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WO2001000667A3 - Anti-thrombin peptide from anopheles albimanus salivary gland - Google Patents

Anti-thrombin peptide from anopheles albimanus salivary gland Download PDF

Info

Publication number
WO2001000667A3
WO2001000667A3 PCT/US2000/018078 US0018078W WO0100667A3 WO 2001000667 A3 WO2001000667 A3 WO 2001000667A3 US 0018078 W US0018078 W US 0018078W WO 0100667 A3 WO0100667 A3 WO 0100667A3
Authority
WO
WIPO (PCT)
Prior art keywords
thrombin peptide
salivary gland
anopheles albimanus
anophelin
disclosed
Prior art date
Application number
PCT/US2000/018078
Other languages
French (fr)
Other versions
WO2001000667A9 (en
WO2001000667A2 (en
Inventor
Jesus G Valenzuela
Jose Ribeiro
Ivo Francischetti
Original Assignee
Us Health
Jesus G Valenzuela
Jose Ribeiro
Ivo Francischetti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health, Jesus G Valenzuela, Jose Ribeiro, Ivo Francischetti filed Critical Us Health
Priority to AU59030/00A priority Critical patent/AU5903000A/en
Publication of WO2001000667A2 publication Critical patent/WO2001000667A2/en
Publication of WO2001000667A3 publication Critical patent/WO2001000667A3/en
Publication of WO2001000667A9 publication Critical patent/WO2001000667A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The DNA and amino acid sequences are disclosed for a novel anti-thrombin peptide, anophelin, one embodiment of which was isolated form the salivary glands of the mosquito Anopheles albimanus. Also disclosed are anti-thrombotic therapeutic applications of anophelin.
PCT/US2000/018078 1999-06-29 2000-06-29 Anti-thrombin peptide from anopheles albimanus salivary gland WO2001000667A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU59030/00A AU5903000A (en) 1999-06-29 2000-06-29 Novel anti-thrombin peptide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14142399P 1999-06-29 1999-06-29
US60/141,423 1999-06-29

Publications (3)

Publication Number Publication Date
WO2001000667A2 WO2001000667A2 (en) 2001-01-04
WO2001000667A3 true WO2001000667A3 (en) 2001-05-25
WO2001000667A9 WO2001000667A9 (en) 2002-08-01

Family

ID=22495626

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/018078 WO2001000667A2 (en) 1999-06-29 2000-06-29 Anti-thrombin peptide from anopheles albimanus salivary gland

Country Status (2)

Country Link
AU (1) AU5903000A (en)
WO (1) WO2001000667A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201121513D0 (en) 2011-12-14 2012-01-25 Cambridge Entpr Ltd Thrombin-binding antibody molecules and uses thereof
US9518128B2 (en) 2011-12-14 2016-12-13 Janssen Pharmaceuticals, Inc. Thrombin-binding antibody molecules
EP3555116A4 (en) 2016-12-16 2020-07-22 The University Of Sydney THROMBINE INHIBITORS FOR TREATING STROKE AND RELATED COAGULATIVE DISORDERS
BR102017005783A2 (en) * 2017-03-21 2018-10-02 Fund Butantan process for obtaining esculptin and fragments thereof, recombinant sculptin and its uses
WO2019030706A1 (en) 2017-08-10 2019-02-14 Janssen Pharmaceutica Nv Anti-thrombin antibody molecules and methods for use in orthopedic surgery
WO2019035055A1 (en) 2017-08-16 2019-02-21 Janssen Pharmaceutica Nv Anti-thrombin antibody molecules and methods for use with antiplatelet agents
KR102789819B1 (en) * 2021-10-21 2025-03-31 중앙대학교 산학협력단 Novel peptide for specific detection of thrombin and Uses Thereof
KR102734588B1 (en) * 2021-10-21 2024-11-25 중앙대학교 산학협력단 Novel peptide for specific detection of thrombin

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0541507A2 (en) * 1991-11-04 1993-05-12 IMMUNO Aktiengesellschaft Thrombin and method for its production

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0541507A2 (en) * 1991-11-04 1993-05-12 IMMUNO Aktiengesellschaft Thrombin and method for its production

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ARCA BRUNO ET AL: "Trapping cDNAs encoding secreted proteins from the salivary glands of the malaria vector Anopheles gambiae.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 96, no. 4, 16 February 1999 (1999-02-16), Feb. 16, 1999, pages 1516 - 1521, XP002159261, ISSN: 0027-8424 *
FRANCISCHETTI IVO M B ET AL: "Anophelin: Kinetics and mechanism of thrombin inhibition.", BIOCHEMISTRY, vol. 38, no. 50, 14 December 1999 (1999-12-14), pages 16678 - 16685, XP002159263, ISSN: 0006-2960 *
RIBEIRO JOSE M C ET AL: "Purification and cloning of the salivary peroxidase/catechol oxidase of the mosquito Anopheles albimanus.", JOURNAL OF EXPERIMENTAL BIOLOGY, vol. 202, no. 7, April 1999 (1999-04-01), pages 809 - 816, XP002159260, ISSN: 0022-0949 *
STARK KENNETH R ET AL: "Salivary gland anticoagulants in culicine and anopheline mosquitoes (Diptera: Culicidae).", JOURNAL OF MEDICAL ENTOMOLOGY, vol. 33, no. 4, 1996, pages 645 - 650, XP000979478, ISSN: 0022-2585 *
VALENZUELA, J.G ET AL.: "Purification, cloning, and synthesis of a novel salivary anti-thrombin from the mosquito Anopheles albimanus.", BIOCHEMISTRY, vol. 38, 31 August 1999 (1999-08-31), pages 11209 - 15, XP002159262 *
WAIDHET-KOUADIO PHILOMENE ET AL: "Purification and characterization of a thrombin inhibitor from the salivary glands of a malarial vector mosquito, Anopheles stephensi.", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1381, no. 2, 23 July 1998 (1998-07-23), pages 227 - 233, XP000979497, ISSN: 0006-3002 *

Also Published As

Publication number Publication date
AU5903000A (en) 2001-01-31
WO2001000667A9 (en) 2002-08-01
WO2001000667A2 (en) 2001-01-04

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