WO2002090337A1 - Sulfonamides - Google Patents
Sulfonamides Download PDFInfo
- Publication number
- WO2002090337A1 WO2002090337A1 PCT/US2002/014412 US0214412W WO02090337A1 WO 2002090337 A1 WO2002090337 A1 WO 2002090337A1 US 0214412 W US0214412 W US 0214412W WO 02090337 A1 WO02090337 A1 WO 02090337A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- disease
- compound
- hydrogen
- formula
- Prior art date
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Definitions
- U-II and GPR14 are both expressed within the mammalian CNS (Ames et. al. Nature 1999, 401, 282), they also may be useful in the treatment of addiction, schizophrenia, cognitive disorders/Alzheimers disease, (Gartlon J. Psychopharmacology (Berl) 2001 June; 155(4):426-33), impulsivity, anxiety, stress, depression, pain, migraine, neuromuscular function, parkinsons, movement disorders, sleep-wake cycle, and incentive motivation (Clark et al.Brain Research 923 (2001) 120-127. Functional U-II receptors are expressed in rhabdomyosarcomas cell lines and therefore may have oncological indications.
- the urotensin antagonist may be administered alone or in conjunction with one or more other therapeutic agents, said agents being selected from the group consisting of endothelin receptor antagonists, angiotensin converting enzyme (ACE) inhibitors, A-II receptor antagonists, vasopeptidase inhibitors, diuretics, digoxin, and dual non-selective ⁇ -adrenoceptor and o -adrenoceptor antagonists.
- ACE angiotensin converting enzyme
- the mixture was filtered through Celite ® and the residue washed well with hot ethyl acetate.
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Abstract
L'invention concerne des sulfonamides, des compositions pharmaceutiques les contenant, et leur utilisation comme antagonistes de l'urotensine II.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02731701A EP1385830A4 (fr) | 2001-05-07 | 2002-05-07 | Sulfonamides |
| JP2002587417A JP2004529168A (ja) | 2001-05-07 | 2002-05-07 | スルホンアミド |
| US10/477,066 US20040152895A1 (en) | 2002-05-07 | 2002-05-07 | Sulfonamides |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28930901P | 2001-05-07 | 2001-05-07 | |
| US60/289,309 | 2001-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2002090337A1 true WO2002090337A1 (fr) | 2002-11-14 |
Family
ID=23110967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2002/014412 WO2002090337A1 (fr) | 2001-05-07 | 2002-05-07 | Sulfonamides |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1385830A4 (fr) |
| JP (1) | JP2004529168A (fr) |
| WO (1) | WO2002090337A1 (fr) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7265122B2 (en) | 2003-02-28 | 2007-09-04 | Encysive Pharmaceuticals, Inc. | Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists |
| US7288538B2 (en) | 2003-02-20 | 2007-10-30 | Encysive Pharmaceuticals, Inc. | Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists |
| US7319111B2 (en) | 2003-02-20 | 2008-01-15 | Encysive Pharmaceuticals, Inc. | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists |
| US7320989B2 (en) | 2003-02-28 | 2008-01-22 | Encysive Pharmaceuticals, Inc. | Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists |
| US7750161B2 (en) | 2003-09-26 | 2010-07-06 | Daniel Bur | Pyridine derivatives |
| US8067601B2 (en) | 2004-10-12 | 2011-11-29 | Actelion Pharmaceticals Ltd. | 1-[2-(4-benzyl-4-hydroxy-piperidin-1 -yl )-ethyl]-3-(2-methyl-quinolin- 4-yl)- urea as crystalline sulfate salt |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008137530A1 (fr) * | 2007-05-03 | 2008-11-13 | One Lambda, Inc. | Procédés de criblage d'interactions de liaisons utilisant des ensembles de microparticules et des sondes uniques |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001045694A1 (fr) * | 1999-12-21 | 2001-06-28 | Smithkline Beecham Corporation | Antagonistes des recepteurs de l'urotensine ii |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DZ2376A1 (fr) * | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
-
2002
- 2002-05-07 WO PCT/US2002/014412 patent/WO2002090337A1/fr not_active Application Discontinuation
- 2002-05-07 JP JP2002587417A patent/JP2004529168A/ja active Pending
- 2002-05-07 EP EP02731701A patent/EP1385830A4/fr not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001045694A1 (fr) * | 1999-12-21 | 2001-06-28 | Smithkline Beecham Corporation | Antagonistes des recepteurs de l'urotensine ii |
Non-Patent Citations (1)
| Title |
|---|
| See also references of EP1385830A4 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7288538B2 (en) | 2003-02-20 | 2007-10-30 | Encysive Pharmaceuticals, Inc. | Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists |
| US7319111B2 (en) | 2003-02-20 | 2008-01-15 | Encysive Pharmaceuticals, Inc. | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists |
| US7265122B2 (en) | 2003-02-28 | 2007-09-04 | Encysive Pharmaceuticals, Inc. | Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists |
| US7320989B2 (en) | 2003-02-28 | 2008-01-22 | Encysive Pharmaceuticals, Inc. | Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists |
| US7750161B2 (en) | 2003-09-26 | 2010-07-06 | Daniel Bur | Pyridine derivatives |
| US8067601B2 (en) | 2004-10-12 | 2011-11-29 | Actelion Pharmaceticals Ltd. | 1-[2-(4-benzyl-4-hydroxy-piperidin-1 -yl )-ethyl]-3-(2-methyl-quinolin- 4-yl)- urea as crystalline sulfate salt |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1385830A1 (fr) | 2004-02-04 |
| JP2004529168A (ja) | 2004-09-24 |
| EP1385830A4 (fr) | 2005-08-17 |
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