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WO2002053714A3 - Regulation de la phosphatidylinositol-4-phosphate 5-kinase humaine - Google Patents

Regulation de la phosphatidylinositol-4-phosphate 5-kinase humaine Download PDF

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Publication number
WO2002053714A3
WO2002053714A3 PCT/EP2001/015321 EP0115321W WO02053714A3 WO 2002053714 A3 WO2002053714 A3 WO 2002053714A3 EP 0115321 W EP0115321 W EP 0115321W WO 02053714 A3 WO02053714 A3 WO 02053714A3
Authority
WO
WIPO (PCT)
Prior art keywords
phosphate
kinase
human phosphatidylinositol
regulation
phosphatidylinositol
Prior art date
Application number
PCT/EP2001/015321
Other languages
English (en)
Other versions
WO2002053714A2 (fr
Inventor
Zhimin Zhu
Original Assignee
Bayer Ag
Zhimin Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Zhimin Zhu filed Critical Bayer Ag
Priority to AU2002217161A priority Critical patent/AU2002217161A1/en
Publication of WO2002053714A2 publication Critical patent/WO2002053714A2/fr
Publication of WO2002053714A3 publication Critical patent/WO2002053714A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention se rapporte à des réactifs qui régulent la phosphatidylinositol-4-phosphate 5-kinase humaine ainsi qu'à des réactifs qui se lient à des produits géniques de la phosphatidylinositol-4-phosphate 5-kinase humaine pouvant jouer un rôle dans la prévention, l'amélioration ou le traitement de dysfonctionnements ou de maladies, tels que le cancer, l'asthme et la broncho-pneumopathie chronique obstructive.
PCT/EP2001/015321 2001-01-03 2001-12-27 Regulation de la phosphatidylinositol-4-phosphate 5-kinase humaine WO2002053714A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002217161A AU2002217161A1 (en) 2001-01-03 2001-12-27 Regulation of human phosphatidylinositol-4-phosphate 5-kinase

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25921701P 2001-01-03 2001-01-03
US60/259,217 2001-01-03
US33147401P 2001-11-16 2001-11-16
US60/331,474 2001-11-16

Publications (2)

Publication Number Publication Date
WO2002053714A2 WO2002053714A2 (fr) 2002-07-11
WO2002053714A3 true WO2002053714A3 (fr) 2002-12-05

Family

ID=26947164

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/015321 WO2002053714A2 (fr) 2001-01-03 2001-12-27 Regulation de la phosphatidylinositol-4-phosphate 5-kinase humaine

Country Status (2)

Country Link
AU (1) AU2002217161A1 (fr)
WO (1) WO2002053714A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7705120B2 (en) 2001-06-21 2010-04-27 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
GB0610778D0 (en) * 2006-05-31 2006-07-12 Het Nl Kanker I Phosphatidylinositol phospahte and apoptosis

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 28 September 2000 (2000-09-28), XP002210264, retrieved from EBI Database accession no. BE867387 *
DATABASE TREMBL [online] 29 September 2000 (2000-09-29), XP002210263, retrieved from EBI Database accession no. AK02578 *
DATABASE TREMBL [online] 5 August 1998 (1998-08-05), retrieved from EBI Database accession no. AF030558 *
ITOH TOSHIKI ET AL: "A novel phosphatidylinositol-5-phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 32, 7 August 1998 (1998-08-07), pages 20292 - 20299, XP002210261, ISSN: 0021-9258 *
SINGHAL R L ET AL: "1-Phosphatidylinositol 4-phosphate 5-kinase (EC 2.7.1.68): a proliferation- and malignancy-linked signal transduction enzyme.", CANCER RESEARCH. UNITED STATES 1 NOV 1994, vol. 54, no. 21, 1 November 1994 (1994-11-01), pages 5574 - 5578, XP001096230, ISSN: 0008-5472 *
WEBER GEORGE ET AL: "Regulation of the signal transduction program by drugs.", K 10159-2101, USA, vol. 37, 1997, Thirty-seventh Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues;Indianapolis, Indiana, USA; September 30-October 1, 1996, 1997 Elsevier Science Publishers B.V., pages 35 - 55, XP002210262, ISBN: 0-08-043095-3 *

Also Published As

Publication number Publication date
WO2002053714A2 (fr) 2002-07-11
AU2002217161A1 (en) 2002-07-16

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