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WO2001036980A3 - Procede d'identification du site actif dans une cible biologique - Google Patents

Procede d'identification du site actif dans une cible biologique Download PDF

Info

Publication number
WO2001036980A3
WO2001036980A3 PCT/GB2000/004420 GB0004420W WO0136980A3 WO 2001036980 A3 WO2001036980 A3 WO 2001036980A3 GB 0004420 W GB0004420 W GB 0004420W WO 0136980 A3 WO0136980 A3 WO 0136980A3
Authority
WO
WIPO (PCT)
Prior art keywords
identifying
type
active site
biological target
interaction
Prior art date
Application number
PCT/GB2000/004420
Other languages
English (en)
Other versions
WO2001036980A2 (fr
Inventor
Torbjoern Lundstedt
Per Andersson
Jarl Wikberg
Ruta Muceniece
Peteris Prusis
Original Assignee
Melacure Therapeutics Ab
Pett Christopher Phineas
Torbjoern Lundstedt
Per Andersson
Jarl Wikberg
Ruta Muceniece
Peteris Prusis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melacure Therapeutics Ab, Pett Christopher Phineas, Torbjoern Lundstedt, Per Andersson, Jarl Wikberg, Ruta Muceniece, Peteris Prusis filed Critical Melacure Therapeutics Ab
Priority to NZ518980A priority Critical patent/NZ518980A/en
Priority to CA002392086A priority patent/CA2392086A1/fr
Priority to AU15305/01A priority patent/AU1530501A/en
Priority to EP00977666A priority patent/EP1232466A2/fr
Publication of WO2001036980A2 publication Critical patent/WO2001036980A2/fr
Publication of WO2001036980A3 publication Critical patent/WO2001036980A3/fr
Priority to HK03101309.1A priority patent/HK1049218A1/zh

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30—Drug targeting using structural data; Docking or binding prediction

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des procédés de caractérisation de sites d'interaction entre un ligand Y et une cible X. Ces procédés comprennent les étapes consistant à (1) entrer des informations sur les propriétés chimiques/physiques d'au moins deux cibles du type X; (2) entrer des informations sur les propriétés chimiques/physiques d'au moins deux ligands du type Y; (3) entrer des informations sur l'interaction entre au moins des cibles du type X avec au moins deux ligands du type Y; et mettre ensuite en corrélation les informations recueillies au cours des étapes 1, 2 et 3 au moyen d'une ou de plusieurs procédés multicritères de façon à créer un modèle d'interaction entre le ligand Y et la cible X, les sites d'interaction pouvant être identifiés et/ou caractérisés à partir de ce modèle.
PCT/GB2000/004420 1999-11-18 2000-11-20 Procede d'identification du site actif dans une cible biologique WO2001036980A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
NZ518980A NZ518980A (en) 1999-11-18 2000-11-20 A process for identifying the active site in a biological target by producing a model of the interaction between a ligand and a target
CA002392086A CA2392086A1 (fr) 1999-11-18 2000-11-20 Procede d'identification du site actif dans une cible biologique
AU15305/01A AU1530501A (en) 1999-11-18 2000-11-20 A process for identifying the active site in a biological target
EP00977666A EP1232466A2 (fr) 1999-11-18 2000-11-20 Procede d'identification du site actif dans une cible biologique
HK03101309.1A HK1049218A1 (zh) 1999-11-18 2003-02-20 在生物主體內區別活性部位的方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9927346.8 1999-11-18
GBGB9927346.8A GB9927346D0 (en) 1999-11-18 1999-11-18 Method for analysis and design of entities of a chemical or biochemical nature

Publications (2)

Publication Number Publication Date
WO2001036980A2 WO2001036980A2 (fr) 2001-05-25
WO2001036980A3 true WO2001036980A3 (fr) 2002-03-14

Family

ID=10864777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/004420 WO2001036980A2 (fr) 1999-11-18 2000-11-20 Procede d'identification du site actif dans une cible biologique

Country Status (8)

Country Link
EP (1) EP1232466A2 (fr)
AU (1) AU1530501A (fr)
CA (1) CA2392086A1 (fr)
GB (1) GB9927346D0 (fr)
HK (1) HK1049218A1 (fr)
NZ (1) NZ518980A (fr)
WO (1) WO2001036980A2 (fr)
ZA (1) ZA200203963B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL138214A0 (en) 1998-03-09 2001-10-31 Zealand Pharmaceuticals As Pharmacolgically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
SE9801571D0 (sv) 1998-05-05 1998-05-05 Wapharm Ab Melanokortin-1-receptorselektiva föreningar
AU2002231706A1 (en) * 2000-11-28 2002-06-11 Clairbio Capital Management Apparatus and method for determining affinity data between a target and a ligand
EP1209610A1 (fr) * 2000-11-28 2002-05-29 Valentin Capital Management Dispositif et procédé de détermination de données d'affinité entre une cible et un ligand
US20030158671A1 (en) * 2001-07-18 2003-08-21 Structural Genomix, Inc. Systems and methods for predicting active site residues in a protein
WO2003040994A2 (fr) * 2001-11-02 2003-05-15 Arqule, Inc. Modeles de liaison cyp2c9
DE10241793A1 (de) * 2002-09-06 2004-06-17 Roos, Gudrun, Dr. Vorrichtung zur Ermittlung der Wirksamkeit von Pflanzenextrakten
AU2005335905C1 (en) 2005-08-26 2011-12-22 Abbvie Inc. Therapeutically active alpha-MSH analogues
CA2868827C (fr) * 2012-04-24 2022-05-10 Laboratory Corporation Of America Holdings Procedes et systemes d'identification d'un site de liaison proteique

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587293A (en) * 1994-01-06 1996-12-24 Terrapin Technologies, Inc. Method to identify binding partners
WO1999006839A1 (fr) * 1997-08-01 1999-02-11 Novalon Pharmaceutical Corporation Procede d'identification et de developpement de chefs de file de medicaments
WO1999031267A1 (fr) * 1997-12-18 1999-06-24 Sepracor Inc. Techniques d'identification simultanee de nouvelles cibles biologiques et structures conductrices pour mise au point d'un medicament

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587293A (en) * 1994-01-06 1996-12-24 Terrapin Technologies, Inc. Method to identify binding partners
US5798275A (en) * 1994-01-06 1998-08-25 Terrapin Technologies, Inc. Profiling reference panel enriched by non-IG proteins
WO1999006839A1 (fr) * 1997-08-01 1999-02-11 Novalon Pharmaceutical Corporation Procede d'identification et de developpement de chefs de file de medicaments
WO1999031267A1 (fr) * 1997-12-18 1999-06-24 Sepracor Inc. Techniques d'identification simultanee de nouvelles cibles biologiques et structures conductrices pour mise au point d'un medicament

Also Published As

Publication number Publication date
GB9927346D0 (en) 2000-01-12
EP1232466A2 (fr) 2002-08-21
AU1530501A (en) 2001-05-30
WO2001036980A2 (fr) 2001-05-25
ZA200203963B (en) 2003-05-19
HK1049218A1 (zh) 2003-05-02
NZ518980A (en) 2005-05-27
CA2392086A1 (fr) 2001-05-25

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