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WO2002066498A3 - Peptide inhibant l'activite du facteur de croissance derive de plaquettes (pdgf-bb) et du facteur de croissance fibroblastique (bfgf) - Google Patents

Peptide inhibant l'activite du facteur de croissance derive de plaquettes (pdgf-bb) et du facteur de croissance fibroblastique (bfgf) Download PDF

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Publication number
WO2002066498A3
WO2002066498A3 PCT/IT2002/000098 IT0200098W WO02066498A3 WO 2002066498 A3 WO2002066498 A3 WO 2002066498A3 IT 0200098 W IT0200098 W IT 0200098W WO 02066498 A3 WO02066498 A3 WO 02066498A3
Authority
WO
WIPO (PCT)
Prior art keywords
growth factor
bfgf
pdgf
fibroblast growth
platelet derived
Prior art date
Application number
PCT/IT2002/000098
Other languages
English (en)
Other versions
WO2002066498A2 (fr
Inventor
Antonio Facchiano
Francesco Facchiano
Angelo Facchiano
Original Assignee
Idi Irccs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idi Irccs filed Critical Idi Irccs
Priority to JP2002566211A priority Critical patent/JP2004529103A/ja
Priority to EP02707088A priority patent/EP1414855A2/fr
Priority to CA002451089A priority patent/CA2451089A1/fr
Priority to AU2002241240A priority patent/AU2002241240B2/en
Publication of WO2002066498A2 publication Critical patent/WO2002066498A2/fr
Publication of WO2002066498A3 publication Critical patent/WO2002066498A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne un nouveau peptide, dérivé du facteur de croissance fibroblastique humain (bFGF). Ladite molécule est capable d'inhiber in vitro les effets du facteur de croissance dérivé de plaquettes (PDGF-BB) et du facteur de croissance fibroblastique de base (bFGF) sur des cellules primaires de muscles lisses de rats (RASMC) et des cellules primaires endothéliales bovines (BAEC). Ladite molécule est également capable d'inhiber in vivo des souris CD1 d'angiogenèse.
PCT/IT2002/000098 2001-02-21 2002-02-19 Peptide inhibant l'activite du facteur de croissance derive de plaquettes (pdgf-bb) et du facteur de croissance fibroblastique (bfgf) WO2002066498A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2002566211A JP2004529103A (ja) 2001-02-21 2002-02-19 血小板由来成長因子（ＰＤＧＦ−ＢＢ）および繊維芽細胞成長因子（ｂＦＧＦ）活性を阻害するペプチド
EP02707088A EP1414855A2 (fr) 2001-02-21 2002-02-19 Peptide inhibant l'activite du facteur de croissance derive de plaquettes (pdgf-bb) et du facteur de croissance fibroblastique (bfgf)
CA002451089A CA2451089A1 (fr) 2001-02-21 2002-02-19 Peptide inhibant l'activite du facteur de croissance derive de plaquettes (pdgf-bb) et du facteur de croissance fibroblastique (bfgf)
AU2002241240A AU2002241240B2 (en) 2001-02-21 2002-02-19 Peptide inhibiting platelet derived growth factor (PDGF-BB) and fibroblast growth factor (BFGF) activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001RM000088A ITRM20010088A1 (it) 2001-02-21 2001-02-21 Peptide in grado di inibire l'attivita' del fattore di crescita derivato dalle piastrine (pdgf-bb) e del fattore di crescita derivato dai fi
ITRM2001A000088 2001-02-21

Publications (2)

Publication Number Publication Date
WO2002066498A2 WO2002066498A2 (fr) 2002-08-29
WO2002066498A3 true WO2002066498A3 (fr) 2004-02-19

Family

ID=11455243

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2002/000098 WO2002066498A2 (fr) 2001-02-21 2002-02-19 Peptide inhibant l'activite du facteur de croissance derive de plaquettes (pdgf-bb) et du facteur de croissance fibroblastique (bfgf)

Country Status (7)

Country Link
US (2) US7009036B2 (fr)
EP (1) EP1414855A2 (fr)
JP (1) JP2004529103A (fr)
AU (1) AU2002241240B2 (fr)
CA (1) CA2451089A1 (fr)
IT (1) ITRM20010088A1 (fr)
WO (1) WO2002066498A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0509776A (pt) * 2004-04-16 2007-10-23 Scripps Research Inst método de modulação da vascularização em um tecido de um mamìfero
KR20070111556A (ko) * 2005-10-24 2007-11-22 (주)케어젠 섬유아세포 성장인자의 기능을 가지는 펩티드 및 이를이용한 화장품
US9756360B2 (en) 2011-07-19 2017-09-05 Qualcomm Incorporated Coefficient scanning in video coding
CN104693287A (zh) * 2015-03-31 2015-06-10 苏州普罗达生物科技有限公司 成纤维细胞生长因子抑制多肽及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252718A (en) * 1986-04-22 1993-10-12 The Salk Institute For Biological Studies Fibroblast growth factor antagonists
WO2000053219A2 (fr) * 1999-03-11 2000-09-14 Entremed, Inc. Compositions et techniques permettant de traiter le cancer et les troubles hyperproliferatifs
WO2000072004A2 (fr) * 1999-05-26 2000-11-30 The Regents Of The University Of California Procede de determination de la forme tridimensionnelle d'une macromolecule

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0246753B1 (fr) * 1986-04-22 1994-07-13 The Salk Institute For Biological Studies Antagonistes du facteur de croissance des fibroblastes
JP4394169B2 (ja) * 1997-04-04 2010-01-06 バーンズ − ジューウィッシュ・ホスピタル 新軟骨および使用方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252718A (en) * 1986-04-22 1993-10-12 The Salk Institute For Biological Studies Fibroblast growth factor antagonists
WO2000053219A2 (fr) * 1999-03-11 2000-09-14 Entremed, Inc. Compositions et techniques permettant de traiter le cancer et les troubles hyperproliferatifs
WO2000072004A2 (fr) * 1999-05-26 2000-11-30 The Regents Of The University Of California Procede de determination de la forme tridimensionnelle d'une macromolecule

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FACCHIANO ANTONIO ET AL: "Identification of a novel domain of fibroblast growth factor 2 controlling its angiogenic properties.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 7 MAR 2003, vol. 278, no. 10, 7 March 2003 (2003-03-07), pages 8751 - 8760, XP002255225, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
CA2451089A1 (fr) 2002-08-29
US20020119931A1 (en) 2002-08-29
ITRM20010088A1 (it) 2002-08-21
US7009036B2 (en) 2006-03-07
ITRM20010088A0 (it) 2001-02-21
EP1414855A2 (fr) 2004-05-06
US20060014693A1 (en) 2006-01-19
AU2002241240B2 (en) 2008-05-29
WO2002066498A2 (fr) 2002-08-29
JP2004529103A (ja) 2004-09-24

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