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WO2001090321A3 - 55158, a novel human carbonic anhydrase and uses thereof - Google Patents

55158, a novel human carbonic anhydrase and uses thereof Download PDF

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Publication number
WO2001090321A3
WO2001090321A3 PCT/US2001/016270 US0116270W WO0190321A3 WO 2001090321 A3 WO2001090321 A3 WO 2001090321A3 US 0116270 W US0116270 W US 0116270W WO 0190321 A3 WO0190321 A3 WO 0190321A3
Authority
WO
WIPO (PCT)
Prior art keywords
cah
nucleic acid
acid molecules
carbonic anhydrase
expression vectors
Prior art date
Application number
PCT/US2001/016270
Other languages
French (fr)
Other versions
WO2001090321A2 (en
Inventor
Rosana Kapeller-Libermann
Original Assignee
Millennium Pharm Inc
Kapeller Libermann Rosana
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc, Kapeller Libermann Rosana filed Critical Millennium Pharm Inc
Priority to AU2001264715A priority Critical patent/AU2001264715A1/en
Publication of WO2001090321A2 publication Critical patent/WO2001090321A2/en
Publication of WO2001090321A3 publication Critical patent/WO2001090321A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides isolated nucleic acid molecules, designated CAH nucleic acid molecules, which encode novel CAH-related carbonic anhydrase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CAH nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a CAH gene has been introduced or disrupted. The invention still further provides isolated CAH proteins, fusion proteins, antigenic peptides and anti-CAH antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
PCT/US2001/016270 2000-05-19 2001-05-18 55158, a novel human carbonic anhydrase and uses thereof WO2001090321A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001264715A AU2001264715A1 (en) 2000-05-19 2001-05-18 55158, a novel human carbonic anhydrase and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20544900P 2000-05-19 2000-05-19
US60/205,449 2000-05-19

Publications (2)

Publication Number Publication Date
WO2001090321A2 WO2001090321A2 (en) 2001-11-29
WO2001090321A3 true WO2001090321A3 (en) 2002-05-10

Family

ID=22762234

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/016270 WO2001090321A2 (en) 2000-05-19 2001-05-18 55158, a novel human carbonic anhydrase and uses thereof

Country Status (2)

Country Link
AU (1) AU2001264715A1 (en)
WO (1) WO2001090321A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2385982A4 (en) * 2009-01-09 2013-05-29 Codexis Inc Carbonic anhydrase polypeptides and uses thereof
CA2803952C (en) 2010-06-30 2020-03-24 Codexis, Inc. Highly stable beta-class carbonic anhydrases useful in carbon capture systems
US8354261B2 (en) 2010-06-30 2013-01-15 Codexis, Inc. Highly stable β-class carbonic anhydrases useful in carbon capture systems
US8354262B2 (en) 2010-06-30 2013-01-15 Codexis, Inc. Chemically modified carbonic anhydrases useful in carbon capture systems

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972684A (en) * 1997-11-25 1999-10-26 Incyte Pharmaceuticals, Inc. Carbonic anhydrase VIII
WO2001064834A2 (en) * 2000-02-28 2001-09-07 Hyseq, Inc. Novel nucleic acids and polypeptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972684A (en) * 1997-11-25 1999-10-26 Incyte Pharmaceuticals, Inc. Carbonic anhydrase VIII
WO2001064834A2 (en) * 2000-02-28 2001-09-07 Hyseq, Inc. Novel nucleic acids and polypeptides

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BELLINGHAM JAMES ET AL: "Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 253, no. 2, 18 December 1998 (1998-12-18), pages 364 - 367, XP002191045, ISSN: 0006-291X *
FUJIKAWA-ADACHI K ET AL: "cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI", BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, ELSEVIER, AMSTERDAM,, NL, vol. 1431, no. 2, 18 May 1999 (1999-05-18), pages 518 - 524, XP004278704, ISSN: 0167-4838 *
HEWETT-EMMETT DAVID ET AL: "Functional diversity, conservation, and convergence in the evolution of the alpha-, beta-, and gamma-carbonic anhydrase gene families.", MOLECULAR PHYLOGENETICS AND EVOLUTION, vol. 5, no. 1, 1996, pages 50 - 77, XP001056423, ISSN: 1055-7903 *
KLEIDERLEIN JOHN J ET AL: "CCG repeats in cDNAs from human brain.", HUMAN GENETICS, vol. 103, no. 6, December 1998 (1998-12-01), pages 666 - 673, XP000907453, ISSN: 0340-6717 *
LOVEJOY DAVID A ET AL: "Evolutionarily conserved, "acatalytic" carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: The human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3.", GENOMICS, vol. 54, no. 3, 15 December 1998 (1998-12-15), pages 484 - 493, XP001056419, ISSN: 0888-7543 *
OKAMOTO N ET AL: "cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain", BIOCHIMICA ET BIOPHYSICA ACTA. GENE STRUCTURE AND EXPRESSION, ELSEVIER, AMSTERDAM, NL, vol. 1518, no. 3, 16 April 2001 (2001-04-16), pages 311 - 316, XP004235052, ISSN: 0167-4781 *
SLY W S ET AL: "HUMAN CARBONIC ANHYDRASES AND CARBONIC ANHYDRASE DEFICIENCIES", ANNUAL REVIEW OF BIOCHEMISTRY, PALTO ALTO, CA, US, vol. 64, 1995, pages 375 - 401, XP000943172, ISSN: 0066-4154 *

Also Published As

Publication number Publication date
WO2001090321A2 (en) 2001-11-29
AU2001264715A1 (en) 2001-12-03

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