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WO2001029032A8 - Nouveaux procedes - Google Patents

Nouveaux procedes

Info

Publication number
WO2001029032A8
WO2001029032A8 PCT/GB2000/004066 GB0004066W WO0129032A8 WO 2001029032 A8 WO2001029032 A8 WO 2001029032A8 GB 0004066 W GB0004066 W GB 0004066W WO 0129032 A8 WO0129032 A8 WO 0129032A8
Authority
WO
WIPO (PCT)
Prior art keywords
paroxetine
preparation
arecoline
starting
disclosed
Prior art date
Application number
PCT/GB2000/004066
Other languages
English (en)
Other versions
WO2001029032A1 (fr
Inventor
David Crowe
Neal Ward
Andrew Stephen Wells
Original Assignee
Smithkline Beecham Plc
David Crowe
Neal Ward
Andrew Stephen Wells
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc, David Crowe, Neal Ward, Andrew Stephen Wells filed Critical Smithkline Beecham Plc
Priority to AU10385/01A priority Critical patent/AU1038501A/en
Publication of WO2001029032A1 publication Critical patent/WO2001029032A1/fr
Publication of WO2001029032A8 publication Critical patent/WO2001029032A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne trois schémas (1, 2 and 3) de procédés destinés à la fabrication de paroxétine à partir d'arécoline.
PCT/GB2000/004066 1999-10-20 2000-10-20 Nouveaux procedes WO2001029032A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU10385/01A AU1038501A (en) 1999-10-20 2000-10-20 Novel processes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9924882.5A GB9924882D0 (en) 1999-10-20 1999-10-20 Novel process
GB9924882.5 1999-10-20

Publications (2)

Publication Number Publication Date
WO2001029032A1 WO2001029032A1 (fr) 2001-04-26
WO2001029032A8 true WO2001029032A8 (fr) 2001-05-25

Family

ID=10863097

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/004066 WO2001029032A1 (fr) 1999-10-20 2000-10-20 Nouveaux procedes

Country Status (3)

Country Link
AU (1) AU1038501A (fr)
GB (1) GB9924882D0 (fr)
WO (1) WO2001029032A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9930577D0 (en) * 1999-12-23 2000-02-16 Smithkline Beecham Plc Novel process
US7138523B2 (en) 2002-05-16 2006-11-21 Apotex Pharmachem Inc. Preparation of 4-(4-fluorophenyl)-N-alkylnipecotinate esters, 4-(4-fluorophenyl)-N-arylnipecotinate esters and 4-(4-fluorophenyl)-N-aralkylnipecotinate esters
WO2004043921A1 (fr) * 2002-11-11 2004-05-27 Natco Pharma Limited Nouveau procede de preparation de 4-aryl-3-hydroxymethyl-1-methylpiperidines
WO2005063707A1 (fr) * 2003-12-26 2005-07-14 Natco Pharma Limited Procede enantiospecifique permettant de preparer un intermediaire de paroxetine
WO2007015262A2 (fr) * 2005-04-25 2007-02-08 Sun Pharmaceutical Industries Limited Procede pour preparer de la (-)-trans-4-(4-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl]piperidine
CN101205211B (zh) * 2006-12-19 2011-12-14 北京德众万全药物技术开发有限公司 一种盐酸帕罗西汀重要中间体的制备方法
CN117964546B (zh) * 2024-03-28 2024-06-11 成都硕德药业有限公司 一种尼拉帕利中间体的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
EP0223334B1 (fr) * 1985-08-10 1991-07-10 Beecham Group Plc Procédé de préparation d'aryl-pipéridine-carbinols
GB8520154D0 (en) * 1985-08-10 1985-09-18 Beecham Group Plc Chemical process
FR2702220B1 (fr) * 1993-03-03 1995-05-12 Synthelabo Dédoublement enzymatique de dérivés de 4-alkyl-2-pipéridine-carboxylate et utilisation des composés obtenus, comme intermédiaires de synthèse.
EP0812827B1 (fr) * 1996-06-13 2009-09-02 Sumitomo Chemical Company, Limited Dérivés de pipéridine comme intermédiaire pour la production de paroxétine et procédé pour leur préparation
WO1998002556A2 (fr) * 1996-07-15 1998-01-22 Smithkline Beecham Plc Criblage et utilisation d'esterase pour dedoublement stereospecifique
CA2284732C (fr) * 1997-04-07 2008-06-17 Georgetown University Analogues de cocaine
CA2346537A1 (fr) * 1998-10-07 2000-04-13 Gian Luca Araldi Heterocycles monomeres et dimeres et leurs utilisations therapeutiques

Also Published As

Publication number Publication date
AU1038501A (en) 2001-04-30
WO2001029032A1 (fr) 2001-04-26
GB9924882D0 (en) 1999-12-22

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