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WO2001028493A3 - Inhibiteurs a petite molecule de la necrose - Google Patents

Inhibiteurs a petite molecule de la necrose Download PDF

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Publication number
WO2001028493A3
WO2001028493A3 PCT/US2000/028475 US0028475W WO0128493A3 WO 2001028493 A3 WO2001028493 A3 WO 2001028493A3 US 0028475 W US0028475 W US 0028475W WO 0128493 A3 WO0128493 A3 WO 0128493A3
Authority
WO
WIPO (PCT)
Prior art keywords
necrosis
small molecule
molecule inhibitors
features methods
features
Prior art date
Application number
PCT/US2000/028475
Other languages
English (en)
Other versions
WO2001028493A2 (fr
Inventor
Junying Yuan
Alexei Degterev
Timothy Mitchison
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of WO2001028493A2 publication Critical patent/WO2001028493A2/fr
Publication of WO2001028493A3 publication Critical patent/WO2001028493A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/205—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
    • C07C43/2055—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring containing more than one ether bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Cette invention concerne des méthodes permettant de réduire la nécrose ainsi que des méthodes de traitement pour un sujet atteint d'une pathologie entraînant une nécrose. L'invention porte également sur des composés chimiques utilisés pour réduire le phénomène de nécrose.
PCT/US2000/028475 1999-10-15 2000-10-13 Inhibiteurs a petite molecule de la necrose WO2001028493A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15966899P 1999-10-15 1999-10-15
US60/159,668 1999-10-15
US17474900P 2000-01-06 2000-01-06
US60/174,749 2000-01-06

Publications (2)

Publication Number Publication Date
WO2001028493A2 WO2001028493A2 (fr) 2001-04-26
WO2001028493A3 true WO2001028493A3 (fr) 2001-06-07

Family

ID=26856169

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/028475 WO2001028493A2 (fr) 1999-10-15 2000-10-13 Inhibiteurs a petite molecule de la necrose

Country Status (1)

Country Link
WO (1) WO2001028493A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006521377A (ja) * 2003-03-27 2006-09-21 ランケナー インスティテュート フォー メディカル リサーチ 新型ｉｄｏ阻害剤とその使用方法
PL2384753T3 (pl) * 2003-08-29 2016-09-30 Pochodne hydantoiny jako inhibitory martwicy komórkowej
JP4797351B2 (ja) * 2003-09-17 2011-10-19 住友化学株式会社 シンナモイル化合物及びその用途
US7691883B2 (en) * 2003-09-17 2010-04-06 Sumitomo Chemical Company, Limited Cinnamoyl compound and use of the same
CN101674826A (zh) * 2005-12-20 2010-03-17 哈佛大学校长及研究员协会 化合物、筛选和治疗方法
EP2381775A4 (fr) 2008-12-23 2012-08-15 Harvard College Inhibiteurs de la nécroptose de petite taille moléculaire
EP2560629B1 (fr) 2010-04-23 2020-06-03 Massachusetts Eye & Ear Infirmary Compositions et procédés de conservation de cellules de photorécepteurs et de cellules épithéliales de pigment rétinien
US20140024598A1 (en) 2010-11-01 2014-01-23 Demetrios Vavvas Methods and compositions for preserving retinal ganglion cells
EP2773341A2 (fr) 2011-10-21 2014-09-10 Massachusetts Eye & Ear Infirmary Compositions comprenant des inhibiteurs de la necrose, tels que des necrostatines, seuls ou en combinaison, pour la promotion de la régénération axonale et de la fonction nerveuse, ainsi pour traiter les maladies du snc
JP2016514693A (ja) 2013-03-15 2016-05-23 プレジデント アンド フェローズ オブ ハーバード カレッジ ハイブリッド型ネクロトーシス阻害剤
US9944628B2 (en) 2014-12-11 2018-04-17 President And Fellows Of Harvard College Inhibitors of cellular necrosis and related methods
KR102635317B1 (ko) * 2017-01-26 2024-02-08 중앙대학교 산학협력단 네크로스타틴-1을 포함하는 정원줄기세포의 동결보존용 조성물 및 이를 이용한 정원줄기세포의 동결보존 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693643A (en) * 1991-09-16 1997-12-02 Merck & Co., Inc. Hydantoin and succinimide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693643A (en) * 1991-09-16 1997-12-02 Merck & Co., Inc. Hydantoin and succinimide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists

Also Published As

Publication number Publication date
WO2001028493A2 (fr) 2001-04-26

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