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WO2001098359A3 - Cyr61 as a target for treatment and diagnosis of breast cancer - Google Patents

Cyr61 as a target for treatment and diagnosis of breast cancer Download PDF

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Publication number
WO2001098359A3
WO2001098359A3 PCT/US2001/019823 US0119823W WO0198359A3 WO 2001098359 A3 WO2001098359 A3 WO 2001098359A3 US 0119823 W US0119823 W US 0119823W WO 0198359 A3 WO0198359 A3 WO 0198359A3
Authority
WO
WIPO (PCT)
Prior art keywords
cyr61
methods
breast cancer
diagnosis
target
Prior art date
Application number
PCT/US2001/019823
Other languages
French (fr)
Other versions
WO2001098359A2 (en
Inventor
Deepak Sampath
Zhiming Zhang
Richard Winneker
Original Assignee
American Home Prod
Deepak Sampath
Zhiming Zhang
Richard Winneker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod, Deepak Sampath, Zhiming Zhang, Richard Winneker filed Critical American Home Prod
Priority to US10/312,459 priority Critical patent/US20040086504A1/en
Priority to AU2001271365A priority patent/AU2001271365A1/en
Publication of WO2001098359A2 publication Critical patent/WO2001098359A2/en
Publication of WO2001098359A3 publication Critical patent/WO2001098359A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention contemplates methods of preventing or inhibiting breast cancer cell proliferation, compounds and compositions that interfere with or block sex steroid or growth factor binding to and induction of the Cyr61 gene and methods of screening ligands that regulate Cyr61 protein expression. The present invention further contemplates compounds that block Cyr61 activity. The invention further relates to methods of diagnosing and staging patients with cancers associated with an upregulation of Cyr61 expression. Assay methods and kits are also disclosed.
PCT/US2001/019823 2000-06-21 2001-06-21 Cyr61 as a target for treatment and diagnosis of breast cancer WO2001098359A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/312,459 US20040086504A1 (en) 2001-06-21 2001-06-21 Cyr61 as a target for treatment and diagnosis of breast cancer
AU2001271365A AU2001271365A1 (en) 2000-06-21 2001-06-21 Cyr61 as a target for treatment and diagnosis of breast cancer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21318200P 2000-06-21 2000-06-21
US60/213,182 2000-06-21
US29151001P 2001-05-16 2001-05-16
US60/291,510 2001-05-16

Publications (2)

Publication Number Publication Date
WO2001098359A2 WO2001098359A2 (en) 2001-12-27
WO2001098359A3 true WO2001098359A3 (en) 2002-06-06

Family

ID=26907838

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/019823 WO2001098359A2 (en) 2000-06-21 2001-06-21 Cyr61 as a target for treatment and diagnosis of breast cancer

Country Status (2)

Country Link
AU (1) AU2001271365A1 (en)
WO (1) WO2001098359A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003082258A1 (en) * 2002-03-25 2003-10-09 The Government Of The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Use of cyr61 for the diagnosis of acute renal failure
WO2004091383A2 (en) 2003-04-01 2004-10-28 Genzyme Corporation Breast endothelial cell expression patterns
JP2004315480A (en) * 2003-04-21 2004-11-11 Yoshiyuki Kakehi Medicinal composition for prostate disease treatment
US7056674B2 (en) * 2003-06-24 2006-06-06 Genomic Health, Inc. Prediction of likelihood of cancer recurrence
WO2006089212A2 (en) * 2005-02-18 2006-08-24 Children's Medical Center Corporation Cyr61 as a biomarker for diagnosis and prognosis of cancers of epithelial origin
TW201102086A (en) 2009-06-04 2011-01-16 Hoffmann La Roche Antibodies against human CCN1 and uses thereof
EP2540742A4 (en) * 2009-12-04 2014-02-12 Shanghai Inst Of Immunology Anti-cyr61 protein monoclonal antibodies and uses thereof
WO2011107590A1 (en) 2010-03-04 2011-09-09 Wolfgang Poller Cnn1 (cyr61) for prevention and therapy of inflammatory disease
DE102010010288A1 (en) 2010-03-04 2011-09-08 Wolfgang Poller Medicament, useful to prevent or treat e.g. ulcerative colitis, comprises polypeptide sequences of cysteine-rich protein 61 (CCN1) and/or cyclic arginine-glycine-aspartic acid peptide, or nucleic acid encoding polypeptide sequence of CCN1

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997033995A2 (en) * 1996-03-15 1997-09-18 Munin Corporation Extracellular matrix signalling molecules
WO2001005353A2 (en) * 1999-07-14 2001-01-25 Novo Nordisk A/S USE OF FVIIa OR A TISSUE FACTOR ANTAGONIST FOR REGULATING GENE EXPRESSION AND CELL MIGRATION OR CHEMOTAXIS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997033995A2 (en) * 1996-03-15 1997-09-18 Munin Corporation Extracellular matrix signalling molecules
WO2001005353A2 (en) * 1999-07-14 2001-01-25 Novo Nordisk A/S USE OF FVIIa OR A TISSUE FACTOR ANTAGONIST FOR REGULATING GENE EXPRESSION AND CELL MIGRATION OR CHEMOTAXIS

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
D. SAMPATH ET AL.: "Cyr61, a member of the CCN family, is required for MCF-7 cell proliferation: Regulation by 17beta-estradiol and overexpression in human breast cancer.", ENDOCRINOLOGY, vol. 142, no. 6, June 2001 (2001-06-01), Philadelphia, PA, USA, pages 2540 - 2548, XP001053141 *
D. XIE ET AL.: "CYR61, an angiogenic inducer, is over-expressed and estrogen inducible in breast cancer.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 41, March 2000 (2000-03-01), New York, NY, USA, pages 338, XP002194654 *
M. TSAI ET AL.: "Involvement of Cyr61, a ligand for an integrin, in breast cancer progression.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 40, March 1999 (1999-03-01), New York, NY, USA, pages 560, XP002194653 *
P. JAY ET AL.: "The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p.", ONCOGENE, vol. 14, 10 April 1997 (1997-04-10), pages 1753 - 1757, XP000619714 *

Also Published As

Publication number Publication date
WO2001098359A2 (en) 2001-12-27
AU2001271365A1 (en) 2002-01-02

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