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WO2002053574A3 - Modified pna molecules - Google Patents

Modified pna molecules Download PDF

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Publication number
WO2002053574A3
WO2002053574A3 PCT/DK2002/000005 DK0200005W WO02053574A3 WO 2002053574 A3 WO2002053574 A3 WO 2002053574A3 DK 0200005 W DK0200005 W DK 0200005W WO 02053574 A3 WO02053574 A3 WO 02053574A3
Authority
WO
WIPO (PCT)
Prior art keywords
pna
nucleic acid
peptide nucleic
modified
amino acid
Prior art date
Application number
PCT/DK2002/000005
Other languages
French (fr)
Other versions
WO2002053574A2 (en
Inventor
Peter Eigil Nielsen
Muthiah Manoharan
Ask Pueschl
Original Assignee
Pantheco As
Peter Eigil Nielsen
Muthiah Manoharan
Ask Pueschl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pantheco As, Peter Eigil Nielsen, Muthiah Manoharan, Ask Pueschl filed Critical Pantheco As
Priority to AU2002216946A priority Critical patent/AU2002216946A1/en
Publication of WO2002053574A2 publication Critical patent/WO2002053574A2/en
Publication of WO2002053574A3 publication Critical patent/WO2002053574A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention concerns peptide nucleic acid (PNA) sequences, which are modified in order to obtain novel PNA molecules with enhanced properties. The peptide nucleic acid (PNA) oligomers are characterized in that the single units of the oligomer consists of different amino acid backbones selected from aminoethylglycine (aeg), aminoethylprolyl (aep), aminoethylpyrrolidine (pyr) or an amino acid more over is modified PNA conjugate of formula (I):Q - L - PNA (I) claimed, wherein L is a linker or a bond; Q is the peptide and PNA is the peptide nucleic acid oligomer.
PCT/DK2002/000005 2001-01-05 2002-01-03 Modified pna molecules WO2002053574A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002216946A AU2002216946A1 (en) 2001-01-05 2002-01-03 Modified pna molecules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200100021 2001-01-05
DKPA200100021 2001-01-05

Publications (2)

Publication Number Publication Date
WO2002053574A2 WO2002053574A2 (en) 2002-07-11
WO2002053574A3 true WO2002053574A3 (en) 2002-10-24

Family

ID=8159969

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2002/000005 WO2002053574A2 (en) 2001-01-05 2002-01-03 Modified pna molecules

Country Status (2)

Country Link
AU (1) AU2002216946A1 (en)
WO (1) WO2002053574A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10370415B2 (en) 2013-04-11 2019-08-06 Carnegie Mellon University Divalent nucleobase compounds and uses therefor
WO2014169216A2 (en) 2013-04-11 2014-10-16 Carnegie Mellon University TEMPLATE-DIRECTED γPNA SYNTHESIS AND γPNA TARGETING COMPOUNDS
JP7573965B2 (en) 2016-09-26 2024-10-28 カーネギー メロン ユニバーシティ Divalent nucleobase compounds and their uses
US20230242587A1 (en) * 2020-04-17 2023-08-03 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Thyclotides

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016550A1 (en) * 1996-10-14 1998-04-23 Isis Innovation Limited Chiral peptide nucleic acids
WO1998052614A2 (en) * 1997-05-21 1998-11-26 The Board Of Trustees Of The Leland Stanford Junior University Composition and method for enhancing transport across biological membranes
WO1999005302A1 (en) * 1997-07-24 1999-02-04 The Perkin-Elmer Corporation Conjugates of transporter peptides and nucleic acid analogs, and their use
WO2000040742A1 (en) * 1999-01-08 2000-07-13 Amaxa Gmbh Use of the cell's own transport system for transferring nucleic acids across the nuclear membrane
WO2001027261A2 (en) * 1998-11-11 2001-04-19 Pantheco A/S Conjugates between a peptides and a nucleic acid analog, such as a pna, lna or a morpholino
WO2001076636A2 (en) * 2000-04-06 2001-10-18 Pantheco A/S Pharmaceutical composition of modified pna molecules

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016550A1 (en) * 1996-10-14 1998-04-23 Isis Innovation Limited Chiral peptide nucleic acids
WO1998052614A2 (en) * 1997-05-21 1998-11-26 The Board Of Trustees Of The Leland Stanford Junior University Composition and method for enhancing transport across biological membranes
WO1999005302A1 (en) * 1997-07-24 1999-02-04 The Perkin-Elmer Corporation Conjugates of transporter peptides and nucleic acid analogs, and their use
WO2001027261A2 (en) * 1998-11-11 2001-04-19 Pantheco A/S Conjugates between a peptides and a nucleic acid analog, such as a pna, lna or a morpholino
WO2000040742A1 (en) * 1999-01-08 2000-07-13 Amaxa Gmbh Use of the cell's own transport system for transferring nucleic acids across the nuclear membrane
WO2001076636A2 (en) * 2000-04-06 2001-10-18 Pantheco A/S Pharmaceutical composition of modified pna molecules

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
BASU S ET AL: "SYNTHESIS AND CHARACTERIZATION OF A PEPTIDE NUCLEIC AICD CONJUGATED TO A D-PEPTIDE ANALOG OF INSULIN-LIKE GROWTH FACTOR 1 FOR INCREASED CELLULAR UPTAKE", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 8, no. 8, 1997, pages 481 - 488, XP002902380, ISSN: 1043-1802 *
GANGAMANI B P ET AL: "SPERMINE CONJUGATED PEPTIDE NUCLEIC ACIDS (SPPNA): UV AND FLUORESCENCE STUDIES OF PNA-DNA HYBRIDS WITH IMPROVED STABILITY", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 240, no. 3, 1997, pages 778 - 782, XP002902382, ISSN: 0006-291X *
HARRISON J G ET AL: "INHIBITION OF HUMAN TELOMERASE BY PNA-CATIONIC PEPTIDE CONJUGATES", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 9, 1999, pages 1273 - 1278, XP002901880, ISSN: 0960-894X *
ISHIHARA ET AL: "Rules for Strand Invasion by Chemically Modified Oligonucleotides", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 121, no. 10, 1999, pages 2012 - 2020, XP002140165, ISSN: 0002-7863 *
JORDAN S ET AL: "Synthesis of new building blocks for peptide nucleic acids containing monomers with variations in the backbone", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 7, no. 6, 18 March 1997 (1997-03-18), pages 681 - 686, XP004136108, ISSN: 0960-894X *
KUMAR V ET AL: "PYRROLIDINE NUCLEIC ACIDS: DNA/PNA OLIGOMERS WITH 2-HYDROXY/AMINOMETHYL-4-(THYMIN-1-YL)PYRROLIDINE-N-ACETIC ACID", ORGANIC LETTERS, ACS, WASHINGTON, DC, US, vol. 9, no. 3, 2001, pages 1269 - 1272, XP002902385, ISSN: 1523-7060 *
MONEESHA D'COSTA ET AL: "Aminoethylprolyl (aep) PNA: Mixed purine/pyrimidine oligomers and binding orientation preferences for PNA:DNA duplex formation.", ORGANIC LETTERS, vol. 3, no. 9, 2001, pages 1281 - 1284, XP002902588 *
MONEESHA D'COSTA ET AL: "Aminoethylprolyl peptide nucleic acids (aepPNA): Chiral PNA analogues that form highly stable DNA:aepPNA2 triplexes.", ORGANIC LETTERS, vol. 1, no. 10, 1999, pages 1513 - 1516, XP002902586 *
PUSCHL A ET AL: "Peptide Nucleic Acids (PNAs) with a Functional Backbone", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 39, no. 26, 25 June 1998 (1998-06-25), pages 4707 - 4710, XP004130902, ISSN: 0040-4039 *
PÜSCHL A ET AL: "Peptide nucleic acids with a constrained cyclic backbone.", INNOVATION AND PERSPECTIVES IN SOLID PHASE SYNTHESIS & COMBINATONAL LIBRARIES, 6TH INTERNATIONAL SYMPOSIUM, 31 August 1999 (1999-08-31), YORK, ENGLAND EDITOR R. EPTON, MAYFLOWER WORLDWIDE LTD 2000, pages 343 - 346, XP002902585 *
PUSCHL A ET AL: "Pyrrolidine PNA: A novel conformationally restricted PNA analogue.", ORGANIC LETTERS, vol. 2, no. 26, 2000, pages 4161 - 4163, XP002902587 *
SIMMONS C G ET AL: "Synthesis and membrane permeability of pna-peptide conjugates", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 7, no. 23, 2 December 1997 (1997-12-02), pages 3001 - 3006, XP004136573, ISSN: 0960-894X *
VILAIVAN T ET AL: "Synthesis and properties of chiral peptide nucleic acids with a N-Aminoethyl-d-proline backbone", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 10, no. 22, 20 November 2000 (2000-11-20), pages 2541 - 2545, XP004224259, ISSN: 0960-894X *
VILAIVAN T ET AL: "Synthesis and properties of novel pyrrolidinyl PNA carrying beta-amino acid spacers", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 42, no. 32, 6 August 2001 (2001-08-06), pages 5533 - 5536, XP004255002, ISSN: 0040-4039 *

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Publication number Publication date
WO2002053574A2 (en) 2002-07-11
AU2002216946A1 (en) 2002-07-16

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