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WO2001006005A3 - Diagnostic method comprising wt1 sequences - Google Patents

Diagnostic method comprising wt1 sequences Download PDF

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Publication number
WO2001006005A3
WO2001006005A3 PCT/GB2000/002741 GB0002741W WO0106005A3 WO 2001006005 A3 WO2001006005 A3 WO 2001006005A3 GB 0002741 W GB0002741 W GB 0002741W WO 0106005 A3 WO0106005 A3 WO 0106005A3
Authority
WO
WIPO (PCT)
Prior art keywords
sequences
diagnostic method
cancer
long term
term prognosis
Prior art date
Application number
PCT/GB2000/002741
Other languages
French (fr)
Other versions
WO2001006005A2 (en
Inventor
Karim Malik
Keith Brown
Original Assignee
Univ Bristol
Karim Malik
Keith Brown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9916669.6A external-priority patent/GB9916669D0/en
Priority claimed from GBGB9926293.3A external-priority patent/GB9926293D0/en
Application filed by Univ Bristol, Karim Malik, Keith Brown filed Critical Univ Bristol
Priority to EP20000946122 priority Critical patent/EP1200623A2/en
Priority to JP2001511214A priority patent/JP2003505035A/en
Priority to AU60006/00A priority patent/AU6000600A/en
Publication of WO2001006005A2 publication Critical patent/WO2001006005A2/en
Publication of WO2001006005A3 publication Critical patent/WO2001006005A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention provides a method of detection of cancer in a subject by detecting altered genomic imprinting and a method determining the long term prognosis of a subject diagnosed with cancer, using the differential methylation state of a specific nucleotide sequence to predict the long term prognosis.
PCT/GB2000/002741 1999-07-15 2000-07-17 Diagnostic method comprising wt1 sequences WO2001006005A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP20000946122 EP1200623A2 (en) 1999-07-15 2000-07-17 Diagnostic method comprising wt1 sequences
JP2001511214A JP2003505035A (en) 1999-07-15 2000-07-17 Diagnosis method
AU60006/00A AU6000600A (en) 1999-07-15 2000-07-17 Diagnostic method

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9916669.6 1999-07-15
GBGB9916669.6A GB9916669D0 (en) 1999-07-15 1999-07-15 Diagnostic method
GB9926293.3 1999-11-05
GBGB9926293.3A GB9926293D0 (en) 1999-11-05 1999-11-05 Diagnostic method

Publications (2)

Publication Number Publication Date
WO2001006005A2 WO2001006005A2 (en) 2001-01-25
WO2001006005A3 true WO2001006005A3 (en) 2001-05-25

Family

ID=26315771

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/002741 WO2001006005A2 (en) 1999-07-15 2000-07-17 Diagnostic method comprising wt1 sequences

Country Status (4)

Country Link
EP (1) EP1200623A2 (en)
JP (1) JP2003505035A (en)
AU (1) AU6000600A (en)
WO (1) WO2001006005A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2421102A1 (en) 2000-08-25 2002-03-07 Lovelace Respiratory Research Institute Nested methylation-specific polymerase chain reaction cancer detection method
WO2003062441A1 (en) * 2002-01-18 2003-07-31 Genzyme Corporation Methods for fetal dna detection and allele quantitation
GB0209776D0 (en) * 2002-04-29 2002-06-05 Univ Bristol Diagnostic method
FR2854903A1 (en) * 2003-05-13 2004-11-19 Centre Nat Rech Scient USE OF LOCI BAGE (B MELANOMA ANTIGENS) AS TUMOR MARKERS
WO2016041010A1 (en) 2014-09-15 2016-03-24 Garvan Institute Of Medical Research Methods for diagnosis, prognosis and monitoring of breast cancer and reagents therefor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5350840A (en) * 1989-11-13 1994-09-27 Massachusetts Institute Of Technology Localization and characterization of the Wilms' tumor gene
WO1999001580A1 (en) * 1997-07-03 1999-01-14 Case Western Reserve University Compositions and methods for detection of genomic imprinting disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5350840A (en) * 1989-11-13 1994-09-27 Massachusetts Institute Of Technology Localization and characterization of the Wilms' tumor gene
WO1999001580A1 (en) * 1997-07-03 1999-01-14 Case Western Reserve University Compositions and methods for detection of genomic imprinting disorders

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
CAMPBELL C E ET AL.: "Antisense transcripts and protein binding motifs within the Wilms tumour (WT1) locus", ONCOGENE, vol. 9, 1994, pages 583 - 595, XP000981271 *
FEINBERG A P: "Imprinting of a genomic domain of 11p15 and loss of imprinting in cancer: an introduction", CANCER RESEARCH, vol. 59, 1999, pages 1743s - 1746s, XP002161164 *
GESSLER M AND BRUNS G A P: "Sequence of the WT1 upstream region including the Wit-1 gene", GENOMICS, vol. 17, 1993, pages 499 - 501, XP000981270 *
HILTUNEN M O ET AL.: "Hypermethylation of the WT1 and calcitonin gene promoter regions at chromosome 11p in human colorectal cancer", BRITISH JOURNAL OF CANCER, vol. 76, no. 9, 1997, pages 1124 - 1130, XP000979772 *
HUANG T H-M ET AL.: "Identification of DNA methylation markers for human breast carcinomas using the methylation-sensitive restriction fingerprinting technique", CANCER RESEARCH, vol. 57, 1997, pages 1030 - 1034, XP002161163 *
LAUX D E ET AL.: "Hypermethylation of the Wilms' tumor suppressor gene CpG island in human breast carcinomas", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 38, 1997, pages A1195, XP000979879 *
MALIK K ET AL.: "Identification and differential methylation of the WT1 antisense regulatory region and relaxation of imprinting in Wilms' tumor", CANCER RESEARCH, vol. 60, 2000, pages 2356 - 2360, XP002161165 *
MALIK K T A ET AL: "IDENTIFICATION OF AN ANTISENSE WT1 PROMOTER IN INTRON 1: IMPLICATIONS FOR WT1 REGULATION", ONCOGENE,GB,BASINGSTOKE, HANTS, vol. 11, 1995, pages 1589 - 1595, XP002910386, ISSN: 0950-9232 *
MOORWOOD K ET AL.: "Antisense WT1 transcription paralleles sense mRNA and protein expression in fetal kidney and can elevate protein levels in vitro", JOURNAL OF PATHOLOGY, vol. 185, 1998, pages 352 - 359, XP000981275 *
MOORWOOD K ET AL.: "Definition of a novel negative regulatory element of the WT1 antisense promotor", ANTICANCER RESEARCH, vol. 18, no. 6C, 1998, pages 4909 - 4910, XP000979768 *
MOULTON T ET AL.: "Genomic imprinting and Wilms' tumor", MEDICAL AND PEDIATRIC ONCOLOGY, vol. 27, 1996, pages 476 - 483, XP000979774 *
TYCKO B: "DNA METHYLATION IN GENOMIC IMPRINTING", MUTATION RESEARCH,NL,AMSTERDAM, vol. 386, no. 2, 1997, pages 131 - 140, XP002070305, ISSN: 0027-5107 *

Also Published As

Publication number Publication date
EP1200623A2 (en) 2002-05-02
WO2001006005A2 (en) 2001-01-25
AU6000600A (en) 2001-02-05
JP2003505035A (en) 2003-02-12

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