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WO2002056668A3 - Methodes permettant de reguler le spectre d'activite de vecteurs retroviraux - Google Patents

Methodes permettant de reguler le spectre d'activite de vecteurs retroviraux Download PDF

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Publication number
WO2002056668A3
WO2002056668A3 PCT/US2001/050284 US0150284W WO02056668A3 WO 2002056668 A3 WO2002056668 A3 WO 2002056668A3 US 0150284 W US0150284 W US 0150284W WO 02056668 A3 WO02056668 A3 WO 02056668A3
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WO
WIPO (PCT)
Prior art keywords
host range
retroviral vectors
methods
control
disclosed
Prior art date
Application number
PCT/US2001/050284
Other languages
English (en)
Other versions
WO2002056668A2 (fr
Inventor
Andrea L Ferris
Stephen H Hughes
Original Assignee
Us Gov Health & Human Serv
Andrea L Ferris
Stephen H Hughes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Andrea L Ferris, Stephen H Hughes filed Critical Us Gov Health & Human Serv
Priority to AU2002246829A priority Critical patent/AU2002246829A1/en
Publication of WO2002056668A2 publication Critical patent/WO2002056668A2/fr
Publication of WO2002056668A3 publication Critical patent/WO2002056668A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13045—Special targeting system for viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Image Processing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne une méthode permettant de générer et de sélectionner des vecteurs rétroviraux présentant un spectre d'activité modifié, par exemple un spectre d'activité élargi ou réduit. Cette méthode consiste à manipuler les éléments de régulation du spectre d'activité dans un vecteur rétroviral. L'invention concerne également des méthodes d'utilisation de ces vecteurs rétroviraux.
PCT/US2001/050284 2000-12-22 2001-12-21 Methodes permettant de reguler le spectre d'activite de vecteurs retroviraux WO2002056668A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002246829A AU2002246829A1 (en) 2000-12-22 2001-12-21 Methods to control the host range of retroviral vectors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25782100P 2000-12-22 2000-12-22
US60/257,821 2000-12-22

Publications (2)

Publication Number Publication Date
WO2002056668A2 WO2002056668A2 (fr) 2002-07-25
WO2002056668A3 true WO2002056668A3 (fr) 2003-03-13

Family

ID=22977891

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/050284 WO2002056668A2 (fr) 2000-12-22 2001-12-21 Methodes permettant de reguler le spectre d'activite de vecteurs retroviraux

Country Status (2)

Country Link
AU (1) AU2002246829A1 (fr)
WO (1) WO2002056668A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005534326A (ja) * 2002-08-07 2005-11-17 バヴァリアン・ノルディック・アクティーゼルスカブ アビポックスウイルスの力価を増加させるためのワクシニアウイルス宿主域遺伝子
KR102245638B1 (ko) * 2019-10-25 2021-04-29 부산대학교 산학협력단 구제역바이러스 유전자의 특정 변이 부위를 이용한 구제역바이러스 감염숙주 종판별용 바이오마커 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998012339A2 (fr) * 1996-09-20 1998-03-26 Cold Spring Harbor Laboratory Vecteurs viraux et leurs utilisations
US6096534A (en) * 1995-05-22 2000-08-01 The United States Of America As Represented By The Department Of Health And Human Services Retrovirus vectors derived from avian sarcoma leukosis viruses permitting transfer of genes into mammalian cells

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096534A (en) * 1995-05-22 2000-08-01 The United States Of America As Represented By The Department Of Health And Human Services Retrovirus vectors derived from avian sarcoma leukosis viruses permitting transfer of genes into mammalian cells
WO1998012339A2 (fr) * 1996-09-20 1998-03-26 Cold Spring Harbor Laboratory Vecteurs viraux et leurs utilisations

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ADAMS R M ET AL: "INFECTION BY RETROVIRAL VECTORS OUTSIDE OF THEIR HOST RANGE IN THE PRESENCE OF REPLICATION-DEFECTIVE ADENOVIRUS", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 69, no. 3, 1 March 1995 (1995-03-01), pages 1887 - 1894, XP002004830, ISSN: 0022-538X *
BARSOV E ET AL: "GENE TRANSFER INTO MAMMALIAN CELLS BY A ROUS SARCOMA VIRUS -BASED RETROVIRAL VECTOR WITH THE HOST RANGE OF THE AMPHOTROPIC MURINE LEUKEMIA VIRUS", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 70, no. 6, 1 June 1996 (1996-06-01), pages 3922 - 3929, XP002011559, ISSN: 0022-538X *
BEATTIE E ET AL: "HOST-RANGE RESTRICTION OF VACCINIA VIRUS E3L-SPECIFIC DELETION MUTANTS", VIRUS GENES, KLUWER ACADEMIC PUBLISHERS, BOSTON, US, vol. 12, no. 1, 1996, pages 89 - 94, XP000990662, ISSN: 0920-8569 *
BROUGH D ET AL: "RESTRICTED CHANGES IN THE ADENOVIRUS DNA-BINDING, PROTEIN THAT LEAD TO EXTENDED HOST RANGE OR TEMPERATURE-SENSITIVE PHENOTYPES", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 55, no. 1, 1 July 1985 (1985-07-01), pages 206 - 212, XP002012304, ISSN: 0022-538X *
JIANYUN DONG ET AL: "A CHIMERIC AVIAN RETROVIRUS CONTAINING THE INFLUENZA VIRUS HEMAGGLUTININ GENE HAS AN EXPANDED HOST RANGE", JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, READING, GB, vol. 66, no. 12, 1 December 1992 (1992-12-01), pages 7374 - 7382, XP000572226, ISSN: 0022-1317 *
LUCHER L A: "ABORTIVE ADENOVIRUS INFECTION AND HOST RANGE DETERMINANTS", CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, SPRINGER, BERLIN,, DE, vol. 199, 1995, pages 119 - 152, XP002926241, ISSN: 0070-217X *
MORGAN R A ET AL: "ANALYSIS OF THE FUNCTIONAL AND HOST RANGE-DETERMINING REGIONS OF THE MURINE ECOTROPIC AND AMPHOTROPIC RETROVIRUS ENVELOPE PROTEINS", JOURNAL OF VIROLOGY, NEW YORK, US, US, vol. 67, no. 8, August 1993 (1993-08-01), pages 4712 - 4721, XP001062470, ISSN: 0022-538X *
PERKUS M E ET AL: "VACCINIA VIRUS HOST RANGE GENES", VIROLOGY, RAVEN PRESS, NEW YORK, NY, US, vol. 179, 1990, pages 276 - 286, XP000255782, ISSN: 0042-6822 *
YEE J-K ET AL: "GENERATION OF HIGH-TITER PSEUDOTYPED RETROVIRAL VECTORS WITH VERY BROAD HOST RANGE", METHODS IN CELL BIOLOGY, LONDON, GB, vol. 43, 1994, pages 99 - 112, XP002930286 *

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Publication number Publication date
WO2002056668A2 (fr) 2002-07-25
AU2002246829A1 (en) 2002-07-30

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