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WO2002000021A2 - Procede et compositions visant a inhiber la capacite des moustiques a detecter l'odeur humaine ou animale - Google Patents

Procede et compositions visant a inhiber la capacite des moustiques a detecter l'odeur humaine ou animale Download PDF

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Publication number
WO2002000021A2
WO2002000021A2 PCT/US2001/020254 US0120254W WO0200021A2 WO 2002000021 A2 WO2002000021 A2 WO 2002000021A2 US 0120254 W US0120254 W US 0120254W WO 0200021 A2 WO0200021 A2 WO 0200021A2
Authority
WO
WIPO (PCT)
Prior art keywords
inhibiting compound
inhibiting
linalyl
linalyl ester
ester
Prior art date
Application number
PCT/US2001/020254
Other languages
English (en)
Other versions
WO2002000021A3 (fr
Inventor
James A. Nolen
Robert H. Bedoukian
Daniel L. Kline
Original Assignee
Biosensory, Inc.
Bedoukian Research, Inc.
United States Of America, Represented By The Secretary Of Agriculture
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosensory, Inc., Bedoukian Research, Inc., United States Of America, Represented By The Secretary Of Agriculture filed Critical Biosensory, Inc.
Priority to JP2002504815A priority Critical patent/JP2004501168A/ja
Priority to AU7145401A priority patent/AU7145401A/xx
Publication of WO2002000021A2 publication Critical patent/WO2002000021A2/fr
Publication of WO2002000021A3 publication Critical patent/WO2002000021A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof

Definitions

  • This invention relates to a method and compositions for inhibiting the ability of mosquitoes to locate or track a human or animal body by scent detection. More particularly, the invention relates to the use of certain compounds in compositions and apparatus to inhibit mosquitoes' ability to detect humans or animals by scent detection.
  • compositions and formulations for protecting human beings from being bitten by mosquitoes are known in the art. Generally, these compounds, compositions and formulations are based on their ability to persist on the skin of the person upon topical or surface application for a time sufficient to repel mosquitoes. Numerous adjuvant materials have been added to mosquito repellants to increase the persistence of the repellents to the skin of a person. However, despite the various attempts to improve the repelling activity of the known mosquito repellents, these attempts have generally not been successful, as almost anyone who has used such mosquito repellents can attest.
  • the present invention provides compositions and formulations containing compounds usable in methods and apparatus for inhibiting the olfactory target tracking abilities of mosquitoes when an effective amount of the inhibiting compound(s) is/are dispersed in a three dimensional atmospheric space.
  • the ability of mosquitoes to locate a target is inhibited by dispensing into a spatial area an inhibiting effective amount of at least one inhibiting compound selected from the group consisting of lower alkyl esters of 1-alkene- 3-ols of the formula:
  • R is or an alkyl group of from 1 to 4 carbon atoms
  • R 1 and R 2 are each independently a saturated or unsaturated aliphatic hydrocarbon group containing from 1 to about 12 carbon atoms
  • R 3 is hydrogen or CH 3 , preferably CH 3 .
  • R is H or CH 3
  • R 1 and R 2 are C 6 Hn
  • R 3 is CH 3 , i.e., formate and acetate esters of linalool.
  • the inhibiting compound can be dispensed into the three dimensional atmospheric space by any suitable means sufficient to provide an inhibiting effective amount of the inhibiting compound(s).
  • Such dispensing means includes, for example, evaporation, atomization and ionic dispersion of the inhibiting compound from any suitable composition or formulation.
  • Such composition or formulation will generally comprise a base vehicle containing at least one of the inhibiting compounds.
  • R is an alkyl group of from 1 to 4 carbon atoms
  • R 1 and R 2 are each independently a saturated or unsaturated aliphatic hydrocarbon group containing from 1 to about 12 carbon atoms
  • R 3 is hydrogen or CH 3 is dispensed into the atmosphere of a three dimensional environmental space, the ability of mosquitoes to locate and track a target, such as humans or livestock, by the target's olfactory emissions is inhibited.
  • Any suitable lower alkyl esters of 1-alkene-3-ols or 1-alkyn-3-ols of the formulas may be employed in the method, compositions and apparatus of this invention.
  • Preferred suitable inhibiting compounds are the formate and acetate esters of nerolidol, 3-methyl-1-octen-3-ol, linalool and dehydrolinalool.
  • the esters of 1-alkyn-3-ols or the esters of 1-alkene-3-ols are better inhibitors than the other class of components and will be preferred for that species of mosquito.
  • the inhibiting compounds may be utilized singly or as mixtures of two or more of such compounds.
  • inhibiting effective amount of the inhibiting compound(s) may be employed.
  • Such inhibiting effective amounts can include amounts, based on the square footage of land or base surface area of the environmental area to be treated, within the range of from about 0.000005 g/hr/ft 2 to about 0.004 g/hr/ft 2 , preferably amounts within the range of from about 0.00015 g/hr/ft 2 to about 0.0002 g/hr/ft 2 , and especially an amount of about 0.00016 g/hr/ft 2 .
  • the inhibiting compounds for use in this invention may be provided in an essentially pure form of the inhibiting compounds or as a component of a natural essential oil having a concentration of an inhibiting compound sufficient to make it practical and feasible to dispense an inhibiting effective amount of inhibiting compound.
  • the essential oil will contain a concentration of the inhibiting compound of at least about 2%, preferably at least about 5%, and especially at least about 50% by weight.
  • the inhibiting compound can be provided as a synthetically produced, essentially pure compound or as a component of an essential oil such as basil oil, ho wood oil and the like.
  • the inhibiting compounds of this invention may be employed in any formulation suitable for dispensing inhibiting effective amounts of the compounds.
  • the compounds will generally be employed in formulations comprising a suitable vehicle containing the inhibiting compounds.
  • the inhibiting compound can be formulated in a specially formulated waxy medium or vehicle engineered to release desired amounts of vaporous inhibiting compound at ambient temperatures, such as those mediums or vehicles available from Koster Keunen of Watertown, Connecticut.
  • An example of such a waxy medium available from Koster Keunen is known as Insect Repellent Wax Bar No.
  • waxes having the following general composition: fatty acids ranging in carbon chain length of from C- ⁇ 6 to C 22 , fatty alcohols ranging in carbon chain length of from C ⁇ 6 to C 2 2, paraffinic hydrocarbons ranging in carbon chain length of from C 19 to C 7 , branched hydrocarbons ranging in carbon chain length of from C 23 to C ⁇ g, beeswax and other natural waxes such as candelilla and carnauba.
  • the wax mixture will generally be formulated with concentrations of the inhibiting compounds of this invention ranging from about 20% to 60% and the formulation has a congealing point which may vary from about 75°C to about 45°C.
  • the inhibiting compound can be formulated in a porous medium or vehicle suitable for releasing effective amounts of the inhibiting compound.
  • a porous medium or vehicle is a polyester membrane material having micropores encasing a block of inhibiting compound saturated fibers that gradually releases the inhibiting compound so that it permeates the microporous membrane and is released to the environment.
  • Such porous membrane known as World of FragranceTM cups is available from Waterbury Companies, Inc. of Waterbury, Connecticut.
  • the formulations can be placed in any suitable container or device for dispensing the inhibiting compound.
  • the formulations can be placed in a suitable fan-equipped device so that one can obtain, for example, fan-driven evaporation of the inhibiting compound from a porous medium or wax-like medium containing the inhibiting compound.
  • fan-equipped devices there can be mentioned the devices disclosed in US Patent 5,370,829 of Waterbury Companies, Inc. and the apparatus disclosed in US Patent 5,799,436 of Biosensory Insect Control Corporation, each of said patents being incorporated herein by reference thereto.
  • Another suitable means of dispensing the inhibiting compound is by atomization and/or ionic dispersion of the compound as suitable-sized, positively- charged droplets from a suitable atomization or ionic dispersing apparatus, such as the Ionic WindTM device, available from Brandenburg, Ltd. of Brierery Hill, United Kingdom.
  • a suitable atomization or ionic dispersing apparatus such as the Ionic WindTM device, available from Brandenburg, Ltd. of Brierery Hill, United Kingdom.
  • the inhibiting compounds of this invention are effective against mosquitoes, such as for example, Aedes taeniorhyncus (Black Salt Marsh mosquito),
  • Culex nigripalpus Aedes aegypti, Aedes albopictus (Asian Tiger mosquito), Culex pipiens (common house mosquito), Culex quinquefasciatus, Anopheles gambiae and the like.
  • a triple cage, dual-port olfactometer illustrated and described in detail by Posey et al. J. Med. Entomol. 35(3), 330-334 (1998), was used to study the responses of 6 to 8 day old, laboratory-reared adult female Aedes aegypti mosquitoes. This system allows mosquitoes to choose between two different stimuli.
  • the olfactometer is constructed of clear acrylic, comprises three test chambers in a tiered configuration, has paired removable sleeves, and mosquito traps on each chamber, and is equipped with a filtered external air supply system that allows precise temperature (+/- 0.5°C) and relative humidity (+/- 2%) control. Only one chamber at a time was used for the tests. Outside air was conditioned prior to entry through the choice ports, the mosquito trap, and the olfactometer by passing through a series of charcoal filters and then heated and humidified, if necessary.
  • Each test was conducted for a period of 3 minutes; the number of mosquitoes trapped in the baited ports, and those remaining in the cage, were counted. The data are then presented as a percentage of total mosquitoes in the cage that were attracted to each port and the percentage of mosquitoes remaining in the cage (i.e., not attracted to either port).

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Insects & Arthropods (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Catching Or Destruction (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne un procédé visant à inhiber la capacité des moustiques à localiser une cible par détection des émissions odorantes de cette cible. Ce procédé consiste à disperser, dans un espace, une dose efficace d'au moins un composé inhibiteur choisi dans le groupe constitué par des esters de 1-alcène-3-ols de formule (I) et des esters de 1-alcyne-3-ols de formule (II), où R est un groupe alkyle comprenant entre 1 et 4 atomes de carbone, R1 et R2 sont chacun indépendamment un groupe hydrocarboné aliphatique saturé ou non saturé contenant entre 1 et environ 12 atomes de carbone, et R¿3? est hydrogène ou CH3.
PCT/US2001/020254 2000-06-28 2001-06-26 Procede et compositions visant a inhiber la capacite des moustiques a detecter l'odeur humaine ou animale WO2002000021A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2002504815A JP2004501168A (ja) 2000-06-28 2001-06-26 人や動物の臭いを追跡する蚊の能力を阻害する方法と組成物
AU7145401A AU7145401A (en) 2000-06-28 2001-06-26 Method and compositions for inhibiting the human and animal scent tracking ability of mosquitoes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60487500A 2000-06-28 2000-06-28
US09/604,875 2000-06-28

Publications (2)

Publication Number Publication Date
WO2002000021A2 true WO2002000021A2 (fr) 2002-01-03
WO2002000021A3 WO2002000021A3 (fr) 2002-06-06

Family

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PCT/US2001/020254 WO2002000021A2 (fr) 2000-06-28 2001-06-26 Procede et compositions visant a inhiber la capacite des moustiques a detecter l'odeur humaine ou animale

Country Status (4)

Country Link
JP (1) JP2004501168A (fr)
CN (1) CN1444447A (fr)
AU (1) AU7145401A (fr)
WO (1) WO2002000021A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005517715A (ja) * 2002-02-19 2005-06-16 バイオセンソリー，インコーポレイテッド バイティングミッジのにおいの追跡能力を抑制するための方法及び組成物
EP2972299A4 (fr) * 2013-03-15 2017-01-25 The Regents of The University of California Procédés pour l'identification de répulsifs et d'attractifs pour arthropodes, et composés et compositions identifiés pour de tels procédés
US9910044B2 (en) 2013-03-14 2018-03-06 The Regents Of The University Of California Methods for identifying arthropod repellents based on modulation of specific ionotropic receptors, and compounds and compositions identified by such methods
US10292396B2 (en) 2011-10-17 2019-05-21 The Regents Of The University Of California Methods for assessing repellant quality of organic materials and methods and compositions for repelling arthropods
US11186560B2 (en) 2015-03-18 2021-11-30 The Regents Of The University Of California Arthropod repellent chemicals

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104427866A (zh) * 2013-06-12 2015-03-18 慕克萨实验室私人有限公司 杀蚊装置
CN106172393A (zh) * 2016-07-31 2016-12-07 黄劼 含有1‑辛烯‑3‑醇的驱蚊水

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9303636A (es) * 1992-08-07 1994-07-29 Us Agriculture Composicion y metodo para repeler a las hormigas.

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005517715A (ja) * 2002-02-19 2005-06-16 バイオセンソリー，インコーポレイテッド バイティングミッジのにおいの追跡能力を抑制するための方法及び組成物
JP4838495B2 (ja) * 2002-02-19 2011-12-14 バイオセンソリー，インコーポレイテッド バイティングミッジのにおいの追跡能力を抑制するための方法及び組成物
US10292396B2 (en) 2011-10-17 2019-05-21 The Regents Of The University Of California Methods for assessing repellant quality of organic materials and methods and compositions for repelling arthropods
US9910044B2 (en) 2013-03-14 2018-03-06 The Regents Of The University Of California Methods for identifying arthropod repellents based on modulation of specific ionotropic receptors, and compounds and compositions identified by such methods
EP2972299A4 (fr) * 2013-03-15 2017-01-25 The Regents of The University of California Procédés pour l'identification de répulsifs et d'attractifs pour arthropodes, et composés et compositions identifiés pour de tels procédés
US9897592B2 (en) 2013-03-15 2018-02-20 The Regents Of The University Of California Methods for identifying arthropod repellents and attractants, and compounds and compositions identified by such methods
US10768168B2 (en) 2013-03-15 2020-09-08 The Regents Of The University Of California Methods for identifying arthropod repellents and attractants, and compounds and compositions identified by such methods
US11186560B2 (en) 2015-03-18 2021-11-30 The Regents Of The University Of California Arthropod repellent chemicals

Also Published As

Publication number Publication date
AU7145401A (en) 2002-01-08
JP2004501168A (ja) 2004-01-15
CN1444447A (zh) 2003-09-24
WO2002000021A3 (fr) 2002-06-06

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