comprises an actuator cover.
  • the second end may simply be provided with an aperture such that when the cover is rotated from the closed position to the open position, the aperture overlies the actuator enabling the actuator to be depressed.
  • the second end of the cover is provided with a floating push button. In the closed position the push button abuts the outer surface of the casing of the inhalation device. In the open position the floating push button overlies the actuator and may therefore be depressed enabling the actuator to operate.
  • the cover comprises a third portion which is distal to the first portion.
  • the third portion is adapted to facilitate gripping and rotation of the cover by a patient. Therefore the gripping portion may be positioned on the opposite side to the axis of rotation of the first portion or, alternatively, the third portion may be offset at an angle against the first portion. Therefore, when the cover comprises a plastics strip comprising two angled portions, when the cover is rotated to the open position the mouthpiece is preferentially exposed by the area between the two angled portions.
  • a dry powder inhaler comprising a plurality of metering members adapted to dispense a measured amount of medicament and held on a substantially circular cartridge, an inhalation passage and a mouthpiece, and a push button which engages a push rod adapted to move one of the plurality of metering members from a medicament retaining position to a medicament dispensing position characterised in that the mouthpiece and push button are provided with an integral cover.
  • the cover may comprise any material conventionally used in inhalation devices.
  • the cover comprises a plastics material.
  • the inhalation device also comprises a plastics material, the cover and the inhalation device may comprise the same or different material.
  • medicaments may be administered by using the medicament delivery device of the invention, such medicaments would be well known to one skilled in the art.
  • suitable medicaments would generally include antibiotics, bronchodilators or other anti- asthma drugs.
  • antibiotics include, but are not limited to bronchodilators, e.g. fenoterol, formoterol, pirbuterol, reproterol, rimiterol, salbutamol, salmeterol and terbutaline; non-selective beta-stimulants such as isoprenaline; xanthine bronchodilators, e.g.
  • bronchial anti-inflammatory agents e.g. nedocromil sodium
  • steroids e.g. beclomethasone dipropionate, fluticasone, budesonide and flunisolide
  • Specific combinations of medicaments which may be mentioned include combinations of steroids, such as, beclomethasone dipropionate, fluticasone, budesonide and flunisolide; and combinations of to bronchodilators, such as, formoterol and salmeterol. It is also within the scope of this invention to include combinations of one or more of the aforementioned steroids with one or more of the aforementioned bronchodilator.
  • a specific combination which is preferred is a combination of fluticasone and salmeterol.
  • medicaments which may be mentioned include systemically active materials, such as, proteinaceous compounds and/or macromolecules, for example, hormones and mediators, such as insulin, human growth hormone, leuprolide and alpha interferon; growth factors, anticoagulants, immunomodulators, cytokines and nucleic acids.
  • hormones and mediators such as insulin, human growth hormone, leuprolide and alpha interferon
  • growth factors such as growth factors, anticoagulants, immunomodulators, cytokines and nucleic acids.
  • Figure 2 is a plan view of an inhaler in the open position
  • Figure 3 is a cross-sectional view of an inhaler of the invention.
  • Figure 4 is a partially cut away plan view of an inhaler in the closed position
  • Figure 5 is a perspective view of an inhaler of the first embodiment of the invention.
  • Figure 6 a-c is a plan view of a plunger, a locking disc and an actuator disc respectively;
  • Figure 7 is a perspective view of an inhaler in the locked position
  • Figure 8 is a schematic representation of the locking mechanism in the locked position
  • Figure 9 is a perspective view of an inhaler in the unlocked position
  • Figure 10 is a schematic representation of the locking mechanism in the unlocked position
  • Figure 11 is a perspective view of an inhaler in the actuated position
  • Figure 12 is a schematic representation of the locking mechanism in the actuated position
  • Figure 13 is a perspective view of an inhaler in the reset position
  • Figure 14 is a schematic representation of the locking mechanism in the reset position
  • Figure 15 is a perspective view of an inhaler returned to the rest position.
  • Figure 16 is a schematic representation of the locking mechanism returned to the rest position.
  • an inhaler (1) is provided with a mouthpiece (2) and an actuator (3).
  • a cover (4) is adapted in the closed position to cover the mouthpiece (2) and the actuator (3).
  • the cover (4) is also provided with a floating push button (5) which, when in the closed position, is remote from the actuator (3).
  • the cover (4) is rotatable about a central spigot (6) (not shown in Figures 1 and 2) to an open position in which the mouthpiece (2) is exposed and the floating push button (5) overlies the actuator (3).
  • the actuator system comprises a push rod (7) connected to an actuator (3).
  • the actuator (3) is biassed away from the push rod (7) by means of a spring (8).
  • the actuator (3) is held in position by a circumferential shoulder (9) in the body (10) of the inhaler (1).
  • the cover (4) is provided with a floating push button (5) which is held in position by the surface of body (10) of the inhaler (1) or the actuator (3) and a circumferential shoulder (11) in the cover (4).
  • an inhaler (101) comprises a body (102), a mouthpiece cover (103) and an actuator (104).
  • a locking mechanism comprises a plunger (105), a locking plate (106) and an actuator plate (107).
  • the plunger (105) comprises a push rod (108) adapted to engage a medicament metering member (not shown).
  • the plunger (105) is provided with a spigot (110).
  • the locking plate (106) comprises a thin rotatable disc and is provided with an aperture (111) in the form of a channel comprising an arcuate circumferential portion (112) with a closed end (114). The open end (113) opens into a radial portion (115).
  • the actuator plate (107) comprises a think disc provided with a peripheral lever (116) and an aperture (117) in the form of an arcuate radial channel.
  • the actuator plate (107) is also provided with a circumferential rim (118) which enables the locking plate (106) to sit in position on the actuator plate (107).
  • the actuator plate (107) rests upon the plunger (105) and the spigot (110) protrudes through the aperture (117).
  • the locking plate (106) sits inside the rim (118) of the actuator plate (107) and the closed end (113) of the locking plate aperture (111) overlies the actuator plate aperture (117).
  • the spigot (110) also protrudes through the locking plate aperture (111) at the point of overlap.
  • the spigot (110) protrudes through the apertures (111 and 117). Radial movement of the spigot (110) is prevented by the wall (118) of the arcuate circumferential portion (112) of the locking disc aperture (111).
  • the mouthpiece cover (103) is operably linked to the locking plate (106) via a central point (119). Referring to Figures 9 and 10, the mouthpiece cover (103) is rotated to expose the mouthpiece (120). This also causes the locking plate (106) to rotate so that the spigot (110) is altered from the closed end (113) of the locking plate aperture (111) to the open end (114).
  • the actuator lever (104) is rotated to activate the inhaler.
  • the outer wall (121) of the arcuate aperture (117) acts against the spigot
  • an intermediate plate (not shown) may be positioned between the actuator plate (107) and the plunger (105).
  • Such an intermediate plate may be provided with a radial aperture which may assist in guiding the spigot (110) when it undergoes radial travel.
  • the actuator lever (104) may be returned to the rest position without the locking mechanism reactivating.
  • the spigot (110) returns to the open end (114) of the arcuate circumferential portion (112) of the aperture
  • the locking plate (106) rotates to return the spigot (110) to the closed end (113) of the aperture, deactivating the actuator.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif d'administration de médicaments constitué d'un élément doseur conçu pour libérer une certaine dose de médicament, d'un actionneur (3), d'un passage d'administration du médicament et d'un enveloppe (4) de protection dudit passage, conçue pour passer d'une position fermée à une position ouverte, et vice-versa. L'invention est caractérisée en ce que ledit dispositif comporte des moyens destinés à empêcher l'actionnement de l'actionneur (3) jusqu'à ce que l'enveloppe (4) se trouve en position ouverte, ledit actionneur (3) pouvant ensuite faire l'objet de plusieurs opérations d'actionnement, sans que l'enveloppe (4) ait à repasser en position fermée. L'invention concerne également une méthode de traitement, qui consiste à utiliser un dispositif de ce type.
PCT/GB2001/002854 2000-06-28 2001-06-28 Dispositif d'administration WO2002000279A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001270749A AU2001270749A1 (en) 2000-06-28 2001-06-28 Delivery device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0015801.4 2000-06-28
GB0015801A GB0015801D0 (en) 2000-06-28 2000-06-28 Cover

Publications (1)

Publication Number Publication Date
WO2002000279A1 true WO2002000279A1 (fr) 2002-01-03

Family

ID=9894553

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/002854 WO2002000279A1 (fr) 2000-06-28 2001-06-28 Dispositif d'administration

Country Status (3)

Country Link
AU (1) AU2001270749A1 (fr)
GB (1) GB0015801D0 (fr)
WO (1) WO2002000279A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005053646A1 (fr) 2003-12-03 2005-06-16 Microdrug Ag Tiotropium inhalable et son contenant
US7401713B2 (en) 2001-08-16 2008-07-22 Meridica Limited Pack containing medicament and dispensing device
EP1487524A4 (fr) * 2002-03-15 2011-01-12 Valois Sas Inhalateur pour poudre seche
US8161968B2 (en) 2003-07-24 2012-04-24 Glaxo Group Limited Medicament dispenser
US8201556B2 (en) 2004-08-16 2012-06-19 Glaxo Group Limited Medicament dispenser
US8397714B2 (en) 2004-03-10 2013-03-19 Glaxo Group Limited Dispensing device
US8746242B2 (en) 2005-07-28 2014-06-10 Glaxo Group Limited Medicament dispenser
US8776788B2 (en) 2006-11-15 2014-07-15 Glaxo Group Limited Sheet driver for use in a drug dispenser
US9179691B2 (en) 2007-12-14 2015-11-10 Aerodesigns, Inc. Delivering aerosolizable food products
WO2018094392A1 (fr) * 2016-11-21 2018-05-24 Lupin Inc. Distributeur de médicament
EP2647399B2 (fr) † 2008-01-24 2018-07-04 Boehringer Ingelheim International GmbH Inhalateur
US10265484B2 (en) 2012-09-27 2019-04-23 3M Innovative Properties Company Dispensing assembly

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678106A (en) * 1984-07-31 1987-07-07 Glaxo Group Limited Dispensing device
US4834083A (en) 1988-05-12 1989-05-30 Minnesota Mining And Manufacturing Company Aerosol device
WO1993016748A2 (fr) * 1992-02-21 1993-09-02 Innovata Biomed Limited Dispositif de dosage
EP0428380B1 (fr) 1989-11-14 1993-10-13 Riker Laboratories, Inc. Inhalateur et boîtier de protection
US5447151A (en) * 1990-10-04 1995-09-05 Valois Powder inhaler with suction actuated locking means
US5921237A (en) * 1995-04-24 1999-07-13 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6055980A (en) * 1991-05-20 2000-05-02 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6065472A (en) * 1996-01-03 2000-05-23 Glaxo Wellcome Inc. Multidose powder inhalation device

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678106A (en) * 1984-07-31 1987-07-07 Glaxo Group Limited Dispensing device
US4834083A (en) 1988-05-12 1989-05-30 Minnesota Mining And Manufacturing Company Aerosol device
EP0428380B1 (fr) 1989-11-14 1993-10-13 Riker Laboratories, Inc. Inhalateur et boîtier de protection
US5447151A (en) * 1990-10-04 1995-09-05 Valois Powder inhaler with suction actuated locking means
US6055980A (en) * 1991-05-20 2000-05-02 Dura Pharmaceuticals, Inc. Dry powder inhaler
WO1993016748A2 (fr) * 1992-02-21 1993-09-02 Innovata Biomed Limited Dispositif de dosage
US5921237A (en) * 1995-04-24 1999-07-13 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6065472A (en) * 1996-01-03 2000-05-23 Glaxo Wellcome Inc. Multidose powder inhalation device

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7401713B2 (en) 2001-08-16 2008-07-22 Meridica Limited Pack containing medicament and dispensing device
US7987985B2 (en) 2001-08-16 2011-08-02 Pfizer Limited Pack containing medicament and dispensing device
EP1487524A4 (fr) * 2002-03-15 2011-01-12 Valois Sas Inhalateur pour poudre seche
US8161968B2 (en) 2003-07-24 2012-04-24 Glaxo Group Limited Medicament dispenser
WO2005053646A1 (fr) 2003-12-03 2005-06-16 Microdrug Ag Tiotropium inhalable et son contenant
US8397714B2 (en) 2004-03-10 2013-03-19 Glaxo Group Limited Dispensing device
US9327087B2 (en) 2004-03-10 2016-05-03 Glaxo Group Limited Dispensing device
US8201556B2 (en) 2004-08-16 2012-06-19 Glaxo Group Limited Medicament dispenser
US9333310B2 (en) 2004-08-16 2016-05-10 Glaxo Group Limited Medicament dispenser
US8746242B2 (en) 2005-07-28 2014-06-10 Glaxo Group Limited Medicament dispenser
US8776788B2 (en) 2006-11-15 2014-07-15 Glaxo Group Limited Sheet driver for use in a drug dispenser
US9179691B2 (en) 2007-12-14 2015-11-10 Aerodesigns, Inc. Delivering aerosolizable food products
EP2647399B2 (fr) † 2008-01-24 2018-07-04 Boehringer Ingelheim International GmbH Inhalateur
US10265484B2 (en) 2012-09-27 2019-04-23 3M Innovative Properties Company Dispensing assembly
WO2018094392A1 (fr) * 2016-11-21 2018-05-24 Lupin Inc. Distributeur de médicament

Also Published As

Publication number Publication date
GB0015801D0 (en) 2000-08-16
AU2001270749A1 (en) 2002-01-08

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