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WO2002053700A3 - Molecules isolees renfermant des epitopes a fractions sulfatees, anticorps vis-a-vis de ces epitopes, et utilisations correspondantes - Google Patents

Molecules isolees renfermant des epitopes a fractions sulfatees, anticorps vis-a-vis de ces epitopes, et utilisations correspondantes Download PDF

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Publication number
WO2002053700A3
WO2002053700A3 PCT/US2001/049442 US0149442W WO02053700A3 WO 2002053700 A3 WO2002053700 A3 WO 2002053700A3 US 0149442 W US0149442 W US 0149442W WO 02053700 A3 WO02053700 A3 WO 02053700A3
Authority
WO
WIPO (PCT)
Prior art keywords
epitopes
antibodies
present
isolated molecules
containing sulfated
Prior art date
Application number
PCT/US2001/049442
Other languages
English (en)
Other versions
WO2002053700A2 (fr
Inventor
Janette Lazarovits
Yocheved Hagai
Daniel Plaksin
Tikva Vogel
Abraham Nimrod
Hagit Mar-Haim
Ester Szanthon
Tamar Richter
Boaz Amit
Lena Kooperman
Tuvia Peretz
Avigdor Levanon
Original Assignee
Bio Technology General Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Technology General Corp filed Critical Bio Technology General Corp
Priority to JP2002555211A priority Critical patent/JP2005503756A/ja
Priority to MXPA03005945A priority patent/MXPA03005945A/es
Priority to CA002433225A priority patent/CA2433225A1/fr
Priority to KR10-2003-7008890A priority patent/KR20030091953A/ko
Priority to BRPI0116764-2A priority patent/BR0116764A/pt
Priority to HU0700079A priority patent/HUP0700079A2/hu
Priority to EP01994330A priority patent/EP1406930A4/fr
Priority to IL15668901A priority patent/IL156689A0/xx
Publication of WO2002053700A2 publication Critical patent/WO2002053700A2/fr
Publication of WO2002053700A3 publication Critical patent/WO2002053700A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des épitopes propres aux cellules cancéreuses, qui jouent un rôle important dans certains phénomènes physiologiques comme le roulement cellulaire, la métastase et l'inflammation. L'invention concerne également des procédés et des compositions thérapeutiques et diagnostiques faisant intervenir des anticorps capables de se lier avec les épitopes. Les procédés et les compositions en question peuvent s'appliquer au diagnostic et à la thérapie pour une série de maladies, à savoir par exemple: cancer, y compris la croissance tumorale et la métastase, leucémie, maladie auto-immune, et maladie inflammatoire.
PCT/US2001/049442 2000-12-29 2001-12-31 Molecules isolees renfermant des epitopes a fractions sulfatees, anticorps vis-a-vis de ces epitopes, et utilisations correspondantes WO2002053700A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2002555211A JP2005503756A (ja) 2000-12-29 2001-12-31 硫酸化部分を含むエピトープを含む単離分子、当該エピトープに対する抗体、及びその使用
MXPA03005945A MXPA03005945A (es) 2000-12-29 2001-12-31 Moleculas aisladas que comprenden epitopes que contienen grupos sulfato, anticuerpos para tales epitopes y usos de ellos.
CA002433225A CA2433225A1 (fr) 2000-12-29 2001-12-31 Molecules isolees renfermant des epitopes a fractions sulfatees, anticorps vis-a-vis de ces epitopes, et utilisations correspondantes
KR10-2003-7008890A KR20030091953A (ko) 2000-12-29 2001-12-31 황산화된 부분을 함유하는 에피토프를 포함하는 분리된분자, 그러한 에피토프에 대한 항체, 및 그들의 용도
BRPI0116764-2A BR0116764A (pt) 2000-12-29 2001-12-31 moléculas isoladas compreendendo epitopos contendo porções sulfatadas, anticorpos para os referidos epitopos e seus usos
HU0700079A HUP0700079A2 (en) 2000-12-29 2001-12-31 Isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
EP01994330A EP1406930A4 (fr) 2000-12-29 2001-12-31 Molecules isolees renfermant des epitopes a fractions sulfatees, anticorps vis-a-vis de ces epitopes, et utilisations correspondantes
IL15668901A IL156689A0 (en) 2000-12-29 2001-12-31 Isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25894800P 2000-12-29 2000-12-29
US75118100A 2000-12-29 2000-12-29
US60/258,948 2000-12-29
US09/751,181 2000-12-29

Publications (2)

Publication Number Publication Date
WO2002053700A2 WO2002053700A2 (fr) 2002-07-11
WO2002053700A3 true WO2002053700A3 (fr) 2004-02-12

Family

ID=26946974

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/049442 WO2002053700A2 (fr) 2000-12-29 2001-12-31 Molecules isolees renfermant des epitopes a fractions sulfatees, anticorps vis-a-vis de ces epitopes, et utilisations correspondantes

Country Status (13)

Country Link
EP (1) EP1406930A4 (fr)
JP (1) JP2005503756A (fr)
KR (1) KR20030091953A (fr)
CN (1) CN100347194C (fr)
BR (1) BR0116764A (fr)
CA (1) CA2433225A1 (fr)
CZ (1) CZ20031982A3 (fr)
HU (1) HUP0700079A2 (fr)
IL (1) IL156689A0 (fr)
MX (1) MXPA03005945A (fr)
PL (1) PL366223A1 (fr)
RU (1) RU2003123101A (fr)
WO (1) WO2002053700A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7744888B2 (en) 2001-08-03 2010-06-29 Abgenomics Cooperatief U.A. Methods of modulating T cell or natural killer cell activity with anti-P-selectin glycoprotein ligand 1 antibodies
US20040116333A1 (en) 2001-08-03 2004-06-17 Rong-Hwa Lin Modulators of P-selectin glycoprotein ligand 1
EP1551452A4 (fr) * 2002-07-01 2006-08-30 Savient Pharmaceuticals Inc Compositions et procedes pour traitement therapeutique
RU2006102570A (ru) * 2003-06-30 2007-08-20 Био-Текнолоджи Дженерал(Израиль) Лтд. (IL) Антитела и их применение
CA2531283A1 (fr) * 2003-06-30 2005-01-20 Bio-Technology General (Israel) Ltd. Anticorps humains specifiques
ITMI20031714A1 (it) * 2003-09-05 2005-03-06 Gentium Spa Formazioni ad azione antitumorale.
MY148646A (en) * 2004-05-10 2013-05-15 Abgenomics Cooperatief Ua Anti-psgl-1 antibodies
AR048840A1 (es) * 2004-05-11 2006-05-31 Boehringer Ingelheim Int Epitopes inductores de la muerte de las celulas t
ES2694239T3 (es) 2010-11-12 2018-12-19 Gentium S.R.L. Defibrótido para su uso en profilaxis y/o tratamiento de la enfermedad de Injerto contra huésped (GVHD)
CN103732626A (zh) 2011-06-13 2014-04-16 艾比吉诺米克斯合作公司 抗psgl-1抗体及其用途
KR102038357B1 (ko) 2012-06-22 2019-10-31 젠티엄 에스알엘 디파이브로타이드의 생물학적 활성 측정을 위한 유우글로불린에 기초한 방법
WO2016013828A1 (fr) * 2014-07-21 2016-01-28 연세대학교 산학협력단 Mutant de domaine extracellulaire 1 de récepteur de chimiokines duffy sulfaté et utilisation associée
EP3026122A1 (fr) 2014-11-27 2016-06-01 Gentium S.p.A. Procédé à base cellulaire pour déterminer la puissance de défibrotide
JP2019031486A (ja) * 2017-08-04 2019-02-28 公立大学法人福島県立医科大学 新規ポリペプチド及びその用途
CN109929036B (zh) * 2017-12-19 2024-12-03 泰州迈博太科药业有限公司 一种表位特异的抗体筛选方法及所筛选到的抗体

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
WO1993011778A1 (fr) * 1991-12-12 1993-06-24 The Scripps Research Institute Molecules anti-thrombotiques bifonctionnelles et polypetptides anti-trhombotiques
TR199701620T1 (xx) * 1995-06-14 1998-05-21 The General Hospital Corporation P-Selektin ligandlar� ve ilgili molek�lleri ve metodlar�.
EP0850243B1 (fr) * 1995-08-03 2003-10-08 Board Of Regents Of The University Of Oklahoma o-glycanes inhibiteurs de l'inflammation induite par la selectine
US5985833A (en) * 1996-09-17 1999-11-16 Wisconsin Alumni Research Foundation Thrombin inhibitor
US6593459B1 (en) * 1998-06-16 2003-07-15 The Board Of Regents Of The University Of Oklahoma Synthetic glycosulfopeptides and methods of synthesis thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SNAPP ET AL.: "A novel P-selectin glycoprotein ligand-1 monoclonal antibody recognizes an epitope within the tyrosine sulfate motif of human PSGL-1 and blocks recognition of both P- and L-selectin", BLOOD, vol. 91, no. 1, 1 January 1998 (1998-01-01), pages 154 - 164, XP002968095 *

Also Published As

Publication number Publication date
CZ20031982A3 (cs) 2004-09-15
EP1406930A4 (fr) 2007-01-10
PL366223A1 (en) 2005-01-24
MXPA03005945A (es) 2004-10-15
CA2433225A1 (fr) 2002-07-11
HUP0700079A2 (en) 2007-05-02
EP1406930A2 (fr) 2004-04-14
CN100347194C (zh) 2007-11-07
WO2002053700A2 (fr) 2002-07-11
JP2005503756A (ja) 2005-02-10
KR20030091953A (ko) 2003-12-03
RU2003123101A (ru) 2005-03-10
BR0116764A (pt) 2007-01-09
CN1649900A (zh) 2005-08-03
IL156689A0 (en) 2004-01-04

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