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WO2001012260A1 - Dispositif d'iontophorese destine a accroitre la penetration dans la peau de substances bioactives et/ou de supports de medicaments - Google Patents

Dispositif d'iontophorese destine a accroitre la penetration dans la peau de substances bioactives et/ou de supports de medicaments Download PDF

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Publication number
WO2001012260A1
WO2001012260A1 PCT/KR2000/000805 KR0000805W WO0112260A1 WO 2001012260 A1 WO2001012260 A1 WO 2001012260A1 KR 0000805 W KR0000805 W KR 0000805W WO 0112260 A1 WO0112260 A1 WO 0112260A1
Authority
WO
WIPO (PCT)
Prior art keywords
bioactive material
control unit
transducer
drug carrier
ionphoresor
Prior art date
Application number
PCT/KR2000/000805
Other languages
English (en)
Inventor
Young Wook Choi
Sang Kil Lee
Original Assignee
Young Wook Choi
Sang Kil Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Young Wook Choi, Sang Kil Lee filed Critical Young Wook Choi
Publication of WO2001012260A1 publication Critical patent/WO2001012260A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Definitions

  • Iontophoretic device to enhance skin penetration of bioactive material(s) and/or drug carrier(s)
  • This invention relates to an ionphoresor used for supply of electric
  • ionphoresor which can facilitate penetration of a bioactive material or a
  • bioactive material or a drug carrier encapsulating a bioactive material
  • bioactive material or a drug carrier may easily penetrate into the skin.
  • the ionphoresor of the present invention can maximize
  • a bioactive material including an
  • antioxidant like vitamin C exists in a charged form after ionization and a
  • drug carrier including liposomes encapsulates bioactive material(s) of either
  • hydrophilic or lipophilic properties and surface -charged as either negatively
  • Figure 1 is a block diagram illustrating structural arrangements of
  • Figure 2 is a conceptual sketch of the ionphoresor in actual use.
  • a topical preparation 110 drug carrier
  • transducer 1 transducer 2
  • an ionphoresor of the present invention is so designed as to
  • bioactive material or the drug carrier may penetrate easily into the skin by massaging with tender pressure to which a topical preparation, containing
  • an ionphoresor of the present invention characteristically
  • a power supply which provides electricity to each component ;
  • control unit which monitors and regulates functions of each component ;
  • a timer connected to the outlet of the current direction changer, which is operated by the signals from the control unit and controls time period for
  • transducer 1 two transducer, designated as transducer 1 and transducer 2, respectively,
  • a pressure sensor installed at one side of the tranducer 1, which is
  • control unit and prevents overcurrents being applied to the human body by opening the line between the current direction changer and the transducer
  • the ionphoresor of the present invention if a level of the signal from the pressure sensor is less than predetermined level. Furthermore, the ionphoresor of the present invention
  • a resistance sensor which senses resistance of a
  • ionphoresor of the present invention consists of a hydrophilic gel matrix in
  • a bioactive material or a charged drug carrier(for example, liposome) for example, liposome
  • encapsulating a bioactive material is homogeneously suspended.
  • a bioactive material refers to any material that can exist in a charged form after ionization and includes such exemplary materials as
  • whitening and antiageing agents such as arbutin, vitamin C and its
  • antiinflammatory drugs including ketoprofen, corticosteroids including
  • hydrocortisone and etc.
  • a charged drug carrier refers to any drug carrier that exists in the
  • vesicles and includes, e.g., liposome or niosome, and etc. Accordingly, no
  • bioactive materials which are frequently encapsulated into the carriers of the present invention include lipid- soluble vitamins like gamma oryzanol
  • anticancer agents like fluorouracils, antivirals like acyclovir, antihistamines
  • seeweed extracts including chlorelline, aloe extracts, and etc.
  • Figure 1 is a block diagram illustrating structural arrangements of the components of the ionphoresor of the present invention.
  • Figure 2 is a conceptual sketch of the ionphoresor in actual use.
  • the ionphoresor (200) of the present invention consists of such
  • the power supply (210) provides electricity to each component of the ionphoresor(200).
  • the control unit(220) monitors and controls functions of
  • each component of the system and especially regulates the voltage level by
  • timer(250 ) controls the timer(250 ) to allow flow of currents for a time
  • level of the transducer 1(270) is less than predetermined level.
  • the voltage adjuster(230 ) is operated by the signals from the
  • control unit(220) and connected to the outlet of the power supply(210) in
  • control unit(220) changes direction of the electric current supplied
  • transducers designated as transducer 1(270) and transducer 2(271), respectively, connected to each of two outlets of the current direction
  • transducer 2(271) installed on the outside of the
  • control unit(220 ) which a topical preparation (100) has been applied. Then, control unit(220 )
  • the human body by controlling the voltage adjuster(230). As illustrated in
  • control unit(220) will change the direction of current flow, control
  • the control unit(220) will control the skin determined by the pressure sensor(280).
  • the ionphoresor of the present invention offers
  • the ionphoresor of the present invention can maximize the effects
  • hydrophilic matrix a bioactive material including an antioxidant like
  • vitamin C exists in a charged form after ionization and a drug carrier including liposomes encapsulates bioactive material(s) of either hydrophilic

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Electrotherapy Devices (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un dispositif d'iontophorèse capable de maximiser les effets d'une substance bioactive ou d'un médicament en facilitant sa pénétration dans la peau, en raison d'une force de répulsion exercée entre les mêmes charges électriques, dans le cas de massage de la peau après application d'une préparation à usage local, formulée par dispersion homogène d'une substance bioactive ou d'un support de médicament dans une matrice hydrophile. La substance bioactive renfermant un antioxydant tel que la vitamine C se présente sous une forme chargée après ionisation, et un support de médicament comprenant des liposomes encapsule la/ ou les substances bioactives de propriétés soit hydrophiles, soit lipophiles, avec charges superficielles négatives ou positives.
PCT/KR2000/000805 1999-08-18 2000-07-26 Dispositif d'iontophorese destine a accroitre la penetration dans la peau de substances bioactives et/ou de supports de medicaments WO2001012260A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019990034155A KR20010018270A (ko) 1999-08-18 1999-08-18 전하공급 및 피부 맛사지 장치
KR1999/34155 1999-08-18

Publications (1)

Publication Number Publication Date
WO2001012260A1 true WO2001012260A1 (fr) 2001-02-22

Family

ID=19607698

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2000/000805 WO2001012260A1 (fr) 1999-08-18 2000-07-26 Dispositif d'iontophorese destine a accroitre la penetration dans la peau de substances bioactives et/ou de supports de medicaments

Country Status (2)

Country Link
KR (1) KR20010018270A (fr)
WO (1) WO2001012260A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094369A1 (fr) * 2001-05-25 2002-11-28 Nova Technical Research Gmbh Dispositif d'introduction de substances
WO2004073794A3 (fr) * 2003-02-19 2004-11-25 Yissum Res Dev Co Dispositifs, procedes et eponges pour administration iontophoretique de medicament
EP2319445A3 (fr) * 2001-05-17 2011-09-28 Transpharma Ltd. Application de courant monopolaire et bipolaire pour administration transdermique de médicaments et extraction d'analytes

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2866240B1 (fr) * 2004-02-16 2006-06-23 Oreal Kit de traitement comportant une structure composite a appliquer sur la peau et un excitateur electrique
KR101479058B1 (ko) * 2013-05-24 2015-01-07 주식회사 케이헬쓰웨어 이온토포레시스 투약 장치 및 투약 방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0309093A1 (fr) * 1987-08-27 1989-03-29 Hayashibara, Ken Dispositif pour électrothérapie à basse fréquence
US5090402A (en) * 1987-08-12 1992-02-25 L'oreal Massaging appliance
WO1997004731A2 (fr) * 1995-07-25 1997-02-13 Shmuel Pelz Appareil pour massages

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03218763A (ja) * 1988-12-12 1991-09-26 Shinatsushin Kurinitsuku:Kk マッサージ器
KR950008402Y1 (ko) * 1993-02-10 1995-10-09 황현배 휴대용 피부관리기
KR960014098B1 (ko) * 1993-12-17 1996-10-14 황현배 피부 관리기 및 그의 제어방법
KR960040387A (ko) * 1995-05-12 1996-12-17 김응정 피부 미용 맛사지기
KR970020075A (ko) * 1995-10-20 1997-05-28 이승진 이온 마사지기
KR200148926Y1 (ko) * 1997-02-15 1999-06-15 김홍대 이온 맛사지기

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5090402A (en) * 1987-08-12 1992-02-25 L'oreal Massaging appliance
EP0309093A1 (fr) * 1987-08-27 1989-03-29 Hayashibara, Ken Dispositif pour électrothérapie à basse fréquence
WO1997004731A2 (fr) * 1995-07-25 1997-02-13 Shmuel Pelz Appareil pour massages

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2319445A3 (fr) * 2001-05-17 2011-09-28 Transpharma Ltd. Application de courant monopolaire et bipolaire pour administration transdermique de médicaments et extraction d'analytes
WO2002094369A1 (fr) * 2001-05-25 2002-11-28 Nova Technical Research Gmbh Dispositif d'introduction de substances
WO2004073794A3 (fr) * 2003-02-19 2004-11-25 Yissum Res Dev Co Dispositifs, procedes et eponges pour administration iontophoretique de medicament
US8290579B2 (en) 2003-02-19 2012-10-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Device, methods and sponges for iontophoretic drug delivery

Also Published As

Publication number Publication date
KR20010018270A (ko) 2001-03-05

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