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WO2002047720A3 - Treatment and prevention of ebv infection and ebv-associated disorders - Google Patents

Treatment and prevention of ebv infection and ebv-associated disorders Download PDF

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Publication number
WO2002047720A3
WO2002047720A3 PCT/US2001/047885 US0147885W WO0247720A3 WO 2002047720 A3 WO2002047720 A3 WO 2002047720A3 US 0147885 W US0147885 W US 0147885W WO 0247720 A3 WO0247720 A3 WO 0247720A3
Authority
WO
WIPO (PCT)
Prior art keywords
ebv
env
herv
seq
associated disorders
Prior art date
Application number
PCT/US2001/047885
Other languages
French (fr)
Other versions
WO2002047720A2 (en
Inventor
Brigitte T Huber
David A Thorley-Lawson
Natalie Sutkowski
Original Assignee
Univ Tufts
Brigitte T Huber
David A Thorley-Lawson
Natalie Sutkowski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tufts, Brigitte T Huber, David A Thorley-Lawson, Natalie Sutkowski filed Critical Univ Tufts
Priority to CA002429755A priority Critical patent/CA2429755A1/en
Priority to US10/432,114 priority patent/US20040096457A1/en
Priority to EP01991002A priority patent/EP1385542A4/en
Priority to JP2002549290A priority patent/JP2004517839A/en
Priority to AU2002230758A priority patent/AU2002230758A1/en
Publication of WO2002047720A2 publication Critical patent/WO2002047720A2/en
Publication of WO2002047720A3 publication Critical patent/WO2002047720A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
    • C12N2710/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides substances suitable for use as vaccines for the prevention of EBV infection and EBV-associated disorders and methods for administering them. The vaccines are directed against HERV-K18 env (SEQ ID:1) and most preferably comprise antigens obtained from HERV-K18 env. Preferred antigens include SEQ ID:2, SEQ ID:3 and SEQ ID:4. Most preferably, the SAg T cell stimulatory activity of the HERV-K18 env is diminished or eliminated. In another embodiment, the vaccine contains a nucleic acid encoding HERV-K18 env or an immunogenic fragment thereof. The present invention also provides methods for treating EBV infection and EBV-associated disorders.
PCT/US2001/047885 2000-12-11 2001-12-11 Treatment and prevention of ebv infection and ebv-associated disorders WO2002047720A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002429755A CA2429755A1 (en) 2000-12-11 2001-12-11 Treatment and prevention of ebv infection and ebv-associated disorders
US10/432,114 US20040096457A1 (en) 2001-12-11 2001-12-11 Treatment and prevention of ebv infection and ebv-associated disorders
EP01991002A EP1385542A4 (en) 2000-12-11 2001-12-11 TREATMENT AND PREVENTION OF EPSTEIN-BARR (EBV) VIRUS INFECTION AND DISORDERS ASSOCIATED WITH IT
JP2002549290A JP2004517839A (en) 2000-12-11 2001-12-11 Treatment and prevention of EBV infection and EBV-related disorders
AU2002230758A AU2002230758A1 (en) 2000-12-11 2001-12-11 Treatment and prevention of EBV infection and EBV-associated disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25467300P 2000-12-11 2000-12-11
US60/254,673 2000-12-11

Publications (2)

Publication Number Publication Date
WO2002047720A2 WO2002047720A2 (en) 2002-06-20
WO2002047720A3 true WO2002047720A3 (en) 2003-10-23

Family

ID=22965136

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/047885 WO2002047720A2 (en) 2000-12-11 2001-12-11 Treatment and prevention of ebv infection and ebv-associated disorders

Country Status (5)

Country Link
EP (1) EP1385542A4 (en)
JP (1) JP2004517839A (en)
AU (1) AU2002230758A1 (en)
CA (1) CA2429755A1 (en)
WO (1) WO2002047720A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1423416A2 (en) * 2001-08-31 2004-06-02 NovImmune S.A. Allelic variants of herv-k18 provirus and their use in analysis
WO2003022867A2 (en) * 2001-09-06 2003-03-20 Novimmune S.A. Peptides derived from the superantigen (sag) env protein of herv-k18 and their use in obtaining sag-inhibitory antibodies and in vaccination against sag
DE102004011564A1 (en) * 2004-03-08 2005-09-29 Rwth Aachen Vaccine for the prevention and / or treatment of a herpes virus infection
CA2561376C (en) * 2004-03-30 2016-06-21 Institut Gustave Roussy Polypeptide sequence involved in the modulation of the immunosuppresive effect of viral proteins
GB0707208D0 (en) * 2007-04-13 2007-05-23 Istituto Superiore Di Sanito Novel disease treatments
CN117656334B (en) * 2024-02-01 2024-04-12 广州市亿安劳保用品有限公司 Glove dipping processing device for glove production line

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858723A (en) * 1995-12-05 1999-01-12 Behringwerke Aktiengesellschaft Polypeptides and antibodies for diagnosing and treating seminoma

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003022867A2 (en) * 2001-09-06 2003-03-20 Novimmune S.A. Peptides derived from the superantigen (sag) env protein of herv-k18 and their use in obtaining sag-inhibitory antibodies and in vaccination against sag

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858723A (en) * 1995-12-05 1999-01-12 Behringwerke Aktiengesellschaft Polypeptides and antibodies for diagnosing and treating seminoma

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CONRAD ET AL.: "A human endogenous retroviral superantigen as candidate autoimmune gene in type I diabetes", CELL, vol. 90, 25 July 1997 (1997-07-25), pages 303 - 313, XP002058200 *
SUTKOWSKI ET AL.: "An Epstein-barr virus-associated superantigen", J. EXP. MED., vol. 184, September 1996 (1996-09-01), pages 971 - 980, XP002909211 *
SUTKOWSKI ET AL.: "Epstein-barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen", IMMUNITY, vol. 15, October 2001 (2001-10-01), pages 579 - 589, XP002909213 *
TONJES ET AL.: "Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells", JOURNAL OF VIROLOGY, vol. 71, no. 4, April 1997 (1997-04-01), pages 2747 - 2756, XP002909212 *

Also Published As

Publication number Publication date
JP2004517839A (en) 2004-06-17
CA2429755A1 (en) 2002-06-20
AU2002230758A1 (en) 2002-06-24
EP1385542A2 (en) 2004-02-04
EP1385542A4 (en) 2005-11-16
WO2002047720A2 (en) 2002-06-20

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