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WO2001021769A3 - STRUCTURE TRIDIMENSIONNELLE ET CRISTAL D'UNE α1,2-MANNOSIDASE DE CLASSE I, ET PROCEDES D'UTILISATION DE CES SUBSTANCES - Google Patents

STRUCTURE TRIDIMENSIONNELLE ET CRISTAL D'UNE α1,2-MANNOSIDASE DE CLASSE I, ET PROCEDES D'UTILISATION DE CES SUBSTANCES Download PDF

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Publication number
WO2001021769A3
WO2001021769A3 PCT/CA2000/001093 CA0001093W WO0121769A3 WO 2001021769 A3 WO2001021769 A3 WO 2001021769A3 CA 0001093 W CA0001093 W CA 0001093W WO 0121769 A3 WO0121769 A3 WO 0121769A3
Authority
WO
WIPO (PCT)
Prior art keywords
crystal
dimensional structure
mannosidase
class
methods
Prior art date
Application number
PCT/CA2000/001093
Other languages
English (en)
Other versions
WO2001021769A2 (fr
Inventor
Annette Herscovics
Francesco Lipari
Barry Sleno
Lynne P Howell
Francois Vallee
Pedro A Romero
Original Assignee
Univ Mcgill
Hospital For Sick Children
Annette Herscovics
Francesco Lipari
Barry Sleno
Lynne P Howell
Francois Vallee
Pedro A Romero
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Mcgill, Hospital For Sick Children, Annette Herscovics, Francesco Lipari, Barry Sleno, Lynne P Howell, Francois Vallee, Pedro A Romero filed Critical Univ Mcgill
Priority to AU73989/00A priority Critical patent/AU7398900A/en
Publication of WO2001021769A2 publication Critical patent/WO2001021769A2/fr
Publication of WO2001021769A3 publication Critical patent/WO2001021769A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01113—Mannosyl-oligosaccharide 1,2-alpha-mannosidase (3.2.1.113), i.e. alpha-1,2-mannosidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2477—Hemicellulases not provided in a preceding group
    • C12N9/2488—Mannanases

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cristal et structure tridimensionnelle pour la famille enzymatique α1,2-mannosidase du réticulum endoplasmique, utiles pour l'identification de déterminants structuraux responsables de la spécificité des différentes enzymes de ladite famille et du développement d'inhibiteurs destinés à stabiliser les glycoprotéines anormales dans des maladies génétiques telles que la mucoviscidose et l'emphysème pulmonaire.
PCT/CA2000/001093 1999-09-23 2000-09-22 STRUCTURE TRIDIMENSIONNELLE ET CRISTAL D'UNE α1,2-MANNOSIDASE DE CLASSE I, ET PROCEDES D'UTILISATION DE CES SUBSTANCES WO2001021769A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU73989/00A AU7398900A (en) 1999-09-23 2000-09-22 Three-dimensional structure and crystal of a class i alpha1,2-mannosidase, and methods of use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15546999P 1999-09-23 1999-09-23
US60/155,469 1999-09-23

Publications (2)

Publication Number Publication Date
WO2001021769A2 WO2001021769A2 (fr) 2001-03-29
WO2001021769A3 true WO2001021769A3 (fr) 2001-11-29

Family

ID=22555564

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/001093 WO2001021769A2 (fr) 1999-09-23 2000-09-22 STRUCTURE TRIDIMENSIONNELLE ET CRISTAL D'UNE α1,2-MANNOSIDASE DE CLASSE I, ET PROCEDES D'UTILISATION DE CES SUBSTANCES

Country Status (2)

Country Link
AU (1) AU7398900A (fr)
WO (1) WO2001021769A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002364783A1 (en) * 2001-11-21 2003-06-10 Affinium Pharmaceuticals, Inc. Purified polypeptides involved in general metabolism
FR2861991B1 (fr) 2003-11-07 2008-01-18 Centre Nat Rech Scient Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose
ES2434494T3 (es) * 2005-12-08 2013-12-16 Amgen, Inc. Células huésped mejoradas y métodos de cultivo

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CAMIRAND ET AL.: "Glycoprotein biosynthesis in Saccharomyces cerevisiae", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 23, 15 August 1991 (1991-08-15), pages 15120 - 15127, XP000993101 *
DOLE ET AL.: "Crystallization and preliminary X-ray analysis of the class 1 aplha 1,2-mannosidase from Saccharomyces cerevisiae", JOURNAL OF STRUCTURAL BIOLOGY, vol. 120, no. 1, October 1997 (1997-10-01), pages 69 - 72, XP002166201 *
VALLÉE ET AL.: "Crystal structureof a class I alpha 1.2-mannosidase involved in N-glycan processing and endoplasmatic reticulum quality control", EMBO JOURNAL, vol. 19, no. 4, February 2000 (2000-02-01), pages 581 - 588, XP002166202 *
VALLÉE ET AL.: "Purification, crystallization and preliminary X-ray crystallographic analysis of recombinant murine Golgi mannosidase IA, a class I alpha-mannosidase involved in Asn-linked oligosaccharide maturation", ACTA CRYSTALLOGRAPHICA SECTION D BIOLOGICAL CRYSTALLOGRAPHY, vol. 55, no. 2, February 1999 (1999-02-01), pages 571 - 573, XP001001118 *

Also Published As

Publication number Publication date
WO2001021769A2 (fr) 2001-03-29
AU7398900A (en) 2001-04-24

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