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WO2001008664A1 - Compositions a liberation controlee d'acide acetylsalicylique - Google Patents

Compositions a liberation controlee d'acide acetylsalicylique Download PDF

Info

Publication number
WO2001008664A1
WO2001008664A1 PCT/EP2000/007277 EP0007277W WO0108664A1 WO 2001008664 A1 WO2001008664 A1 WO 2001008664A1 EP 0007277 W EP0007277 W EP 0007277W WO 0108664 A1 WO0108664 A1 WO 0108664A1
Authority
WO
WIPO (PCT)
Prior art keywords
controlled
acetylsalicylic acid
release
release tablets
fatty
Prior art date
Application number
PCT/EP2000/007277
Other languages
English (en)
Inventor
Mauro Valenti
Flavio Fabiani
Original Assignee
Farmaceutici Formenti S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Formenti S.P.A. filed Critical Farmaceutici Formenti S.P.A.
Priority to AU66983/00A priority Critical patent/AU6698300A/en
Publication of WO2001008664A1 publication Critical patent/WO2001008664A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Definitions

  • Acetylsalicylic acid has been commercially available for a long time, as an analgesic and antipyretic drug, in the form of conventional pharmaceutical compositions such as tablets, drops, suppositories and the like.
  • ASA slow- or controlled- release formulations would be desirable, in that the number of administrations could be reduced while maintaining the plasma concentrations of the drug within the therapeutical range.
  • Each tablet contains :
  • Each tablet contains :
  • Each tablet contains :
  • Each tablet contains :
  • Each tablet contains :
  • Each tablet contains:
  • a microencapsulation process is carried out with acetylsalicylic acid and ethylcellulose starting from an organic solution.
  • the resulting product was mixed with the other excipients and tabletted.
  • the determination of the in vitro release was carried out as in the above Examples .
  • Each tablet contains :

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention porte sur des préparations orales solides à libération contrôlée d'acide acétylsalicylique (ASA) obtenues en soumettant le principe actif à une granulation par fusion avec un composé gras, puis en mélangeant le granulat résultant à un polymère hydrophile et à des excipients usuels.
PCT/EP2000/007277 1999-08-03 2000-07-28 Compositions a liberation controlee d'acide acetylsalicylique WO2001008664A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU66983/00A AU6698300A (en) 1999-08-03 2000-07-28 Acetylsalicylic acid controlled-release compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI001738A IT1313590B1 (it) 1999-08-03 1999-08-03 Composizioni a rilascio controllato di acido acetilsalicilico.
ITMI99A001738 1999-08-03

Publications (1)

Publication Number Publication Date
WO2001008664A1 true WO2001008664A1 (fr) 2001-02-08

Family

ID=11383488

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/007277 WO2001008664A1 (fr) 1999-08-03 2000-07-28 Compositions a liberation controlee d'acide acetylsalicylique

Country Status (3)

Country Link
AU (1) AU6698300A (fr)
IT (1) IT1313590B1 (fr)
WO (1) WO2001008664A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0384514A2 (fr) * 1989-02-21 1990-08-29 Norwich Eaton Pharmaceuticals, Inc. Comprimé à double effet
WO1993018755A1 (fr) * 1992-03-25 1993-09-30 Depomed Systems, Incorporated Formes galeniques de medicament oral a liberation prolongee a base de cellulose a substitution alkyle
WO1996041617A1 (fr) * 1995-06-09 1996-12-27 Apr Applied Pharma Research S.A. Forme pharmaceutique solide a usage par voie orale

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0384514A2 (fr) * 1989-02-21 1990-08-29 Norwich Eaton Pharmaceuticals, Inc. Comprimé à double effet
WO1993018755A1 (fr) * 1992-03-25 1993-09-30 Depomed Systems, Incorporated Formes galeniques de medicament oral a liberation prolongee a base de cellulose a substitution alkyle
WO1996041617A1 (fr) * 1995-06-09 1996-12-27 Apr Applied Pharma Research S.A. Forme pharmaceutique solide a usage par voie orale

Also Published As

Publication number Publication date
IT1313590B1 (it) 2002-09-09
AU6698300A (en) 2001-02-19
ITMI991738A0 (it) 1999-08-03
ITMI991738A1 (it) 2001-02-03

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