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WO2001094377A3 - Procedes et substrats peptidiques de metalloproteinase - Google Patents

Procedes et substrats peptidiques de metalloproteinase Download PDF

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Publication number
WO2001094377A3
WO2001094377A3 PCT/US2001/018244 US0118244W WO0194377A3 WO 2001094377 A3 WO2001094377 A3 WO 2001094377A3 US 0118244 W US0118244 W US 0118244W WO 0194377 A3 WO0194377 A3 WO 0194377A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
peptide substrates
metalloprotease
adam15
adam8
Prior art date
Application number
PCT/US2001/018244
Other languages
English (en)
Other versions
WO2001094377A2 (fr
Inventor
Anne Fourie
Lars Karlsson
Robin Thurmond
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Priority to AU6975001A priority Critical patent/AU6975001A/xx
Priority to JP2002501925A priority patent/JP2006515265A/ja
Priority to MXPA02012030A priority patent/MXPA02012030A/es
Priority to CA002414061A priority patent/CA2414061A1/fr
Priority to IL15327601A priority patent/IL153276A0/xx
Priority to AU2001269750A priority patent/AU2001269750B2/en
Priority to EP01948280A priority patent/EP1506312A4/fr
Priority to BRPI0111983-4A priority patent/BR0111983A/pt
Publication of WO2001094377A2 publication Critical patent/WO2001094377A2/fr
Publication of WO2001094377A3 publication Critical patent/WO2001094377A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne des substrats peptidiques naturels ou synthétiques, des métalloprotéinases, ADAM8, ADAM15 et DMC-L. Elle concerne également des procédés mettant en application ces peptides afin de rechercher des agents pharmaceutiques modulant ces protéinases.
PCT/US2001/018244 2000-06-06 2001-06-05 Procedes et substrats peptidiques de metalloproteinase WO2001094377A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU6975001A AU6975001A (en) 2000-06-06 2001-06-05 Metalloprotease peptide substrates and methods
JP2002501925A JP2006515265A (ja) 2000-06-06 2001-06-05 メタロプロテアーゼのペプチド基質および方法
MXPA02012030A MXPA02012030A (es) 2000-06-06 2001-06-05 Sustratos peptidicos de metalorpoteasas y metodos.
CA002414061A CA2414061A1 (fr) 2000-06-06 2001-06-05 Procedes et substrats peptidiques de metalloproteinase
IL15327601A IL153276A0 (en) 2000-06-06 2001-06-05 Metalloprotease peptide substrates and methods
AU2001269750A AU2001269750B2 (en) 2000-06-06 2001-06-05 Metalloprotease peptide substrates and methods
EP01948280A EP1506312A4 (fr) 2000-06-06 2001-06-05 Procedes et substrats peptidiques de metalloproteinase
BRPI0111983-4A BR0111983A (pt) 2000-06-06 2001-06-05 métodos e substratos de peptìdeo de metaloprotease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/588,417 2000-06-06
US09/588,417 US6458552B1 (en) 2000-06-06 2000-06-06 Metalloprotease peptide substrates and methods

Publications (2)

Publication Number Publication Date
WO2001094377A2 WO2001094377A2 (fr) 2001-12-13
WO2001094377A3 true WO2001094377A3 (fr) 2004-10-14

Family

ID=24353751

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/018244 WO2001094377A2 (fr) 2000-06-06 2001-06-05 Procedes et substrats peptidiques de metalloproteinase

Country Status (10)

Country Link
US (1) US6458552B1 (fr)
EP (1) EP1506312A4 (fr)
JP (1) JP2006515265A (fr)
AU (2) AU6975001A (fr)
BR (1) BR0111983A (fr)
CA (1) CA2414061A1 (fr)
IL (1) IL153276A0 (fr)
MX (1) MXPA02012030A (fr)
WO (1) WO2001094377A2 (fr)
ZA (1) ZA200300033B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2355055T3 (es) * 1999-07-28 2011-03-22 Genentech, Inc. Composiciones y procedimientos para el tratamiento de tumores.
KR20040088059A (ko) * 2002-02-05 2004-10-15 와이어쓰 절두된 아그레카나제 분자
US7157567B2 (en) * 2002-02-20 2007-01-02 Astellas Pharma, Inc. Polypeptide
EP1525307A2 (fr) * 2002-07-29 2005-04-27 Wyeth Molecules adamts4 modifiees et procede d'utilisation de ces molecules
GB2453589A (en) 2007-10-12 2009-04-15 King S College London Protease inhibition
CN103561771B (zh) 2011-03-17 2019-01-04 伯明翰大学 重新定向的免疫治疗

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0867694A (ja) * 1994-06-21 1996-03-12 Suntory Ltd ペプチド基質並びにこれを用いるプロテイナーゼａ活性およびビールの泡安定性の測定方法
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
US20020081692A1 (en) * 1998-02-04 2002-06-27 Roy A. Black Crystalline tnf-alpha-converting enzyne and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK281544B6 (sk) * 1994-01-20 2001-04-09 British Biotech Pharmaceuticals Limited Inhibítory metaloproteinázy, farmaceutické prostriedky s ich obsahom, spôsob ich výroby a ich použitie
US5891661A (en) * 1996-03-26 1999-04-06 Merck & Co., Inc. Low temperature assay for active HCMV protease in dimeric form
EP0900272A2 (fr) 1996-03-26 1999-03-10 Glaxo Group Limited Convertase du facteur alpha de necrose tumorale
AU4721901A (en) * 2000-02-25 2001-09-03 Immunex Corp Integrin antagonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
JPH0867694A (ja) * 1994-06-21 1996-03-12 Suntory Ltd ペプチド基質並びにこれを用いるプロテイナーゼａ活性およびビールの泡安定性の測定方法
US20020081692A1 (en) * 1998-02-04 2002-06-27 Roy A. Black Crystalline tnf-alpha-converting enzyne and uses thereof

Also Published As

Publication number Publication date
IL153276A0 (en) 2003-07-06
CA2414061A1 (fr) 2001-12-13
JP2006515265A (ja) 2006-05-25
US6458552B1 (en) 2002-10-01
EP1506312A4 (fr) 2005-05-04
WO2001094377A2 (fr) 2001-12-13
MXPA02012030A (es) 2004-08-19
AU6975001A (en) 2001-12-17
EP1506312A2 (fr) 2005-02-16
ZA200300033B (en) 2005-05-09
BR0111983A (pt) 2006-05-09
AU2001269750B2 (en) 2006-08-03

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