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WO2001027269A3 - Vip54 protein and related materials - Google Patents

Vip54 protein and related materials Download PDF

Info

Publication number
WO2001027269A3
WO2001027269A3 PCT/IB2000/001578 IB0001578W WO0127269A3 WO 2001027269 A3 WO2001027269 A3 WO 2001027269A3 IB 0001578 W IB0001578 W IB 0001578W WO 0127269 A3 WO0127269 A3 WO 0127269A3
Authority
WO
WIPO (PCT)
Prior art keywords
vip54
protein
detected
related materials
vaca
Prior art date
Application number
PCT/IB2000/001578
Other languages
French (fr)
Other versions
WO2001027269A2 (en
Inventor
Bernard Marina De
Cesare Montecucco
Rino Rappuoli
Original Assignee
Chiron Spa
Bernard Marina De
Cesare Montecucco
Rino Rappuoli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Spa, Bernard Marina De, Cesare Montecucco, Rino Rappuoli filed Critical Chiron Spa
Priority to EP00969750A priority Critical patent/EP1222268A2/en
Priority to JP2001530473A priority patent/JP2003511072A/en
Priority to CA002387188A priority patent/CA2387188A1/en
Publication of WO2001027269A2 publication Critical patent/WO2001027269A2/en
Publication of WO2001027269A3 publication Critical patent/WO2001027269A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

'VIP54' protein was identified by yeast two-hybrid screening using H.pylori VacA as bait. VIP54 is not detected in neurons, but is detected in neuroblastoma cells removed from a tumour. Furthermore, VIP54 co-distributes with vimentin and decorates intermediate filaments with a dotted pattern. The invention provides proteins comprising the amino acid sequence of VIP54, as well as related peptides, nucleic acid and antibodies. These are useful as diagnostic reagents for neuroblastoma, as markers for intermediate filaments, and for the inhibition of the VIP54/VacA interaction.
PCT/IB2000/001578 1999-10-11 2000-10-11 Vip54 protein and related materials WO2001027269A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00969750A EP1222268A2 (en) 1999-10-11 2000-10-11 Vip54 protein and related materials
JP2001530473A JP2003511072A (en) 1999-10-11 2000-10-11 VIP54 protein and related materials
CA002387188A CA2387188A1 (en) 1999-10-11 2000-10-11 Vip54 protein and related materials

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9924060.8 1999-10-11
GBGB9924060.8A GB9924060D0 (en) 1999-10-11 1999-10-11 VIP54 protein

Publications (2)

Publication Number Publication Date
WO2001027269A2 WO2001027269A2 (en) 2001-04-19
WO2001027269A3 true WO2001027269A3 (en) 2001-11-22

Family

ID=10862545

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2000/001578 WO2001027269A2 (en) 1999-10-11 2000-10-11 Vip54 protein and related materials

Country Status (5)

Country Link
EP (1) EP1222268A2 (en)
JP (1) JP2003511072A (en)
CA (1) CA2387188A1 (en)
GB (1) GB9924060D0 (en)
WO (1) WO2001027269A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002097093A1 (en) 2001-05-30 2002-12-05 Chiba-Prefecture Nucleic acids isolated in neuroblastoma
GB201214007D0 (en) 2012-08-07 2012-09-19 Scancell Ltd Anti-tumour immune responses to modified self-epitopes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018150A1 (en) * 1992-03-02 1993-09-16 Biocine S.P.A. Helicobacter pylori proteins useful for vaccines and diagnostics
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'
WO2000060077A2 (en) * 1999-04-02 2000-10-12 Corixa Corporation Compounds for therapy and diagnosis of lung cancer and methods for their use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018150A1 (en) * 1992-03-02 1993-09-16 Biocine S.P.A. Helicobacter pylori proteins useful for vaccines and diagnostics
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'
WO2000060077A2 (en) * 1999-04-02 2000-10-12 Corixa Corporation Compounds for therapy and diagnosis of lung cancer and methods for their use

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 18 April 1997 (1997-04-18), XP002172521 *
DATABASE EMBL 26 April 1999 (1999-04-26), XP002172520 *
DATABASE EMBL 9 July 1997 (1997-07-09), XP002172519 *
DE BERNARD M. ET AL.: "The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein", THE EMBO JOURNAL, vol. 19, no. 1, 4 January 2000 (2000-01-04), pages 48 - 56, XP002172517 *
SANO K. ET AL.: "Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with (3;11)(p21;q23)", BLOOD, vol. 95, no. 3, 1 February 2000 (2000-02-01), pages 1066 - 1068, XP002172518 *

Also Published As

Publication number Publication date
WO2001027269A2 (en) 2001-04-19
JP2003511072A (en) 2003-03-25
GB9924060D0 (en) 1999-12-15
CA2387188A1 (en) 2001-04-19
EP1222268A2 (en) 2002-07-17

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