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WO2001012819A3 - Protein phosphatases and diagnosis and treatment of phosphatase-related disorders - Google Patents

Protein phosphatases and diagnosis and treatment of phosphatase-related disorders Download PDF

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Publication number
WO2001012819A3
WO2001012819A3 PCT/US2000/022158 US0022158W WO0112819A3 WO 2001012819 A3 WO2001012819 A3 WO 2001012819A3 US 0022158 W US0022158 W US 0022158W WO 0112819 A3 WO0112819 A3 WO 0112819A3
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Prior art keywords
polypeptides
protein
proteins
present
phosphatase
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PCT/US2000/022158
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French (fr)
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WO2001012819A2 (en
Inventor
Gregory D Plowman
Ricardo Martinez
David Whyte
Ron Hill
Peter Flanagan
Mario Lioubin
Original Assignee
Sugen Inc
Gregory D Plowman
Ricardo Martinez
David Whyte
Ron Hill
Peter Flanagan
Mario Lioubin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc, Gregory D Plowman, Ricardo Martinez, David Whyte, Ron Hill, Peter Flanagan, Mario Lioubin filed Critical Sugen Inc
Priority to AU69038/00A priority Critical patent/AU6903800A/en
Priority to CA002377662A priority patent/CA2377662A1/en
Priority to EP00957413A priority patent/EP1212433A2/en
Priority to JP2001516906A priority patent/JP2003507016A/en
Publication of WO2001012819A2 publication Critical patent/WO2001012819A2/en
Publication of WO2001012819A3 publication Critical patent/WO2001012819A3/en

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    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
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    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03016—Phosphoprotein phosphatase (3.1.3.16), i.e. calcineurin
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    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03048—Protein-tyrosine-phosphatase (3.1.3.48)
    • G—PHYSICS
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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Abstract

The present invention concerns polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to the polypeptides, assays utilizing the polypeptides, and methods relating to all of the foregoing. Preferably, the polypeptides of the present invention are phosphatases. Through the use of a 'motif extraction' bioinformatics script, additional mammalian members of the phosphatase family are herein presented. These phosphatases include MKP-like proteins, a CDC14-like protein, a PTEN-like protein, and myotubularin (MTM)-like proteins. Classification of proteins as new members of established families has proven highly accurate not only in predicting motifs present in the remaining non-catalytic portion of each protein, but also in their regulation, substrates, and signaling pathways.
PCT/US2000/022158 1999-08-13 2000-08-11 Protein phosphatases and diagnosis and treatment of phosphatase-related disorders WO2001012819A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU69038/00A AU6903800A (en) 1999-08-13 2000-08-11 Novel protein phosphatases and diagnosis and treatment of phosphatase-related disorders
CA002377662A CA2377662A1 (en) 1999-08-13 2000-08-11 Novel protein phosphatases and diagnosis and treatment of phosphatase-related disorders
EP00957413A EP1212433A2 (en) 1999-08-13 2000-08-11 Protein phosphatases and diagnosis and treatment of phosphatase-related disorders
JP2001516906A JP2003507016A (en) 1999-08-13 2000-08-11 Diagnosis and treatment of novel protein phosphatases and phosphatase-related diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14900599P 1999-08-13 1999-08-13
US60/149,005 1999-08-13

Publications (2)

Publication Number Publication Date
WO2001012819A2 WO2001012819A2 (en) 2001-02-22
WO2001012819A3 true WO2001012819A3 (en) 2002-01-24

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PCT/US2000/022158 WO2001012819A2 (en) 1999-08-13 2000-08-11 Protein phosphatases and diagnosis and treatment of phosphatase-related disorders

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EP (1) EP1212433A2 (en)
JP (1) JP2003507016A (en)
AU (1) AU6903800A (en)
CA (1) CA2377662A1 (en)
WO (1) WO2001012819A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001002581A1 (en) * 1999-07-02 2001-01-11 Ceptyr, Inc. Dsp-3 dual-specificity phosphatase
US7504223B2 (en) * 1999-08-05 2009-03-17 Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Knockout mouse for the tumor suppressor gene ANX7
US6420153B1 (en) 2000-02-29 2002-07-16 Millennium Pharmaceuticals, Inc. 18232, a novel dual specificity phosphatase and uses therefor
EP1268818A2 (en) * 2000-03-24 2003-01-02 Millennium Pharmaceuticals, Inc. 18221, dual specificity phosphatase and uses thereof
WO2002010363A2 (en) * 2000-07-28 2002-02-07 Incyte Genomics, Inc. Protein phosphatases
AU2002212164A1 (en) * 2000-09-07 2002-03-22 Bayer Aktiengesellschaft Regulation of human map kinase phosphatase-like enzyme
WO2002020747A2 (en) * 2000-09-11 2002-03-14 Bayer Aktiengesellschaft Regulation of human tyrosine phosphatase-like enzyme
US6825021B2 (en) * 2000-09-19 2004-11-30 Ceptyr, Inc. DSP-15 dual-specificity phosphatase
AU2002228599A1 (en) * 2000-11-20 2002-06-03 Pe Corporation (Ny) Isolated human phosphatase proteins, nucleic acid molecules encoding them, and uses thereof
JP2005506040A (en) 2000-12-20 2005-03-03 ブリストル−マイヤーズ　スクイブ　カンパニー Polynucleotide encoding a novel human phosphatase
WO2002090530A2 (en) * 2001-01-18 2002-11-14 Incyte Genomics, Inc. Kinases and phosphatases
JPWO2003038118A1 (en) * 2001-10-31 2005-02-24 藤沢薬品工業株式会社 Method for evaluating phosphatase inhibitor
US20030148341A1 (en) * 2001-11-15 2003-08-07 Sin Wun Chey Gene amplification and overexpression in cancer
US20050281743A1 (en) * 2002-03-28 2005-12-22 Delaney Allen D Cancer associated protein phosphatases and their uses
JP2006500413A (en) * 2002-09-27 2006-01-05 デヴェロゲン アクチエンゲゼルシャフト フュア エントヴィックルングスビオローギッシェ フォルシュング SKRP, astry, string, VACM related to metabolic control
JP2010535503A (en) 2007-08-10 2010-11-25 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ（エー＊エスティーエーアール） VHZ for cancer diagnosis and treatment
CN102176914B (en) 2008-08-08 2014-12-17 新加坡科技研究局 VHZ for diagnosis and treatment of cancers

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002704A2 (en) * 1997-07-08 1999-01-21 Cold Spring Harbor Laboratory Dual specifically phosphatase and methods of use
WO2000006728A2 (en) * 1998-07-28 2000-02-10 Incyte Pharmaceuticals, Inc. Phosphorylation effectors
WO2000018890A2 (en) * 1998-09-30 2000-04-06 Millennium Pharmaceuticals, Inc. Protein phosphatase molecules and uses therefor
WO2000055332A2 (en) * 1999-03-18 2000-09-21 Incyte Pharmaceuticals, Inc. Human regulators of intracellular phosphorylation
WO2000056899A1 (en) * 1999-03-24 2000-09-28 Ceptyr, Inc. Dsp-2 dual-specificity map kinase phosphatase
WO2000060099A1 (en) * 1999-04-07 2000-10-12 Ceptyr, Inc. Dsp-4 dual-specificity map kinase phosphatase
WO2000060098A1 (en) * 1999-04-07 2000-10-12 Ceptyr, Inc. Dsp-7 dual-specificity map kinase phosphatase
WO2000063393A1 (en) * 1999-04-20 2000-10-26 Ceptyr, Inc. Dsp-8 dual-specificity map kinase phosphatase
WO2000065068A1 (en) * 1999-04-23 2000-11-02 Ceptyr, Inc. Dsp-10 dual-specificity map kinsase phosphatase
WO2000065069A1 (en) * 1999-04-27 2000-11-02 Ceptyr, Inc. Dsp-5 dual-specificity map kinase phosphatase
WO2001002582A1 (en) * 1999-07-02 2001-01-11 Ceptyr, Inc. Dsp-3 dual-specificity phosphatase
WO2001005983A1 (en) * 1999-07-20 2001-01-25 Ceptyr, Inc. Dsp-11 dual-specificity map kinase phosphatase
WO2001020004A2 (en) * 1999-09-15 2001-03-22 Incyte Genomics, Inc. Protein phosphatase and kinase proteins

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002704A2 (en) * 1997-07-08 1999-01-21 Cold Spring Harbor Laboratory Dual specifically phosphatase and methods of use
WO2000006728A2 (en) * 1998-07-28 2000-02-10 Incyte Pharmaceuticals, Inc. Phosphorylation effectors
WO2000018890A2 (en) * 1998-09-30 2000-04-06 Millennium Pharmaceuticals, Inc. Protein phosphatase molecules and uses therefor
WO2000055332A2 (en) * 1999-03-18 2000-09-21 Incyte Pharmaceuticals, Inc. Human regulators of intracellular phosphorylation
WO2000056899A1 (en) * 1999-03-24 2000-09-28 Ceptyr, Inc. Dsp-2 dual-specificity map kinase phosphatase
WO2000060099A1 (en) * 1999-04-07 2000-10-12 Ceptyr, Inc. Dsp-4 dual-specificity map kinase phosphatase
WO2000060098A1 (en) * 1999-04-07 2000-10-12 Ceptyr, Inc. Dsp-7 dual-specificity map kinase phosphatase
WO2000063393A1 (en) * 1999-04-20 2000-10-26 Ceptyr, Inc. Dsp-8 dual-specificity map kinase phosphatase
WO2000065068A1 (en) * 1999-04-23 2000-11-02 Ceptyr, Inc. Dsp-10 dual-specificity map kinsase phosphatase
WO2000065069A1 (en) * 1999-04-27 2000-11-02 Ceptyr, Inc. Dsp-5 dual-specificity map kinase phosphatase
WO2001002582A1 (en) * 1999-07-02 2001-01-11 Ceptyr, Inc. Dsp-3 dual-specificity phosphatase
WO2001002581A1 (en) * 1999-07-02 2001-01-11 Ceptyr, Inc. Dsp-3 dual-specificity phosphatase
WO2001005983A1 (en) * 1999-07-20 2001-01-25 Ceptyr, Inc. Dsp-11 dual-specificity map kinase phosphatase
WO2001020004A2 (en) * 1999-09-15 2001-03-22 Incyte Genomics, Inc. Protein phosphatase and kinase proteins

Non-Patent Citations (68)

* Cited by examiner, † Cited by third party
Title
ADAMS, M.D. ET AL.: "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence", NATURE, vol. 377, 28 September 1995 (1995-09-28), pages 3 - 174, XP002920293 *
CAMPS MONTSERRAT ET AL: "Dual specificity phosphatases: A gene family for control of MAP kinase function", FASEB JOURNAL,FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD,US, vol. 14, no. 1, January 2000 (2000-01-01), pages 6 - 16, XP002160024, ISSN: 0892-6638 *
CHEN HAIMING ET AL: "A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y.", HUMAN GENETICS, vol. 105, no. 5, November 1999 (1999-11-01), pages 399 - 409, XP001000438, ISSN: 0340-6717 *
CHEN HAIMING ET AL: "Chromosome 21cen contains a testis-expressed gene encoding a protein with transmembrane, tyrosine phosphatase, and tensin domains and has homologous copies on chromosomes 13, 15, 22 and Y.", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 61, no. 4 SUPPL., October 1997 (1997-10-01), 47th Annual Meeting of the American Society of Human Genetics;Baltimore, Maryland, USA; October 28-November 1, 1997, pages A168, XP001000400, ISSN: 0002-9297 *
DATABASE EMBL 1 September 1999 (1999-09-01), THEODOSIOU, A. ET AL.: "Homo sapiens dual specificity phosphatase MKP5 (MKP5) mRNA, complete cds.", XP002167812 *
DATABASE EMBL 10 August 1996 (1996-08-10), MARRA, M. ET AL.: "mh66e03.r1 Soares mouse placenta 4NbMP13.5 14.5 Mus musculus cDNA clone", XP002159242 *
DATABASE EMBL 12 July 1999 (1999-07-12), HILLIER, L. ET AL.: "au45g10.y1 Schneider fetal brain 00004 Homo sapiens cDNA clone; IMAGE:2517762 5' similar to TR:P91585 P91585 COS41.7. mRNA sequence.", XP002167459 *
DATABASE EMBL 13 June 1997 (1997-06-13), HILLIER, L. ET AL.: "zx70e02.s1 Soares_total_fetus_Nb2HF8_9w Homo sapiens cDNA clone IMAGE:796826 3' similar to WP:ZK757.2 CE00468 PROTEIN-TYROSINE PHOSPHATASE ; mRNA sequence.", XP002167685 *
DATABASE EMBL 14 December 1996 (1996-12-14), HILLIER, L. ET AL.: "zl51g08.r1 Soares_pregnant_uterus_NbHPU Homo sapiens cDNA clone IMAGE:505502 5' similar to SW:PVH1_YEAST Q02256 PROTEIN-TYROSINE PHOSPHATASE YVH1 ; mRNA sequence.", XP002167453 *
DATABASE EMBL 14 January 2000 (2000-01-14), NAKAMURA, K. ET AL.: "Homo sapiens mRNA for protein phosphatase, complete cds.", XP002167688 *
DATABASE EMBL 14 November 1997 (1997-11-14), HILLIER, L. ET AL.: "ae74a06.s1 Stratagene schizo brain S11 Homo sapiens cDNA clone IMAGE:969874 3', mRNA sequence.", XP002167554 *
DATABASE EMBL 16 April 1998 (1998-04-16), STRAUSBERG, R.: "on18c06.s1 NCI_CGAP_Lu5 Homo sapiens cDNA clone IMAGE:1557034 3' similar to TR:Q91790 Q91790 MAP KINASE PHOSPHATASE ; mRNA sequence.", XP002167451 *
DATABASE EMBL 16 December 1999 (1999-12-16), HOWDEN P.: "Human DNA sequence from clone RP11-386N14 on chromosome Xp11.23-11.4. Contains ESTs, STSs, GSSs and CpG islands. Contains a gene for a novel protein similat to a dual specifity phosphatase...", XP002167620 *
DATABASE EMBL 16 February 1998 (1998-02-16), STRAUSBERG, R:: "aj33b01.s1 Soares_testis_NHT Homo sapiens cDNA clone 1392073 3' similar to TR:Q93592 Q93592 F26A3.4. ; mRNA sequence.", XP002167608 *
DATABASE EMBL 16 November 1998 (1998-11-16), STRAUSBERG, R.: "qx66f03.x1 NCI_CGAP_Ov36 Homo sapiens cDNA clone IMAGE:2006333 3' similar to TR:Q91790 Q91790 MAP KINASE PHOSPHATASE ; mRNA sequence.", XP002167456 *
DATABASE EMBL 17 August 1996 (1996-08-17), MARRA, M. ET AL.: "mh87f02.r1 Soares mouse placenta 4NbMP13.5 14.5 Mus musculus cDNA clone IMAGE:457947 5', mRNA sequence.", XP002159243 *
DATABASE EMBL 17 November 1998 (1998-11-17), LAPORTE, J. ET AL.: "Homo sapiens myotubularin related protein 7 mRNA, partial cds.", XP002167553 *
DATABASE EMBL 18 April 1997 (1997-04-18), ADAMS, M.D. ET AL.: "EST186775 HCC cell line (matastasis to liver in mouse) II Homo sapiens cDNA 5' end similar to similar to tyrosine phosphatase CL100.", XP002167455 *
DATABASE EMBL 18 April 1997 (1997-04-18), ADAMS, M.D. ET AL.: "EST25309 Cerebellum II Homo sapiens cDNA 5' end.", XP002167747 *
DATABASE EMBL 18 April 1997 (1997-04-18), ADAMS, M.D. ET AL.: "EST86937 HSC172 cells I Homo sapiens cDNA 5' end similar to similar to tyrosine phosphatase CL100.", XP002167448 *
DATABASE EMBL 18 June 1998 (1998-06-18), MARRA, M. ET AL.: "ub03e08.r1 Soares mouse mammary gland NbMMG Mus musculus cDNA clone IMAGE:1365926 5' similar to TR:P91585 P91585 COS41.7. ; mRNA sequence.", XP002159207 *
DATABASE EMBL 18 June 1998 (1998-06-18), STRAUSBERG, R.: "ou47g09.x1 NCI_CGAP_Br2 Homo sapiens cDNA clone IMAGE:1631008 3' similar to TR:Q29449 Q29449 CHROMAFFIN GRANULE ATPASE II. ; mRNA sequence.", XP002167458 *
DATABASE EMBL 18 June 1999 (1999-06-18), MAHAIRAS, G.G. ET AL.: "HS_2119_B1_F10_MR CIT Approved Human Genomic Sperm Library D Homo sapiens genomic clone Plate=2119 Col=19 Row=L, genomic survey sequence.", XP002167746 *
DATABASE EMBL 18 November 1997 (1997-11-18), MURRAY, J. ET AL.: "Human BAC clone CTA-963H5 from 22q12.1-qter, complete sequence.", XP002167452 *
DATABASE EMBL 19 June 1998 (1998-06-19), STRAUSBERG, R.: "ov67c10.x1 Soares_testis_NHT Homo sapiens cDNA clone IMAGE:1642386 3' similar to WP:F26A3.4 CE09669 PROTEIN-TYROSINE PHOSPHATASE ; mRNA seqeunce.", XP002167609 *
DATABASE EMBL 19 June 1998 (1998-06-19), STRAUSBERG, R.: "ow27b10.s1 Soares_parathyroid_tumor_NbHPA Homo sapiens cDNA clone IMAGE:1648027 3' similar to SW:DUS5_HUMAN Q16690 DUAL SPECIFICITY PROTEIN PHOSPHATASE 5 ; mRNA sequence.", XP002167610 *
DATABASE EMBL 19 May 1999 (1999-05-19), STRAUSBERG, R.: "wa03b04.x1 NCI_CGAP_Kid11 Homo sapiens cDNA clone IMAGE:2296975 3' similar to TR:Q29449 Q29449 CHROMAFFIN GRANULE ATPASE II. ; mRNA sequence.", XP002167457 *
DATABASE EMBL 2 July 1997 (1997-07-02), HILLIER, L. ET AL.: "ab40g09.r1 Stratagene HeLa cell s3 937216 Homo sapiens cDNA clone IMAGE:843328 5' similar to SW:PVH1_YEAST Q02256 PROTEIN-TYROSINE PHOSPHATASE YVH1 ; mRNA sequence.", XP002167454 *
DATABASE EMBL 22 August 1997 (1997-08-22), LLOYD, D.: "Human DNA sequence from clone RP3-449O17 on chromosome 22q13.1-13.2 Contains the 3' part of the gene for a novel protein similar to TPTE (transmembrane phosphatase with tensin homology), ESTs and GSSs.", XP002167614 *
DATABASE EMBL 22 February 2000 (2000-02-22), ISOGAI, T. ET AL.: "Homo sapiens cDNA FLJ10928 fis, clone OVARC1000473, weakly similar to DUAL SPECIFICITY PROTEIN PHOSPHATASE 3 (EC 3.1.3.48) (EC 3.1.3.16).", XP002167749 *
DATABASE EMBL 22 February 2000 (2000-02-22), SUGANO, S. ET AL.: "Homo sapiens cDNA FLJ20442 fis, clone KAT04828", XP002167463 *
DATABASE EMBL 24 June 1998 (1998-06-24), "ow48e06.x1 Soares_parathyroid_tumor_NbHPA Homo sapiens cDNA clone IMAGE:1650082 3' similar to SW:PTP3_CHLEU Q39491 PUTATIVE PROTEIN TYROSINE PHOSPHATASE ; mRNA sequence.", XP002167612 *
DATABASE EMBL 24 November 1998 (1998-11-24), STRAUSBERG, R.: "qk50g08.x1 NCI_CGAP_Co8 Homo sapiens cDNA clone IMAGE:1872446 3' similar to WP:F26A3.4 CE09669 PROTEIN-TYROSINE PHOSPHATASE ; mRNA sequence.", XP002167450 *
DATABASE EMBL 25 August 1999 (1999-08-25), MUDA, M. ET AL.: "Homo sapiens dual-specificity tyrosine phosphatase YVH1 mRNA, complete cds.", XP002167462 *
DATABASE EMBL 26 April 2000 (2000-04-26), STRAUSBERG, R.: "bb09h04.y1 NIH_MGC_14 Homo sapiens cDNA clone IMAGE:2958967 5' similar to TR:Q9ZR37 Q9ZR37 DSPTP1 PROTEIN. ;contains Alu repetitive element;, mRNA sequence.", XP002167748 *
DATABASE EMBL 26 December 1999 (1999-12-26), MARRA, M. ET AL.: "um74f03.y1 Sugano mouse kidney mkia Mus musculus cDNA clone IMAGE:2300957 5' similar to TR:P91585 COS41.7; mRNA sequence", XP002159210 *
DATABASE EMBL 28 June 1999 (1999-06-28), TANOUE, T. ET AL.: "Homo sapiens mRNA for dual specificity phosphatase MKP-5, complete cds.", XP002167549 *
DATABASE EMBL 28 October 1998 (1998-10-28), STRAUSBERG, R.: "qg72h10.x1 Soares_NFL_T_GBC_S1 Homo sapiens cDNA clone IMAGE:1840771 3', mRNA sequence.", XP002167551 *
DATABASE EMBL 31 December 1998 (1998-12-31), STRAUSBERG, R.: "qt44f08.x1 Soares_fetal_lung_NbHL19W Homo sapiens cDNA clone IMAGE:1950855 3', mRNA sequence.", XP002167552 *
DATABASE EMBL 4 May 1997 (1997-05-04), HILLIER, L. ET AL.: "zv10h07.r1 Soares_NhHMPu_S1 Homo sapiens cDNA clone IMAGE:753277 5' similar to TR:E218398 E218398 DUAL SPECIFICITY PHOSPHATASE, mRNA sequence.", XP002167449 *
DATABASE EMBL 5 February 1999 (1999-02-05), STRAUSBERG, R.: "tg11g09.x1 NCI_CGAP_CLL1 Homo sapiens cDNA clone IMAGE:2108512 3' similar to SW:DUS5_HUMAN Q16690 DUAL SPECIFICITY PROTEIN PHOSPHATASE 5 ; mRNA sequence.", XP002167611 *
DATABASE EMBL 5 March 1997 (1997-03-05), HILLIER, L. ET AL.: "zr27d12.r1 Stratagene NT2 neuronal precursor 937230 Homo sapiens cDNA clone IMAGE:664631 5' similar to SW:YJ80_YEAST P47147 HYPOTHETICAL 80.2 KD PROTEIN IN CPA2-ATP2 INTERGENIC REGION. ; mRNA sequence.", XP002167550 *
DATABASE EMBL 5 May 2000 (2000-05-05), STRAUSBERG, R.: "hn68c07.x1 NCI_CGAP_Kid11 Homo sapiens cDNA clone IMAGE:3033036 3' similar to TR:O95147 O95147 MKP-1 LIKE PROTEIN TYROSINE PHOSPHATASE ; mRNA sequence.", XP002167461 *
DATABASE EMBL 6 February 1998 (1998-02-06), STRAUSBERG, R.: "ai27e05.s1 Soares_testis_NHT Homo sapiens cDNA clone 1344032 3' similar to SW:DUS3_HUMAN P51452 DUAL SPECIFICITY PROTEIN PHOSPHATASE 3 ; mRNA sequence.", XP002168516 *
DATABASE EMBL 6 January 1999 (1999-01-06), YUAN Y. ET AL.: "Homo sapiens MKP-1 like protein tyrosine phosphatase mRNA, complete cds.", XP002167460 *
DATABASE EMBL 8 January 1998 (1998-01-08), HILLIER, L. ET AL.: "zg88b02.s1 Soares_fetal_heart_NbHH19W Homo sapiens cDNA clone IMAGE:409611 3' similar to SW:DUS3_HUMAN P51452 DUAL SPECIFICITY PROTEIN PHOSPHATASE 3 ; mRNA sequence.", XP002167684 *
DATABASE EMBL 9 September 1998 (1998-09-09), CHEN, H. ET AL.: "Homo sapiens putative tyrosine phosphatase mRNA, complete cds.", XP002167616 *
DATABASE SWALL 1 February 1997 (1997-02-01), WILSON, R. ET AL.: "F26A3.4 Protein (EC 3.1.3.48)", XP002167618 *
DATABASE SWALL 1 June 1998 (1998-06-01), LI, L. ET AL.: "Tyrosine phosphatase CDC14B", XP002159208 *
DATABASE SWALL 1 May 1997 (1997-05-01), BIRD, A.P. ET AL.: "COS41.7 from Ciona intestinalis; Tyr phosphatase", XP002159209 *
DATABASE SWALL 1 May 1999 (1999-05-01), GUPTA, R. ET AL.: "DSPTP1 PROTEIN", XP002167794 *
DATABASE SWALL 1 May 1999 (1999-05-01), YUAN, Y. ET AL.: "MKP-1 LIKE PROTEIN TYROSINE PHOSPHATASE (EC 3.1.3.48) (MAP KINASE PHOSPHATASE 6).", XP002167617 *
DATABASE SWALL 1 May 2000 (2000-05-01), NAKAMURA, K. ET AL.: "PROTEIN PHOSPHATASE", XP002167687 *
DATABASE SWALL 1 November 1997 (1997-11-01), HARING, M.A. ET AL.: "DUAL SPECIFICITY PROTEIN PHOSPHATASE (EC 3.1.3.48) (EC 3.1.3.16)", XP002167613 *
DATABASE SWALL 1 November 1997 (1997-11-01), KIOSCHIS, P. ET AL.: "MYOTUBULARIN-RELATED PROTEIN 1 (FRAGMENT).", XP002167556 *
DATABASE SWALL 1 October 1996 (1996-10-01), ISHIBASHI, T. ET AL.: "DUAL SPECIFICITY PROTEIN PHOSPHATASE 3 (EC 3.1.3.48) (EC 3.1.3.16)", XP002167686 *
DATABASE SWALL 15 July 1999 (1999-07-15), CHEN, H. ET AL.: "Putative protein-tyrosine phosphatase TPTE (EC 3.1.3.48).", XP002167615 *
DATABASE SWISS PROT 1 February 1996 (1996-02-01), RAMEZANI RAD, M. ET AL.: "HYPOTHETICAL 80.2 KDA PROTEIN IN CPA2-NNF1 INTERGENIC REGION.", XP002167555 *
GUAN K ET AL: "The yeast open reading frame encoding a dual specificity phosphatase", TIBS TRENDS IN BIOCHEMICAL SCIENCES,ELSEVIER PUBLICATION, CAMBRIDGE,EN, vol. 18, no. 1, January 1993 (1993-01-01), pages 6, XP002145709, ISSN: 0968-0004 *
GUPTA RAJEEV ET AL: "Identification of a dual-specificity protein phosphatase that inactivates a MAP kinase from Arabidopsis.", PLANT JOURNAL, vol. 16, no. 5, December 1998 (1998-12-01), pages 581 - 589, XP002167745, ISSN: 0960-7412 *
KEYSE S M: "AN EMERGING FAMILY OF DUAL SPECIFICITY MAP KINASE PHOSPHATASES", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 1265, 1995, pages 152 - 160, XP000196716, ISSN: 0167-4889 *
LAPORTE JOCELYN ET AL: "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.", HUMAN MOLECULAR GENETICS, vol. 7, no. 11, October 1998 (1998-10-01), pages 1703 - 1712, XP001000442, ISSN: 0964-6906 *
LI, L. ET AL.: "A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast.", J. BIOL. CHEM, vol. 272, no. 47, 21 November 1997 (1997-11-21), pages 29403 - 29406, XP002159206 *
MUDA MARCO ET AL: "Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function", JOURNAL OF BIOLOGICAL CHEMISTRY,THE AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, INC.,,US, vol. 274, no. 34, 20 August 1999 (1999-08-20), pages 23991 - 23995, XP002145708, ISSN: 0021-9258 *
MUDA MARCO ET AL: "Molecular cloning and functional characterization of a novel mitogen-activated protein kinase phosphatase, MKP-4", JOURNAL OF BIOLOGICAL CHEMISTRY,THE AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, INC.,,US, vol. 272, no. 8, 1997, pages 5141 - 5151, XP002144712, ISSN: 0021-9258 *
NAKAMURA KOJI ET AL: "Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis", BIOCHEMICAL JOURNAL,THE BIOCHEMICAL SOCIETY, LONDON,GB, vol. 344, no. 3, 15 December 1999 (1999-12-15), pages 819 - 825, XP002144926, ISSN: 0264-6021 *
TANOUE TAKUJI ET AL: "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5", JOURNAL OF BIOLOGICAL CHEMISTRY,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD,US, vol. 274, no. 28, 9 July 1999 (1999-07-09), pages 19949 - 19956, XP002148678, ISSN: 0021-9258 *
THEODOSIOU A ET AL: "MKP5, A NEW MEMBER OF THE MAP KINASE PHOSPHATASE FAMILY, WHICH SELECTIVELY DEPHOSPHORYLATES STRESS-ACTIVATED KINASES", ONCOGENE,BASINGSTOKE, HANTS,GB, vol. 18, no. 50, 25 November 1999 (1999-11-25), pages 6981 - 6988, XP000946628, ISSN: 0950-9232 *

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