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WO2002046194A3 - Imidazopyridines substituees - Google Patents

Imidazopyridines substituees Download PDF

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Publication number
WO2002046194A3
WO2002046194A3 PCT/US2001/046915 US0146915W WO0246194A3 WO 2002046194 A3 WO2002046194 A3 WO 2002046194A3 US 0146915 W US0146915 W US 0146915W WO 0246194 A3 WO0246194 A3 WO 0246194A3
Authority
WO
WIPO (PCT)
Prior art keywords
useful
compounds
substituted imidazopyridines
biosynthesis
induce
Prior art date
Application number
PCT/US2001/046915
Other languages
English (en)
Other versions
WO2002046194A2 (fr
Inventor
Kyle J Lindstrom
Original Assignee
3M Innovative Properties Co
Kyle J Lindstrom
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to UA2003042937A priority Critical patent/UA74593C2/uk
Priority to KR10-2003-7007533A priority patent/KR20030070048A/ko
Priority to JP2002547931A priority patent/JP2004525868A/ja
Priority to CA002431040A priority patent/CA2431040A1/fr
Priority to MXPA03005013A priority patent/MXPA03005013A/es
Priority to PL01365739A priority patent/PL365739A1/xx
Priority to HU0600592A priority patent/HUP0600592A2/hu
Priority to SK714-2003A priority patent/SK7142003A3/sk
Priority to EEP200300273A priority patent/EE200300273A/xx
Application filed by 3M Innovative Properties Co, Kyle J Lindstrom filed Critical 3M Innovative Properties Co
Priority to AU2002239547A priority patent/AU2002239547B2/en
Priority to NZ526085A priority patent/NZ526085A/xx
Priority to BR0116034-6A priority patent/BR0116034A/pt
Priority to AU3954702A priority patent/AU3954702A/xx
Priority to IL15588501A priority patent/IL155885A0/xx
Priority to EP01987315A priority patent/EP1343783A2/fr
Publication of WO2002046194A2 publication Critical patent/WO2002046194A2/fr
Publication of WO2002046194A3 publication Critical patent/WO2002046194A3/fr
Priority to NO20032453A priority patent/NO20032453L/no
Priority to HR20030465A priority patent/HRP20030465A2/hr
Priority to HK04106187A priority patent/HK1063466A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

L'invention concerne des composés d'imidazopyridine renfermant une fonctionnalité amine substituée en position 1. Ces composés sont utiles comme modificateurs de la réponse immune. Les composés et compositions selon l'invention peuvent induire la biosynthèse de différentes cytokines et sont utiles dans le traitement d'une palette de pathologies, notamment des maladies virales et néoplastiques.
PCT/US2001/046915 2000-12-08 2001-12-06 Imidazopyridines substituees WO2002046194A2 (fr)

Priority Applications (18)

Application Number Priority Date Filing Date Title
UA2003042937A UA74593C2 (en) 2000-12-08 2001-06-12 Substituted imidazopyridines
JP2002547931A JP2004525868A (ja) 2000-12-08 2001-12-06 置換イミダゾピリジン類
CA002431040A CA2431040A1 (fr) 2000-12-08 2001-12-06 Imidazopyridines substituees
MXPA03005013A MXPA03005013A (es) 2000-12-08 2001-12-06 Imidazopiridinas sustituidas.
PL01365739A PL365739A1 (en) 2000-12-08 2001-12-06 Substituted imidazopyridines
HU0600592A HUP0600592A2 (en) 2000-12-08 2001-12-06 Substituted imidazopyridines, pharmaceutical compositions containing them and intermediates
SK714-2003A SK7142003A3 (en) 2000-12-08 2001-12-06 Substituted imidazopyridines
EEP200300273A EE200300273A (et) 2000-12-08 2001-12-06 Asendatud imidasopüridiinid
AU2002239547A AU2002239547B2 (en) 2000-12-08 2001-12-06 Substituted imidazopyridines
KR10-2003-7007533A KR20030070048A (ko) 2000-12-08 2001-12-06 치환 이미다조피리딘
AU3954702A AU3954702A (en) 2000-12-08 2001-12-06 Substituted imidazopyridines
BR0116034-6A BR0116034A (pt) 2000-12-08 2001-12-06 Imidazopiridinas substituìdas
NZ526085A NZ526085A (en) 2000-12-08 2001-12-06 Substituted imidazopyridines
IL15588501A IL155885A0 (en) 2000-12-08 2001-12-06 Substituted imidazopyridines
EP01987315A EP1343783A2 (fr) 2000-12-08 2001-12-06 Imidazopyridines substituees
NO20032453A NO20032453L (no) 2000-12-08 2003-05-28 Substituerte imidazopyridiner
HR20030465A HRP20030465A2 (en) 2000-12-08 2003-06-06 Substituted imidazopyridines
HK04106187A HK1063466A1 (en) 2000-12-08 2004-08-18 Substituted imidazopyridines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25422800P 2000-12-08 2000-12-08
US60/254,228 2000-12-08

Publications (2)

Publication Number Publication Date
WO2002046194A2 WO2002046194A2 (fr) 2002-06-13
WO2002046194A3 true WO2002046194A3 (fr) 2003-02-06

Family

ID=22963437

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/046915 WO2002046194A2 (fr) 2000-12-08 2001-12-06 Imidazopyridines substituees

Country Status (24)

Country Link
EP (1) EP1343783A2 (fr)
JP (1) JP2004525868A (fr)
KR (1) KR20030070048A (fr)
CN (1) CN1249062C (fr)
AR (1) AR035670A1 (fr)
AU (2) AU3954702A (fr)
BR (1) BR0116034A (fr)
CA (1) CA2431040A1 (fr)
CZ (1) CZ20031593A3 (fr)
EE (1) EE200300273A (fr)
HK (1) HK1063466A1 (fr)
HR (1) HRP20030465A2 (fr)
HU (1) HUP0600592A2 (fr)
IL (1) IL155885A0 (fr)
MX (1) MXPA03005013A (fr)
NO (1) NO20032453L (fr)
NZ (1) NZ526085A (fr)
PL (1) PL365739A1 (fr)
RU (1) RU2294934C2 (fr)
SK (1) SK7142003A3 (fr)
TW (1) TWI243819B (fr)
UA (1) UA74593C2 (fr)
WO (1) WO2002046194A2 (fr)
ZA (1) ZA200305238B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7030129B2 (en) 2002-02-22 2006-04-18 3M Innovative Properties Company Method of reducing and treating UVB-induced immunosuppression
US7612083B2 (en) 2000-12-08 2009-11-03 Coley Pharmaceutical Group, Inc. Urea substituted imidazoquinoline ethers
US8871782B2 (en) 2003-10-03 2014-10-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
US8961477B2 (en) 2003-08-25 2015-02-24 3M Innovative Properties Company Delivery of immune response modifier compounds

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5741908A (en) 1996-06-21 1998-04-21 Minnesota Mining And Manufacturing Company Process for reparing imidazoquinolinamines
UA67760C2 (uk) 1997-12-11 2004-07-15 Міннесота Майнінг Енд Мануфакчурінг Компані Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки
US6541485B1 (en) 1999-06-10 2003-04-01 3M Innovative Properties Company Urea substituted imidazoquinolines
US6756382B2 (en) 1999-06-10 2004-06-29 3M Innovative Properties Company Amide substituted imidazoquinolines
US6331539B1 (en) 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
US6667312B2 (en) 2000-12-08 2003-12-23 3M Innovative Properties Company Thioether substituted imidazoquinolines
US20020107262A1 (en) * 2000-12-08 2002-08-08 3M Innovative Properties Company Substituted imidazopyridines
US6660735B2 (en) 2000-12-08 2003-12-09 3M Innovative Properties Company Urea substituted imidazoquinoline ethers
US6545016B1 (en) 2000-12-08 2003-04-08 3M Innovative Properties Company Amide substituted imidazopyridines
US6677348B2 (en) 2000-12-08 2004-01-13 3M Innovative Properties Company Aryl ether substituted imidazoquinolines
US6545017B1 (en) 2000-12-08 2003-04-08 3M Innovative Properties Company Urea substituted imidazopyridines
US6664264B2 (en) 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
US6677347B2 (en) 2000-12-08 2004-01-13 3M Innovative Properties Company Sulfonamido ether substituted imidazoquinolines
US6664265B2 (en) 2000-12-08 2003-12-16 3M Innovative Properties Company Amido ether substituted imidazoquinolines
US6525064B1 (en) 2000-12-08 2003-02-25 3M Innovative Properties Company Sulfonamido substituted imidazopyridines
IL161786A0 (en) 2001-11-29 2005-11-20 3M Innovative Properties Co Pharmaceutical formulations comprising an immune
CA2365732A1 (fr) 2001-12-20 2003-06-20 Ibm Canada Limited-Ibm Canada Limitee Etalonnages
AU2003233519A1 (en) * 2002-05-29 2003-12-19 3M Innovative Properties Company Process for imidazo(4,5-c)pyridin-4-amines
CA2495570C (fr) 2002-08-15 2012-12-04 3M Innovative Properties Company Compositions immunostimulantes et procedes de stimulation d'une reponse immune
US6818650B2 (en) 2002-09-26 2004-11-16 3M Innovative Properties Company 1H-imidazo dimers
WO2004058759A1 (fr) 2002-12-20 2004-07-15 3M Innovative Properties Company Imidazoquinoleines a substitution aryle/heteroaryle
JP2006512391A (ja) 2002-12-30 2006-04-13 スリーエム イノベイティブ プロパティズ カンパニー 組み合わせ免疫賦活薬
WO2004071459A2 (fr) 2003-02-13 2004-08-26 3M Innovative Properties Company Procedes et compositions associes a des composes modificateurs de reponse immunitaire et recepteur 8 de type toll
US7485432B2 (en) 2003-02-27 2009-02-03 3M Innovative Properties Company Selective modulation of TLR-mediated biological activity
US8110582B2 (en) 2003-03-04 2012-02-07 3M Innovative Properties Company Prophylactic treatment of UV-induced epidermal neoplasia
CA2518282C (fr) 2003-03-13 2012-11-06 3M Innovative Properties Company Procedes pour ameliorer la qualite de la peau
EP1603476A4 (fr) 2003-03-13 2010-01-13 3M Innovative Properties Co Procede d'elimination d'un tatouage
EP1608282A4 (fr) * 2003-03-13 2010-12-08 3M Innovative Properties Co Methodes de diagnostic de lesions de la peau
US20040192585A1 (en) 2003-03-25 2004-09-30 3M Innovative Properties Company Treatment for basal cell carcinoma
CA2521682A1 (fr) 2003-04-10 2004-12-16 3M Innovative Properties Company Distribution de composes modifiant une reponse immunitaire au moyen de materiaux de support particulaires contenant du metal
US6943255B2 (en) 2003-06-06 2005-09-13 3M Innovative Properties Company Process for imidazo[4,5-c]pyridin-4-amines
US8673932B2 (en) 2003-08-12 2014-03-18 3M Innovative Properties Company Oxime substituted imidazo-containing compounds
AR045529A1 (es) 2003-08-27 2005-11-02 3M Innovative Properties Co Imidazoquinolinas sustituidas con grupos ariloxi o arilalquilenoxi
AU2004270201A1 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for CD5+ B cell lymphoma
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
EP1685129A4 (fr) 2003-11-14 2008-10-22 3M Innovative Properties Co Composes d'un anneau d'imidazo substitues par oxime
US8598192B2 (en) 2003-11-14 2013-12-03 3M Innovative Properties Company Hydroxylamine substituted imidazoquinolines
SG148201A1 (en) 2003-11-25 2008-12-31 3M Innovative Properties Co Substituted imidazo ring systems and methods
WO2005055932A2 (fr) 2003-12-02 2005-06-23 3M Innovative Properties Company Combinaisons therapeutiques et methodes faisant appel a des composes irm
JP2007517035A (ja) 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン
CN1922178A (zh) 2003-12-29 2007-02-28 3M创新有限公司 哌嗪、[1, 4 ]二氮杂环庚烷([1,4]diazepane ) 、[1, 4 ]二氮杂环辛烷([1, 4]diazocane)、和[1,5]二氮杂环辛烷([1,5] diazocane) 稠合的咪唑并环化合物
US8735421B2 (en) 2003-12-30 2014-05-27 3M Innovative Properties Company Imidazoquinolinyl sulfonamides
US8697873B2 (en) 2004-03-24 2014-04-15 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006065280A2 (fr) 2004-06-18 2006-06-22 3M Innovative Properties Company Composes a noyau imidazo a substitutif d'isoxazole, de dihydroisoxazole et d'oxadiazole
WO2006009826A1 (fr) 2004-06-18 2006-01-26 3M Innovative Properties Company Thiazoloquinolines et thiazolonaphtyridines substitues par aryloxy et arylalkyleneoxy
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
WO2006074003A2 (fr) 2004-12-30 2006-07-13 3M Innovative Properties Company Composes chiraux a cycle [1,2]imidazo[4,5] fusionne
WO2006083440A2 (fr) 2004-12-30 2006-08-10 3M Innovative Properties Company Composes chiraux [1,2]imidazo[4,5-c] substitues a noyau fusionne
CA2597092A1 (fr) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Formulations des gel aqueux contenant des modificateurs de reponse immunitaire
JP2008530113A (ja) 2005-02-11 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド オキシムおよびヒドロキシラミン置換イミダゾ［４，５−ｃ］環化合物および方法
US7943610B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company Pyrazolopyridine-1,4-diamines and analogs thereof
JP2008538550A (ja) 2005-04-01 2008-10-30 コーリー ファーマシューティカル グループ，インコーポレイテッド ウイルス感染および腫瘍性疾患を処置するためのサイトカイン生合成の調節因子としての１−置換ピラゾロ（３，４−ｃ）環状化合物
JP4551962B2 (ja) * 2005-09-23 2010-09-29 コーリー ファーマシューティカル グループ，インコーポレイテッド １Ｈ−イミダゾ［４，５−ｃ］ピリジンおよびその類似体のための方法
CN100344325C (zh) * 2005-10-17 2007-10-24 华南师范大学 一种治疗宫颈癌的药物及其制备方法与应用
WO2008008432A2 (fr) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Composés à cycle [1,2] imidazo [4,5-c] fusionné chiral substitué et procédés correspondants
WO2009034411A1 (fr) * 2007-09-12 2009-03-19 Centre National De La Recherche Scientifique Perharidines en tant qu'inhibiteurs de cdk
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WO2015086519A1 (fr) * 2013-12-09 2015-06-18 Ucb Biopharma Sprl Dérivés d'imidazopyridine comme modulateurs de l'activité du tnf
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Citations (10)

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US4689338A (en) * 1983-11-18 1987-08-25 Riker Laboratories, Inc. 1H-Imidazo[4,5-c]quinolin-4-amines and antiviral use
US4929624A (en) * 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
US5268376A (en) * 1991-09-04 1993-12-07 Minnesota Mining And Manufacturing Company 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5389640A (en) * 1991-03-01 1995-02-14 Minnesota Mining And Manufacturing Company 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5494916A (en) * 1993-07-15 1996-02-27 Minnesota Mining And Manufacturing Company Imidazo[4,5-C]pyridin-4-amines
EP0894797A1 (fr) * 1997-01-09 1999-02-03 Terumo Kabushiki Kaisha Nouveaux derives d'amide et intermediaires utilises pour leur synthese
WO1999029693A1 (fr) * 1997-12-11 1999-06-17 Minnesota Mining And Manufacturing Company Imidazonaphthyridines et leur utilisation dans l'activation de la biosynthese de cytokines
WO2000076505A1 (fr) * 1999-06-10 2000-12-21 3M Innovative Properties Company Imidazoquinolines substituees amides
WO2000076519A1 (fr) * 1999-06-10 2000-12-21 3M Innovative Properties Company Imidazoquinolines substituees sulfonamide et sulfamide
WO2000076518A1 (fr) * 1999-06-10 2000-12-21 3M Innovative Properties Company Imidazoquinolines substituees par uree

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US4988815A (en) * 1989-10-26 1991-01-29 Riker Laboratories, Inc. 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
UA32546C2 (uk) * 1991-03-01 2001-02-15 Міннесота Майнінг Енд Мен'Юфекчурінг Компані 1,2-заміщені 1н-імідазо[4,5-с]хінолін-4-аміни, проміжні сполуки для їх синтезу, антивірусна фармацевтична композиція, спосіб лікування інфікованих ссавців, спосіб індукування біосинтезу інтерферону у ссавців, спосіб уповільнення росту бластом

Patent Citations (10)

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Publication number Priority date Publication date Assignee Title
US4689338A (en) * 1983-11-18 1987-08-25 Riker Laboratories, Inc. 1H-Imidazo[4,5-c]quinolin-4-amines and antiviral use
US4929624A (en) * 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
US5389640A (en) * 1991-03-01 1995-02-14 Minnesota Mining And Manufacturing Company 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5268376A (en) * 1991-09-04 1993-12-07 Minnesota Mining And Manufacturing Company 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5494916A (en) * 1993-07-15 1996-02-27 Minnesota Mining And Manufacturing Company Imidazo[4,5-C]pyridin-4-amines
EP0894797A1 (fr) * 1997-01-09 1999-02-03 Terumo Kabushiki Kaisha Nouveaux derives d'amide et intermediaires utilises pour leur synthese
WO1999029693A1 (fr) * 1997-12-11 1999-06-17 Minnesota Mining And Manufacturing Company Imidazonaphthyridines et leur utilisation dans l'activation de la biosynthese de cytokines
WO2000076505A1 (fr) * 1999-06-10 2000-12-21 3M Innovative Properties Company Imidazoquinolines substituees amides
WO2000076519A1 (fr) * 1999-06-10 2000-12-21 3M Innovative Properties Company Imidazoquinolines substituees sulfonamide et sulfamide
WO2000076518A1 (fr) * 1999-06-10 2000-12-21 3M Innovative Properties Company Imidazoquinolines substituees par uree

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7612083B2 (en) 2000-12-08 2009-11-03 Coley Pharmaceutical Group, Inc. Urea substituted imidazoquinoline ethers
US7030129B2 (en) 2002-02-22 2006-04-18 3M Innovative Properties Company Method of reducing and treating UVB-induced immunosuppression
US8961477B2 (en) 2003-08-25 2015-02-24 3M Innovative Properties Company Delivery of immune response modifier compounds
US8871782B2 (en) 2003-10-03 2014-10-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines

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CN1478090A (zh) 2004-02-25
KR20030070048A (ko) 2003-08-27
UA74593C2 (en) 2006-01-16
AR035670A1 (es) 2004-06-23
JP2004525868A (ja) 2004-08-26
CA2431040A1 (fr) 2002-06-13
MXPA03005013A (es) 2003-09-05
SK7142003A3 (en) 2003-10-07
AU3954702A (en) 2002-06-18
WO2002046194A2 (fr) 2002-06-13
CN1249062C (zh) 2006-04-05
NZ526085A (en) 2004-12-24
HUP0600592A2 (en) 2006-11-28
RU2003116648A (ru) 2005-02-10
RU2294934C2 (ru) 2007-03-10
EP1343783A2 (fr) 2003-09-17
HRP20030465A2 (en) 2004-06-30
TWI243819B (en) 2005-11-21
AU2002239547B2 (en) 2006-11-30
HK1063466A1 (en) 2004-12-31
CZ20031593A3 (cs) 2004-01-14
IL155885A0 (en) 2003-12-23
NO20032453D0 (no) 2003-05-28
NO20032453L (no) 2003-07-16
EE200300273A (et) 2004-02-16
PL365739A1 (en) 2005-01-10
BR0116034A (pt) 2004-08-03
ZA200305238B (en) 2004-08-27

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